Humanpapilloma Virus

2. Human Papillomavirus ( HPV )
‫الفيروس‬
‫الحليمومي‬
‫البشري‬
Non Enveloped DNA
‫من‬ ‫أكثر‬ ‫يوجد‬
100
‫نوع‬
‫الفيروسات‬ ‫تنقل‬
‫الحليمومية‬
‫أو‬ ، ‫الذاتية‬ ‫العدوى‬ ‫أو‬ ، ‫المباشر‬ ‫التماس‬ ‫بواسطة‬
‫بالطريق‬
‫الجنسي‬
Transmission of human papillomavirus occurs by direct
contact, by autoinoculation
،
or sexual.

3. Transmission of HPV infection requires
direct contact with infected individuals
(for example, sexual contact) or with contaminated
surfaces (fomites) such as bathroom floors.
HPV can also be transmitted from mother to infant
during passage down the birth canal.
canal.

4. ‫ت‬ ‫أن‬ ‫ويمكن‬ ، ‫الخاليا‬ ‫تكاثر‬ ‫تنشيط‬ ‫خاصة‬ ‫الفيروسات‬ ‫هذه‬ ‫تملك‬
‫سبب‬
‫تنشؤات‬
(
‫أورام‬
)
‫خبيثة‬ ‫أو‬ ‫حميدة‬
Pathogenesis
its specificity for epithelial cells and its dependence
on the differentiation state of the epithelial host cell.
_ Epithelial cell Hyperplasia Mostly Benign
- (HPV-type 16 &18) 70% in malignancy

5. Clinical Manifestations
Human Papillomavirus can cause : ‫تسبب‬ ‫أن‬ ‫يمكن‬
common warts, anogenital warts
‫الثآليل‬
‫العادية‬ ‫الشائعة‬
‫والثآليل‬
‫التناسلية‬
Oral squamous and warts.
‫الثآليل‬
‫والتنبتات‬
‫الفموية‬
some strains of Human Papillomavirus are associated
with cervical cancer .
‫بحدوث‬ ‫مرتبطة‬ ‫الفيروس‬ ‫من‬ ‫األنماط‬ ‫بعض‬
‫سرطانة‬
‫الرحم‬ ‫عنق‬

7. Common warts

12. Diagnosis ‫التشخيص‬
cutaneous warts generally involves no more than visual
inspection (Diagnosed clinically).
1) determine whether HPV is present in abnormal tissue
recovered by biopsy or cervical swab and
2) whether the HPV type detected is one considered a
high risk for progression to malignancy
Typing the virus is by quantitative DNA amplification
techniques (PCR) (polymerase chain reaction),

13. Treatment :-
Liquid nitrogen (Cryotherapy) ‫النيتروجين‬ ‫سائل‬
Laser vaporization ‫الليزر‬ ‫أشعه‬
Surgical removing ‫جراحي‬ ‫استئصال‬
cytotoxic chemical (trichloroacetic acid)

14. Treatment for Mucosal warts
laryngeal papilloma
• we used Interferon

15. Prevention :-
vaccine is now recommended for infection with
the high-risk HPV types, 16 and 18.
protection against cervical cancer.