Human papillomavirus (HPV) is a non-enveloped DNA virus that infects basal cells of the epidermis and mucous membranes. There are over 120 HPV types, with high-risk types like 16 and 18 able to cause cancers such as cervical cancer while low-risk types cause genital warts. HPV is very common and easily transmitted through skin-to-skin contact, with over 75% of individuals having an HPV infection at some point in their lives. While condoms provide some protection, HPV transmission is still possible due to infection sites beyond the areas covered.

1. Human papillomavirus
Presented by Kyoung
Scale 50-60 nanometer
1 nanometer = 0.000001 millimeter

2. What is HPV ?
●Human papillomavirus is host and tissue-tropic DNA virus
●Non-enveloped virus, meaning the outer shell or capsid of the
virus is not covered by a lipid membrane
●Replicate in the basal layer as well as mucous membrane,
such as inside cheek or walls of the vagina or throat.
●More than 120 types of HPV have been identified
●It can survive at low temperature for many months without
a host
●Responsible for most cases of cervical cancer

3. Connecting the Dot
In 1935, Francis Peyton
Rous demonstrated a virus
can cause cancer
* Electron microscope constructed by
Ernst Ruska in 1933

4. HPV-Induced cancer
Annual number of cases worldwide
HPV-induced cancers
500000
HPV-Induced
450000 Total
400000
350000
annual cases
300000
250000
200000
150000
100000
50000
Total
0 HPV-Induced
Cervix Anus Vaginal/Vulva Penis Mouth Throat

5. How does it transmit?
Risk factors
● Skin abrasions ( micro-trauma)
● Sexual intercourse

6. High-risk and Low-risk HPV
High-risk HPV Low-risk HPV
● Oncogenic HPV types are ● Cause skin and genital
to intergrate into DNA of warts ( condyloma )
the cell and modify its ● Plantar wart is cause by
behaviour. ex) cervical
HPV type1, 2 infect hands
cancer, type 16 and 18
and feet
linked to throat cancer
● HPV type 6 and 11 cause
● 16, 18, 31, 33, 35, 39, 45,
pre-cancerous lesions
51, 52, 56, 58, 59, 68, 73,
82 ● 1, 2, 3, 4, 6, 7, 8, 10, 11,
32, 42, 44, 53, 63

7. HPV is very common.
More than 75% women and men will have HPV
infection sometime in their life. HPV can be
transmitted through skin to skin sexual contact,
whether or not there is penetration. Use of
condom will not protect one from transmission.
People may transfer HPV to others without display
of symptoms. An individual can be infected with
multiple HPV, both low-risk and high-risk.