Human Milk Feedings of High-Risk Infants - State of the Science, State of the Art. The Prolacta Bioscience mission is to make a meaningful difference in the lives of thousands of the most vulnerable infants through world class research and innovative products.

1. Human Milk Feedings of High-Risk Infants State of the Science, State of the Art

12. Human Milk Feeding in the NICU 0 5 10 15 20 25 30 35 40 45 50 [Fortified Mother ’s Milk >50 mL/kg/day] 0 5 10 15 20 25 30 35 40 45 50 Mother ’s Milk Preterm Formula % Infants Late onset sepsis Necrotizing enterocolitis LOS/NEC p < 0.01 Schanler, PEDIATRICS 1999;103:1150 Effect of predominant mother ’s milk feeding on late onset sepsis (LOS) and NEC in premature infants

36. n=207 Preterm Infants BW ≤ 1250 g Own Mothers Milk Bovine HMF @100 mL/kg/d Human HMF @ 40 mL/kg/d Human HMF @ 100 mL/kg/d Donor Milk When OMM is not available in sufficient quantity H100 n=69 H40 n=71 B100 n=69 Study Protocol Sullivan, S et al 10.1016/j.jpeds.2009.10.040 Preterm Formula When OMM is not available in sufficient quantity 1 NEC surgery will be eliminated for every 10 babies treated with 100% human diet. 1 case of NEC or death will be eliminated for every 7.7 babies treated with exclusive human milk diet. For infants <1250 g these data strongly support an entirely human milk-based diet, including HM fortifier, through 60 days of age. Human Milk Feeding of High-Risk Infants