To open Reason, go to Applications > Music > Reason and select "Run with multi license" to be able to save work. This will open the Reason mixer where you can adjust volume, pan, EQ, mute channels, and the master volume. To create a synth track, click Create > Instruments > Subtract or Synthesizer. Adjusting the pan and EQ is important to balance the track and get the sound to come from one side or the other. Using a MIDI keyboard allows recording notes by pressing record and playing, or entering notes one by one.