This document provides guidance on how to choose and implement a quality improvement project. It explains that you should organize a team, identify improvement topics using available data or staff input, prioritize topics using a decision matrix, develop a problem statement, set an aim, conduct a root cause analysis, develop an action plan, implement and test the plan, and evaluate results over time. As an example, it describes how one agency improved their syphilis testing rate among HIV patients from 46% to 78% by identifying a lack of tracking as the root cause and implementing a simple solution of testing all patients at their first visit each year.