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HL TYPES.pptx
- 1. SUBTYPE
MORPHOLOGY AND
IMMUNOPHENOTYPE
REED STERNBERG CELLS CLINICAL FEATURE
NODULAR SCLEROSIS -
HL
LACUNAR RS CELLS
B/G:- T lymphocyte, Eosinophil,
Macrophage, Plasma cell
Fibrous bands divide cellular area
into nodules
CD 15 +VE
CD 30 +VE
EBV -VE
M = F
Young adult
Mediastinal LN involvement
M/C stage I & II
MIXED CELLULARITY –
HL
MONONUCLEAR RS CELLS
B/G:- T lymphocyte, Eosinophil,
Macrophage, Plasma cell
CD 15 +VE
CD 30 +VE
70 % cases – EBV +VE
M > F
Biphasic age
>50 % stage III & IV
LYMPHOCYTE RICH –
HL
MONONUCLEAR RS CELLS
B/G:- T lymphocyte
CD 15 +VE
CD 30 +VE
40 % cases – EBV -VE
M > F
Older adults
LYMPHOCYTE
DEPLETION – HL
RETICULAR RS CELLS
Paucity of background reactive
cells
CD 15 +VE
CD 30 +VE
mostly – EBV +VE
Older males
Advanced stage
M/C – HIV + ve patients
LYMPHOCYTE
PREDOMINANT - HL
POPCORN CELLS
B/G:- follicular dendritic cells &
reactive B cell
CD 15 -VE
CD 30 -VE
CD 20 +VE
Uncommon
Young male
Axillary lymphadenopathy
Classical RS
