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cytoskeleton.pptx
- 1. MICROFILAMENT • Size = 7 nm • Fine strands of ACTIN. • Seen as intertwined chains. • 2 forms: G and F. • Helps in MUSCLE CONTRACTION. MICROTUBULE • Size – 15 to 25 nm. • Hollow tube with a wall of 13 protofilaments. • Alpha and Beta tubulin. • Function: vesicular transport. INTERMEDIATE FILAMENT • 8 to 12 nm. • Antiparallel orientation of tetramers. • 6 types. CYTOSKELETON – network of fibers between cells.Help cells to maintain their shape and give them support.
- 2. INTERMEDIATE FILAMENT TYPE 1 &2: acidic and basic keratin. Helps cells to stabilize in mechanical stress. TYPE 3: desmin, GFAP, peripherin, vimentin. TYPE 4: neurofilaments. TYPE 5: nuclear lamin. TYPE 6: nestin – embryonic neurons.
- 3. Cardiac diseases Neurodegenerative diseases Infectious diseases Skeletal muscle diseases RBC membrane defects Skin disorders Laminopathies Cilia dysfunction Miscellaneous
- 4. Cardiomyopathy Arrhythmias Heart failure Alzeimers disease Parkinson disease Amyotrophic lateral sclerosis Entero-invasive bacteria Viruses Intracellular parasites Myopathies and Muscular dystrophies Hereditary spherocytosis Hereditary elliptocytosis Epidermolysis bullosa simplex Keratoderma Hair & nail defects Lipodystrophies Muscle laminopathies Premature aging syndromes Immotile cilia syndrome Kartagener syndrome Infertility Wiskott-Aldrich syndrome Diabetes Cytoskeleton in oncology
- 5. WISKOTT ALDRICH SYNDROME WASP protein Chromosome X p defect X linked recessive disorder Microthrombo cytopenia Bloody diarrhea Immunodeficie ncy disorder with eczema Actin reorganization affected WBC and Megakaryocyt es affected