Poliomyelitis, also known as polio, is a viral disease that affects the nervous system and can cause paralysis. The first clinical description of polio was in 1789, and the first major outbreak in the US occurred in 1894 in Vermont. In the early 20th century, the iron lung machine was developed to help polio patients breathe. Jonas Salk developed the first successful polio vaccine, the Salk vaccine, in the 1950s through extensive clinical trials. Albert Sabin later created an oral polio vaccine that was also effective at preventing the disease. Due to widespread vaccination efforts, polio is now eradicated in most countries and no longer presents a significant public health risk.