This study aimed to determine the histopathological patterns of cutaneous malignant melanoma in Sudanese patients. The study found that males represented 57.1% of cases and the majority of lesions (81.6%) were on the lower limbs. The most common clinic-pathological type was acral-lentiginous melanoma (75.5%). Microscopy showed epithelioid cell type in 61.2% of cases and deep invasion, ulceration, and lymphovascular invasion were common, indicating late stage at presentation. The findings were similar to previous studies in other African populations.
Malignant melanoma is one of the most aggressive neoplasms of the skin. It originates from the melanocytes, which are cells derived embryologically from the neural crest and migrate to the epidermal basal layer. It is characterized by producing pigmentation as well as being susceptible to metastasis. We report the case of a 36-year-old female patient with advanced clinical stage and distant commitment. The biopsy confirmed the presence of Grade III invasive nodular cutaneous melanoma in the left subscapular region with lymph node metastasis with reactive hyperplasia. An exploratory research is carried out with the bibliographic review in scientific journals with evidence level II–IV. In portals PubMed, Redalyc, BVS, and UpToDate. 81241 met criteria 2248 of which 629 were chosen for having access to the full text and of these 496 are more current (as of 2008), and in the end, 27 articles were selected that met all the inclusion criteria to this article. Due to the increase in the incidence of this disease in recent years and its poor prognosis in short to medium term, it is important to know and follow-up on patients with known risk factors for this disease such as the presence of previous nevi, with emphasis on measures of prevention.
Anaesthesia considerations and Implications during Oncologic and Non-Oncologi...Apollo Hospitals
Cancer has been the leading cause of mortality in both developed and developing countries. With the advancement in chemotherapeutic agents, the quality and lifespan of patients with advanced malignancies has improved. These patients often come to hospitals for various types of elective and emergency surgeries. The attending anaesthesiologist faces a daunting task while managing these patients as there can be gross physiological derangements in most of the organ systems. A careful and thorough preoperative assessment, optimisation of physiological milieu, vigilant intraoperative monitoring, anticipation of potential complications and postoperative pain control is essential for reducing perioperative mortality and morbidity in these patients.
Malignant melanoma is one of the most aggressive neoplasms of the skin. It originates from the melanocytes, which are cells derived embryologically from the neural crest and migrate to the epidermal basal layer. It is characterized by producing pigmentation as well as being susceptible to metastasis. We report the case of a 36-year-old female patient with advanced clinical stage and distant commitment. The biopsy confirmed the presence of Grade III invasive nodular cutaneous melanoma in the left subscapular region with lymph node metastasis with reactive hyperplasia. An exploratory research is carried out with the bibliographic review in scientific journals with evidence level II–IV. In portals PubMed, Redalyc, BVS, and UpToDate. 81241 met criteria 2248 of which 629 were chosen for having access to the full text and of these 496 are more current (as of 2008), and in the end, 27 articles were selected that met all the inclusion criteria to this article. Due to the increase in the incidence of this disease in recent years and its poor prognosis in short to medium term, it is important to know and follow-up on patients with known risk factors for this disease such as the presence of previous nevi, with emphasis on measures of prevention.
Anaesthesia considerations and Implications during Oncologic and Non-Oncologi...Apollo Hospitals
Cancer has been the leading cause of mortality in both developed and developing countries. With the advancement in chemotherapeutic agents, the quality and lifespan of patients with advanced malignancies has improved. These patients often come to hospitals for various types of elective and emergency surgeries. The attending anaesthesiologist faces a daunting task while managing these patients as there can be gross physiological derangements in most of the organ systems. A careful and thorough preoperative assessment, optimisation of physiological milieu, vigilant intraoperative monitoring, anticipation of potential complications and postoperative pain control is essential for reducing perioperative mortality and morbidity in these patients.
Nurses' Knowledge Concerning Neuroblastoma in Children at Oncology Units in B...iosrjce
IOSR Journal of Nursing and health Science is ambitious to disseminate information and experience in education, practice and investigation between medicine, nursing and all the sciences involved in health care.
Nursing & Health Sciences focuses on the international exchange of knowledge in nursing and health sciences. The journal publishes peer-reviewed papers on original research, education and clinical practice.
By encouraging scholars from around the world to share their knowledge and expertise, the journal aims to provide the reader with a deeper understanding of the lived experience of nursing and health sciences and the opportunity to enrich their own area of practice.The journal publishes original papers, reviews, special and general articles, case management etc.
EARLY CANCER DIAGNOSIS - guide from World Health Organization, 2017oncoportal.net
GUIDE TO CANCER EARLY DIAGNOSIS - World Health Organization 2017
Руководство по РАННЕЙ ДИАГНОСТИКЕ РАКА, Всемирная организация здравоохранения, 2017 год, 48 страниц, на английском языке.
Pilomatrix carcinoma is extremely rare malignant tumours
arising from hair follicles with around 80 cases reported till date.
Owing to the paucity of literature and similarity of clinic pathological features with its benign counterpart they are oft en misdiagnosed.These tumors are known to be locally aggressive with low albeit significant metastatic potential. Surgical excision is the mainstay of treatment with adjucant radiotherapy being used historically for improving local control. We present a case of an extremely unusual site (breast) of Pilomatrix carcinoma. To the best of our knowledge no case of Pilomatrix carcinoma of the mammary skin has been reported till date.
Liposarcoma: A Pictorial and Literature Reviewasclepiuspdfs
Liposarcomas (LSs) are uncommon malignant mesenchymal tumors with adipose differentiation. There are different histological subtypes, and they can present in different anatomic regions. LSs are classified into five different categories: Well differentiated, dedifferentiated, myxoid, pleomorphic, and mixed type. The most common involved anatomical sites are the lower extremities, retroperitoneum, and trunk. It is important to understand that the anatomical distribution for LSs presentation is closely related to the histological subtype; however, there are some important differences regarding their presentation, radiological features, diagnosis, treatment, and prognosis.
The study of disease transmission
By and large, the frequency of disease is higher in men than in ladies and higher in industrialized areas and countries.
Metastatic Atypical Fibroxanthoma: Case Report of an Uncommon Pathology in the Head and Neck by Luis Boccalatte in Experiments in Rhinology & Otolaryngology
Atypical fibroxanthoma (AFX) is an uncommon skin neoplasm developed mainly in the head and neck region in older senior patients. Prolonged sun exposure, actinic damaged, history of previous neoplasms and immunosuppressant are considered the most important risks factors. Subcutaneous extension of these tumors is related to a more aggressive biology.
https://crimsonpublishers.com/ero/fulltext/ERO.000521.php
Pattern of Head and Neck Cancer in a Tertiary Institution in Lagos Nigeriaiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Acoustic Duration of Arabic Utterances Spoken by the Indonesian Learners of A...iosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
Mixed Methods Research Approaches:Warrant Consideration Phenomena in theMetho...iosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
Nurses' Knowledge Concerning Neuroblastoma in Children at Oncology Units in B...iosrjce
IOSR Journal of Nursing and health Science is ambitious to disseminate information and experience in education, practice and investigation between medicine, nursing and all the sciences involved in health care.
Nursing & Health Sciences focuses on the international exchange of knowledge in nursing and health sciences. The journal publishes peer-reviewed papers on original research, education and clinical practice.
By encouraging scholars from around the world to share their knowledge and expertise, the journal aims to provide the reader with a deeper understanding of the lived experience of nursing and health sciences and the opportunity to enrich their own area of practice.The journal publishes original papers, reviews, special and general articles, case management etc.
EARLY CANCER DIAGNOSIS - guide from World Health Organization, 2017oncoportal.net
GUIDE TO CANCER EARLY DIAGNOSIS - World Health Organization 2017
Руководство по РАННЕЙ ДИАГНОСТИКЕ РАКА, Всемирная организация здравоохранения, 2017 год, 48 страниц, на английском языке.
Pilomatrix carcinoma is extremely rare malignant tumours
arising from hair follicles with around 80 cases reported till date.
Owing to the paucity of literature and similarity of clinic pathological features with its benign counterpart they are oft en misdiagnosed.These tumors are known to be locally aggressive with low albeit significant metastatic potential. Surgical excision is the mainstay of treatment with adjucant radiotherapy being used historically for improving local control. We present a case of an extremely unusual site (breast) of Pilomatrix carcinoma. To the best of our knowledge no case of Pilomatrix carcinoma of the mammary skin has been reported till date.
Liposarcoma: A Pictorial and Literature Reviewasclepiuspdfs
Liposarcomas (LSs) are uncommon malignant mesenchymal tumors with adipose differentiation. There are different histological subtypes, and they can present in different anatomic regions. LSs are classified into five different categories: Well differentiated, dedifferentiated, myxoid, pleomorphic, and mixed type. The most common involved anatomical sites are the lower extremities, retroperitoneum, and trunk. It is important to understand that the anatomical distribution for LSs presentation is closely related to the histological subtype; however, there are some important differences regarding their presentation, radiological features, diagnosis, treatment, and prognosis.
The study of disease transmission
By and large, the frequency of disease is higher in men than in ladies and higher in industrialized areas and countries.
Metastatic Atypical Fibroxanthoma: Case Report of an Uncommon Pathology in the Head and Neck by Luis Boccalatte in Experiments in Rhinology & Otolaryngology
Atypical fibroxanthoma (AFX) is an uncommon skin neoplasm developed mainly in the head and neck region in older senior patients. Prolonged sun exposure, actinic damaged, history of previous neoplasms and immunosuppressant are considered the most important risks factors. Subcutaneous extension of these tumors is related to a more aggressive biology.
https://crimsonpublishers.com/ero/fulltext/ERO.000521.php
Pattern of Head and Neck Cancer in a Tertiary Institution in Lagos Nigeriaiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Acoustic Duration of Arabic Utterances Spoken by the Indonesian Learners of A...iosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
Mixed Methods Research Approaches:Warrant Consideration Phenomena in theMetho...iosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
IOSR journal of VLSI and Signal Processing (IOSRJVSP) is a double blind peer reviewed International Journal that publishes articles which contribute new results in all areas of VLSI Design & Signal Processing. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced VLSI Design & Signal Processing concepts and establishing new collaborations in these areas.
Design and realization of microelectronic systems using VLSI/ULSI technologies require close collaboration among scientists and engineers in the fields of systems architecture, logic and circuit design, chips and wafer fabrication, packaging, testing and systems applications. Generation of specifications, design and verification must be performed at all abstraction levels, including the system, register-transfer, logic, circuit, transistor and process levels
Marathi Text-To-Speech Synthesis using Natural Language Processingiosrjce
IOSR journal of VLSI and Signal Processing (IOSRJVSP) is a double blind peer reviewed International Journal that publishes articles which contribute new results in all areas of VLSI Design & Signal Processing. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced VLSI Design & Signal Processing concepts and establishing new collaborations in these areas.
Design and realization of microelectronic systems using VLSI/ULSI technologies require close collaboration among scientists and engineers in the fields of systems architecture, logic and circuit design, chips and wafer fabrication, packaging, testing and systems applications. Generation of specifications, design and verification must be performed at all abstraction levels, including the system, register-transfer, logic, circuit, transistor and process levels
Al Qur’an as A Media of Journalism for Da’wahiosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
Teaching Mathematics through Integrated Brain Gym in Pair Checks of Cooperati...iosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
Of Love and Betrayal, Sin and Redemption, Exile and Return: Recapturing the S...iosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
The Improvement of the Quality of Documentary Services At Civil Registration ...iosrjce
IOSR Journal of Humanities and Social Science is a double blind peer reviewed International Journal edited by International Organization of Scientific Research (IOSR).The Journal provides a common forum where all aspects of humanities and social sciences are presented. IOSR-JHSS publishes original papers, review papers, conceptual framework, analytical and simulation models, case studies, empirical research, technical notes etc.
“Morbidity profile of children [6-11 years] attending Municipal Corporation P...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Case study on Holistic Diabetic Care using Diet, Yoga, Resisted Exercises usi...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Prospective Study to Compare the Suture Technique (Continuous Versus Interr...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Study of Bacterial Isolates and their Susceptibility Pattern in Chronic Suppu...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
An Examination of Effectuation Dimension as Financing Practice of Small and M...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Does Goods and Services Tax (GST) Leads to Indian Economic Development?iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Optimization of Digitally Controlled Oscillator with Low Poweriosrjce
IOSR journal of VLSI and Signal Processing (IOSRJVSP) is a double blind peer reviewed International Journal that publishes articles which contribute new results in all areas of VLSI Design & Signal Processing. The goal of this journal is to bring together researchers and practitioners from academia and industry to focus on advanced VLSI Design & Signal Processing concepts and establishing new collaborations in these areas.
Design and realization of microelectronic systems using VLSI/ULSI technologies require close collaboration among scientists and engineers in the fields of systems architecture, logic and circuit design, chips and wafer fabrication, packaging, testing and systems applications. Generation of specifications, design and verification must be performed at all abstraction levels, including the system, register-transfer, logic, circuit, transistor and process levels
Effect of Indian Spices to Manage the Diabetes and Associated Metabolic Disorderiosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Corrective Surgery for Malunited Tibial Plateau Fractureiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
A case report of open reduction, internal fixation and platting of clavicle f...iosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Melanoma epidemiology, etiopathogenesis and prevention - Professor Torello L...VR Foundation
Melanoma incidence has continued to increase significantly during the last half of 20th century wherever available data exist.
The incidence of malignant melanoma appears to be lower and stable in dark-skin individuals (Africans, Native Americans, Asians, and Hispanics).
Decreased incidence reported from some countries is probably partly due to an influx of low risk immigrants.
FNAC & Histopathology correlation of various thyroid esionsiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Skin cancer exposed - Background informationXplore Health
This guide provides background information on melanoma, the most serious type of skin cancer. Explore all aspects of melanoma from the causes to treatment. Investigate the latest research, and uncover the ethical, legal and social issues surrounding this disease.
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We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
We know that mesothelioma patients would rather stay local when receiving treatment,rnso we will review options for private medical centers, surgical consultants, clinical trials,rnand match you up with friendly, local physicians wherever we can.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Head & Neck Oncology is an open access, peer reviewed, scholarly journal dedicated to publish articles covering all areas of Head & Neck Oncology.
The journal aims to promote research communications and provide a forum for doctors, researchers, physicians and healthcare professionals to find most recent advances in all areas of head & neck oncology. Austin Head & Neck Oncology accepts original research articles, reviews, mini reviews, case reports and rapid communication covering all aspects of Head & Neck Oncology.
Austin Head & Neck Oncology strongly supports the scientific up gradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
The spectrum of childhood neoplasms – Evaluation of 161 cases in surgical pat...Apollo Hospitals
Although major cause of childhood morbidity and mortality in the developing world is still malnutrition and infections, pediatric neoplasms are also rising in number. Although pediatric neoplasms occur infrequently, they present a challenging diagnostic and therapeutic problem. Unfamiliarity with these conditions may lead to the erroneous diagnosis and unnecessary aggressive therapy. This was a retrospective analysis of 161 cases of pediatric tumors, both benign and malignant, in surgical pathology department excluding neurosurgery, cardiothoracic, and hemato-lymphoid malignancies (age group 0–12 years) encountered over a period of 5 years: January 2004–December 2008. The clinical, radiological, and therapeutic data were obtained from patients’ case paper records. Pattern of childhood tumors was studied with a focus on tumor incidence, age and sex distribution, demographic pattern, and histological type.
Childhood Factors that influence success in later lifeiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Emotional Intelligence and Work Performance Relationship: A Study on Sales Pe...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Customer’s Acceptance of Internet Banking in Dubaiiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study of Employee Satisfaction relating to Job Security & Working Hours amo...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Consumer Perspectives on Brand Preference: A Choice Based Model Approachiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Student`S Approach towards Social Network Sitesiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Broadcast Management in Nigeria: The systems approach as an imperativeiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study on Retailer’s Perception on Soya Products with Special Reference to T...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
A Study Factors Influence on Organisation Citizenship Behaviour in Corporate ...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Consumers’ Behaviour on Sony Xperia: A Case Study on Bangladeshiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Design of a Balanced Scorecard on Nonprofit Organizations (Study on Yayasan P...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Public Sector Reforms and Outsourcing Services in Nigeria: An Empirical Evalu...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Media Innovations and its Impact on Brand awareness & Considerationiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Customer experience in supermarkets and hypermarkets – A comparative studyiosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Social Media and Small Businesses: A Combinational Strategic Approach under t...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Secretarial Performance and the Gender Question (A Study of Selected Tertiary...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Implementation of Quality Management principles at Zimbabwe Open University (...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Organizational Conflicts Management In Selected Organizaions In Lagos State, ...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Impact of education on innovation performance: evidence from Azerbaijan const...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Performance Assessment of Agricultural Research Organisation Priority Setting...iosrjce
IOSR Journal of Business and Management (IOSR-JBM) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of business and managemant and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications inbusiness and management. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
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Histopathological patterns of cutaneous malignant melanoma in Sudan
1. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 14, Issue 11 Ver. I (Nov. 2015), PP 133-136
www.iosrjournals.org
DOI: 10.9790/0853-14111133136 www.iosrjournals.org 133 | Page
Histopathological patterns of cutaneous malignant melanoma in
Sudan
Rihab M Ibrahim1
(MD), Tarig H Merghani2
(MD, PhD)
Ismail O Khalid (MD) 3
, Sawsan A Mohammed 4 (MD)
1
Department of Pathology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia
2
Department of Physiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia
3
Dermatopathology specialist ,military hospital Khartoum ,Sudan.
4 Department of pathology ,Faculty of Medicine ,University Of Khartoum, Sudan
Abstract:
Objectives: To determine the histopathological patterns of cutaneous malignant melanoma in Sudanese patients.
Methods: This is a cross sectional laboratory based descriptive study that included all tissue slides presented
during the study period. The tissue blocks and the slides of 55 cases were collected and re-examined by the
principal investigator.
Results: Males represented 57.1% of the cases. The majority of lesions (81.6%) were found in the lower limbs.
The major clinic-pathological feature was the acrallentiginus type (in 75.5%). Microscopy showed epithelioid
cell type (61.2%), spindle cell type (32.7%), extremely bizarre cells (4.1%), and mixed cell types (spindle and
epithelioid) in 2.0% of all cases.
Conclusion: The histo-pathological features of cutaneous malignant melanoma in Sudan are similar to previous
findings in black people.
I. Introduction
Malignant melanoma is an aggressive malignancy of melanocytes. Its incidence has been steadily
increasing in many countries worldwide. Incidence and mortality rates are generally high in white population
and low in Asian and African populations (1). Its prognosis depends on many factors like depth of invasion,
presence or absence of ulceration, and nodal status at the time of diagnosis. In general, the lesion used to have
very poor prognosis in the past, but during the new millennium, the mortality rates have been stabilized in many
high risk populations (2).
One of the major determinants of melanoma development is increased exposure to ultraviolet light
(UVR). This can be assessed indirectly by history of sun-burns whereas non-melanomatous skin cancers are
more linked to cumulative sun exposure (3). The risk of melanoma varies on the basis of type, size, number and
location of melanocytic nevi. In about one quarter of cases, melanoma occurs in conjunction with a preexisting
nevus (4). Previously reportedrisk factors included estrogen, progesterone, obesity, congenital nevus, and use of
immunosuppressant drugs (5). A patient with a family history of melanoma in a first degree relative has higher
risk of developing melanoma than those with negative family history(6).
Histologic examination of tissue biopsy is the best way to diagnose melanoma. Major histologic types
of cutaneous malignant melanoma are superficial spreading melanoma (SSM), nodular melanoma (NM),
lentigomaligna (LM), and acral-lentiginous melanoma (ALM). SSM is the most common histological pattern of
malignant melanoma. It can occur at any surface of the body and represents about 75% of all melanomas. It
typically develops after a long-standing stable nevus changes. Changes include ulceration, increase in size, or
change in color. NM is the second most common subtype of MM, and accounts for 10-15% of all melanomas in
Caucasian people. It occurs most commonly in middle-aged adults with predilection for the trunk, head and
neck, and lower legs. LM also known as Hutchinson melanotic freckle, is a form of melanoma in situ that occurs
on the sun exposed skin of elderly people; mainly on the face, but also in neck,upper back and forearm. ALM
occurs in palms, soles and subungual sites and has a characteristic histologic picture. It comprises 80% of
cutaneous melanomas in dark-skinned patients.Surgery is the definitive treatment for early stages of melanoma.
Medical management is reserved for patients with advanced disease. It is worth mentioning that the Food and
Drug Administration (FDA) has recently approved the first combination therapy for treatment of patients with
unresectable melanoma (7).
Over the past few decades, reports from many countries around the world described annual increase in
cutaneous malignant melanoma; however, there is paucity of data from the Sudan. The aim of this study is to
2. Histopathological patterns of cutaneous malignant melanoma in Sudan
DOI: 10.9790/0853-14111133136 www.iosrjournals.org 134 | Page
determine the differenthistopathological patterns of cutaneous malignant melanoma and to investigate their
relations to age and sex distribution in Sudanese patients.
II. Materials And Methods
This is a cross sectional laboratory based descriptive study conducted in the National Health
Laboratory (NHL) and Soba University Hospital (SUH) in Khartoum- Sudan, during the period from January
2006 to December 2010. The study included tissue slides from 55 cases of malignant melanoma presented to the
NHL and SUH during the study period. All histopathological reports issued during the five years of the study
period were revised to identify the cases. Then tissue blocks and slides of all identified cases were collected.
Additional new slides were prepared and stained by routine haematoxyline-eosin stain. All slides were re-
examined by the principal investigator. Data were analyzed using Statistical Package for Social Sciences (SPSS)
version 18.
III. Results
Fifty five cases of malignant melanoma were identified. Six cases (10.9%) with inadequate specimens
were excluded from this study. The remaining 49 cases were re-examined. Table 1 shows general characteristics
of cases in the study group. More than one half of cases (57.1%)were males.Ages ranged from 30 to 94 years
old. Table 2 shows distribution of malignant melanoma in different sites of the body. The majority of lesions
(81.6%) were found in the lower limbs. Other sites were the trunk (6.1%), upper limbs (4.1%) and lower limbs
with lymph node invasion (4.1%). Clinico-pathological features and cell types are presented in table 3. About
three quarters of cases (75.5%) were of the acrallentiginus type and all the remaining cases were of the nodular
type. Pigmentation was found in 83.7% of all cases. Microscopy showed epithelioidcell type (61.2%), spindle
cell type (32.7%), extremely bizarre cells (4.1%), and mixed cell types (spindle and epithelioid) in 2.0% of all
cases (table 3).Table 4 shows frequency of invasion, ulceration and lymphocyte infiltration in the lesions.
Table 1: Gender and age distribution of the study group
Character No. %
Gender
Males 28 57.1
Females 21 42.9
Age
30-45 12 24.5
46-61 20 40.8
62-77 14 28.6
78-90 3 6.1
Table 2: Locations of malignant melanoma in the body
Sites of lesions No. %
Lower limbs (LL) 40 81.6
Lt foot 17 42.5
Rt foot 20 50
Lt thigh 1 2.5
Gluteal abscess 1 2.5
Right thigh 1 2.5
Trunk 3 6.1
Upper limbs 2 4.1
LL with lymph node invasion 2 4.1
Absent data about the site 2 4.1
Table 3: Clinico-pathological features and cell types of all lesions in the study group
Feature No. %
Pathological type
Acrallentiginus type 37 75.5
Nodal type 12 24.5
Pigmentation
Pigmented 41 83.7
Non pigmented 8 16.3
Cell types
Epithelioid 30 61.2
Spindle 16 32.7
Bizarre shaped 2 4.1
Mixed (spindle &epithelioid) 1 2
3. Histopathological patterns of cutaneous malignant melanoma in Sudan
DOI: 10.9790/0853-14111133136 www.iosrjournals.org 135 | Page
Table 4: Different histological features of malignant melanoma in the study group
Feature No. %
Cytoplasm
Eosinophilic 24 49
Basophilic 25 51
Invasion
Intraepithelial- junction 1 2.0
In papillary dermis but not filling it 2 4.1
Filling papillary dermis 7 14.3
Into reticular dermis 5 10.2
Into sub-cutis 25 51.0
No invasion 9 18.4
Ulceration
Present 23 46.9
Absent 26 53.1
Lymphovascular invasion
Present 23 46.9
Absent 26 53.1
Lymphocyte infiltration
Present 45 91.8
Absent 4 8.2
IV. Discussion
Old articles in Sudan Medical Journal, dating back to more than 50 years ago, showed that skin cancer
had been the most common type of registered malignancy in Sudanese patients accounting for 18.5% of all
malignancies in old reports (8). Unfortunately, there is fewrecent updated data regarding prevalence and
mortality rates. Malignant melanoma is the most serious form of skin cancers, responsible for the largest number
of deaths attributed to these lesions; however, its incidence in black people is much lower than incidence of
other non-melanoma skin cancers like squamous cell and basal cell carcinomas. In this study, cutaneous
malignant melanoma was more prevalent in males compared to females. Predominance of males was noticed in
other African countries (9). However, in Western countries, contradictory results were obtained even from the
same country(10,11). On the other hand, the mortality rates and risk of distant metastasis are lower among
women compared to men(12).
A recent review of skin cancers in Sudan showed that the most common site is the head and neck (13).
Our finding that the lower limb wasthe most commonly affected sitewas similar to findings in black patients
(14). In general melanomas in Africans occur on the less pigmented, non-exposed skin, especially the palms,
soles, mucous membranes and nail regions. Possible causative factors include repeated trauma and presence of
pre-existing naevi in the soles of feet (14).
In this study, the most frequent clinicopathological type was ALM which was prevalent in more than 3
quarters of patients in the study group. ALM was reported as the most frequent type of malignant melanomain
many studies conducted among black people (15,16) .Previous studies conducted in the United States showed
that ALM is the least common subtype of melanoma in white persons whereas it is rather common in dark
skinned individual (17).It is worth noting that the majority of lesions in our study were pigmented.
Bad prognostic features such as deep invasion of melanoma, ulceration, and lympho-vascular invasion
were present in large number of our patients indicating late presentation which is a common practice in the
developing countries. On the contrary, patients in Europe and America present early for diagnosis and
management(18,19). This may explain why mortality rates of malignant melanoma are higher in Africa than in
the developed countries. Greater efforts are needed to educate people about benefits of early presentation to
health care providers for immediate management. The only good prognostic factor was the presence of tumor
infiltrating lymphocytes in almost all cases. Previous studies showed that only thickness and presence of tumor
infiltrating lymphocytes are significant and independent positive histologic prognostic factors (20).These
findings are almost similar to what was reported about melanoma in Black Americans, with late presentation
and aggressive type of malignant melanoma being mainly ALM (21).
One of the limitations in this study is missing or incomplete history and clinical information about the
lesions, including lymph node infiltration and distant metastasis. However; our resultsindicated that MM is an
important health problem in our country. Further work is needed to shed more light on the natural history of
MM in Sudanese patients.
4. Histopathological patterns of cutaneous malignant melanoma in Sudan
DOI: 10.9790/0853-14111133136 www.iosrjournals.org 136 | Page
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[12]. Josse A, Vries E, Eckel R, Nijsten T, et al. Gender differences in melanoma survival: Female patients have a decreased risk of
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