The study analyzed 110 patients with breast cancer registered at Al-Amal Oncology Unit in Yemen from 2008. The majority of patients were female (99.1%) and most common age group was 40-49 years. Late diagnosis and high rates of metastasis were observed due to the absence of early detection procedures like mammography. The study highlights the need for establishing early detection programs, nuclear medicine and radiotherapy centers, and improving laboratory quality to better tackle breast cancer in Yemen.