Heat stroke is a life-threatening condition that occurs when the body becomes unable to regulate its core temperature, causing it to rise rapidly. Left untreated, it can cause damage to the brain, organs and other body systems. The main symptoms include a core body temperature above 104°F, altered mental state, and hot, dry skin. First aid involves rapidly cooling the body through methods like cold water immersion or ice packs while seeking immediate medical help, as rapid cooling is key to preventing complications. Risk factors include high heat and humidity, dehydration, strenuous physical activity, and age. Proper prevention focuses on staying hydrated, limiting time outdoors in extreme heat, and wearing loose-fitting, light clothing.