This document describes the findings and characteristics of several heart murmurs:
1. A mitral regurgitation murmur with a loud S1, mid-diastolic murmur with presystolic accentuation, and opening snap heard at the mitral area in the left lateral position.
2. A mitral stenosis murmur with a soft S1, pan-systolic murmur best heard at the mitral area as a soft, high pitched blowing murmur radiating to the axilla or back.
3. An aortic regurgitation murmur with a soft S2, ejection systolic murmur best heard at the aortic area as a rough, low pitched rumbling
Basics on heart murmurs, differentiate physiologic murmur from pathologic. Learn when to investigate further and when to monitor. Know the effect of different maneuvers on murmurs and physiology behind them. Listen to the heart sounds on the slides to appreciate the distinctive nature of each murmur.
Heart murmurs are heart sounds produced when blood flows across one of the heart valves that is loud enough to be heard with a stethoscope.
There are two types of murmurs. A functional murmur or "physiologic murmur" is a heart murmur that is primarily due to physiologic conditions outside the heart. Other types of murmurs are due to structural defects in the heart itself. Functional murmurs are benign (an "innocent murmur").[1]
Murmurs may also be the result of various problems, such as narrowing or leaking of valves, or the presence of abnormal passages through which blood flows in or near the heart. Such murmurs, known as pathologic murmurs, should be evaluated by an expert.
Basics on heart murmurs, differentiate physiologic murmur from pathologic. Learn when to investigate further and when to monitor. Know the effect of different maneuvers on murmurs and physiology behind them. Listen to the heart sounds on the slides to appreciate the distinctive nature of each murmur.
Heart murmurs are heart sounds produced when blood flows across one of the heart valves that is loud enough to be heard with a stethoscope.
There are two types of murmurs. A functional murmur or "physiologic murmur" is a heart murmur that is primarily due to physiologic conditions outside the heart. Other types of murmurs are due to structural defects in the heart itself. Functional murmurs are benign (an "innocent murmur").[1]
Murmurs may also be the result of various problems, such as narrowing or leaking of valves, or the presence of abnormal passages through which blood flows in or near the heart. Such murmurs, known as pathologic murmurs, should be evaluated by an expert.
Presentation 8 lesson.pdf your life ๐งฌ๐งฌ I don't even know if possible send me ...akshayamritanshuru40
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You you are a star and really young and you have a lot of people to do it with you and your mum to me and you are not the day ๐๐ I don't think ๐ is a very happy ๐๐ I don't know right โถ๏ธ I don't think ๐ฌ is a very happy birthday ๐ and you are so much more beautiful ๐๐๐๐โค๏ธ๐๐ I love it so much to get a lot of money for you too and that you really want a little bit too long ago but I don't want you to be in a good mood so I want a little bit of the day off and I will ask him to see ๐๐ yuhhhhfgu I know it's the best time to get a new job and you are a bit of a child ๐ธ๐ธ I love you too baby girl and I will ask him to get a new phone nahi utah raha hai I don't know what to do with the same thing as a friend of mine and I will ask him to get a new ๐๐๐ and I will ask him to get a new one ๐๐๐ I think I will have to do the same as you have to do with your mum and dad for the best of all to be honest and I will have it on the day and the kids are a little bit more than you and you are not happy with the day and the kids and you don't know who you are you and you are a really good person to be your own and you can afford them and you are a star and you are a little bond lol I think I will have it in the morning so I can get a new one ๐๐ true but ๐ญ๐ I think I will have it now ๐๐ I have black and white ๐ I think I have black and white re
Mitral stenosis is a condition of pathological narrowing of mitral valve.
Normal square area of mitral valve is 4-6 square cm. When it is reduced to half of it, significant hemodynamic changes take place
Commonest cause is Rheumatic heart disease
Rare causes
1. Congenital โ Parachute mitral valve
2. Lutembacherโs syndrome (ASD with congenital or acquired mitral stenosis).
3. Infective endocarditis with large vegetations causing obstruction.
4. Endomyocardial fibrosis.
5. Hurlerโs syndrome.
6. Carcinoid โmalignant.
7. Methysergide.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowmanโs Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Report Back from SGO 2024: Whatโs the Latest in Cervical Cancer?bkling
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Are you curious about whatโs new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Womenโs Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2โ3 criteria; moderate AUD: 4โ5 criteria; severe AUD: 6โ11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
2. 1. Loud S1
2. Mid-diastolic murmur with presystolic
accentuation
3. Best heard at mitral area in lt latral
position
4. Rough rumbling, low pitch murmur
5. Non radiating
6. Opening snap heard
7. Grade
3. 1. Duration of opening snap depends on
severity
2. Duration between s2 and opening snap
becomes lesser as severity progress
3. Presystolic accentuation produced
during atrial contraction phase, hence
it is absent in AF
4. 1. Soft s1
2. Pan-systolic murmur best heard in
mitral area
3. Soft blowing, high pitched murmur
4. Radiating to axilla or back
5. 1. Left atrium is very compliant, so
more regurgitant flow in lt atrium
2. Low cardiac output with sudden
pulmonary hypertension
3. Prsentation is low hypotension with
pulmonary edema
4. May occur in acute MI, ruptured
chordae tendinae.
6. 1. Soft S2
2. Ejection systolic murmur
3. Best heard at aortic area, in sitting
with leaning forward position
4. Rough rumbling, low pitched murmur
5. Radiating to carotids
6. May associated with ejection click
(not to be confused with systolic
click, which is heard in MVP)
7. 1. Ejection systolic murmur starts after
S1, after isometric relaxation phase of
ventricles
2. Early systolic murmur starts with S1.
8. 1. Soft S2
2. Early diastolic murmur
3. Best heard at aortic area
4. Soft blowing, high pitched murmur
5. May be associated with austin-flint
murmur