Measuring the performance of chemical management systems is important to assess impact with limited resources and ensure efficiency. There are several types of indicators to measure performance, including impact indicators related to chemicals-related diseases and environmental impacts, result indicators on chemical levels in human and environmental samples, and output indicators like restricted substances. However, accurately measuring impact indicators is challenging due to complex attribution of health effects and lack of data, and result indicators are limited to known chemicals with inconsistent monitoring. Harmonization of research, monitoring, and testing is needed to strengthen performance measurement of chemical management systems.