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Epidemiological evidence for a role of UV-induced vitamin D in cancer (and other disease) prevention    William B. Grant, Ph.D. Sunlight, Nutrition, and Health Research Center (SUNARC) San Francisco, CA 94109, USA www.sunarc.org
Disclosure ,[object Object],[object Object],[object Object],[object Object]
Outline  Health Effects of UV and Vitamin D ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Ecological Studies of UVB and Cancer Incidence and Mortality ,[object Object],[object Object],[object Object]
350 400 450 500 400 500 450 350 300 300 350 300 300 350
 
Cohort Studies of Vitamin D and Cancer Risk ,[object Object],[object Object],[object Object],[object Object]
Prospective Study of Vitamin D and Calcium and Cancer Risk ,[object Object],[object Object]
Studies Based on Indices of UVB Irradiance Rather than Dose ,[object Object],[object Object]
Meta-analysis of Risk of Second Cancer After Diagnosis of NMSC When adjusted for smoking (lung cancer risk ratio = 1.0), diagnosis of NMSC is significantly inversely correlated with colon cancer risk
Meta-analysis of Risk of Second Cancer After Diagnosis of NMSC ,[object Object],[object Object]
Cancer in Spain ,[object Object],[object Object]
Cancer in Spain Results ,[object Object],[object Object]
Spain: Breast cancer vs. NMSC
Tuohimaa P, et al.  Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: Vitamin D as a possible explanation.  Eur J Cancer. 2007 May 29;43:1701-1712. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tuohimaa P, et al.  Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: Vitamin D as a possible explanation.  Eur J Cancer. 2007 May 29;43:1701-1712. ,[object Object],[object Object],[object Object]
Number of Observational Studies on UVB and Cancer Risk Reduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dose-Response Relations ,[object Object],[object Object],[object Object],[object Object]
 
Respiratory Viral Diseases ,[object Object],[object Object],[object Object]
Aloia JF, Li-Ng M. Links    Correspondence. Epidemiol Infect. 2007 Mar 12;:1-4 [Epub ahead of print] Results of a prospective double blind vitamin D supplementation study involving 208 African-American post-menopausal women living in or near Mineola, New York.  The numbers refer to cases of common cold or influenza.
Human Cathelicidin ,[object Object],[object Object]
Vitamin D and  Innate Immune System ,[object Object]
Sepsis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Extension to Autoimmune Diseases ,[object Object],[object Object],[object Object],[object Object]
Multiple Sclerosis (MS) ,[object Object],[object Object],[object Object]
 
Hypothesis for MS ,[object Object],[object Object]
Metabolic Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Autier P.   Gandini S .  Arch Intern Med. 2007 Sep 10;167(16):1730-7. ,[object Object],[object Object],[object Object],[object Object]
Estimated Health Benefit of 2000 IU of Vitamin D3 per day - Canada  ,[object Object],[object Object],[object Object],[object Object]
Summary and Conclusion ,[object Object],[object Object],[object Object],[object Object]

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Grant Euroskin Presentation

  • 1. Epidemiological evidence for a role of UV-induced vitamin D in cancer (and other disease) prevention   William B. Grant, Ph.D. Sunlight, Nutrition, and Health Research Center (SUNARC) San Francisco, CA 94109, USA www.sunarc.org
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  • 10. Meta-analysis of Risk of Second Cancer After Diagnosis of NMSC When adjusted for smoking (lung cancer risk ratio = 1.0), diagnosis of NMSC is significantly inversely correlated with colon cancer risk
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  • 21. Aloia JF, Li-Ng M. Links Correspondence. Epidemiol Infect. 2007 Mar 12;:1-4 [Epub ahead of print] Results of a prospective double blind vitamin D supplementation study involving 208 African-American post-menopausal women living in or near Mineola, New York. The numbers refer to cases of common cold or influenza.
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