This document describes the Genomic and Proteomic Knowledge Base (GPKB), which integrates data from multiple sources like KEGG, OMIM, Gene Ontology, and UniProt. GPKB allows users to perform both basic searches on single features as well as more complex queries across multiple features using its "Easy search" functionality. It contains over 20 million genes and proteins along with their various annotations. GPKB has advantages over other systems through its flexible data schema, ability to highlight relationships between data elements from different sources, and capability to answer multi-domain biomedical questions.