- The document discusses the physiological changes that occur with aging and their implications for anesthesia and surgery. Some key points:
1. Aging is associated with declines in organ function, functional capacity, and homeostatic mechanisms. Approximately 15-25% of surgical patients are aged 65 or older.
2. Common physiological changes with aging include declines in brain/nervous system function, cardiovascular function, respiratory function, renal/hepatic function, and altered pharmacokinetics.
3. These changes require special considerations for preoperative evaluation and perioperative management, including more judicious use of medications, fluid management, and temperature regulation. Regional anesthesia may provide some benefits over general anesthesia for elderly patients.
Anaesthetic Management of Elderly PatientsMd Rabiul Alam
The Scopes of the presentations are: Anaesthetic definition of elderly & workload, Brief on age-related changes, Importance of good anaesthetic evaluation, Practice of functional reserve/capacity assessment, Morbidity and Mortality, Decision of Surgery & Planning of Anaesthesia & Perioperative management in nutshell.
DIABETES AND ITS ANAESTHETIC IMPLICATIONSSelva Kumar
This presentation deals with diabetes mellitus and its anaesthetic implications. All about preoperative investigations and intra-operative management are discussed.
Anaesthetic Management of Elderly PatientsMd Rabiul Alam
The Scopes of the presentations are: Anaesthetic definition of elderly & workload, Brief on age-related changes, Importance of good anaesthetic evaluation, Practice of functional reserve/capacity assessment, Morbidity and Mortality, Decision of Surgery & Planning of Anaesthesia & Perioperative management in nutshell.
DIABETES AND ITS ANAESTHETIC IMPLICATIONSSelva Kumar
This presentation deals with diabetes mellitus and its anaesthetic implications. All about preoperative investigations and intra-operative management are discussed.
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
diagnosis & complication of Diabetes mellitus including Diabetic ketoacidosis & HHS
anaesthesia managment for patient with DM posted for surgery both emergency and elective surgery
gestational diabetes mellitus
Geriatric anesthesia with special consideration Petrus IitulaPetrus Iitula
With age, comes changes in normal physiological functions of the body and different diseases are picked up in certain population groups as we age. all this factors predisposes the geriatric population to certain complications once under anesthesia. Hence anesthetic preparation for the geriatric patients is needed to avoid mortality and morbidity in this population.
In critical care medicine the invasive life saving techniques are often employed and when all goes well such interventions will be withdrawn to all for normal physiology to resume. Identifying this point for safe withdrawal for the resumption of normal respiratory function is of utmost importance.
diagnosis & complication of Diabetes mellitus including Diabetic ketoacidosis & HHS
anaesthesia managment for patient with DM posted for surgery both emergency and elective surgery
gestational diabetes mellitus
Geriatric anesthesia with special consideration Petrus IitulaPetrus Iitula
With age, comes changes in normal physiological functions of the body and different diseases are picked up in certain population groups as we age. all this factors predisposes the geriatric population to certain complications once under anesthesia. Hence anesthetic preparation for the geriatric patients is needed to avoid mortality and morbidity in this population.
Preanesthetic checkups in Geriatric PopulationReema Chaudhary
There are many important physiological age related changes in geriatric population,so before going to any surgery we plan to do PAC ,this presentation defines all the important anesthetic consideration worth keeping in mind.
Age-Related Physiological Changes and Their Clinical SignificanceTrading Game Pty Ltd
Physiological changes occur with aging in all organ systems. The cardiac output decreases, blood pressure increases and arteriosclerosis develops. The lungs show impaired gas exchange, a decrease in vital capacity and slower
expiratory flow rates. The creatinine clearance decreases with age although the serum creatinine level remains relatively constant due to a proportionate age-related decrease in creatinine production. Functional'changes, largely
related to altered motility patterns, occur in the gastrointestinal system with senescence, and atrophic gastritis and altered hepatic drug metabolism are common in the elderly. Progressive elevation of blood glucose occurs with age on a multifactorial basis and osteoporosis is frequently seen due 'to a linear
decline in bone mass after the fourth decade. The epidermis of the skin atrophies with age and due to changes in collagen and elastin the skin loses its tone and elasticity. Lean body mass declines with ag'e and this is primarily due to loss and atrophy of muscle cells. Degenerative changes occur in many
joints and this, combined with the loss of muscle mass, inhibits elderly patients locomotion. These changes with age have important practical implications for the clinical management of elderly patients: metabolism is altered, changes
in response to commonly used drugs make different drug dosages necessary and there is need for rational preventive programs of diet and exercise in an effort to delay or reverse some of these changes.
heart failure (HF) is a syndrome of ventricular dysfunction. Left ventricular failure causes shortness of breath and fatigue, and right ventricular failure causes peripheral and abdominal fluid accumulation; the ventricles can be involved together or separately. Diagnosis is initially clinical, supported by chest x-ray, echocardiography, and levels of plasma natriuretic peptides. Treatment includes patient education, diuretics, ACE inhibitors, angiotensin II receptor blockers, beta-blockers, aldosterone antagonists, neprilysin inhibitors, specialized implantable pacemakers/defibrillators and other devices, and correction of the cause(s) of the HF syndrome.
Chapter 12 Chronic Kidney Disease and DialysisKalvinSmith4
For DH Theory III, students must give a presentation on a specific module in the class. The purpose of these presentations is to inform students on how treat patients in a dental setting who may be compromised by a certain medical condition. I was tasked with presenting on chronic kidney disease and dialysis, as well as on sexually transmitted diseases. This is the presentation that I modified on CKD and dialysis.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
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Geriatric anesthesia
1.
2. Usually we refer to patients aged ≥65 yr as the elderly, but there is no
precise definition of ‘the aged’, ‘the elderly’ or ‘advanced age’ as there is
no specific clinical marker of the ‘geriatric’ patient, and ageing does not
occur abruptly.
Approximately 15% of the Western population, and about 25% of
surgical patients are aged ≥65 yr. Half of these will undergo surgery in
the remainder of their life time.
Age itself is an independent morbidity and mortality risk factor for a
long list of diseases and injuries, hospitalization, length of
hospitalization, and adverse drug reactions.
Aging is a progressive physiologic process characterized by :
1- decreased end-organ reserve
2- decreased functional capacity
3- increasing imbalance of homeostatic mechanisms
4- increasing incidence of pathologic processes.
3. Physiological changes
Nervous system
Memory decline occurs in > 40% of individuals older than age 60 years.
There is a decrease in the volume of gray and white matter. The decrease in gray matter volume is
thought to be secondary to neuronal shrinkage or neuronal loss. Such loss results in gyral atrophy
and increased ventricular size.
Decreases in brain reserve are manifested by :
increased sensitivity to anesthetic medications
increased risk for perioperative delirium and postoperative cognitive dysfunction.
Neuraxial changes :
a) reduction of the area of the epidural space, increased permeability of the dura, and decreased
volume of CSF.
b) The diameter and number of myelinated fibers in the dorsal and ventral nerve roots are decreased.
c) decreased conduction velocity in peripheral nerves.
These changes tend to make elderly individuals more sensitive to neuraxial and PNBs.
Dementia and parkinsonism
Cognitive deficits are associated with poorer rehabilitation outcomes and higher surgical mortality.
Parkinson's patients are at increased risk for:
postoperative pharyngeal dysfunction, and risk of aspiration.
autonomic instability.
4. Cardiovascular changes
Heart:
decreased myocytes number,
left ventricular wall thickening
Aortic valve sclerosis and mitral annular calcification
decreased conduction fiber density and sinus node cell number.
Functionally, these changes translate to
decreased contractility,
increased myocardial stiffness and ventricular filling pressures,
decreased β-adrenergic sensitivity.
Ageing is associated with structural and functional changes in the coronary vasculature, which could
affect myocardial perfusion with advancing age
Vascular:
The large arteries dilate, their walls thicken, and smooth muscle tone increases. As a result, vascular
stiffness increases with advancing age. This is related to:
breakdown of elastin and collagen
Alterations in nitric oxide–induced vasodilation.
Functionally, these changes are observed as: elevated MAP and pulse pressure.
5. Fig 1 Cardiac adjustments to arterial stiffening during ageing.
MDO2=myocardial oxygen supply. MVO2=myocardial
oxygen demand.
6. Decreased ventricular compliance and increased afterload
compensatory prolongation of myocardial contraction
decreased early diastolic filling time
making the contribution of atrial contraction to late ventricular filling more important :
this explains why cardiac rhythm other than sinus is often poorly tolerated in elderly
individuals.
Changes in the autonomic system with aging include:
a) decrease in response to β-receptor stimulation
b) increase in sympathetic nervous system activity.
Decreased β-receptor responsiveness :
1) causes the increased peripheral flow demand to be met primarily by preload reserve.
2) is 2ry to:
decreased receptor affinity and alterations in signal transduction.
sympathetic overactivity leading to desensitization of β‐adrenoceptors
Cardiovascular diseases (IHD, CHF and arrhythmias) are superimposed on
age‐associated changes.
7. Fig 2 Cardiac response to increased flow demand in the young and the elderly.
The young meet the increased flow demand primarily by β‐adrenoceptor‐mediated augmentation of heart rate and contractility, thus
preserving preload reserve. In contrast, the elderly employ primarily the preload reserve to augment cardiac performance, thereby
losing additional cardiovascular reserve and becoming susceptible to cardiac insufficiency.
8. Respiratory System
Changes in control of respiration, lung structure, mechanics, and pulmonary blood flow
place the elderly patients at increased risk for perioperative pulmonary complications.
A) Centrally: Ventilatory responses to hypoxia, hypercapnia, and mechanical stress are
impaired secondary to reduced CNS activity. The respiratory depressant effects of BZD,
opioids, and volatile anesthetics are exaggerated.
B) Structural changes in the lung with aging include:
.. loss of elastic recoil with enlargement of the respiratory bronchioles and alveolar ducts
.. tendency for early collapse of the small airways on exhalation.
.. progressive loss of alveolar surface area.
The functional results of these changes are
.. Increased anatomic DS
.. decreased diffusing capacity
.. increased closing capacity
C) Loss of height and calcification of the vertebral column and rib cage lead to a typical
barrel chest appearance with diaphragmatic flattening: making the diaphragm less efficient,
and its function is impaired further by a significant loss of muscle mass associated with
aging.
Functionally, the chest wall becomes less compliant, and work of breathing is increased.
9.
Residual Volume increases by 5- 10% per decade.
Vital capacity decreases.
Closing capacity increases with age. The change in the relationship between FRC and CC
cause an increased ventilation-perfusion mismatch (increased Shunt) and represent the
most important mechanism for the increase in alveolar-arterial oxygen gradient.
formula P(A–a)O2 = 3 + (0.21 x patient's age)
In younger individuals, CC is below FRC.
At 44 years of age, CC equals FRC in the supine position,
At 66 years of age, CC equals FRC in the upright position.
Increased closing capacity and depletion of muscle mass causes a progressive decrease in
FEV1 by 6% to 8% per decade.
Hypoxic pulmonary vasoconstriction is blunted and may cause difficulty with one-lung
ventilation.
Pneumonia may be presented by uncharacteristic features such as confusion, lethargy, and
deterioration of general condition.
10. Renal and Hepatic changes with age
Renal
mass may decrease 30% by age 80 years with a decrease in functioning glomeruli.
RBF decreases about 10% per decade.
There is a progressive decline in creatinine clearance with age, yet with “normal”
aging, S.Cr. remains relatively unchanged : because muscle mass also decreases
with aging, so,
S. Cr. is a poor predictor of renal function in elderly patients.
Functional changes in the kidneys with aging include alterations in electrolyte
handling and the ability to concentrate and dilute urine.
Renal capacity to conserve sodium is decreased. This, paired with a decreased
thirst response, may place an elderly patient at risk for dehydration and sodium
depletion.
Liver
volume decreases approximately 20% to 40% with aging.
Hepatic blood flow decreases about 10% per decade.
There is a variable decrease in the liver's intrinsic capacity to metabolize drugs.
11. Other problems
Polypharmacy
The number of medications used is directly proportional to the likelihood of
having an adverse drug reaction with an incidence of 5 - 35% in patients older
than age 65.
Malnutrition
The prevalence of malnutrition ranges from 15% to 26% among hospitalized
elderly patients. Surgical patients who are malnourished have increased
morbidity and mortality and increased length of stay.
Dehydration
Dehydration accounts for approximately 6.7% of admissions (in USA) and is often
associated with hypernatremia and accompanied by infection, e.g. pneumonia and UTI.
Immobility
Bed rest leads to ventricular atrophy, hypovolemia, and orthostatic intolerance.
Prolonged bed rest causes decreases in muscle mass, which may influence pulmonary
function.
12. Depression
Depression is estimated to occur in 10% of the community-dwelling population older
than age 65 years. The presence of Depression may influence the occurrence of delirium
and length of stay, and have a significant impact on postoperative quality of life.
Antidepressants should be continued during the perioperative period as discontinuing
antidepressants may increase symptoms of depression and confusion.
Hypothermia
Advancing age predisposes the patient to perioperative hypothermia. Contributing
factors include frail constitution, reduced metabolic rate, reduced subcutaneous fat layer,
major and long operations, and impaired thermoregulation
unintentional hypothermia has been associated with myocardial ischemia, angina, and
hypoxemia during the early postoperative period.
13. Pharmacological changes
Factors that affect the pharmacologic responses of elderly patients include changes in
(1) plasma protein binding,
(3) drug metabolism,
(2) body content,
(4) pharmacodynamics.
The main plasma binding protein for acidic drugs is albumin and for basic drugs is α1-acid
glycoprotein.
The level of albumin decreases with age, whereas α1-acid glycoprotein levels increase.
The effect of alterations in plasma binding protein on drug effect depend on which protein the
drug is bound to, and the resulting change in fraction of unbound drug.
Changes in body composition with aging reflect a decrease in lean body mass, an increase in
body fat, and a decrease in total body water.
A decrease in TBW could lead to a smaller central compartment and increased serum
concentrations after bolus administration of a drug. In addition, the increase in body fat might
result in a greater volume of distribution and prolonged effect of a given medication.
Depending on the degradation pathway, decreases in liver and kidney reserve can affect a
drug's pharmacokinetics profile.
Slow circulation: IV vs. Inhalation anesthetics : onset & effect
14. Preoperative Evaluation
Common diseases of elderly patients may have a major impact on anesthetic management
and require special care and diagnosis. Cardiovascular disease and diabetes are
particularly prominent in this population.
Laboratory and diagnostic studies, history, physical examination, and determination of
functional capacity should attempt to evaluate the patient's physiologic reserve.
Laboratory testing should be guided by the patient's history, physical examination, and
proposed surgical procedure, and should not be based on age alone.
The decision to operate should not be based on age alone, but should reflect an assessment
of the risk-to-benefit ratio of individual cases.
15. Risk Assessment
The preoperative assessment of perioperative cardiovascular risk relies on the evaluation of
a) clinical markers,
Major : unstable coronary syndromes, decompensated congestive heart failure, significant arrhythmias,
severe valvular disease
Intermediate : mild angina pectoris, previous myocardial infarction (>30 days old), compensated or
previous congestive heart failure, DM
Minor : advanced age, abnormal ECG, rhythm other than sinus, low functional capacity, history of stroke,
uncontrolled systemic hypertension
b) functional capacity (1 - >10 METs)
4 METs : can you climb a flight of stairs or walk up a hill or walk on level ground at 4 mph ??
c) surgery‐specific risk.
High : emergent major operations; aortic and other major vascular; peripheral vascular; anticipated
prolonged surgical procedures associated with large fluid shifts and/or blood loss
intermediate : carotid endarterectomy; head and neck; intraperitoneal and intrathoracic;
orthopaedic; prostate
low : endoscopic procedures; superficial procedures; cataract; breast
16. Anesthetic Management
Airway management : mask ventilation and laryngoscopy may be challenging especially in edentulous
or debilitated patients.
Monitoring
positioning
equipments (e.g. warming device) ….etc.
Older patients may come to the OR with depleted volume because of : NPO orders, reduced thirst,
age‐related decline in renal capacity to conserve water and salt, disease‐associated fluid and
electrolyte losses, inadequate intravenous fluid substitution and more frequent use of diuretics.
Because of decreased left ventricular compliance and limited β‐adrenoceptor responsiveness, the
elderly, particularly those with hypertension, must be expected to be more sensitive to fluid overload.
Careful volume assessment. (Volume Dependant yet volume intolerant)
preoxygenation
More frequent and severe hypotension on induction of anaesthesia must be anticipated in the elderly
because of the effects of the anaesthetics which occur on top of age‐related impaired cardiovascular
compensatory mechanisms, so, more judicious use and selection of agents, and slow titration of
reduced doses during induction and maintenance of anaesthesia, are required with advancing age
17. Inhaled Anesthetics
The (MAC) decreases approximately 6% per decade for most inhaled
anesthetics. Changes in ion channels, synaptic activity, or receptor sensitivity
may account for these changes in pharmacodynamics.
Intravenous Anesthetics and Benzodiazepines
There is no change in brain sensitivity to thiopental with age, yet, the dose of
thiopental required decreases with age, due to an age-related decrease in the
initial distribution volume of the drug resulting in higher serum drug levels.
Likewise, in the case of etomidate, decreased clearance and initial Vd, rather
than altered brain responsiveness, account for the decrease in etomidate dose.
The brain becomes more sensitive to the effects of propofol with age. In
addition, clearance of propofol is reduced.
The dose requirement of midazolam to produce sedation is decreased
approximately 75% due to increased brain sensitivity and decreased drug
clearance.
18. Opiates
Morphine clearance is decreased in elderly patients. Patients
with renal insufficiency may have impaired elimination of
morphine glucuronides, and this may account for some of the
enhanced analgesia from a given dose of morphine.
Sufentanil, alfentanil, and fentanyl are approximately twice as
potent in elderly patients. These findings are primarily related to
an increase in brain sensitivity to opioids with age, rather than
alterations in pharmacokinetics.
There is an increase in brain sensitivity to remifentanil with age.
Remifentanil is approximately twice as potent in elderly patients,
and one half the bolus dose is required. The volume of the central
compartment, V1, and clearance decrease with age, and
approximately one third the infusion rate is required in elderly
patients.
19. Muscle Relaxants
Generally, age does not significantly affect the
pharmacodynamics of muscle relaxants. Duration of action
may be prolonged, however, if the drug depends on liver or
renal metabolism.
Neuraxial Anesthesia and Peripheral Nerve Blocks
Age has no effect on duration of motor blockade with
bupivacaine spinal anesthesia. The time of onset is
decreased, however, and spread is more extensive with
hyperbaric bupivacaine solution. In Epidural anesthesia,
time of onset is shorter, and extent of block is greater.
Reduced plasma clearance of local anesthetics observed in
elderly patients can become a factor during repeated
dosing and continuous infusion techniques prompting a
reduction in top-up doses and infusion rates.
20. Anesthetic Technique
.
It is recommended to use shorter acting anesthetics, opioids, and muscle
relaxants in caring for elderly patients. When comparing inhaled anesthetics,
there does not seem to be a significant difference in recovery profile of
cognitive function.
Desflurane is associated with the most rapid emergence.
Studies have shown that elderly patients can safely receive controlled
hypotensive epidural anesthesia (MAP range 45 to 55 mm Hg) during
orthopedic procedures without increased risk.
Controversy surrounds the question of whether better outcomes are obtained
when invasive hemodynamic monitoring is used to optimize hemodynamics
and fluid therapy.
21. Regional versus General Anesthesia
Specific effects of regional anesthesia may provide some benefit.
First, regional anesthesia affects the coagulation system by preventing
postoperative inhibition of fibrinolysis. Regional anesthesia may decrease the
incidence of DVT after total hip arthroplasty.
In lower extremity revascularization, regional anesthesia is associated with a
decreased incidence of postoperative graft thrombosis compared with GA.
Second, the hemodynamic effects of regional anesthesia may be associated with
decreased blood loss in pelvic and lower extremity surgery.
Third, regional anesthesia does not require instrumentation of the airway and
may allow patients to maintain their own airway and level of pulmonary
function.
Use of regional anesthesia does not seem to decrease the incidence of
postoperative cognitive dysfunction compared with general anesthesia.
22. Postoperative Considerations
The incidence of common postoperative morbidities is
17% for atelectasis,
12% for acute bronchitis,
10% for pneumonia,
6% for heart failure or myocardial infarction (or both),
7% for delirium,
and 1% for new focal neurologic signs.
Elderly patients may be at higher risk for aspiration secondary to the progressive
decrease in laryngopharyngeal sensory discrimination.
In addition, dysfunctional swallowing predisposes elderly patients to aspiration.
Swallowing dysfunction after cardiac surgery is closely associated with the use of
TEE and carries with it a 90% rate of pulmonary aspiration and pneumonia.
Pulmonary complications are the third leading cause of postoperative morbidity in
elderly patients undergoing noncardiac surgery.
23. Delirium
The incidence of postoperative delirium in elderly patients varies widely depending on the
type of surgery.
incidence : 10% after major elective surgery, but higher after cardiac surgery.
Delirium is a syndrome characterized by acute onset of variable and fluctuating changes in
level of consciousness accompanied by a range of other mental symptoms.
“The essential feature of a delirium is a disturbance in consciousness that is accompanied by
a change in cognition that cannot be better accounted for by a preexisting or evolving
dementia”.
Risk and precipitating factors for delirium : include :
cognitive impairment or depression,
sleep deprivation, immobility, polypharmacy, pain, ICU admission,
visual impairment, hearing impairment, and dehydration
Anesthetic interventions include:
.. correction of metabolic and electrolyte disorders
.. perioperative continuation of pharmacologic therapy for neuropsychiatric disorders.
.. avoiding triggering agents: drugs (e.g., anticholinergics) or inadequately controlled pain.
Delirium has been associated with greater intraoperative blood loss, postop. blood
transfusions, and postop. HCT less than 30%.
24. Postoperative Cognitive Dysfunction
Short-term changes involve multiple cognitive domains, such as attention,
memory, and psychomotor speed.
Cardiac surgery is associated with a higher incidence of cognitive decline
compared to major non-cardiac surgery.
Predictors of early postoperative cognitive decline include: age, low educational
level, preoperative cognitive impairment, depression, and surgical procedure.
Short-term cognitive dysfunction may be attributed to:
microemboli (especially with cardiac surgery),
hypoperfusion,
systemic inflammatory response (CPB),
anesthesia, depression, and genetic factors.
Postoperative cognitive decline after major non-cardiac surgery is reversible in
most cases, but may persist in approximately 1% of patients.
long-term cognitive changes may be related to underlying cerebrovascular
disease risk factors, such as blood pressure, cholesterol, and DM.
25. Treatment of Acute Postoperative Pain
Experimental and clinical studies provide support for the notion of an age-related decrease
in pain perception.
Evaluation of pain, in a severely cognitively impaired individual, is difficult even for a
geriatrician
The combination of pain assessment and drug dose adjustment provides challenges in the
management of postoperative pain in elderly patients.
Several general principles should be kept in mind when managing frail elderly patients.
First, it is important to try to incorporate multiple modalities of analgesia, such as
intravenous PCA and regional nerve blocks.
Second, the use of site-specific analgesia is a helpful adjunct: local nerve blocks for UL
surgeries and neuraxial analgesia or intercostal nerve block for thoracotomy.
Third, whenever possible, use of narcotic sparing drugs : NSAIDs and paracetamol, should be
used : keeping in mind, however, the alterations in dose requirements that occur with age.
26. Chronological age is a poor predictor of physiologic age
Geriatric Anesthesiology
Charles H. McLeskey