Genetic Etiology of Parkinson Disease
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This document discusses the genetic etiology of Parkinson's disease. It outlines several major genes and proteins involved in Parkinson's including SNCA, LRRK2, PRKN, and PINK1. It describes the pathways they are involved in such as synaptic transmission, mitochondrial quality control, and lysosome-mediated autophagy. It also covers the clinical features and progression of Parkinson's disease, as well as modes of inheritance and risk factors.
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Flow cytometry is a technique that measures physical and chemical characteristics of particles in a fluid stream as they pass through lasers. It works by hydrodynamically focusing particles into a sample core using sheath fluid as they flow through lasers, where light scatter and fluorescence is detected and analyzed using optical filters and electronics to produce histograms and plots that characterize particles based on parameters like size, granularity and protein expression.
Exophthalmos, thyroid eye disease.
This document discusses exophthalmos, or bulging eyes, and its causes and symptoms. It begins by defining exophthalmos as the Greek word for "eye" combined with the Greek word for "out." The main causes of exophthalmos are thyroid eye disease and Graves' disease, an autoimmune disorder. Symptoms include eye pain, dryness, sensitivity to light, double vision, and potential blindness if the optic nerve is compressed. The document then discusses diagnosing and treating exophthalmos, including measuring bulging, testing vision and eye pressure, and using CT scans to identify the cause, especially if the condition is unilateral. Treatment focuses on managing active thyroid disease and addressing issues like eyelid or
The human evolution
This document summarizes the evolution of early human ancestors from 7 million years ago to present day Homo sapiens. It describes several key species including Ardipithecus ramidus, Australopithecus afarensis, Paranthropus boisei, Homo habilis, Homo neanderthalensis, and Homo sapiens. Each species is briefly discussed with details about when and where they lived as well as important traits that linked them to later human ancestors or differentiated them from other species.
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microRNA Message to T Cell Acute Lymphoblastic Leukemia
microRNA Message to T Cell Acute Lymphoblastic Leukemia
Extracellular Vesicle Flow Cytometry Analysis and Standardization
Extracellular Vesicle Flow Cytometry Analysis and Standardization
Photosynthesis, plants,algae and certain bacteria, energy and light
Photosynthesis, plants,algae and certain bacteria, energy and light
Recently uploaded
ESR spectroscopy in liquid food and beverages.pptx
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
20240520 Planning a Circuit Simulator in JavaScript.pptx
Evaporation step counter work. I have done a physical experiment.
(Work in progress.)
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
Micronuclei test.M.sc.zoology.fisheries.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Equivariant neural networks and representation theory
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
Bob Reedy - Nitrate in Texas Groundwater.pdf
Presented at June 6-7 Texas Alliance of Groundwater Districts Business Meeting
bordetella pertussis.................................ppt
Bordettela is a gram negative cocobacilli spread by air born drop let
SAR of Medicinal Chemistry 1st by dk.pdf
In this presentation include the prototype drug SAR on thus or with their examples .
Syllabus of Second Year B. Pharmacy
2019 PATTERN.
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...
Travis Hills of Minnesota developed a method to convert waste into high-value dry fertilizer, significantly enriching soil quality. By providing farmers with a valuable resource derived from waste, Travis Hills helps enhance farm profitability while promoting environmental stewardship. Travis Hills' sustainable practices lead to cost savings and increased revenue for farmers by improving resource efficiency and reducing waste.
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Although Artemia has been known to man for centuries, its use as a food for the culture of larval organisms apparently began only in the 1930s, when several investigators found that it made an excellent food for newly hatched fish larvae (Litvinenko et al., 2023). As aquaculture developed in the 1960s and ‘70s, the use of Artemia also became more widespread, due both to its convenience and to its nutritional value for larval organisms (Arenas-Pardo et al., 2024). The fact that Artemia dormant cysts can be stored for long periods in cans, and then used as an off-the-shelf food requiring only 24 h of incubation makes them the most convenient, least labor-intensive, live food available for aquaculture (Sorgeloos & Roubach, 2021). The nutritional value of Artemia, especially for marine organisms, is not constant, but varies both geographically and temporally. During the last decade, however, both the causes of Artemia nutritional variability and methods to improve poorquality Artemia have been identified (Loufi et al., 2024).
Brine shrimp (Artemia spp.) are used in marine aquaculture worldwide. Annually, more than 2,000 metric tons of dry cysts are used for cultivation of fish, crustacean, and shellfish larva. Brine shrimp are important to aquaculture because newly hatched brine shrimp nauplii (larvae) provide a food source for many fish fry (Mozanzadeh et al., 2021). Culture and harvesting of brine shrimp eggs represents another aspect of the aquaculture industry. Nauplii and metanauplii of Artemia, commonly known as brine shrimp, play a crucial role in aquaculture due to their nutritional value and suitability as live feed for many aquatic species, particularly in larval stages (Sorgeloos & Roubach, 2021).
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
The debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/Recently uploaded (20)
ESR spectroscopy in liquid food and beverages.pptx
ESR spectroscopy in liquid food and beverages.pptx
aziz sancar nobel prize winner: from mardin to nobel
aziz sancar nobel prize winner: from mardin to nobel
Compexometric titration/Chelatorphy titration/chelating titration
Compexometric titration/Chelatorphy titration/chelating titration
20240520 Planning a Circuit Simulator in JavaScript.pptx
20240520 Planning a Circuit Simulator in JavaScript.pptx
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Equivariant neural networks and representation theory
Equivariant neural networks and representation theory
bordetella pertussis.................................ppt
bordetella pertussis.................................ppt
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...
Travis Hills' Endeavors in Minnesota: Fostering Environmental and Economic Pr...
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
The use of Nauplii and metanauplii artemia in aquaculture (brine shrimp).pptx
Immersive Learning That Works: Research Grounding and Paths Forward
Immersive Learning That Works: Research Grounding and Paths Forward
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
mô tả các thí nghiệm về đánh giá tác động dòng khí hóa sau đốt
The debris of the ‘last major merger’ is dynamically young
The debris of the ‘last major merger’ is dynamically young
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...
Genetic Etiology of Parkinson Disease
- 1. Genetic Etiology of Parkinson Disease Parisa Sadat Naji Esfahani Dr. Khatami Summer 2018
- 2. 2
- 3. Clinical Features of Parkinson Disease 3
- 4. 4
- 5. 5 Pathways on Parkinson Disease i. Synaptic Transmission or Dopamine Signaling SNCA ii. Mitochondrial Quality Control or mitochondrial damage repair pathway DJ1, PINK1, PRKN iii. Lysosome – Mediated Autophagy or MAPKKK Signaling LRRK2
- 6. Major Genes and Proteins in Parkinson Disease 6
- 7. SNCA at 4q21 7 • PARK1 & 4 or α-synuclein of Synuclein Family • 140 amino acid • AD Gene • Roles: 1. Integrate Presynaptic Signaling & Membrane Trafficking 2. Regulate the Release of Dopamine 3. Microtubules Movements
- 8. LRRK2 at 12q12 8 • PARK8 or Leucine_rich repeat kinase 2 or Dardarin • 2527 amino acid • AD Gene • Roles: 1. SNCA Phosphorylation 2. Microtubule Dynamics 3. Immune System Cells 4. Autophagic Alterations 5. Synthesis & Trafficking of Vesicles 6. Mitochondrial Function 7. UPS Alterations
- 9. PRKN at 6q26 9 • PARK2 or Parkin • 456 amino acid • AR Gene • Roles: 1. E3 Ubiquitin Ligases 2. Trigger the Destruction of Mitochondria 3. Tumor Suppressor Protein 4. Release Synaptic Vesicles from Nerve Cells
- 10. PINK1 at 1p36.12 10 • PARK6 or PTEN-induced putative kinase 1 • 581 amino acid • AR Gene • Roles: 1. Mitochondrial Dysfunction
- 11. DJ1 at 1p36.23 11 • PARK7 • Oncogene • AR Gene • Roles: 1. A Positive Regulator of Androgen Receptor-dependent Transcription 2. Redox-sensitive Chaperone (as a Sensor for Oxidative Stress) 3. Protects Neurons against Oxidative Stress & Cell Death
- 12. 13
- 13. Mutation of Parkinson Disease 14
- 14. 15
- 15. Mode of Inheritance in Parkinson Disease 16
- 16. Mode of Inheritance in Parkinson‘s Disease 17
- 18. Risk Factors 19
- 19. Progression of Parkinson’s disease pathology 20
- 20. Progression of Parkinson’s disease pathology 21
- 21. New Informations about Parkinson‘s Disease 22 Elements concentration in CSF and serum of PD versus control
- 22. 23
Editor's Notes
- PINK1, parkin and FBXO7 (F-box only protein 7): mitochondria quality control and mitophagy
- PARK 1,2,6,7,8,9,15,17,
- Dopamine: controlling the start and stop of voluntary and involuntary movements.