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Gastric Emptying
Dr. Sara Sadiq
(MBBS, M.Phil)
Factors Affecting Gastric Emptying
• Pylorus  Tonically constricted
• Antral Peristalsis  Pyloric pump
 Pump chyme into duodenum
Regulation of Gastric Emptying
• Gastric factors  Promote emptying
• Duodenal factors  Inhibit emptying
Gastric Factors  Promote Stomach Emptying
• Gastric Food Volume
 Myenteric reflex
 Vagal stimulation
 Pyloric pump
Gastric Factors  Promote Stomach Emptying
• Gastrin
 Food Volume
 stretch of stomach wall
 Gastrin released by antral mucosa
 Increase activity of pyloric pump
and relaxation of pylorus
Duodenal Factors  Inhibit Stomach Emptying
• Entero-gastric reflex
 Distension of duodenum
 Irritation of duodenal mucosa
 Acidity of duodenal chime
 Increase osmolality of chime
 Protein and fat breakdown products
Duodenal Factors  Inhibit Stomach Emptying
• Hormones
 Cholecystokinin
 Secretin
 Gastric inhibitory peptide
• Stimulatory factors for hormones
 Fat contents in chyme
 Acidity of duodenal chime
THANKYOU

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Gastric emptying

  • 1. Gastric Emptying Dr. Sara Sadiq (MBBS, M.Phil)
  • 2. Factors Affecting Gastric Emptying • Pylorus  Tonically constricted • Antral Peristalsis  Pyloric pump  Pump chyme into duodenum
  • 3.
  • 4.
  • 5. Regulation of Gastric Emptying • Gastric factors  Promote emptying • Duodenal factors  Inhibit emptying
  • 6. Gastric Factors  Promote Stomach Emptying • Gastric Food Volume  Myenteric reflex  Vagal stimulation  Pyloric pump
  • 7. Gastric Factors  Promote Stomach Emptying • Gastrin  Food Volume  stretch of stomach wall  Gastrin released by antral mucosa  Increase activity of pyloric pump and relaxation of pylorus
  • 8. Duodenal Factors  Inhibit Stomach Emptying • Entero-gastric reflex  Distension of duodenum  Irritation of duodenal mucosa  Acidity of duodenal chime  Increase osmolality of chime  Protein and fat breakdown products
  • 9.
  • 10.
  • 11. Duodenal Factors  Inhibit Stomach Emptying • Hormones  Cholecystokinin  Secretin  Gastric inhibitory peptide • Stimulatory factors for hormones  Fat contents in chyme  Acidity of duodenal chime