The document discusses the formulation and development of matrix tablets for controlled drug delivery, highlighting their advantages such as cost-effectiveness, improved bioavailability, and treatment efficacy, along with disadvantages like high preparation costs and poor in vitro-in vivo correlation. It classifies matrix tablets based on retardant materials and porosity, describes polymers used, and outlines the manufacturing and evaluation processes. The conclusion emphasizes the benefits of sustained-release formulations in enhancing dosage efficiency and patient compliance, particularly in antibiotics to mitigate resistance.

1. FORMULATION AND
DEVELOPMENT OF MATRIX TABLET
IN DRUG DELIVERY SYSTEM
BENGAL SCHOOL OF TECHNOLOGY
SUBJECT:- PHARMACEUTICS
-SAYAN PRAMANIK
BACHELOR OF PHARMACY
4th YEAR 7th SEM

2. INTRODUCTION
• Matrix tablet is an important tool for controlled and sustained release
dosage forms.
• The oral route remains the most common route for the administration of
drugs.
• Tablets offer the lowest cost approach to sustained and controlled
release dosage forms.
• Type of controlled drug delivery systems, which release the drug in
continuous manner.
• The hydrophilic polymer matrix is widely used in this dosage form.
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3. ADVANTAGES
• Easy to manufacture
• Versatile, effective and low cost
• Can be made to release high molecular
weight compounds
• Improvement in treatment efficacy.
• Usage of less total drug.
• Improvement the bioavailability of some
drugs.
• Reduce the toxicity.
• Minimize the local and systemic side effects.
• Increase the stability.
• The remaining matrix must be removed
after the drug has been released.
• High cost of preparation.
• Poor in vitro-in vivo correlation.
• Higher cost of formulation
DISADVANTAGES
ADVANTAGES AND DISADVANTAGES OF
MATRIX TABLET
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4. CLASSIFICATION OF MATRIX TABLET
• On the Basis of Retardant Material Used
I) Hydrophobic Matrices
II) Lipid Matrices
III) Hydrophilic Matrices
IV) Biodegradable Matrices
V) Mineral Matrices
• On the Basis of Porosity of Matrix
I) Macro porous Systems
II) Microporous System
III) Non-porous System
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5. POLYMERS USED IN SR DRUG DELIVERY
SYSTEMS
• Bio-degradable polymers: Alginates, Guar gum, Chitosan, Gelatin
• Bio-absorbable polymers: Polyethylene glycol and
polyvinylpyrrolidone
• Bio-nondegradable polymers: Hydroxy propyl methyl cellulose
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6. EXPERIMENTAL WORK
Preformulation
Study
Formulation
Of Matrix
Tablet
Optimization
Study
Stability
Studies
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7. Preformulation Study
Bulk Density
Tapped Density
Compressibility Index
Hausner’s Ratio
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8. FORMULATION OF MATRIX TABLET
Manufacturing Process
Sifting
Dry mixing
Binder
Preparation
Granulation Drying
Sifting
Pre-
Lubrication
Lubrication Compression
Coating
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9. Evaluations
of Tablet
1. Weight
Variation
2. Hardness
3. Thickness
4. Friability
5. Dissolution
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10. Optimization Study
on the basis presence of pH
dependent polymer
Formulation were modified with
subject to pH independent
polymer
concentration of polymer and
surfactant were changed
Stability Studies
Definition
• the capacity of a drug substance to maintain its identity, quality and purity
Objective
• quality of the drug substance
• shelf life for drug substance
Method
• 1st and 2nd month Stability testing
• assay and% drug release of optimized batch was compared
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11. CONCLUSION
• By the above discussion, it can be easily concluded that sustained-
release formulation is helpful in increasing the efficiency of the dose as
well as they are also improving the patient’s compatibility. More over all
these comes with reasonable cost. The dosage form is easy to optimize
and very helpful in case of the antibiotics in which irrational use of the
same may result in resistance.
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