This document discusses the historical evolution and use of fluorides for dental caries prevention. It begins with early discoveries of fluoride in enamel in 1805 and the isolation of fluorine as an element in 1771. It then covers fluoride chemistry, sources of fluoride intake from water, food, beverages and air. The document discusses fluoride metabolism, distribution in tissues, and excretion. It also addresses water fluoridation, which began in 1945 in Grand Rapids, USA and defines water fluoridation as the controlled adjustment of fluoride in communal water to maximize caries prevention with minimal fluorosis risk.
This presentation is all about the systemic administration of fluorides ,as it is an easier way for the administration of fluorides to prevent dental caries and tooth decay.the aim is to explain the advantages of systemic fluoride ,their present status in India and in other countries and to create awareness among population.Also raising an issue that how these methods of systemic fluoride administration can be improved so that there is better prevention of decay problems
DEAN’S FLUOROSIS INDEX 1943 (PUBLIC HEALTH DENTISTRY)Jeban Sahu
INTRODUCTION
INDEX:“A NUMERICAL VALUE DESCRIBING THE RELATIVE STATUS OF A POPULATION ON A GRADUATED SCALE WITH DEFINITE UPPER AND LOWER LIMITS, WHICH IS DESIGNED TO PERMIT AND FACILITATE COMPARISION WITH OTHER POPULATIONS CLASSIFIED BY THE SAME CRITERIA AND METHODS.”
-RUSSELL A.L.
INDICES USED TO MEASURE FLUOROSIS
DEAN’S FLUOROSIS INDEX
Introduced by TRENDLEY H. DEAN in 1934.
Devised an index for assessing the presence and severity of mottled enamel.
It is also known as ‘DEAN’S CLASSIFICATION SYSTEM FOR DENTAL FLUOROSIS.’
DEAN’S FLUOROSIS INDEX- Modified Criteria (1942)
SCORING CRITERIA
COMMUNITY FLUOROSIS INDEX (CFI)
SUMMARY
This presentation is all about the systemic administration of fluorides ,as it is an easier way for the administration of fluorides to prevent dental caries and tooth decay.the aim is to explain the advantages of systemic fluoride ,their present status in India and in other countries and to create awareness among population.Also raising an issue that how these methods of systemic fluoride administration can be improved so that there is better prevention of decay problems
DEAN’S FLUOROSIS INDEX 1943 (PUBLIC HEALTH DENTISTRY)Jeban Sahu
INTRODUCTION
INDEX:“A NUMERICAL VALUE DESCRIBING THE RELATIVE STATUS OF A POPULATION ON A GRADUATED SCALE WITH DEFINITE UPPER AND LOWER LIMITS, WHICH IS DESIGNED TO PERMIT AND FACILITATE COMPARISION WITH OTHER POPULATIONS CLASSIFIED BY THE SAME CRITERIA AND METHODS.”
-RUSSELL A.L.
INDICES USED TO MEASURE FLUOROSIS
DEAN’S FLUOROSIS INDEX
Introduced by TRENDLEY H. DEAN in 1934.
Devised an index for assessing the presence and severity of mottled enamel.
It is also known as ‘DEAN’S CLASSIFICATION SYSTEM FOR DENTAL FLUOROSIS.’
DEAN’S FLUOROSIS INDEX- Modified Criteria (1942)
SCORING CRITERIA
COMMUNITY FLUOROSIS INDEX (CFI)
SUMMARY
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
self correcting anomalies in the development of occlusion. this ppt includes the anomalies of a child's developing occlusion which get corrected by itself in some time as the development continues. This includes Retrognathic mandible,infantile swallow,anterior open and deep bite,etc. these topics are important in BDS final examination
Non –pharmacological behavior management in childrenDr. Harsh Shah
Overview on nonpharmacological managent of behaviour in children
Presented by : Mayuri Karad
SDDCH Parbhani
Guided by : Dr. Rehan Khan
Dept, of Pediatric and preventive dentistry
INTRODUCTION
DEFINITION
TYPES OF TRAUMA FROM OCCLUSION
GLICKMAN CONCEPT
WAERHAUG CONCEPT
STAGES OF TISSUE RESPONSE TO INJURY
CLINICAL AND RADIOGRAPHIC FEATURES OF TFO
CLINICAL DIAGNOSIS OF TFO
TFO AND IMPLANTS
TREATMENT OF TFO
CONCLUSION
REFRENCES
A comprehensive presentation about role of fluorides in caries prevention. Their sources, metabolism, history of fluorides, how to administer fluorides, advantages and disadvantages of different kinds of systemic fluorides.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
self correcting anomalies in the development of occlusion. this ppt includes the anomalies of a child's developing occlusion which get corrected by itself in some time as the development continues. This includes Retrognathic mandible,infantile swallow,anterior open and deep bite,etc. these topics are important in BDS final examination
Non –pharmacological behavior management in childrenDr. Harsh Shah
Overview on nonpharmacological managent of behaviour in children
Presented by : Mayuri Karad
SDDCH Parbhani
Guided by : Dr. Rehan Khan
Dept, of Pediatric and preventive dentistry
INTRODUCTION
DEFINITION
TYPES OF TRAUMA FROM OCCLUSION
GLICKMAN CONCEPT
WAERHAUG CONCEPT
STAGES OF TISSUE RESPONSE TO INJURY
CLINICAL AND RADIOGRAPHIC FEATURES OF TFO
CLINICAL DIAGNOSIS OF TFO
TFO AND IMPLANTS
TREATMENT OF TFO
CONCLUSION
REFRENCES
A comprehensive presentation about role of fluorides in caries prevention. Their sources, metabolism, history of fluorides, how to administer fluorides, advantages and disadvantages of different kinds of systemic fluorides.
HISTORY & MECHANISM OF ACTION SYSTEMIC FLUORIDES.pptxRUCHIKA BAGARIA
EVERYTHING YOU NEED TO KNOW ABOUT SYSTEMIC FLUORIDES.
HISTORY, MECHANISM OF ACTION, METABOLISM, DIETARY SUPPLEMENTS AND RECENT ADVANCES.
LETS STUDY SYSTEMIC FLUORIDE TOGETHER.
LETS LEARN AND SHARE OUR KNOWLEDGE.
Fluoride is: natural mineral that helps build strong teeth and prevent cavities
Fluoride treatment; is typically professional treatment containing high concentration of fluoride that dentist or hygienist will apply to a person’s teeth to improve health and reduce the risk of cavities
Benefits of fluoride treatment:
1- Slow or reverse the development of cavities by harming bacteria that cause cavities.
2- Join into tooth structure when tooth develop to strengthen the enamel surface
3- Helps body, better use mineral such as Ca and phosphate, the teeth reabsorb these mineral to repair weak tooth enamel
Side effect of fluoride:
1- Tooth discoloration
2- Allergies or irritation
3- Toxic effect: if person apply it incorrectly or at high doses: nausea, diarrhea, excessive sweating
Common source of dietary fluoride:
Tea, water, sea food, fish eaten with their bones
Grape juice, food cooked in water.
Optimal fluoride intake:
Birth to 3 years: ---- 0.1 to 1.5 mg
4 years of age: ------1 to 2,5mg
7 years of age: ------ 1.5 to 2.5mg
Adolescent and adult: --- 1.5 to 4mg
History:
1802: Sir James Crichton Browne, the 1st hint of possible connection of fluoride and dental health
1901: Fredrek Mckay: present in permanent stains on teeth known as mottled enamel
1902: J.M Eager: stains on teeth
1916: Green Vardmin Black: support the Mckay work with histologic evidence, reported as endemic imperfection of enamel
Fluoride application procedures:
1- Fluoride prophylaxis pastes:
The use of cleaning and polishing pastes (pumic, zircate) and other comparable abrasive pastes before cementing orthodontic bands may lead to removal of significant amount of surface enamel which has more resistant layer and provide a significant amount of fluoride to support enamel surface.
2- Topical fluoride solution:
The most commonly used topical solutions are;
Sodium fluoride –2% neutral
Acidulated sodium fluoride at PH3 and 1.2 fluoride
8% --10% stannous fluoride.
3- Fluoride gel:
Are available in; sodium fluoride, acidulated sodium fluoride, stannous fluoride
4- Fluoride mouth rinse
5- Fluoride tablets:
Fluoride administration as pills or tablets (0.5 ---1mg/day) according to age show caries reduction in permanent teeth of 20 --- 40% when started at 6 –9 years of age
6- Fluoride dentifrices:
There are large number of dentifrices in market as, sodium fluoride, stannous fluoride, amine fluoride
Sodium monofluorophosphate
The regular use of fluoride dentifrices should be recommended to all patients undergoing orthodontic treatment in addition to other forms of fluoride administration
7- Fluoride cements:
Silicate cements restoration slowly release fluorides and protect surrounding enamel from secondary caries
8- Fluoride varnish:
Topical application of fluoride predisposes to the formation of readily soluble Ca fluoride crystals on the enamel surface
9- Other methods: as elastic containing 10% sodium fluoride.
Some studies:
1- Good oral hygiene was the only
History
Natural Sources Of Fluoride
Physiology and metabolism of fluoride
Fluoride in Dentistry
Control of dental caries
Fluoride toxicity
Dental fluorosis
Fluorosis indices
Water defluoridation
Conclusion
learning objectives
Introduction
History Of Water Fluoridation
How Does Fluoride Act In Dental Caries Prevention?
Goals Of F Administration
Fluoride Administration
Appropriate Levels Of Fluoride in Drinking Water
Methods of water fluoridation
--------------------------------------------------------------------
Efficacy Of topical fluorides
Range Of therapeutic fluoride concentrations used to prevent caries
Recommended doses
Slack (or Teams) Automation for Bonterra Impact Management (fka Social Soluti...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on the notifications, alerts, and approval requests using Slack for Bonterra Impact Management. The solutions covered in this webinar can also be deployed for Microsoft Teams.
Interested in deploying notification automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Kubernetes & AI - Beauty and the Beast !?! @KCD Istanbul 2024Tobias Schneck
As AI technology is pushing into IT I was wondering myself, as an “infrastructure container kubernetes guy”, how get this fancy AI technology get managed from an infrastructure operational view? Is it possible to apply our lovely cloud native principals as well? What benefit’s both technologies could bring to each other?
Let me take this questions and provide you a short journey through existing deployment models and use cases for AI software. On practical examples, we discuss what cloud/on-premise strategy we may need for applying it to our own infrastructure to get it to work from an enterprise perspective. I want to give an overview about infrastructure requirements and technologies, what could be beneficial or limiting your AI use cases in an enterprise environment. An interactive Demo will give you some insides, what approaches I got already working for real.
Smart TV Buyer Insights Survey 2024 by 91mobiles.pdf91mobiles
91mobiles recently conducted a Smart TV Buyer Insights Survey in which we asked over 3,000 respondents about the TV they own, aspects they look at on a new TV, and their TV buying preferences.
State of ICS and IoT Cyber Threat Landscape Report 2024 previewPrayukth K V
The IoT and OT threat landscape report has been prepared by the Threat Research Team at Sectrio using data from Sectrio, cyber threat intelligence farming facilities spread across over 85 cities around the world. In addition, Sectrio also runs AI-based advanced threat and payload engagement facilities that serve as sinks to attract and engage sophisticated threat actors, and newer malware including new variants and latent threats that are at an earlier stage of development.
The latest edition of the OT/ICS and IoT security Threat Landscape Report 2024 also covers:
State of global ICS asset and network exposure
Sectoral targets and attacks as well as the cost of ransom
Global APT activity, AI usage, actor and tactic profiles, and implications
Rise in volumes of AI-powered cyberattacks
Major cyber events in 2024
Malware and malicious payload trends
Cyberattack types and targets
Vulnerability exploit attempts on CVEs
Attacks on counties – USA
Expansion of bot farms – how, where, and why
In-depth analysis of the cyber threat landscape across North America, South America, Europe, APAC, and the Middle East
Why are attacks on smart factories rising?
Cyber risk predictions
Axis of attacks – Europe
Systemic attacks in the Middle East
Download the full report from here:
https://sectrio.com/resources/ot-threat-landscape-reports/sectrio-releases-ot-ics-and-iot-security-threat-landscape-report-2024/
Let's dive deeper into the world of ODC! Ricardo Alves (OutSystems) will join us to tell all about the new Data Fabric. After that, Sezen de Bruijn (OutSystems) will get into the details on how to best design a sturdy architecture within ODC.
DevOps and Testing slides at DASA ConnectKari Kakkonen
My and Rik Marselis slides at 30.5.2024 DASA Connect conference. We discuss about what is testing, then what is agile testing and finally what is Testing in DevOps. Finally we had lovely workshop with the participants trying to find out different ways to think about quality and testing in different parts of the DevOps infinity loop.
UiPath Test Automation using UiPath Test Suite series, part 3DianaGray10
Welcome to UiPath Test Automation using UiPath Test Suite series part 3. In this session, we will cover desktop automation along with UI automation.
Topics covered:
UI automation Introduction,
UI automation Sample
Desktop automation flow
Pradeep Chinnala, Senior Consultant Automation Developer @WonderBotz and UiPath MVP
Deepak Rai, Automation Practice Lead, Boundaryless Group and UiPath MVP
Essentials of Automations: Optimizing FME Workflows with ParametersSafe Software
Are you looking to streamline your workflows and boost your projects’ efficiency? Do you find yourself searching for ways to add flexibility and control over your FME workflows? If so, you’re in the right place.
Join us for an insightful dive into the world of FME parameters, a critical element in optimizing workflow efficiency. This webinar marks the beginning of our three-part “Essentials of Automation” series. This first webinar is designed to equip you with the knowledge and skills to utilize parameters effectively: enhancing the flexibility, maintainability, and user control of your FME projects.
Here’s what you’ll gain:
- Essentials of FME Parameters: Understand the pivotal role of parameters, including Reader/Writer, Transformer, User, and FME Flow categories. Discover how they are the key to unlocking automation and optimization within your workflows.
- Practical Applications in FME Form: Delve into key user parameter types including choice, connections, and file URLs. Allow users to control how a workflow runs, making your workflows more reusable. Learn to import values and deliver the best user experience for your workflows while enhancing accuracy.
- Optimization Strategies in FME Flow: Explore the creation and strategic deployment of parameters in FME Flow, including the use of deployment and geometry parameters, to maximize workflow efficiency.
- Pro Tips for Success: Gain insights on parameterizing connections and leveraging new features like Conditional Visibility for clarity and simplicity.
We’ll wrap up with a glimpse into future webinars, followed by a Q&A session to address your specific questions surrounding this topic.
Don’t miss this opportunity to elevate your FME expertise and drive your projects to new heights of efficiency.
Key Trends Shaping the Future of Infrastructure.pdfCheryl Hung
Keynote at DIGIT West Expo, Glasgow on 29 May 2024.
Cheryl Hung, ochery.com
Sr Director, Infrastructure Ecosystem, Arm.
The key trends across hardware, cloud and open-source; exploring how these areas are likely to mature and develop over the short and long-term, and then considering how organisations can position themselves to adapt and thrive.
Connector Corner: Automate dynamic content and events by pushing a buttonDianaGray10
Here is something new! In our next Connector Corner webinar, we will demonstrate how you can use a single workflow to:
Create a campaign using Mailchimp with merge tags/fields
Send an interactive Slack channel message (using buttons)
Have the message received by managers and peers along with a test email for review
But there’s more:
In a second workflow supporting the same use case, you’ll see:
Your campaign sent to target colleagues for approval
If the “Approve” button is clicked, a Jira/Zendesk ticket is created for the marketing design team
But—if the “Reject” button is pushed, colleagues will be alerted via Slack message
Join us to learn more about this new, human-in-the-loop capability, brought to you by Integration Service connectors.
And...
Speakers:
Akshay Agnihotri, Product Manager
Charlie Greenberg, Host
Neuro-symbolic is not enough, we need neuro-*semantic*Frank van Harmelen
Neuro-symbolic (NeSy) AI is on the rise. However, simply machine learning on just any symbolic structure is not sufficient to really harvest the gains of NeSy. These will only be gained when the symbolic structures have an actual semantics. I give an operational definition of semantics as “predictable inference”.
All of this illustrated with link prediction over knowledge graphs, but the argument is general.
Dev Dives: Train smarter, not harder – active learning and UiPath LLMs for do...UiPathCommunity
💥 Speed, accuracy, and scaling – discover the superpowers of GenAI in action with UiPath Document Understanding and Communications Mining™:
See how to accelerate model training and optimize model performance with active learning
Learn about the latest enhancements to out-of-the-box document processing – with little to no training required
Get an exclusive demo of the new family of UiPath LLMs – GenAI models specialized for processing different types of documents and messages
This is a hands-on session specifically designed for automation developers and AI enthusiasts seeking to enhance their knowledge in leveraging the latest intelligent document processing capabilities offered by UiPath.
Speakers:
👨🏫 Andras Palfi, Senior Product Manager, UiPath
👩🏫 Lenka Dulovicova, Product Program Manager, UiPath
Accelerate your Kubernetes clusters with Varnish CachingThijs Feryn
A presentation about the usage and availability of Varnish on Kubernetes. This talk explores the capabilities of Varnish caching and shows how to use the Varnish Helm chart to deploy it to Kubernetes.
This presentation was delivered at K8SUG Singapore. See https://feryn.eu/presentations/accelerate-your-kubernetes-clusters-with-varnish-caching-k8sug-singapore-28-2024 for more details.
2. CONTENT
Introduction
Historical evolution of fluorides
Fluoride chemistry and occurrence
Total intake of fluoride
From Air
From Water
From Food
Fluoride metabolism and bioavailability
Physiologic distribution of fluoride
In blood and soft tissue
In hard tissue
3. Excretion of fluoride
Placental transfer of fluoride
Water fluoridation
School water fluoridation
Fluoride tablets
Fluoridated salt
Fluoridated milk
Fluoridated flour and sugar
Toxicity of fluoride
Defluoridation
4. HISTORY
In 1805, Morichini found fluoride in human Enamel.
Fluorine discovered by chemist Scheele in 1771- isolated by Moissan in
1886
First report of fluoride concentration in drinking water quoted in ppm
given by Hillebrand.
Desirabode in 1847 referred to fluates-(silicate or fluate of lime and
alumine, dried and pulverized)
First reference to prophylactic role of fluoride made by Erhadt in 1874
Fluoride pills (KF) recommended in England, comes in pleasant tasting
form as “hunter pills”
Dr A. Denninger (1896)- Fluoride an agent to combat dental disease
and Appendicitis
5. In 1901 Dr. Federick Mckay- “Colorodo Stains”
minute white flecks, yellow or brown spots scattered..
In 1902 Dr. J.M. Eager noticed in Italian emigrants -“denti di chiaie”
1916, Dr. Green supported Mckay work with histologic evidence “ an endemic
imperfection of the enamel of the tooth
In 1918 Dr. O. E. Martin and Mckay- Britton (1898) changed water supply from
shallow wells to deep drilled artesian wells….
1931 Mr. H. V. Churchill- spectrographic analysis of Bauxite
city water 13.7ppm
6. in 1933, Dr. H. Trendley Dean- conducted “Shoe Leather Survey”
in 97 localities, with a aim to find out minimal threshold level….
In 1939 came out with ‘domestic water is primary cause of human
mottled enamel ( dental fluorosis)’
In the same year- hypothesis showing ‘inverse relationship
between endemic fluorosis and dental caries’
7. Fluoride chemistry
& occurrence -
Greek “floris”- destruction
Latin “fluor”- flow or flux
Symbol- “F”
Atomic no.- 9
Atomic weight- 18.99
It is a pale yellow, corrosive
gas, which reacts with
practically all organic and
inorganic substances
Most electronegative of all
elements
8. Reasons for high reactivity:- 1s2, 2s2, 2p5
Most electronegative of all elements
Small size of atom
High electron affinity
Small bond length
9. 17th in order of abundance of all elements
Constitutes about 0.032% in earth’s crust
Fluoride containing minerals-
Fluorspar (CaF2) - 48.8%
Cryolite (Na3AlF6) – rare
Fluorapetite Ca10(PO4)6F2- 3.8%
10. Fluoride In Air
HF or Gaseous F2
Dust of f2 containing soils, gaseous industrial, coal
smoke,
and volcanic emulsion.
Levels of air borne- Aluminum factories: 5micro grams/
m3
11. Fluoride in plants
Roots form soil and Leaves form air
Camellia sinensis –acidic soils,
Indian Tea leaves – 70 to 375 ppm
Vegetables- factories- 10ppm
Fruits and vegetables- 0.2 to 0.5 microgram/gram wet
wt.
grown near aluminums
12. Fluoride In Animal Products
Beef, pork and mutton-0.3ppm
Higher in Chicken- contamination bone and cartilage
fragments
Fish products- up to 20ppm
Dried sea foods also fluoride rich 84.5ppm (South East
Asia)
13. Fluoride In Beverages
Ranges from 0.05 to 1.05 ppm
Fluoride content in alcoholic beverages generally
reflects that of water used.
14. Total daily intake of fluoride
Fluoride from Air
Minimal
Fluoride from Water
Most important single source of fluoride
Dependent on fluoride concentration and amount
Fluctuation –climatic and geographical areas
Fluoride from food
0.3 to 0.6 mg/day
Fluoride intake 6months of life-bottle/breast fed
Breast fed infant receives 0.003 to 0.004mg/day- formula fed
infants (1.2ppm) fluoride intake increased 50 times
15. Excessive consumption of tea and sea foods- increased flr
National Research Council 1980 – safe and adequate
1.5 to 4.0 mg/day in adults
0.05 to 0.07 mg/day in children for optimal dental
health
Threshold level drinking water 2.0ppm- dental fluorosis
16. Fluoride metabolism & Bioavailability
Therapeutic action and safety of fluoride – kinetic process
Mechanism and site of absorption:-
Water soluble fluorides- NaF, HF, H2SiF6, Na2PO3F and
StF
Less soluble fluorides- CaF2 , Ca10(PO4)6F2
Passive in nature
Rapid absorption stomach- nonionic diffusion of HF
Ph of gastric fluid-free F in the form of HF
With milk, F bioavailability decreased..
Formation of low soluble calcium fluoride
Binding to casein and colloidal calcium phosphate
Clotting of milk (acidity)-physical barrier over mucosal
17. Absorption from solid foods is less compare to liquid
80% of ingested is absorbed
From fluoride preparation and dental materials:-
Dentifrices- less
Alginate (4450 to 24,240 ppm)- systemic absorption peak in
30 min
Single impression Zelgan- 119ng/ml in plasma level
Double impression -200ng/ml
150 ng/ml from 3mg F in aqueous solution
Fluoridated anesthesia- halothane, Methoxyfluorane,
Enflurane -630ng/ml
18. PHYSIOLOGIC DISTRIBUTION OF
FLUORIDE
Fluoride in Blood:-
Blood plasma is most reliable indicator
¾ in plasma and ¼ in RBC
Fluoride exists in both forms
-bounded from
-ionic form- varies concentration F in drinking water
Increase in plasma F with age and in presence of renal failure
Drinking water 0.25 or 1.25 ppm –plasma level 0.01 or 0.025ppm
Increased reactive sites and voids in old bone is more saturated and
filled with F than young bone
19. Fluoride In Soft Tissue
Tissue/ plasma ratio = 0.4 to 1
Ectopic calcification loci- F accumulation in Aorta,
tendon, cartilage and placenta
20. Effects On Kidney
Fluoride is normally cleared from the blood by
deposition in bone, excretion in urine- unable to find
toxic effect on kidney endemic fluorosis.
Patients with chronic renal failure- dialysed with
fluoridated have additional load of fluoride
So fluoride free water is used for kidney dialysis
21.
22. Bone:-
Total amount-2.6mg
Most of F in the body retained in the skeleton-vary according
to the renal clearance
F enter in mineralized tissue-replacing 0H-, C03
2- and HC03
-
Remodeling bones deposit more fluoride than older people
Fluoride deposition is a reversible process
23. Teeth:-
Deposition occurs in successive stages.
Initial deposition – organic and mineral phases are laid down
Pre-eruptive maturation phase-before eruption
Post eruptive maturation and aging period
Dentine contains 4 times more than enamel
Fluoride concentration not uniform
Fluoride concentration –initial stages is higher than on completion
( mineralization process- release of F to the bathing fluid)
Primary teeth less fluoride concentration than permanent teeth
25. F concentration in newly erupted teeth- higher in in
incisal than cervical margin
Diffusion of F in enamel NaF and
monoflurophosphate(100pmm)-
10-9cm2/sec
Speed at which F penetrates in enamel-
38 micrometer/ hour (186micrometer/ day)
26. Concentration in dentin:-
more than enamel-apatite crystals are smaller
-surface area and capacity to take is much larger
In permanent teeth:
Highest near the pulpal surface
low in secondary dentin
In primary teeth
complicated –physiologic resorption occurs towards pulpal side
greatest rise and fall – Pulpal surface of multirooted teeth
27. Fluoride concentration in
Cementum:-
Higher than any skeleton or dental tissue
Tissue is very thin
Near the tissue surface- accessible to fluoride present in
blood
Increases with age
28. Mechanism Of Action Of Fluoride
In Caries Reduction.
Increased enamel resistance (or) reduction in enamel
solubility
Increased rate of post eruptive maturation
Remineralization of incipient lesions
Interference with plaque microorganisms
Modification in tooth morphology
29. Enamel Fluorosis
Enamel mottling described by Eager in 1901 in Naples & Italy
Black and Mckay In 1916 in Colorodo and Arizona
Relationship between enamel mottling & excessive intake of fluoride in
1931 by Smith etal, Churchill JV, and Velu R etal
H. Trendley Dean and Arnold –Mottling : Concentration of fluoride in
drinking water
Moderate to severely pitting and staining: pre-eruptively induced
enamel porosity
30. 2 to 10 ppm- direct inhibitory effect on enzymatic function
of Ameloblasts: resulting in defective matrix formation and
subsequent hypominerlization
Hypocalcified enamel easily becomes hypoplastic after
eruption due to abrasion and wear
No fluorosis- additional intake of F once crown formed and
topical applications
31. CRITERIA FOR DIAGNOSIS OF ENAMEL FLUOROSIS
Dean
score
Criteria
0
0.5
1.0
2.0
3.0
4.0
-Normal enamel
-Questionable mottling: normal
translucency is varied by a few
white flecks or white spots.
-very mild mottling: white opaque
areas are scattered over the teeth;
<25%
-Mild mottling: not more than 50%
-Moderate mottling: all enamel
surfaces are effected
Show marked wear; brownish
stains are frequent
32. OSTEOFLUOROSIS
Common in workers of aluminum factory
Endemic fluorosis :India, China, South Africa
Fluoride dosage: 10 to 25 mg/day for a period of 10 to 20 years
Threshold level for osteofluorosis appears: 4000 to 6000 mg/kg
of dry fat free bone
First stage: asymptomatic (radio graphically – increase density of
vertebrae pelvis)
Advanced cases: bone density increased
bone contours and trabeculae uneven and blurred
extremities show thickening of compact bone
irregular periosteal growth ( exostoses and osteophytes)
increased in calcification in ligaments, tendons, and
muscle insertion
33. At this stage complaints: vague pain in small joints. knee
joints and joints of spine
Increased severity “crippling fluorosis”:
stiffness of spine
limitation of movements
severe pain
34. SOFT TISSUE FLUOROSIS ARE WE
NEGLECTING????
A team of Japanese professors found that children with mottled
teeth have high incidence of heart damage than those without
mottling (Tokushima J 1961)
Chronic exposure to F showed stomatitis and oral ulcer (Sheajjet
etal 1967)
Optical neuritis and visual disturbance may result from direct
effect of fluoride ion on neural tissue (Ellenhorn MJ 1988)
35. Increased cases of reduced IQ, and mentally retarded pt. in endemic
fluoride region (Xang et al 2003)
Pineal gland contains more fluoride than any other soft tissue in the
body (Jennifer Luke,1997)
Chronic atrophic gastritis (Dasavathy et al 1996)
Decreased testosterone concentration (Susheela et al)
Damaged sperms, reduced sperm count and reduced fertility (Gosh et
al 2002)
36. EXCRETION OF FLUORIDE
3 main avenues are urine, feces and perspiration
Via kidneys:-
40 t0 50% of single dose excreted in urine during 24 hours
Factors influencing are
Previous exposure to fluoride
Age
Urinary flow
Urine PH
Kidney status
Glomerular filtration –tubular reabsorption in the form of
HF-greater the acidic urine
37. PH- < 5.6: Excreted fraction of filtered fluoride <5%
Reobsorbtion-95%
Above 5.6: increased fraction of F excretion
In acute poisoning: increased PH urine alkalizing
agents enhance the elimination of F
38. Via the Gut:-
Undissolved and not absorbed excreted unchanged in feces
10% of total fluoride intake is excreted in feces
Via sweat:-
Varying proportions of absorbed fluoride may lost from the
body in perspiration
Under normal conditions of F intake-concentration of Fin
sweating range of 0.07 to 0.5ppm
39. Via saliva:-
Less than 1% of absorbed from saliva was recovered from saliva
0.01 to 0.05ppm
Via breast milk:-
0.01 to 0.05ppm
Selective in taking up fluoride- no evidence of transfer of F from
plasma to milk
Cow’s milk higher F content than human milk
40. PLACENTAL TRANSFER OF FLUORIDE
Fluoride in primary teeth and bones: placental transfer
Placenta does not selectively inhibit fluoride transfer
Higher the fluoride ingestion: partial barrier may exist
43. Fluoride supplementation
Systemic Topical
Dietary fluorides
Salt fluoride
Fluoride in sugar
Water fluoridation
School water fluoridation
Milk fluoridation
Professional application
Self
application
44. Water fluoridation
Definitions:-
‘Water fluoridation is defined as controlled adjustment of the concentration of
fluoride in a communal water supply so as to maximum caries reduction and a
clinically insignificant level of fluorosis.’
Defined as’ upward adjustment of the concentration of fluoride ion in a public
water supply in such way that the concentration of fluoride in the water may be
consistently maintained at 1 ppm by weight to prevent dental caries with
minimum possibility of causing dental fluorosis’
45. • First began in Grand Rapids, U. S. A., in 1945
Studies on water
fluoridation (city)
Control
1. Grand Rapids
(Michigan)
2. Newyork
3. Brantford
(Ontario-Canada)
4. Evanston (Illinois)
5. Teil (Netherlands)
Muskegon
Kingston
Sarnia
Oak-Park
Culemberg
After 1o years -DMFT of fluoridated cities 60%
lower than the control cities
46. Murray and Rugg-gunn
compiled the status of water fluoridation globally
using over 90 studies he compared cariostatic benefits in primary
and permanent dentition.
Early 1960’s successful water fluoridation program –in Singapore
and Hongkong
Backer Dricks conformed caries protection….
Buccal, lingual and gingival smooth surface- 85%
Interproximal surface- 75%
Pit & fissure and occlusal surfaces- 35%
First study on deciduous dentition in UK by Weaver in North
and South Sheilds (41%)
47. Fluoride compounds used in water fluoridation-
Fluorospar
Sodium fluoride- most expensive source
Silicofluoride
Sodium silicofluoride- cheapest form
Hydrofluorosilicic acid
Amonium silicofluoride
Types of equipments for water fluoridation-
Saturation system- 4% NaF (recommended for small towns)
Dry feeder system-NaF or silicofluoride (medium sized towns)
Solution feeder- Hydrofluosilicic acid (large towns)
48. Optimal fluoride concentrations and climatic condition
In Temperate climates (formative stages) - 1ppm
Children living in this area- 1mg/daily
Galagan and Vermillion emperical formula:
Based on daily fluid intake, body wt and temp
ppm F =0.34/E E = -0.038+0.0062 t
E -daily water intake in oz/lb of body wt
t- max daily temp in degrees Fahrenheit
WHO recommended (1994)- 0.5 to 1.0 ppm
49. • Simple modified method to
determine opt fluoride
concentration and mean annual
temp… Richard etall
oC oF Recommen
ded ppm
<18.3
18.9- 26.6
>26.7
<64.9
66.0-79.9
>80.1
1.1 - 1.3
0.8 - 1.0
0.5 - 0.7
In addition to climatic condition total fluoride intak
other than water..
Reasonable goal 60 to 65% caries reduction without f
50. Benefits:-
Both pre eruptive and post eruptive effects
Topical effect through release in saliva
Least expensive and most effective
“Halo effect” or “Diffusion”
Feasibility in INDIA
Ground water btw 1 and 5mg/ml.. (21mg/ml)
Ministry of Health Govt of India prescribed 1.0mg/ml and
2mg/ml
1983 Nanoti & 1988 Nawlakhe given Indian standard specification
desirable limit as 0.6 – 1.2 mg/ml
Short coming- only implemented only in areas have central pipe
water supply system.
Only 30% of population have piped water supply
51. School water fluoridation
Suitable alternative –b’cos f consumed during school days
4.5 to 6.3 ppm- no fluorosis
Caries reduction 45 to 50%
Venturi system is most suitable- almost no maintainance
Advantages:-
Effective public health measure-water supply is not possible
Disadvantages:-
5 to 6 years old upon starting school- will not provide
preeruptive contact..
Intermittent fluoride exposure-less than 180 days in a year
52. Fluoride tablets
Provides systemic effect before mineralization and topical effect after..
In deciduous dentition:-
Caries reduction 50 -80%, started before2 years continued of 3-4 years
Hoskova 1968(4 years)
- fluoride tab started prenatally-93%
- since birth- 54%
In permanent dentition:-
20 to 40% caries reduction
Longest clinical trial carried out by Aasenden and Peebles-0.5mg F tab below 3years
and 1mg thereafter—followed by 8-11 years
mean caries75 to 80% lower
53. • Fluoride level in surface enamel (1-
2micrometer)
– Increased to 3000ppm
– Fluoridated water- 2300ppm
– Non fluoridated water- 1800ppm
• 0.5mgF/day –upper limit desirable level first
year of life
• Concluding that fluoride supplements during
developing dentitions results in caries
reduction than water fluoridation
Recommended dietary fluoride supplements (1999)
Age in years Concentration of fluoride in
drinking water ppm
<
0.3ppm
0.3 to
0.6ppm
>0.6ppm
Birth to 6
years
None None None
6 months-3
year
0.25mg/
day
None None
54. Commercially available NaF (fluoraday, tymaflour and
luride)
– 2.2 mg NaF- 1mg of F
– 1.1 mg NaF -0.5mg of F
– 0.55 mg NaF – 0.25mg of F
• Neuromuscular coordination not fully developed until
16- 18 weeks
-up to 2 years drops are preferable
• Daily recommended dose:-
– Below 2 years – 0.5mg
– 2 to 3 years -0.5 to 0.7mg
– Above 3 years- 1 to 1.5mg
Fluoride tablets: topical caries preventive agent to be
used as Dental Public Health Measure in Rural India
55. To enhance cariostatic effect-
Chew and suck the tab
Preferably at bed time..
Continued at least until 12 to 14 years
Should not given –water supply exceed 0.7ppm
Should not given with milk and milk products
Cannot replace water fluoridation –parents fail to comply with
the regimen
56. Salt fluoridation
Fluoridated salt in Switzerland for the first time in 1955 (90ppm)
90ppm -20 to 25% caries reduction
Optimum level of fluoride in salt –Toth suggested
Urinary fluoride excretion from salt should be similar to that obtained
from fluoridated drinking water
200 to 350 ppm salt- 0.85 and 1.05 similar to populations ingested
fluoridated water for 10 years.
250ppm did not achieve cariostatic effect – optimal fl content water
57. Advantages:-
Low cost
Negligible waste
Ease of implementation
Free choice for individual households
Disadvantages:-
Fluoride dosages of different age in different regions
Lower salt consumption during tooth forming years
58. Feasibility in India:-
Viable and feasible method
Easily monitored
Effective control- supply
Individual monitoring not required
Freely available
Readily acceptable- does not alter the colour
59. Milk fluoridation
First mentioned by Ziegler in 1956
Stephen et al –daily ingestion of 200ml (7ppm) for 4 years, 38.8%
reduction ( 1st permanent molar)
Hellestrom and Ericsson—fluoride uptake by enamel from salt is greater..
Advantages:-
Need to drink under 14 years of age
Disadvantages:-
Incompletely ionized in milk
Lower absorption from milk than water
Variation in intake
60. Requires parental or school efforts
Technical difficulties
Problem in distribution
High cost
Feasibility in India:-
Binding with calcium and protein in milk
Not seem to viable and feasible
Cannot afford milk daily
No central milk supply system
Variation in intake and quantity of milk
61. Fluoridation of flour and sugar
Advantages requiring much less of chemical
Fluoridation of sugar has adv –combining the culprit
and cure (difficulty to provide proper dosage)
62. Exception to school water fluoridation, salt
fluoridation most promising alternative to
water fluoridation.
Method Average % caries
reduction of
dental caries
Community water
fluoridation
School water
fluoridation
Dietary fluoride
supplementation
50 to 65%
40%
50 to 65%
63. Fluoride toxicityToxic effects of fluorides: Acute and chronic
Acute toxicity:
– Accidental contamination of food by NaF and
NaSiF salts
Certainly Lethal
Dose (CLD)
5 to 10 gm NaF
or
32 to 64
mgF/kg
Safely
Tolerated dose
(STD)
¼ CLD
1.25 to 2.5mg
NaF
or
8 to 16 mgF/kgTo prevent accidental poisoning of an infant
weighing (10kg) Council on Dental Therapeutics
of ADA recommended that: no more than 264 mg
of NaF (120mg of F) dispensed at one time
64. Acute poisoning:
– Causes death by blocking normal cellular
metabolism
– Inhibits enzymes causing vital functions-
Initiation and transmission of nerve impulses
to cease
– Interferences with essential body functions
controlled by calcium.
Common signs and symptoms of acute
fluoride toxicity:
Low dosages High dosages
Nausea
Vomiting
Hyper
salivation
Abdominal
pain
Diarrhea
Convulsions
Cardiac
Arrhythmias
Painful
spasms
Paresis
65. Death usually results: cardiac failure or respiratory failure
Serious symptoms : with in 1 to 2 hours after ingestion
Death occurs from 2 to 4 hours after ingestion
Nausea and vomiting : dose 30 t0 80 mg of NaF
Vomiting diarrhea and severe abdominal pain: 100mg NaF
Gastrointestinal symptoms: corrosive effect on gastric mucosa by
HF acid
Treatment : administration of calcium or magnesium or
aluminum salts
66. CHRONIC TOXICITY
Fluoride level Water consumption Effects
0.7 to 1.2 ppm
1.5 to 3.0ppm
3.0 to 8.0ppm
8.0ppm or more
Depending on temp of
area
Period of 5 to 10 years
15 to 20 years
5 to 10 years
Prevents dental caries
Mild dental fluorosis
Severe dental fluorosis
Mild skeletal fluorosis
Severe form of dental
skeletal fluorosis
67. DEFLUORIDATION
• Defluoridation means to improve the quality of
water with high fluoride concentration by
adjusting the optimal level in drinking water
– Absorption and ion exchange method:-
exchange negative ions such OH- group for fluoride
ions depends up on PH, temperature, flow rate, grain
size of the material
common used materials: activated alumina, activated
bauxite, Zeolite, Tricalcium phosphate, activated bone
char, magnesite, magnesite etc
68. Precipitation method:-
In a high PH condition, co-precipitation of
several elements in water with fluoride ions forms
fluoride salts- flocculation (Aluminum ions)
Alum
Alum and lime
Lime softening
Calcium chloride
69. Membrane separation
• Reverse osmosis process
• Expensive developing countries
• 30% of raw water is lost in the process
73. PRASHANTHI TECHNOLOGY
• Activated Alumina- most popular
cost effective
Bio-Science, Department of Sathya Sai
University of Higher Learning in
Prasant Nilayam
74. OTHER METHODS TRIED IN INDIA
• Fish bone charcoal- University of Roorkee
• Drumstick Moringa cleifera- Reduce water turbidity
-calcium and magnesium levels in plants
• Askali- extract mycetial biomass-Osmania university
Aspergillus riger
• Clay materials-Montmosllonite KSF, Kaolin and a Silty
Clay Sediment series
• Tricalcium phosphate(TSP)
75. REFERENCES :-
• Text book of pedodontics- SHOBA TANDON
• Fluorides and Dental caries- AMRIT TEWARI
• Pediatric dentistry- STEWART
• Essentials of preventive and community dentistry-
SHOBAN PETER
• Pediatric dentistry: STEPHEN WEI
• Fluorides in caries prevention- J.J. MURRAY