This document provides fire protection design criteria for U.S. Department of Energy facilities. It establishes requirements for fire suppression systems, structural fire protection, life safety, and protection of special hazards. The document covers water supply and distribution systems, automatic sprinkler systems, fire alarm systems, nuclear filter plenum fire protection, and glovebox fire protection. It is intended to limit potential loss from fire and provide guidance on fire barriers, flame spread, roofing systems, and other structural considerations.