1) A new study found that adding more fiber to the diet can shift gut microbiome profiles in a way linked to leanness. 2) When microbes are starved of fiber, they may feed on the gut's protective mucus layer, potentially triggering inflammation. 3) The Western diet is low in fiber compared to our evolutionary past, containing about 15 grams daily versus an estimated 100 grams for hunter-gatherers. This likely impacts the gut microbiome.

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H E A L T H
Fiber-Famished Gut Microbes Linked to Poor Health
While probiotics receive more attention, key fibers remain the workhorses in maintaining a healthy gut
microbiome
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By Katherine Harmon Courage on March 23, 2015 Véalo en español

2. Fiber has long been linked to better health, but new research shows how the gut microbiota might play a
role in this pattern. Credit: Joe Belanger/Thinkstock

3. KEYSTONE, Colo.—Your gut is the site of constant turf wars. Hundreds of bacterial
species—along with fungi, archaea and viruses—do battle daily, competing for resources.
Some companies advocate for consuming more probiotics, live beneficial bacteria, to
improve microbial communities in our gut, but more and more research supports the idea
that the most powerful approach might be to better feed the good bacteria we already
harbor. Their meal of choice? Fiber.
Fiber has long been linked to better health, but new research shows how the gut
microbiota might play a role in this pattern. One investigation discovered that adding
more fiber to the diet can trigger a shift from a microbial profile linked to obesity to one
correlated with a leaner physique. Another recent study shows that when microbes are
starved of fiber, they can start to feed on the protective mucus lining of the gut, possibly
triggering inflammation and disease.
"Diet is one of the most powerful tools we have for changing the microbiota," Justin
Sonnenburg, a biologist at Stanford University, said earlier this month at a Keystone
Symposia conference on the gut microbiome. "Dietary fiber and diversity of the microbiota
complement each other for better health outcomes." In particular, beneficial microbes
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4. feast on fermentable fibers—which can come from various vegetables, whole grains and
other foods—that resist digestion by human-made enzymes as they travel down the
digestive tract. These fibers arrive in the large intestine relatively intact, ready to be
devoured by our microbial multitudes. Microbes can extract the fiber's extra energy,
nutrients, vitamins and other compounds for us. Short-chain fatty acids obtained from
fiber are of particular interest, as they have been linked to improved immune function,
decreased inflammation and protection against obesity.
Today's Western diet, however, is exceedingly fiber-poor by historical standards. It
contains roughly 15 grams of fiber daily, Sonnenburg noted. For most of our early history
as hunter-gatherers, we were likely eating close to 10 times that amount of fiber each day.
"Imagine the effect that has on our microbiota over the course of our evolution," he said.
Your bugs are what you eat
Not all helpful fiber, however, needs to come from the roots and roughage for which our
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5. ancestors foraged, new research suggests. Kelly Swanson, a professor of comparative
nutrition at the University of Illinois at Urbana-Champaign, and his team found that
simply adding a fiber-enriched snack bar to subjects' daily diets could swing microbial
profiles in a matter of weeks. In a small study of 21 healthy adults with average U.S. fiber
intake, one daily fiber snack bar (containing 21 grams of fiber) for three weeks significantly
increased the number of Bacteroidetes bacteria and decreased the number of Firmicutes
compared with levels before the study or after three weeks of eating fiber-free bars. Such a
ratio—of more Bacteroidetes to fewer Firmicutes—is correlated with lower BMI. The
findings were published in the January issue of the American Journal of Clinical
Nutrition.
"We've known forever that if you eat a lot of fiber, you lose weight," Swanson says. His and
other recent studies suggest that our gut microbes are a key player in this relationship. In
addition to identifying groups of bacteria, a genome scan revealed a shifting pattern of
genes active in the gut microbes. As fiber consumption increased, the activity of genes
associated with protein metabolism declined, a finding that researchers hope will help
them understand the complicated puzzle of diet and weight loss. "We're getting closer to
what is actually cause and effect," Swanson says.
Feed the microbes so they don't feed on you
As gut microbes are starved of fermentable fiber, some do die off. Others, however, are

6. able to switch to another food source in the gut: the mucus lining that helps keep the gut
wall intact and free from infection.
In a recent study presented at the Keystone meeting, Eric Martens of the University of
Michigan Medical School, postdoctoral researcher Mahesh Desai and their colleagues
found that this fuel switch had striking consequences in rodents. A group of mice fed a
high-fiber diet had healthy gut lining, but for mice on a fiber-free diet, "the mucus layer
becomes dramatically diminished," he explained at the meeting. This shift might
sometimes have severe health consequences. Research by a Swedish team, published last
year in the journal Gut, showed a link between bacteria penetrating the mucus layer and
ulcerative colitis, a painful chronic bowel disease.
A third group of mice received high-fiber chow and fiber-free chow on alternating days
—"like what we would do if we were being bad and eating McDonald's one day and eating
our whole grains the next," Martens joked. Even the part-time high-fiber diet was not
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7. enough to keep guts healthy: these mice had a mucus layer about half the thickness of mice
on the consistently high-fiber diet. If we can extend these results to humans, he said, it
"tells us that even eating your whole fiber foods every other day is still not enough to
protect you. You need to eat a high-fiber diet every day to keep a healthy gut." Along the
same lines, Swanson's group found that the gut microbiomes of his adult subjects reverted
back to initial profiles as soon as the high-fiber bars were discontinued.
Martens and his colleagues also observed that mice on the consistently high-fiber diet
consumed fewer calories and were slimmer than those on the fiber-free diet, showing that
fiber benefits the body in multiple ways. "Studies like this are great because it's getting at
the mechanisms to explain why fiber is beneficial," Swanson says.
As all this work underscores, the gut microbiome is exceptionally plastic. Such rapid, diet-
influenced changes likely served us well over the course of our evolutionary history—
shifting faster than our own physiology could, wrote Justin Sonnenburg and Erica
Sonnenburg in a November 2014 article in Cell Metabolism. "In delegating part of our
digestion and calorie harvest to our gut residents, the microbial part of our biology could
easily adjust to day-to-day or season-to-season variation in available food," they noted.
New studies continue to demonstrate that microbial changes due to diet are "largely
reversible on short time scales." But the question remains as to how chronic low-fiber
intake—over a lifetime or generations—might permanently alter our guts and our health.

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A B O UT THE AU T H O R ( S )
Katherine Harmon Courage
Katherine Harmon Courage is a freelance journalist. Her first book, Octopus! The
Most Mysterious Creature in the Sea (Current/Penguin, 2013), examines that
animal's famed intelligence. Her forthcoming book Cultured explores the
microbiome and food.
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