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Fertilization
process
Presented by : Afagh Bapirzadeh
Instructor & Advisor :Dr. Behrouz Aghdam
Syllables of presentation
‫مطالب‬ ‫رئوس‬
1. Sperm Formation & Structure
2. Ovum Formation & Structure
3. Fertilization Process
4. Sperm Activation
5. Ovum Activation
6. Blockage Of Polyspermy
7. Calcium Ion Role In Fertilization
8. Polyspermy And Associated Abnormalities
.1‫اسپرم‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل‬
.2‫تخمک‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل‬
.3‫لقاح‬ ‫روند‬
.4‫اسپرم‬ ‫شدن‬ ‫فعال‬
.5‫تخمک‬ ‫شدن‬ ‫فعال‬
.6‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)‫اسپرم‬ ‫چند‬ ‫ورود‬(
.7‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬
.8‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬
Sperm Formation
‫اسپرم‬ ‫گیری‬ ‫شکل‬
Sperm Structure
‫اسپرم‬ ‫ساختار‬
‫دم‬
‫پالسمایی‬ ‫غشای‬
‫گردن‬
‫سر‬
‫میانی‬ ‫ی‬ ‫تکه‬
‫هسته‬
‫آکروزوم‬
‫میتوکندری‬
(‫مارپیچی‬ ‫شکل‬ ‫با‬)
 Head
 Middle piece
Mitochondrion
 Tail plasma membrane
Nucleus
Acrosome
Ovum Formation
‫تخمک‬ ‫گیری‬ ‫شکل‬
Ovum Structure
‫تخمک‬ ‫ساختار‬
‫پلوسیدا‬ ‫زونا‬
‫پالسمایی‬ ‫غشای‬
‫هسته‬
‫سیتوپالس‬‫م‬
‫فولیکولی‬ ‫سلولهای‬
‫رادیاتا‬ ‫کرونا‬
Fertilization
process
Sperm Activation
‫اسپرم‬ ‫سازی‬ ‫فعال‬
• Capacitation
• Acrosome Reaction
Oocyte Activation
‫تخمک‬ ‫شدن‬ ‫فعال‬
1. Cortical reaction to block against
other sperm cells
2. Activation of egg metabolism
3. Reactivation of meiosis
4. DNA synthesis
Fertilization
‫لقاح‬
Normal Fertilization Versus Abnormal Fertilization
‫طبیعی‬ ‫غیر‬ ‫لقاح‬ ‫با‬ ‫مقایسه‬ ‫در‬ ‫طبیعی‬ ‫لقاح‬
‫طبیعی‬
Polyspermy Blockage Mechanisms
‫مکانی‬‫س‬‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬ ‫های‬ ‫م‬
Slow Blockage Of Polyspermy
(‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)
Involves zonal inhibiting proteins
(‫باشد‬ ‫می‬ ‫زونال‬ ‫ی‬ ‫جلوگیرنده‬ ‫های‬ ‫پروتیین‬ ‫شامل‬)
Fast Blockage Of Polyspermy
(‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)
Membrane depolarization
(‫غشایی‬ ‫شدن‬ ‫دپالریزه‬)
Slow Blockage Of Polyspermy
‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬
Fast Blockage Of Polyspermy
‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬
• Membrane
Depolarization
Calcium Ion Role In Fertilization
‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬
1. Oocyte activation
2. Stimulates cortical reaction
Polyspermy And Associated Abnormalities
‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬
Molar pregnancies
• Partial molar pregnancies
• Complete molar pregnancies

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Fertilization

  • 1. Fertilization process Presented by : Afagh Bapirzadeh Instructor & Advisor :Dr. Behrouz Aghdam
  • 2. Syllables of presentation ‫مطالب‬ ‫رئوس‬ 1. Sperm Formation & Structure 2. Ovum Formation & Structure 3. Fertilization Process 4. Sperm Activation 5. Ovum Activation 6. Blockage Of Polyspermy 7. Calcium Ion Role In Fertilization 8. Polyspermy And Associated Abnormalities .1‫اسپرم‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل‬ .2‫تخمک‬ ‫ساختار‬ ‫و‬ ‫گیری‬ ‫شکل‬ .3‫لقاح‬ ‫روند‬ .4‫اسپرم‬ ‫شدن‬ ‫فعال‬ .5‫تخمک‬ ‫شدن‬ ‫فعال‬ .6‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬)‫اسپرم‬ ‫چند‬ ‫ورود‬( .7‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬ .8‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬
  • 4. Sperm Structure ‫اسپرم‬ ‫ساختار‬ ‫دم‬ ‫پالسمایی‬ ‫غشای‬ ‫گردن‬ ‫سر‬ ‫میانی‬ ‫ی‬ ‫تکه‬ ‫هسته‬ ‫آکروزوم‬ ‫میتوکندری‬ (‫مارپیچی‬ ‫شکل‬ ‫با‬)  Head  Middle piece Mitochondrion  Tail plasma membrane Nucleus Acrosome
  • 6. Ovum Structure ‫تخمک‬ ‫ساختار‬ ‫پلوسیدا‬ ‫زونا‬ ‫پالسمایی‬ ‫غشای‬ ‫هسته‬ ‫سیتوپالس‬‫م‬ ‫فولیکولی‬ ‫سلولهای‬ ‫رادیاتا‬ ‫کرونا‬
  • 8. Sperm Activation ‫اسپرم‬ ‫سازی‬ ‫فعال‬ • Capacitation • Acrosome Reaction
  • 9. Oocyte Activation ‫تخمک‬ ‫شدن‬ ‫فعال‬ 1. Cortical reaction to block against other sperm cells 2. Activation of egg metabolism 3. Reactivation of meiosis 4. DNA synthesis
  • 11. Normal Fertilization Versus Abnormal Fertilization ‫طبیعی‬ ‫غیر‬ ‫لقاح‬ ‫با‬ ‫مقایسه‬ ‫در‬ ‫طبیعی‬ ‫لقاح‬ ‫طبیعی‬
  • 12. Polyspermy Blockage Mechanisms ‫مکانی‬‫س‬‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬ ‫های‬ ‫م‬ Slow Blockage Of Polyspermy (‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬) Involves zonal inhibiting proteins (‫باشد‬ ‫می‬ ‫زونال‬ ‫ی‬ ‫جلوگیرنده‬ ‫های‬ ‫پروتیین‬ ‫شامل‬) Fast Blockage Of Polyspermy (‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬) Membrane depolarization (‫غشایی‬ ‫شدن‬ ‫دپالریزه‬)
  • 13.
  • 14. Slow Blockage Of Polyspermy ‫کند‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬
  • 15. Fast Blockage Of Polyspermy ‫سریع‬ ‫ی‬ ‫شیوه‬ ‫به‬ ‫اسپرمی‬ ‫پلی‬ ‫از‬ ‫ممانعت‬ • Membrane Depolarization
  • 16. Calcium Ion Role In Fertilization ‫لقاح‬ ‫در‬ ‫کلسیم‬ ‫یون‬ ‫نقش‬ 1. Oocyte activation 2. Stimulates cortical reaction
  • 17. Polyspermy And Associated Abnormalities ‫مرتبط‬ ‫ناهنجاریهای‬ ‫و‬ ‫اسپرمی‬ ‫پلی‬ Molar pregnancies • Partial molar pregnancies • Complete molar pregnancies