This document discusses febrile seizures, which are convulsions that occur during fevers in children between 6 months and 6 years old without an underlying cause. Febrile seizures are classified as either simple or complex based on duration and other factors. The differential diagnosis for a febrile seizure includes infections, anoxia, trauma, stroke, metabolic issues, brain tumors, and previous brain injuries. Risk factors for recurrence include family history, age under 18 months, brief duration between fever and seizure, and complex febrile seizures. Physical exams are usually normal but vital signs and neurological exams are important. Investigations depend on individual cases but may include blood tests, lumbar puncture, and imaging in some cases. Management involves educ
Please find the power point on Management of febrile seizures. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Please find the power point on Management of febrile seizures. I tried to present it on understandable way and all the contents are reviewed by experts and from very reliable references. Thank you
Febrile seizure / Pediatrics
Simple vs. Complex seizure
Possible explanation of febrile seizure
Risk Factors for Febrile Seizures
Risk Factors for Recurrence of Febrile Seizure
Risk Factors for Occurrence of Subsequent Epilepsy After a Febrile Seizure
Genetic Factors
Evaluation
Lumbar Puncture
Optional LP
Electroencephalogram
Blood Studies
Neuroimaging
TREATMENT
Febrile convulsions are non-epileptic seizures that commonly occur in children between the age of 6-60 months, and are associated with a rapid rise in body temperature following an underlying condition. We discuss this in detail in the slides above, as well as with its management.
Febrile seizure / Pediatrics
Simple vs. Complex seizure
Possible explanation of febrile seizure
Risk Factors for Febrile Seizures
Risk Factors for Recurrence of Febrile Seizure
Risk Factors for Occurrence of Subsequent Epilepsy After a Febrile Seizure
Genetic Factors
Evaluation
Lumbar Puncture
Optional LP
Electroencephalogram
Blood Studies
Neuroimaging
TREATMENT
Febrile convulsions are non-epileptic seizures that commonly occur in children between the age of 6-60 months, and are associated with a rapid rise in body temperature following an underlying condition. We discuss this in detail in the slides above, as well as with its management.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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2. Definition
• Convulsion that occur at highest temperature of fever with no
evidence of intracranial pathology,metabolic derangement and other
underlying cause
• Occur between 6 months to 6 years old
• Diagnosis of exclusion
3. Classification
• Simple febrile fit
• 75%
• <15 minutes (often 1-2 minutes)
• Generalized tonic-clonic/tonic seizure
• Once in 24h
• Complex febrile fit
• 25%
• >15minutes
• Partial seizure
• Multiple in 24h
• Residual motor neurological deficit post ictally (Todd paralysis)
5. History
• Refer epilepsy slides
• Risk factors of recurrence febrile fits
• Family history of febrile fit
• <18months old
• Low degree of fever during the 1st seizure
• Brief duration between fever and seizure
• Risk factors for subsequent epilepsy
• Family history of epilepsy
• Neurodevelopmental abnormality
• Complex febrile fit
• Brief duration between the fever and seizure
7. Investigations
• Depends on clinical assessment and individual case
• FBC
• RBS
• LP
• Must be done if
• Signs of intracranial infection
• Prior to antibiotic therapy
• Persistent lethargy and fully interactive 6hours after the seizure
• Strongly recommended if
• 12months old
• 1st complex febrile convuslion
• District hospital without paeditrician
• Parent having problem bringing child back
• Urinalysis
• Blood culture
• CXR
• Serum Ca and BUSE
8. Management
• Counsel and educate the parents
• Reassurance
• Loose child's clothing
• Left lateral position
• Wipe vomitus or secretion from the mouth
• Do not insert object into the mouth
• Do not give any fluids or drugs orally
• Comfort the child as she recovering
• Control fever
• Take off clothing
• Tepid sponging
• Antipyretic
• Syrup or rectal PCM 15mg/kg QID
• For comfort but not reducing recurrence rate
• Prophylaxis for recurrence events
• Give rectal diazepam 0.5mg/kg
9. Admission criteria
• 1st episode
• To exclude intracranial pathology especially infection
• Fear of recurrent fit
• To investigate and treat the cause of fever
• To allay parental anxiety (eg. Staying far from the hospital)