SlideShare a Scribd company logo
Epilepsy
Definition
• A group of disorder of unprovoked recurrent seizure (idiopathic
epilepsy)
Pathophysiology
1. Hypersynchronous discharge
2. Large group of neuron activated repetitively
3. Imbalance between excitatory and inhibitory transmitter
4. Abnormal voltage-controlled membrane channel
Etiology
1. Idiopathic
2. Secondary
• Genetic : family history
• Congenital malformation of the brain : hydrocephalus with large head or headache
• Perinatal complications : birth asphyxia or trauma
• Neurocutaneous syndrome : neurofibromatosis with skin lesion
• Intracranial haemorrhage : bleeding disorder,NAI
• CNS infection : meningitis,encephalitis,brain abscess
• Trauma : history of MVA or NAI
• CVA : vasculitis
• Neoplasm : solid CNS tumor
Classifications
• Partial seizures
• Simple partial seizures
• Begin in a specific area of the brain
• Consciousness not impaired
• Motor:originate in the motor cortex cause recurrent contraction of the muscle of one part of the
body
• Sensory:originate from sensory centrer (postcentral gyrus)
• Visual
• somatic
• Psychic : originate from temporal lobe
• Emotional disturbances
• Autonomic disurbances
• Complex partial seizures
• Aura > may be generalized > may be altered consciousness + post ictal confusion and
drowsiness + amnesia
• Partial seizures evolving to secondary generalized seizures
Classification
• Generalized seizures
• Tonic clonic
• Tonic : generalized contraction of muscle and extension of the limb and trunk + cyanosis
• Clonic : bilateral symmetrical and intense jerking then slowly diminish + urine and fecal incontinence +
buccal oral trauma
• For few seconds - minutes
• Post ictal drowsiness or deep sleep for several hours
• Awakening : confused,tired,headache,muscle pain
• Absence seizures
• Frequent brief impairment of consciounsness
• Stop > stares blankly or blink repeatedly not less than 30s
• Consciousness recovered immediately
• No incontinence or falling
• Myoclonic : Sudden brief shock like contractions of one extremity or entire body
• Clonic
• Tonic atonic : Common in retarded children with mixed children disorder
• Atonic > fall abruptly
Classification
• Unclassified epileptic seizure
• Primary childhood seizure
• West syndrome (infantile spasm)
• Juvenile myoclonic epilepsy
• Neonatal seizure
• Febrile convusion
• Status epilepticus
History
• Chief complaint : fitting and duration
• Seizures description by witness
• What is he doing at that time
• Description :
sudden LOC,posture,jerking movement,up rolling eyeball,drooling of saliva,cyanosis,
urine/incontinence
• Post ictal : drowsiness,lethargy,amnesia,insoluble crying,irritability,diarrhea,trauma
• Precipitated factor : flash light,extreme exhaustion,tired,emotionally
unstable,sleep deprivation
• Etiology : fever,vomiting,photophobia,neck stiffness,insoluble
crying,irritability,diarrhea,trauma
Differential diagnosis of seizures
• Neonates and infants
• Jitteriness
• Benign myoclonus
• Apnea
• GERD
• Shuddering attacks
• Benign paroxysmal torticollis
• Hyperekplexia
• Young children
• Breath holding spells
• Reflex anoxic seizures
• Parasomnia
• Benign paroxysmal vertigo
• Paroxysmal choreoathetosis
• Rage attack
• Childhood and adolescent
• Vasovagal syncope
• Migraine
• Narcolepsy
• Panic attacks
• Pseudoseizures
• Others
• Drugs induced dystonia
• Cardiac dysrythmias
Complications of seizures
• Muscle ache
• Head trauma
• Oral or buccal trauma
• Impact on life
Examination
• Normal
• Rule out secondary causes
• Dysmorphism
• Neurocutaneous sign
• Hydrocephalus
• Head trauma
• NF manifestation
Investigation
• Recommended when 2nd afebrile seizures occur
• FBC
• Blood C&S
• RBS
• Serum Ca,PO4,Mg and BUSE
• Skull Xray
• ECG
• EEG
• MRI/CT scan
Principles of anticonvulsant therapy for
epilepsy
1. Treatment initiated after 2 episodes (recurrence risk is 80%)
2. Classify seizure type and epileptic syndrome
3. Monotherapy,most appropriate drug,increase dose gradually (until max
dose or side effects occur)
4. 1st drug fail > optimize 2nd drug then withdraw the 1st drug
5. If combine,use different MOA
6. Monitor drugs level : compliance,well controlled,drug interaction
(polypharmacy)
7. Withdraw drug when seizure free for 2 years (taper within 3-6months)
8. Seizure recur:last dose reduction is reversed and refer
Selecting anticonvulsant
• Partial seizure
• 1st line : Carbamazepine,Sodium Valproate
• 2nd line : Lamotrigine,Topiramate,Levetiracetam,Phenytoin,Phenobarbitone,
Clonazepam
• Generalized seizure
• 1st line : Sodium Valproate,Adrenocorticotrophin,Prednisolone,Vigabatrin
• 2nd line : Lamotrigine,Topiramate,Nitrazepam,Clonazepam,Valproate
Side effect and toxicity of anticonvulsant
• Carbamazepine
• Side effects:drowsiness,dizziness,ataxia,diplopia,rash
• Toxicity:agranulocytosis,Steven-Johnson syndrome
• Sodium Valproate
• Side effects:nausea,epigastric pain,tremor,alopecia,weight gain,hair loss, thrombocytopenia
• Serious toxicity:hepatotoxicity (2years of age),hepatitis,pancreatitis, encephalopathy
• Lamotrigine
• Side effects:Dizziness,somnolence,insomnia,rash
• Serious toxicity:Steven-Johnson syndrome
• Topiramate
• Side effects:Weight loss,somnolence,mental slowing,word finding difficulty,hypohidrosis
• Renal calculi
Advice
• Educate and counsel on epilepsy
• Compliance!
• Don't stop medication by yourself > breakthrough seizure
• Watch TV in bright light room and avoid sleep deprivation
• No cycling,swimming or climbing alone
• Emergency treatment for seizure
• Inform teacher and school about the condition

More Related Content

What's hot

Approach to seizure
Approach to seizureApproach to seizure
Approach to seizure
biplave karki
 
Seizures and epilepsy
Seizures and epilepsySeizures and epilepsy
Seizures and epilepsy
Praveen Nagula
 
Seizure
SeizureSeizure
Seizure
RijoLijo
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
Richard Asare
 
Movement disorders
Movement disordersMovement disorders
Movement disorders
Helao Silas
 
Cerebrovascular Disorder
Cerebrovascular DisorderCerebrovascular Disorder
Cerebrovascular Disorder
mycomic
 
Extrapyramidal disorders
Extrapyramidal disordersExtrapyramidal disorders
Extrapyramidal disorders
rahul arora
 
Epilepsy.....
Epilepsy.....Epilepsy.....
Epilepsy.....
Ravneet Singh
 
Myoclonus
MyoclonusMyoclonus
Myoclonus
Sachin Adukia
 
Epilepsy
Epilepsy Epilepsy
Epilepsy
Dr. Vijay Prasad
 
Wernicke’s encephalopathy
Wernicke’s encephalopathyWernicke’s encephalopathy
Wernicke’s encephalopathy
Amiteshwar Singh
 
Hemiplegia
HemiplegiaHemiplegia
Hemiplegia
Amr Hassan
 
Acute disseminated encephalomyelitis
Acute disseminated encephalomyelitis Acute disseminated encephalomyelitis
Acute disseminated encephalomyelitis
Reyad Al_Faky
 
Seizures
SeizuresSeizures
Seizures
Abhay Rajpoot
 
Hemorrhagic stroke
Hemorrhagic   strokeHemorrhagic   stroke
Hemorrhagic stroke
gbanstha
 
Status Epilepticus
Status EpilepticusStatus Epilepticus
Status Epilepticus
Jack Frost
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
EpilepsyEpilepsy
Guillain-Barré syndrome (GBS)
Guillain-Barré syndrome (GBS)Guillain-Barré syndrome (GBS)
Guillain-Barré syndrome (GBS)
Prof Vijayraddi
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
aishuanju
 

What's hot (20)

Approach to seizure
Approach to seizureApproach to seizure
Approach to seizure
 
Seizures and epilepsy
Seizures and epilepsySeizures and epilepsy
Seizures and epilepsy
 
Seizure
SeizureSeizure
Seizure
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
 
Movement disorders
Movement disordersMovement disorders
Movement disorders
 
Cerebrovascular Disorder
Cerebrovascular DisorderCerebrovascular Disorder
Cerebrovascular Disorder
 
Extrapyramidal disorders
Extrapyramidal disordersExtrapyramidal disorders
Extrapyramidal disorders
 
Epilepsy.....
Epilepsy.....Epilepsy.....
Epilepsy.....
 
Myoclonus
MyoclonusMyoclonus
Myoclonus
 
Epilepsy
Epilepsy Epilepsy
Epilepsy
 
Wernicke’s encephalopathy
Wernicke’s encephalopathyWernicke’s encephalopathy
Wernicke’s encephalopathy
 
Hemiplegia
HemiplegiaHemiplegia
Hemiplegia
 
Acute disseminated encephalomyelitis
Acute disseminated encephalomyelitis Acute disseminated encephalomyelitis
Acute disseminated encephalomyelitis
 
Seizures
SeizuresSeizures
Seizures
 
Hemorrhagic stroke
Hemorrhagic   strokeHemorrhagic   stroke
Hemorrhagic stroke
 
Status Epilepticus
Status EpilepticusStatus Epilepticus
Status Epilepticus
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
 
Guillain-Barré syndrome (GBS)
Guillain-Barré syndrome (GBS)Guillain-Barré syndrome (GBS)
Guillain-Barré syndrome (GBS)
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
 

Similar to Epilepsy

EPILEPSY
EPILEPSYEPILEPSY
EPILEPSY
GamitKinjal
 
status epilepticus
status epilepticus status epilepticus
status epilepticus
Pooja Panjwani
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
OM VERMA
 
Seizure disorders
Seizure disordersSeizure disorders
Seizure disorders
MeghanPowers10
 
Approach to seizure disorder
Approach to seizure disorderApproach to seizure disorder
Approach to seizure disorder
z2jeetendra
 
Seizure disorders
Seizure disordersSeizure disorders
Seizure disorders
gishabay
 
Seizure disorders
Seizure disordersSeizure disorders
Seizure disorders
Engidaw Ambelu
 
AlharebEpilepsy(1).pptx
AlharebEpilepsy(1).pptxAlharebEpilepsy(1).pptx
AlharebEpilepsy(1).pptx
Ahmedalmahdi16
 
Epilepsy and seizure disorders in children
Epilepsy and seizure disorders in childrenEpilepsy and seizure disorders in children
Epilepsy and seizure disorders in children
Joyce Mwatonoka
 
Anticonvulsives
AnticonvulsivesAnticonvulsives
Anticonvulsives
Amila17
 
APPROACH TO SEIZURE CME
APPROACH TO SEIZURE CMEAPPROACH TO SEIZURE CME
APPROACH TO SEIZURE CME
Haffiz Mohdnoor
 
seizure disorder_015608.pptx
seizure disorder_015608.pptxseizure disorder_015608.pptx
seizure disorder_015608.pptx
ShubhrimaKhan
 
Fits, faints and funny turns
Fits, faints and funny turns Fits, faints and funny turns
Fits, faints and funny turns
Alicia Tan
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
Meghana Gowda
 
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.
Dr. Kiran Dhamak
 
Movement disorders
Movement disordersMovement disorders
Movement disorders
Hemali Patel
 
Epilepsy
Epilepsy Epilepsy
Epilepsy
Chindo Mallum
 
335. Epilepsy and Seizures.ppt
335. Epilepsy and Seizures.ppt335. Epilepsy and Seizures.ppt
335. Epilepsy and Seizures.ppt
DrHarshaHarsha
 
Seizure ii
Seizure iiSeizure ii
Seizure ii
Ahmed Al-Dabbas
 
Evaluation and Management of Epilepsy
Evaluation and Management of EpilepsyEvaluation and Management of Epilepsy
Evaluation and Management of Epilepsy
Sudhir Kumar
 

Similar to Epilepsy (20)

EPILEPSY
EPILEPSYEPILEPSY
EPILEPSY
 
status epilepticus
status epilepticus status epilepticus
status epilepticus
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
 
Seizure disorders
Seizure disordersSeizure disorders
Seizure disorders
 
Approach to seizure disorder
Approach to seizure disorderApproach to seizure disorder
Approach to seizure disorder
 
Seizure disorders
Seizure disordersSeizure disorders
Seizure disorders
 
Seizure disorders
Seizure disordersSeizure disorders
Seizure disorders
 
AlharebEpilepsy(1).pptx
AlharebEpilepsy(1).pptxAlharebEpilepsy(1).pptx
AlharebEpilepsy(1).pptx
 
Epilepsy and seizure disorders in children
Epilepsy and seizure disorders in childrenEpilepsy and seizure disorders in children
Epilepsy and seizure disorders in children
 
Anticonvulsives
AnticonvulsivesAnticonvulsives
Anticonvulsives
 
APPROACH TO SEIZURE CME
APPROACH TO SEIZURE CMEAPPROACH TO SEIZURE CME
APPROACH TO SEIZURE CME
 
seizure disorder_015608.pptx
seizure disorder_015608.pptxseizure disorder_015608.pptx
seizure disorder_015608.pptx
 
Fits, faints and funny turns
Fits, faints and funny turns Fits, faints and funny turns
Fits, faints and funny turns
 
Epilepsy
EpilepsyEpilepsy
Epilepsy
 
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.
Central Nervous System, Epilepsy, Parkinson, Alzheimer, Stroke and Migraine.
 
Movement disorders
Movement disordersMovement disorders
Movement disorders
 
Epilepsy
Epilepsy Epilepsy
Epilepsy
 
335. Epilepsy and Seizures.ppt
335. Epilepsy and Seizures.ppt335. Epilepsy and Seizures.ppt
335. Epilepsy and Seizures.ppt
 
Seizure ii
Seizure iiSeizure ii
Seizure ii
 
Evaluation and Management of Epilepsy
Evaluation and Management of EpilepsyEvaluation and Management of Epilepsy
Evaluation and Management of Epilepsy
 

More from Medical Student

Neural tube defect
Neural tube defectNeural tube defect
Neural tube defect
Medical Student
 
Meningitis
MeningitisMeningitis
Meningitis
Medical Student
 
Medical exam checklist
Medical exam checklistMedical exam checklist
Medical exam checklist
Medical Student
 
Febrile seizure
Febrile seizureFebrile seizure
Febrile seizure
Medical Student
 
Sigmoid volvulus
Sigmoid volvulusSigmoid volvulus
Sigmoid volvulus
Medical Student
 
Familial colorectal cancer
Familial colorectal cancerFamilial colorectal cancer
Familial colorectal cancer
Medical Student
 
Stoma
StomaStoma
Fibroadenosis
FibroadenosisFibroadenosis
Fibroadenosis
Medical Student
 
Lung abscess
Lung abscessLung abscess
Lung abscess
Medical Student
 
Empyema
EmpyemaEmpyema
Bronchiectasis
BronchiectasisBronchiectasis
Bronchiectasis
Medical Student
 
Hemophilia
HemophiliaHemophilia
Hemophilia
Medical Student
 
Disseminated intravascular coagulation
Disseminated intravascular coagulationDisseminated intravascular coagulation
Disseminated intravascular coagulation
Medical Student
 
Failure to thrive
Failure to thriveFailure to thrive
Failure to thrive
Medical Student
 
Pulmonary embolism
Pulmonary embolismPulmonary embolism
Pulmonary embolism
Medical Student
 
Pneumothorax
PneumothoraxPneumothorax
Pneumothorax
Medical Student
 
Pleural effusion
Pleural effusionPleural effusion
Pleural effusion
Medical Student
 

More from Medical Student (17)

Neural tube defect
Neural tube defectNeural tube defect
Neural tube defect
 
Meningitis
MeningitisMeningitis
Meningitis
 
Medical exam checklist
Medical exam checklistMedical exam checklist
Medical exam checklist
 
Febrile seizure
Febrile seizureFebrile seizure
Febrile seizure
 
Sigmoid volvulus
Sigmoid volvulusSigmoid volvulus
Sigmoid volvulus
 
Familial colorectal cancer
Familial colorectal cancerFamilial colorectal cancer
Familial colorectal cancer
 
Stoma
StomaStoma
Stoma
 
Fibroadenosis
FibroadenosisFibroadenosis
Fibroadenosis
 
Lung abscess
Lung abscessLung abscess
Lung abscess
 
Empyema
EmpyemaEmpyema
Empyema
 
Bronchiectasis
BronchiectasisBronchiectasis
Bronchiectasis
 
Hemophilia
HemophiliaHemophilia
Hemophilia
 
Disseminated intravascular coagulation
Disseminated intravascular coagulationDisseminated intravascular coagulation
Disseminated intravascular coagulation
 
Failure to thrive
Failure to thriveFailure to thrive
Failure to thrive
 
Pulmonary embolism
Pulmonary embolismPulmonary embolism
Pulmonary embolism
 
Pneumothorax
PneumothoraxPneumothorax
Pneumothorax
 
Pleural effusion
Pleural effusionPleural effusion
Pleural effusion
 

Recently uploaded

Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
Health Advances
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
walterHu5
 
Adhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.comAdhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.com
reignlana06
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Dr. Rabia Inam Gandapore
 
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptxHow STIs Influence the Development of Pelvic Inflammatory Disease.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
FFragrant
 
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
chandankumarsmartiso
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
bkling
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
Donc Test
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
Swastik Ayurveda
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
Swastik Ayurveda
 
Light House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat EuropeLight House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat Europe
Lighthouse Retreat
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
rishi2789
 
OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1
KafrELShiekh University
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
rishi2789
 
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPromoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
PsychoTech Services
 
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
rishi2789
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
suvadeepdas911
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
Jim Jacob Roy
 
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptxIdentification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptx
MGM SCHOOL/COLLEGE OF NURSING
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Ayurveda ForAll
 

Recently uploaded (20)

Cell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune DiseaseCell Therapy Expansion and Challenges in Autoimmune Disease
Cell Therapy Expansion and Challenges in Autoimmune Disease
 
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxDoes Over-Masturbation Contribute to Chronic Prostatitis.pptx
Does Over-Masturbation Contribute to Chronic Prostatitis.pptx
 
Adhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.comAdhd Medication Shortage Uk - trinexpharmacy.com
Adhd Medication Shortage Uk - trinexpharmacy.com
 
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptxEar and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
Ear and its clinical correlations By Dr. Rabia Inam Gandapore.pptx
 
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptxHow STIs Influence the Development of Pelvic Inflammatory Disease.pptx
How STIs Influence the Development of Pelvic Inflammatory Disease.pptx
 
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
Phone Us ❤8107221448❤ #ℂall #gIRLS In Dehradun By Dehradun @ℂall @Girls Hotel...
 
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
Part II - Body Grief: Losing parts of ourselves and our identity before, duri...
 
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
TEST BANK For Community Health Nursing A Canadian Perspective, 5th Edition by...
 
The Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in IndiaThe Best Ayurvedic Antacid Tablets in India
The Best Ayurvedic Antacid Tablets in India
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
 
Light House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat EuropeLight House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat Europe
 
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdfCHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
CHEMOTHERAPY_RDP_CHAPTER 3_ANTIFUNGAL AGENT.pdf
 
OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1OCT Training Course for clinical practice Part 1
OCT Training Course for clinical practice Part 1
 
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 4_ANTI VIRAL DRUGS.pdf
 
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPromoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotes
 
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdfCHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
CHEMOTHERAPY_RDP_CHAPTER 1_ANTI TB DRUGS.pdf
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
 
Osteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdfOsteoporosis - Definition , Evaluation and Management .pdf
Osteoporosis - Definition , Evaluation and Management .pdf
 
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptxIdentification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptx
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
 

Epilepsy

  • 2. Definition • A group of disorder of unprovoked recurrent seizure (idiopathic epilepsy)
  • 3. Pathophysiology 1. Hypersynchronous discharge 2. Large group of neuron activated repetitively 3. Imbalance between excitatory and inhibitory transmitter 4. Abnormal voltage-controlled membrane channel
  • 4. Etiology 1. Idiopathic 2. Secondary • Genetic : family history • Congenital malformation of the brain : hydrocephalus with large head or headache • Perinatal complications : birth asphyxia or trauma • Neurocutaneous syndrome : neurofibromatosis with skin lesion • Intracranial haemorrhage : bleeding disorder,NAI • CNS infection : meningitis,encephalitis,brain abscess • Trauma : history of MVA or NAI • CVA : vasculitis • Neoplasm : solid CNS tumor
  • 5. Classifications • Partial seizures • Simple partial seizures • Begin in a specific area of the brain • Consciousness not impaired • Motor:originate in the motor cortex cause recurrent contraction of the muscle of one part of the body • Sensory:originate from sensory centrer (postcentral gyrus) • Visual • somatic • Psychic : originate from temporal lobe • Emotional disturbances • Autonomic disurbances • Complex partial seizures • Aura > may be generalized > may be altered consciousness + post ictal confusion and drowsiness + amnesia • Partial seizures evolving to secondary generalized seizures
  • 6.
  • 7. Classification • Generalized seizures • Tonic clonic • Tonic : generalized contraction of muscle and extension of the limb and trunk + cyanosis • Clonic : bilateral symmetrical and intense jerking then slowly diminish + urine and fecal incontinence + buccal oral trauma • For few seconds - minutes • Post ictal drowsiness or deep sleep for several hours • Awakening : confused,tired,headache,muscle pain • Absence seizures • Frequent brief impairment of consciounsness • Stop > stares blankly or blink repeatedly not less than 30s • Consciousness recovered immediately • No incontinence or falling • Myoclonic : Sudden brief shock like contractions of one extremity or entire body • Clonic • Tonic atonic : Common in retarded children with mixed children disorder • Atonic > fall abruptly
  • 8. Classification • Unclassified epileptic seizure • Primary childhood seizure • West syndrome (infantile spasm) • Juvenile myoclonic epilepsy • Neonatal seizure • Febrile convusion • Status epilepticus
  • 9. History • Chief complaint : fitting and duration • Seizures description by witness • What is he doing at that time • Description : sudden LOC,posture,jerking movement,up rolling eyeball,drooling of saliva,cyanosis, urine/incontinence • Post ictal : drowsiness,lethargy,amnesia,insoluble crying,irritability,diarrhea,trauma • Precipitated factor : flash light,extreme exhaustion,tired,emotionally unstable,sleep deprivation • Etiology : fever,vomiting,photophobia,neck stiffness,insoluble crying,irritability,diarrhea,trauma
  • 10. Differential diagnosis of seizures • Neonates and infants • Jitteriness • Benign myoclonus • Apnea • GERD • Shuddering attacks • Benign paroxysmal torticollis • Hyperekplexia • Young children • Breath holding spells • Reflex anoxic seizures • Parasomnia • Benign paroxysmal vertigo • Paroxysmal choreoathetosis • Rage attack • Childhood and adolescent • Vasovagal syncope • Migraine • Narcolepsy • Panic attacks • Pseudoseizures • Others • Drugs induced dystonia • Cardiac dysrythmias
  • 11. Complications of seizures • Muscle ache • Head trauma • Oral or buccal trauma • Impact on life
  • 12. Examination • Normal • Rule out secondary causes • Dysmorphism • Neurocutaneous sign • Hydrocephalus • Head trauma • NF manifestation
  • 13. Investigation • Recommended when 2nd afebrile seizures occur • FBC • Blood C&S • RBS • Serum Ca,PO4,Mg and BUSE • Skull Xray • ECG • EEG • MRI/CT scan
  • 14. Principles of anticonvulsant therapy for epilepsy 1. Treatment initiated after 2 episodes (recurrence risk is 80%) 2. Classify seizure type and epileptic syndrome 3. Monotherapy,most appropriate drug,increase dose gradually (until max dose or side effects occur) 4. 1st drug fail > optimize 2nd drug then withdraw the 1st drug 5. If combine,use different MOA 6. Monitor drugs level : compliance,well controlled,drug interaction (polypharmacy) 7. Withdraw drug when seizure free for 2 years (taper within 3-6months) 8. Seizure recur:last dose reduction is reversed and refer
  • 15. Selecting anticonvulsant • Partial seizure • 1st line : Carbamazepine,Sodium Valproate • 2nd line : Lamotrigine,Topiramate,Levetiracetam,Phenytoin,Phenobarbitone, Clonazepam • Generalized seizure • 1st line : Sodium Valproate,Adrenocorticotrophin,Prednisolone,Vigabatrin • 2nd line : Lamotrigine,Topiramate,Nitrazepam,Clonazepam,Valproate
  • 16. Side effect and toxicity of anticonvulsant • Carbamazepine • Side effects:drowsiness,dizziness,ataxia,diplopia,rash • Toxicity:agranulocytosis,Steven-Johnson syndrome • Sodium Valproate • Side effects:nausea,epigastric pain,tremor,alopecia,weight gain,hair loss, thrombocytopenia • Serious toxicity:hepatotoxicity (2years of age),hepatitis,pancreatitis, encephalopathy • Lamotrigine • Side effects:Dizziness,somnolence,insomnia,rash • Serious toxicity:Steven-Johnson syndrome • Topiramate • Side effects:Weight loss,somnolence,mental slowing,word finding difficulty,hypohidrosis • Renal calculi
  • 17. Advice • Educate and counsel on epilepsy • Compliance! • Don't stop medication by yourself > breakthrough seizure • Watch TV in bright light room and avoid sleep deprivation • No cycling,swimming or climbing alone • Emergency treatment for seizure • Inform teacher and school about the condition