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Focused Assessment with
Sonography forTrauma
Nira Beck-Razi, MD*, Diana Gaitini, MD
The use of ultrasound (US) in trauma to detect
abdominal parenchymal injuries, specifically
traumatic splenic hematomas, was described by
Kristensen and colleagues1
back in 1971. In
1976, Asher and colleagues2
reported a sensitivity
of 80% for the detection of splenic injury from
blunt abdominal injuries. US for trauma evaluation
was then abandoned but resurfaced in 1990,
especially for blunt abdominal injuries.3
SONOGRAPHIC TECHNIQUE
The US examination in the emergency room
differs from the examination conducted in the US
suite. The emergency examination is brief
and highly focused, and typically seeks to answer
a single clinically relevant question: ‘‘Is there
a hemoperitoneum?’’
The protocol of the focused assessment with
sonography for trauma (FAST) examination in-
cludes evaluation of the right upper quadrant, the
left upper quadrant, and the pelvis for free fluid.
It is desirable that the bladder be filled, thus creat-
ing an acoustic window, needed to detect small
amounts of hemoperitoneum and to displace
bowel loops.4
The rest of the protocol may differ between insti-
tutions. McGahan and colleagues4
report that their
protocol includes scanning the right upper quad-
rant; the hepatorenal fossa, including the right
kidney, checking the liver for parenchymal anoma-
lies; the right flank; and the pelvis; and evaluation
of the epigastrium; the left upper quadrant; the
spleen; the left kidney; and the left flank. They in-
corporated a subxiphoid view, to check the heart
for pericardial fluid, and pleural views. These addi-
tions to the classic protocol are part of the
extended FAST.
The authors’ protocol includes scanning of the
right (Morison’s pouch) and left upper quadrants,
the right and left gutters, and the pelvis for the
evaluation of free fluid, in transverse and longitudi-
nal planes; a subxiphoid or transthoracic view of
the pericardium for the evaluation of hemopericar-
dium; and an evaluation of the pleurae for pneu-
mothorax (Figs. 1–4).
Although FAST was defined by international
consensus as ‘‘an examination to detect free intra
peritoneal fluid as a marker of injury’’,5
the role of
FAST has been extended to the diagnosis of
hemopericardium and, lately, to pneumothorax
(extended FAST). FAST is not expected to detect
injuries to abdominal organs, associated or not
with intraperitoneal fluid, such as hollow viscous
tear, mesenteric tear, intraparenchymal or sub-
capsular bleeding, and retroperitoneal injuries.6,7
Free fluid will usually appear anechogenic to
homogenously hypoechogenic, sometimes with
low-level echoes. At the site of an injured solid
organ, one may find echogenic blood forming
a subcapsular hematoma, which may be less
obvious than the hypoechoic free fluid.
Richards and colleagues8
evaluated the US
appearance of blunt liver injuries. Parenchymal
injuries were documented in only 12% of patients,
and three different patterns were observed. The
most common pattern was a discrete hyperecho-
genic area; other patterns included a diffuse
hyperechogenic pattern or a discrete hypoechoic
pattern (Fig. 5). An echogenic clot was often
Unit of Ultrasound, Department of Medical Imaging, Rambam Medical Center, Ha’aliya Hashniya 8, 31096,
POB 9602, Haifa, Israel
* Corresponding author.
E-mail address: n_beck_razi@rambam.health.gov.il (N. Beck-Razi).
KEYWORDS
 Focused assessment with sonography for trauma
 Multiple casualty incidents  Diagnosis  Triage
 Ultrasonography
Ultrasound Clin 3 (2008) 23–31
doi:10.1016/j.cult.2007.12.009
1556-858X/08/$ – see front matter ª 2008 Elsevier Inc. All rights reserved.
ultrasound.theclinics.com
seen surrounding the liver. Of course, hypoecho-
genic fluid may be seen in other portions of the ab-
domen. The appearance of hepatic lacerations
changes with time, as is the case in other solid
organs. The laceration may be difficult to recog-
nize or may appear slightly echogenic. Hepatic
lacerations appear more hypoechoic or cystic
when scanned days after the initial injury.4
Ri-
chards and colleagues9
identified parenchymal in-
juries of the spleen in 31 of 162 patients. The most
common pattern was a diffuse heterogeneous ap-
pearance, a pattern that may be difficult to recog-
nize (Fig. 6).
McGahan and associates10
found that US
discovered only 8 injured kidneys from a total of
37. If a kidney was severely injured, the sono-
graphic appearance was that of a large, mixed,
anechogenic renal fossa with loss of normal renal
shape. Mild renal lacerations were difficult to
detect with US.
WHOSE TURF IS IT?
Accurate training and experience are crucial to
accurate US evaluation.
US is first and foremost an operator-dependent
examination; this fact should be especially empha-
sized when surgeons or emergency physicians with
Fig. 1. Components of the modified assessment with
sonography for trauma, including a subxiphoid view
to evaluate possible pericardial blood (1); a right
upper quadrant view to evaluate Morison’s pouch
(2); a right paracolic gutter view (3); a left upper
quadrant view to evaluate the splenorenal recess (4);
a left paracolic gutter view (5); a suprapubic view of
the pouch of Douglas/retrovesical pouch (6). (From
Yen K, Gorelick MH. Ultrasound applications for the
pediatric emergency department: a review of the
current literature. Pediatr Emerg Care 2002;18(3):
226–34; with permission.)
Fig. 2. A longitudinal view of the hepatorenal space
(Morrison’s pouch), illustrating free fluid (short
arrow). Perihepatic fluid (long arrow) is also shown,
as is an appreciable amount of pleural effusion (PE).
Fig. 3. A longitudinal view of the splenorenal space,
illustrating free fluid (short arrow). A diffuse heteroge-
neous area is shown (long arrow) at the lower pole of
the spleen, representing a parenchymal traumatic injury.
Fig. 4. A longitudinal view of the pelvis, illustrating
free fluid in the retrovesical space (arrow).
Beck-Razi  Gaitini24
limited training perform the examination.11
The re-
ported sensitivities for FAST examination vary
among institutions and studies, and among studies
in which the examiners were either radiologists/so-
nographers or nonradiologists. This variability can
be attributed to the differences in methods and pa-
tient population. Some studies screen not only for
fluid but also for abdominal injuries, a fact that
lowers sensitivity (Table 1).
Brown and colleagues11
reported an 84% sensi-
tivity and a negative predictive value of 99%. The
FAST examinations were performed by a staff or
resident radiologist. In this study, it must be
emphasized that US findings were considered
Fig. 5. A transverse view of the right lobe of the liver,
showing a hypoechogenic round area, representing
a posttraumatic hematoma (arrow).
Fig. 6. A longitudinal view of the spleen, showing
a heterogeneous diffuse appearance of the spleen
parenchyma, representing a parenchymal traumatic
injury (arrow).
Table1
Sensitivityofthefocusedassessmentwithsonographyfortraumaexamination,indifferentstudies,comparingradiologistsandnonradiologists
SensitivityOperator
IncludingParenchymal
InjuriesPediatricPatientsOnlyStablePatientsOnly
Brownetal84%Radiologists1ÀÀ
Nuraletal86%Radiologists1ÀÀ
Soudacketal92%RadiologistsÀ1À
Brenchleyetal78%Emergencyphysicians
afterabrieftraining
period
ÀÀÀ
Brooksetal100%TrainednonradiologistsÀÀÀ
Milleretal42%AttendingtraumastaffÀÀ1
Focused Assessment with Sonography for Trauma 25
false-negative if a subsequent study revealed
either free fluid (hemoperitoneum) or any visceral
abdominal injury, also a fact lowering sensitivity.
Nural and colleagues12
reported a sensitivity of
86%. The examinations were performed by radiol-
ogy residents and, again, the sensitivity calculated
was that of intra-abdominal fluid or organ damage
in detecting intra-abdominal injury.
Soudack and colleagues13
reported a sensitivity
of 92% for a pediatric population; false-negative
results were considered to pertain to free fluid
alone, and not parenchymal injuries.
Brenchleyandcolleagues14
reportedasensitivity
of 78% for free fluid. In this study, emergency phy-
sicians performed the FAST after a brief training pe-
riod. Books and colleagues15
reported a sensitivity
of 100% for free fluid; the FAST examinations were
performed by trained nonradiologists. Miller and
colleagues16
evaluated 372 hemodynamically sta-
ble patients who had suspected blunt abdominal
injury. FAST examination had a sensitivity of 42%
for free fluid. The examination was performed by
attending trauma staff.
McGahan and colleagues17
suggested that
trauma sonography has a definite learning curve
and this examination should be performed only
by US technologists with more than 3 years of
experience, and interpreted only by radiologists
with more than 3 years of training in sonographic
techniques.
The American Institute of Ultrasound in Medicine
has recommended that at least 500 abdominal US
examinations be performed with supervision be-
fore physicians are allowed to perform sonography
independently.18
Smith and colleagues19
concluded that senior
surgical residents are capable of performing the
focused US examination for trauma with a high
level of skill after a concise introductory course.
A learning curve was not apparent in their study,
indicating that the criteria for being permitted to
perform trauma sonography that include the
requirement of a large number of examinations or
extensive proctoring should be reassessed. They
reported a sensitivity of 73% for detecting free
fluid, commenting that they believe that it appears
that many recommendations are influenced by
emotional ‘‘turf battles’’ and fear of lost practice
domain.
The authors believe that because one of sonog-
raphy’s main limitations is experience and
operator dependency, it cannot be ignored that
sonographers and radiologists are capable, in
principle, of achieving higher accuracies.
The authors’ radiology department is able to give
24-hour coverage of FAST examination in the
trauma room. They believe that 24-hour coverage
should be the case if a radiology department in
a specific institution can give such service.
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA IN THE ADULTAND PEDIATRIC
POPULATION
In the pediatric patient, physical examination is fre-
quently unreliable and imaging studies are
required.20
Because children differ from adults not
only in size but also in their physiologic response
to trauma,theeffectiveness of FAST in children can-
not be extrapolated from studies in adults.13
The management of solid visceral abdominal
injuries in children differs from that of adults. In
children, parenchymal injury generally does not
require surgery. Surgical treatment of hepatic in-
juries in children is associated with high morbidity
and mortality. Splenectomy is associated with
sepsis and thus, a high risk of fatality.13
According
to Taylor and Sivit,21
abdominal injury was not
associated with free peritoneal fluid in 37% of
children, compared with 22% in the adult popula-
tion.22
Furthermore, sonography is repeatable;
thus, serial follow-up scans can be performed in
cases of conservative management or when
a case is not conclusive.
Several reports on the usefulness of FAST in
children have been published, with conflicting
results.23–25
In the literature, reported sensitivity
ranges from 33%,24
to 81%,26
to 97%.13
Soudack
and colleagues’13
results showed a sensitivity of
92.5% and a specificity of 97.2%, thus concluding
that FAST can be used in pediatric patients as an
effective screening tool adjunct to the clinical
evaluation. In contrast to this study, Richards
and colleagues27
showed a sensitivity of 56% for
the detection of abdominal injuries (hemoperito-
neum and solid organ injury) in pediatric blunt
abdominal trauma.
In contrast to sonography, CT involves ionizing
radiation, which is potentially harmful, especially
to pediatric patients. Sonography produces no
ionizing radiation, is quick and relatively inexpen-
sive, and thus is appropriate as a screening test.
Sonography is a valuable tool as an adjunct to
physical examination in cases of pediatric blunt
abdominal trauma.13
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA IN BLUNTAND PENETRATING
TRAUMA
FAST is rapidly establishing its place in the evalu-
ation of blunt abdominal trauma. However, few
articles have been published concerning its role
in penetrating abdominal trauma. Udobi and
colleagues28
concluded in their study that FAST
Beck-Razi  Gaitini26
can be a useful initial diagnostic study after
penetrating abdominal trauma; furthermore, they
concluded that a positive FAST is a strong predic-
tor of injury, and these patients should proceed
directly to laparotomy. If negative, additional
diagnostic studies should be performed to rule
out occult injury, because their results showed
a low sensitivity of 46%.
Rapid diagnosis and treatment of abdominal
injury is an important factor in decreasing mortality
in patients who have blunt abdominal trauma.
Physical examination is frequently unreliable in
the setting of acute trauma.29
Diagnostic peritoneal lavage has been used
successfully to aid in the diagnosis of
abdominal injury and to determine the need for
laparotomy.30
When CT emerged in clinical practice, it allowed
a more accurate decision-making process and
a better triage of these patients.31,32
Today, US
is used in many centers of the world in the evalua-
tion of blunt abdominal trauma.33–35
Most studies in the literature report a high sensi-
tivity and a high negative predictive value for FAST
in blunt abdominal injury, thus making the exami-
nation an excellent screening test.
Lingawi and colleagues reported a sensitivity of
94%, and a 100% negative predictive value in
blunt abdominal injuries.6
Rothlin and associates 36
reviewed the European literature about US of
blunt abdominal trauma and cited reports of sensi-
tivities of 85% to 100% and specificities of 98% to
100%. Their study showed an overall sensitivity
and specificity of the US examination of 90%
and 99.5%, respectively.
Brown and colleagues11
reported a slightly
lower sensitivity of 84%, probably because they
screened patients for abdominal injury and not
for free fluid alone. US in the emergency room is
not expected to detect abdominal injuries not
associated with free fluid, such as hollow viscous
injuries or parenchymal injuries.
McGahan and colleagues17
reported a low sen-
sitivity of 63% of US in detecting free fluid, in com-
parison to CT, diagnostic peritoneal lavage and
surgery. They explained their results by the fact
that the bladder was not filled during the examina-
tion and small amounts of fluid in the pelvis were
undetected.
The authors believe that FAST plays an impor-
tant part in the evaluation of all trauma injuries,
whether blunt or penetrating, and should be
performed on all of them during the resuscitation
phase. US is fast and noninvasive, does not in-
volve radiation, is portable, and can be integrated
into the resuscitation process in the trauma bay
without disrupting it.
A negative FAST should be received with
caution, especially in penetrating abdominal injury,
because in such injuries it takes time to develop
appreciable hemoperitoneum that can be de-
tected by US.
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA IN STABLE AND UNSTABLE
PATIENTS
In a setting of a blunt abdominal trauma, determin-
ing which patients should be triaged to laparotomy
is important, even more so when these patients
are unstable; rapid and accurate triage is crucial
because delayed treatment is associated with
increased morbidity and mortality.37
In such a set-
ting, clinical history, laboratory test, and a physical
examination are often not reliable in the evaluation
of the patient.38
Brett and colleagues34
evaluated the usefulness
of FAST performed by experienced sonographers
in a setting of a blunt abdominal trauma, compar-
ing hypotensive and normotensive patients. They
found a statistically significant difference between
hypotensive and normotensive patients with small
amounts of free fluid, which reflects the greater
significance of small amounts of fluid in hypoten-
sive patients and the higher associated therapeu-
tic laparotomy rate. They concluded that FAST is
an effective screening tool when performed by ex-
perienced sonographers. In hypotensive patients,
in whom a moderate to large amount of fluid is
found, immediate triage to laparotomy, obviating
CT, is warranted.
Miller and colleagues16
evaluated 372 hemody-
namically stable patients who had suspected blunt
abdominal injury. FAST examination had a sensitiv-
ity of 42% and a negative predictive value of 98%.
They concluded that the use of FAST examination
in hemodynamically stable trauma patients results
in underdiagnosis of intra-abdominal injury.
Thus, FAST evaluation of stable patients who
have suspected abdominal injury is perhaps less
accurate than for unstable patients, but still has
an important role in the triage of all trauma patients.
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA AS ATRIAGE TOOL
IN MULTIPLE-CASUALTY INCIDENTS
In war zones and regions of political conflict, civil-
ians and military personnel are exposed to serious
injuries due to explosives and firearms. Injuries
may be blunt or penetrating, often combined in
a single patient.39–41
Effective initial triage, defined as the art of sort-
ing patients according to the severity of their injury,
Focused Assessment with Sonography for Trauma 27
is the key to dealing successfully with a multiple-
casualty incident.
To proceed to further triage and patient manage-
ment, a quick and efficient imaging diagnosing test
is needed. FAST can be performed rapidly in the ad-
mission area and is repeatable, noninvasive, nonir-
radiating, and inexpensive. It is widely accepted as
an effective initial tool to evaluate trauma victims
with suspected blunt abdominal injuries.42
FAST may play an important role in the work-up of
trauma patients in a multiple-casualty incident be-
cause ofthecomplexityofthe injuries. Some contro-
versies remain concerning the role of FAST in
penetrating trauma.28
Although the role of FAST in
an individual trauma casualty has been reviewed
in the literature, few studies have described the
role of FAST in multiple-casualty incidents.
Miletic and colleagues43
described US screen-
ing of mass war casualties as an efficient and
effective means for detection and on-site triage
of abdominal injuries that were mostly penetrating
(90%), with a similar sensitivity and specificity in
war and civil conditions.
Sarkisian and colleagues44
described a suc-
cessful application of US after a catastrophic
earthquake in Armenia, which involved mostly
crush injuries.
In war conflict and in terror-related injuries, pa-
tients comprise a heterogeneous group of blunt
and penetrating injuries, hemodynamically stable
and unstable patients, adults and children. The
level of care for each casualty in a multiple-casual-
ty incident is less than that provided under regular
circumstances. Attention is given to the moder-
ately to severely injured, because these will benefit
the most from optimal care.
In a study the authors conducted on 102
soldiers and civilians during the second Lebanon
war, they reported a sensitivity of 75% for hemo-
peritoneum detection. Injuries encountered were
blunt and penetrating combined. Their results
show that FAST, as the first imaging examination
during continuous arrival phase in a setting of
a war conflict–related multiple-casualty incident,
enabled immediate triage of casualties to
laparotomy, CT, or clinical observation.
Because of its moderate sensitivity and limita-
tion in diagnosing solid organs or hollow viscous
injury, a negative FAST in the presence of a strong
clinical suspicion must be followed by CT or
laparotomy, according to clinical judgment.45
ROLE OF FOCUSED ASSESSMENT WITH
SONOGRAPHY FOR TRAUMA IN FOLLOW-UP
One of US’s main advantages is the fact that no
ionizing radiation is involved; thus, the examination
can be repeated when needed. Blackbourne and
colleagues46
aimed to evaluate whether delayed,
repeat US study can reveal additional intra-
abdominal injuries and hemoperitoneum. They
found that secondary US of the abdomen signifi-
cantly increases the sensitivity of US to detecting
intra-abdominal injury. The sensitivity of US to
detecting intraperitoneal injury is directly related
to the fact that US relies on the existence of free
intraperitoneal blood and does not routinely in-
clude parenchymal imaging. Studies have shown
that the sensitivity to detecting intraperitoneal fluid
is relatively proportional to the amount of fluid in
the peritoneal cavity, especially for inexperienced
US operators.47,48
The limited intraperitoneal
blood on admission, combined with the necessity
for a significant amount of intraperitoneal blood
(200 mL) for most surgical US operators to be
able to detect hemoperitoneum, may limit the
sensitivity of US in stable blunt trauma patients.49
A secondary abdominal US may allow for the
duration necessary to accumulate the prerequisite
amount of blood for detection by most surgical US
operators. Although FAST has shown lower sensi-
tivity for penetrating trauma,28
a secondary US in
cases of such injuries may give better results for
the same reason. In the case of a multiple-casualty
incident, when resources are overwhelmed, par-
ticularly CT, a secondary US can be helpful,
especially when an initially stable patient who
was left on clinical observation is deteriorating
and CT is not yet available.
A secondary US can be beneficial in cases of
a known trauma to parenchymal organs, in most
cases initially diagnosed by CT. The secondary
US can evaluate the parenchymal injuries and
the amount of free fluid over time. The pediatric
population is more sensitive to ionizing radiation
damage and CT should be limited; a follow-up
US examination is most useful. In addition, treat-
ment of such injuries takes a more conservative
approach in children than in adults.
PITFALLS AND LIMITATIONS
US is first and foremost an operator-dependent
examination; thus, experience plays an important
role and sensitivity drops with little experience.
US showed a low sensitivity of 44% in detecting
free fluid associated with bowel or mesenteric
injury,50
US has a low sensitivity for parenchymal
injuries, injuries to the diaphragm and the pan-
creas, and vascular injuries. These specific limita-
tions must be kept in mind when one performs the
FAST examination, so that the only question that
can be answered with high accuracy is the
presence or absence of free fluid.
Beck-Razi  Gaitini28
Without a full bladder, free fluid may be missed,
because a full bladder creates an acoustic window
that helps detect small amounts of fluid in the
pelvis and displaces bowel loops.17
On the other
hand, false-positive results can be due to physio-
logic pelvic fluid in female patients of reproductive
ages. The mechanism of fluid accumulation is
unclear and is probably multifactorial.51–53
With
transabdominal imaging, physiologic fluid has
been described during all stages of the menstrual
cycle in up to 30% to 40% of healthy volunteers.53
In the obstetric literature, numerous investigators
have quantified the volume of fluid found surgically
in the cul-de-sac and have estimated the upper
limit of physiologic fluid to be about 45 mL.
Although these investigators described the fluid
as ranging from clear to blood tinged, physiologic
fluid is generally anechoic on sonographic imag-
ing. When fluid in the cul-de-sac contains internal
echoes, it is unlikely to be physiologic. And in a pa-
tient with trauma, this fluid likely represents hemo-
peritoneum.54
Because the cul-de-sac is the most
dependent recess in the peritoneum in both supine
and upright positions, pathologic fluid tends to
collect within it.55
Sirlin and colleagues54
reported in their study
that fluid in the cul-de-sac was never the sole
manifestation of a solid organ or enteric injury.
They concluded that in a female patient of repro-
ductive age with blunt abdominal trauma, small
amounts of anechoic fluid isolated to the cul-de-
sac or adjacent pelvic recesses should be consid-
ered physiologic, and further evaluation is not
needed in the absence of other radiologic or
clinical findings.
They emphasized that if the fluid measures at
least 3 cm in depth, has internal echoes, and
extends into the supravesical space or anterior to
the bladder, or if the patient is past her reproduc-
tive years or her reproductive status is unknown,
fluid is regarded with suspicion. US is an opera-
tor-dependent examination, which is a limitation
of the examination in itself. Thus, when the exam-
ination is performed by a resident with less experi-
ence, under the stressful environment of a trauma
room, his or her tendency is to overcall the findings
when in doubt. A similar dilemma occurs when
small amounts of fluid are found in the pelvis in
children. Rathaus and colleagues56
aimed to eval-
uate the significance of the US finding of pelvis
fluid after blunt abdominal trauma in children as
a predictor of an abdominal injury. They concluded
that a normal US examination or the presence of
pelvic fluid is associated with a low probability of
an organ injury, but the presence of peritoneal fluid
outside the pelvis indicates that the probability of
an organ injury is high. Despite this conclusion,
the residence tendency is again to overcall. Last
but not least, the medical history of a trauma
patient arriving in the trauma room is not known;
thus, if the patient has ascites for any number of
reasons, the examination will be positive. In addi-
tion, even if the patient’s condition is known, one
cannot be sure if there is hemoperitoneum on
top of the known ascites.
SUMMARY
The US examination in the trauma room is brief
and focused and should answer a single relevant
question: ‘‘Is there a hemoperitoneum?’’ The pres-
ence of hemopericardium is evaluated also, as is
the presence of pneumothorax.
The answer to this question enables the attend-
ing staff to perform better triage, whether dealing
with an individual trauma patient or in the case
of a multiple-casualty incident, thus improving
patient prognosis.
Because no ionizing radiation is involved, FAST
can be performed consecutively and can spare the
patient from CT, an important fact to remember,
especially when dealing with pediatric trauma
patients.
In the authors’ institution, it is acceptable that
the FAST examination be performed on all trauma
patients, keeping in mind the examination’s limita-
tions, including its lower sensitivity in cases of
penetrating trauma and stable patients.
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Focused Assessment with Sonography for Trauma 31

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Fast 1

  • 1. Focused Assessment with Sonography forTrauma Nira Beck-Razi, MD*, Diana Gaitini, MD The use of ultrasound (US) in trauma to detect abdominal parenchymal injuries, specifically traumatic splenic hematomas, was described by Kristensen and colleagues1 back in 1971. In 1976, Asher and colleagues2 reported a sensitivity of 80% for the detection of splenic injury from blunt abdominal injuries. US for trauma evaluation was then abandoned but resurfaced in 1990, especially for blunt abdominal injuries.3 SONOGRAPHIC TECHNIQUE The US examination in the emergency room differs from the examination conducted in the US suite. The emergency examination is brief and highly focused, and typically seeks to answer a single clinically relevant question: ‘‘Is there a hemoperitoneum?’’ The protocol of the focused assessment with sonography for trauma (FAST) examination in- cludes evaluation of the right upper quadrant, the left upper quadrant, and the pelvis for free fluid. It is desirable that the bladder be filled, thus creat- ing an acoustic window, needed to detect small amounts of hemoperitoneum and to displace bowel loops.4 The rest of the protocol may differ between insti- tutions. McGahan and colleagues4 report that their protocol includes scanning the right upper quad- rant; the hepatorenal fossa, including the right kidney, checking the liver for parenchymal anoma- lies; the right flank; and the pelvis; and evaluation of the epigastrium; the left upper quadrant; the spleen; the left kidney; and the left flank. They in- corporated a subxiphoid view, to check the heart for pericardial fluid, and pleural views. These addi- tions to the classic protocol are part of the extended FAST. The authors’ protocol includes scanning of the right (Morison’s pouch) and left upper quadrants, the right and left gutters, and the pelvis for the evaluation of free fluid, in transverse and longitudi- nal planes; a subxiphoid or transthoracic view of the pericardium for the evaluation of hemopericar- dium; and an evaluation of the pleurae for pneu- mothorax (Figs. 1–4). Although FAST was defined by international consensus as ‘‘an examination to detect free intra peritoneal fluid as a marker of injury’’,5 the role of FAST has been extended to the diagnosis of hemopericardium and, lately, to pneumothorax (extended FAST). FAST is not expected to detect injuries to abdominal organs, associated or not with intraperitoneal fluid, such as hollow viscous tear, mesenteric tear, intraparenchymal or sub- capsular bleeding, and retroperitoneal injuries.6,7 Free fluid will usually appear anechogenic to homogenously hypoechogenic, sometimes with low-level echoes. At the site of an injured solid organ, one may find echogenic blood forming a subcapsular hematoma, which may be less obvious than the hypoechoic free fluid. Richards and colleagues8 evaluated the US appearance of blunt liver injuries. Parenchymal injuries were documented in only 12% of patients, and three different patterns were observed. The most common pattern was a discrete hyperecho- genic area; other patterns included a diffuse hyperechogenic pattern or a discrete hypoechoic pattern (Fig. 5). An echogenic clot was often Unit of Ultrasound, Department of Medical Imaging, Rambam Medical Center, Ha’aliya Hashniya 8, 31096, POB 9602, Haifa, Israel * Corresponding author. E-mail address: n_beck_razi@rambam.health.gov.il (N. Beck-Razi). KEYWORDS Focused assessment with sonography for trauma Multiple casualty incidents Diagnosis Triage Ultrasonography Ultrasound Clin 3 (2008) 23–31 doi:10.1016/j.cult.2007.12.009 1556-858X/08/$ – see front matter ª 2008 Elsevier Inc. All rights reserved. ultrasound.theclinics.com
  • 2. seen surrounding the liver. Of course, hypoecho- genic fluid may be seen in other portions of the ab- domen. The appearance of hepatic lacerations changes with time, as is the case in other solid organs. The laceration may be difficult to recog- nize or may appear slightly echogenic. Hepatic lacerations appear more hypoechoic or cystic when scanned days after the initial injury.4 Ri- chards and colleagues9 identified parenchymal in- juries of the spleen in 31 of 162 patients. The most common pattern was a diffuse heterogeneous ap- pearance, a pattern that may be difficult to recog- nize (Fig. 6). McGahan and associates10 found that US discovered only 8 injured kidneys from a total of 37. If a kidney was severely injured, the sono- graphic appearance was that of a large, mixed, anechogenic renal fossa with loss of normal renal shape. Mild renal lacerations were difficult to detect with US. WHOSE TURF IS IT? Accurate training and experience are crucial to accurate US evaluation. US is first and foremost an operator-dependent examination; this fact should be especially empha- sized when surgeons or emergency physicians with Fig. 1. Components of the modified assessment with sonography for trauma, including a subxiphoid view to evaluate possible pericardial blood (1); a right upper quadrant view to evaluate Morison’s pouch (2); a right paracolic gutter view (3); a left upper quadrant view to evaluate the splenorenal recess (4); a left paracolic gutter view (5); a suprapubic view of the pouch of Douglas/retrovesical pouch (6). (From Yen K, Gorelick MH. Ultrasound applications for the pediatric emergency department: a review of the current literature. Pediatr Emerg Care 2002;18(3): 226–34; with permission.) Fig. 2. A longitudinal view of the hepatorenal space (Morrison’s pouch), illustrating free fluid (short arrow). Perihepatic fluid (long arrow) is also shown, as is an appreciable amount of pleural effusion (PE). Fig. 3. A longitudinal view of the splenorenal space, illustrating free fluid (short arrow). A diffuse heteroge- neous area is shown (long arrow) at the lower pole of the spleen, representing a parenchymal traumatic injury. Fig. 4. A longitudinal view of the pelvis, illustrating free fluid in the retrovesical space (arrow). Beck-Razi Gaitini24
  • 3. limited training perform the examination.11 The re- ported sensitivities for FAST examination vary among institutions and studies, and among studies in which the examiners were either radiologists/so- nographers or nonradiologists. This variability can be attributed to the differences in methods and pa- tient population. Some studies screen not only for fluid but also for abdominal injuries, a fact that lowers sensitivity (Table 1). Brown and colleagues11 reported an 84% sensi- tivity and a negative predictive value of 99%. The FAST examinations were performed by a staff or resident radiologist. In this study, it must be emphasized that US findings were considered Fig. 5. A transverse view of the right lobe of the liver, showing a hypoechogenic round area, representing a posttraumatic hematoma (arrow). Fig. 6. A longitudinal view of the spleen, showing a heterogeneous diffuse appearance of the spleen parenchyma, representing a parenchymal traumatic injury (arrow). Table1 Sensitivityofthefocusedassessmentwithsonographyfortraumaexamination,indifferentstudies,comparingradiologistsandnonradiologists SensitivityOperator IncludingParenchymal InjuriesPediatricPatientsOnlyStablePatientsOnly Brownetal84%Radiologists1ÀÀ Nuraletal86%Radiologists1ÀÀ Soudacketal92%RadiologistsÀ1À Brenchleyetal78%Emergencyphysicians afterabrieftraining period ÀÀÀ Brooksetal100%TrainednonradiologistsÀÀÀ Milleretal42%AttendingtraumastaffÀÀ1 Focused Assessment with Sonography for Trauma 25
  • 4. false-negative if a subsequent study revealed either free fluid (hemoperitoneum) or any visceral abdominal injury, also a fact lowering sensitivity. Nural and colleagues12 reported a sensitivity of 86%. The examinations were performed by radiol- ogy residents and, again, the sensitivity calculated was that of intra-abdominal fluid or organ damage in detecting intra-abdominal injury. Soudack and colleagues13 reported a sensitivity of 92% for a pediatric population; false-negative results were considered to pertain to free fluid alone, and not parenchymal injuries. Brenchleyandcolleagues14 reportedasensitivity of 78% for free fluid. In this study, emergency phy- sicians performed the FAST after a brief training pe- riod. Books and colleagues15 reported a sensitivity of 100% for free fluid; the FAST examinations were performed by trained nonradiologists. Miller and colleagues16 evaluated 372 hemodynamically sta- ble patients who had suspected blunt abdominal injury. FAST examination had a sensitivity of 42% for free fluid. The examination was performed by attending trauma staff. McGahan and colleagues17 suggested that trauma sonography has a definite learning curve and this examination should be performed only by US technologists with more than 3 years of experience, and interpreted only by radiologists with more than 3 years of training in sonographic techniques. The American Institute of Ultrasound in Medicine has recommended that at least 500 abdominal US examinations be performed with supervision be- fore physicians are allowed to perform sonography independently.18 Smith and colleagues19 concluded that senior surgical residents are capable of performing the focused US examination for trauma with a high level of skill after a concise introductory course. A learning curve was not apparent in their study, indicating that the criteria for being permitted to perform trauma sonography that include the requirement of a large number of examinations or extensive proctoring should be reassessed. They reported a sensitivity of 73% for detecting free fluid, commenting that they believe that it appears that many recommendations are influenced by emotional ‘‘turf battles’’ and fear of lost practice domain. The authors believe that because one of sonog- raphy’s main limitations is experience and operator dependency, it cannot be ignored that sonographers and radiologists are capable, in principle, of achieving higher accuracies. The authors’ radiology department is able to give 24-hour coverage of FAST examination in the trauma room. They believe that 24-hour coverage should be the case if a radiology department in a specific institution can give such service. FOCUSED ASSESSMENT WITH SONOGRAPHY FOR TRAUMA IN THE ADULTAND PEDIATRIC POPULATION In the pediatric patient, physical examination is fre- quently unreliable and imaging studies are required.20 Because children differ from adults not only in size but also in their physiologic response to trauma,theeffectiveness of FAST in children can- not be extrapolated from studies in adults.13 The management of solid visceral abdominal injuries in children differs from that of adults. In children, parenchymal injury generally does not require surgery. Surgical treatment of hepatic in- juries in children is associated with high morbidity and mortality. Splenectomy is associated with sepsis and thus, a high risk of fatality.13 According to Taylor and Sivit,21 abdominal injury was not associated with free peritoneal fluid in 37% of children, compared with 22% in the adult popula- tion.22 Furthermore, sonography is repeatable; thus, serial follow-up scans can be performed in cases of conservative management or when a case is not conclusive. Several reports on the usefulness of FAST in children have been published, with conflicting results.23–25 In the literature, reported sensitivity ranges from 33%,24 to 81%,26 to 97%.13 Soudack and colleagues’13 results showed a sensitivity of 92.5% and a specificity of 97.2%, thus concluding that FAST can be used in pediatric patients as an effective screening tool adjunct to the clinical evaluation. In contrast to this study, Richards and colleagues27 showed a sensitivity of 56% for the detection of abdominal injuries (hemoperito- neum and solid organ injury) in pediatric blunt abdominal trauma. In contrast to sonography, CT involves ionizing radiation, which is potentially harmful, especially to pediatric patients. Sonography produces no ionizing radiation, is quick and relatively inexpen- sive, and thus is appropriate as a screening test. Sonography is a valuable tool as an adjunct to physical examination in cases of pediatric blunt abdominal trauma.13 FOCUSED ASSESSMENT WITH SONOGRAPHY FOR TRAUMA IN BLUNTAND PENETRATING TRAUMA FAST is rapidly establishing its place in the evalu- ation of blunt abdominal trauma. However, few articles have been published concerning its role in penetrating abdominal trauma. Udobi and colleagues28 concluded in their study that FAST Beck-Razi Gaitini26
  • 5. can be a useful initial diagnostic study after penetrating abdominal trauma; furthermore, they concluded that a positive FAST is a strong predic- tor of injury, and these patients should proceed directly to laparotomy. If negative, additional diagnostic studies should be performed to rule out occult injury, because their results showed a low sensitivity of 46%. Rapid diagnosis and treatment of abdominal injury is an important factor in decreasing mortality in patients who have blunt abdominal trauma. Physical examination is frequently unreliable in the setting of acute trauma.29 Diagnostic peritoneal lavage has been used successfully to aid in the diagnosis of abdominal injury and to determine the need for laparotomy.30 When CT emerged in clinical practice, it allowed a more accurate decision-making process and a better triage of these patients.31,32 Today, US is used in many centers of the world in the evalua- tion of blunt abdominal trauma.33–35 Most studies in the literature report a high sensi- tivity and a high negative predictive value for FAST in blunt abdominal injury, thus making the exami- nation an excellent screening test. Lingawi and colleagues reported a sensitivity of 94%, and a 100% negative predictive value in blunt abdominal injuries.6 Rothlin and associates 36 reviewed the European literature about US of blunt abdominal trauma and cited reports of sensi- tivities of 85% to 100% and specificities of 98% to 100%. Their study showed an overall sensitivity and specificity of the US examination of 90% and 99.5%, respectively. Brown and colleagues11 reported a slightly lower sensitivity of 84%, probably because they screened patients for abdominal injury and not for free fluid alone. US in the emergency room is not expected to detect abdominal injuries not associated with free fluid, such as hollow viscous injuries or parenchymal injuries. McGahan and colleagues17 reported a low sen- sitivity of 63% of US in detecting free fluid, in com- parison to CT, diagnostic peritoneal lavage and surgery. They explained their results by the fact that the bladder was not filled during the examina- tion and small amounts of fluid in the pelvis were undetected. The authors believe that FAST plays an impor- tant part in the evaluation of all trauma injuries, whether blunt or penetrating, and should be performed on all of them during the resuscitation phase. US is fast and noninvasive, does not in- volve radiation, is portable, and can be integrated into the resuscitation process in the trauma bay without disrupting it. A negative FAST should be received with caution, especially in penetrating abdominal injury, because in such injuries it takes time to develop appreciable hemoperitoneum that can be de- tected by US. FOCUSED ASSESSMENT WITH SONOGRAPHY FOR TRAUMA IN STABLE AND UNSTABLE PATIENTS In a setting of a blunt abdominal trauma, determin- ing which patients should be triaged to laparotomy is important, even more so when these patients are unstable; rapid and accurate triage is crucial because delayed treatment is associated with increased morbidity and mortality.37 In such a set- ting, clinical history, laboratory test, and a physical examination are often not reliable in the evaluation of the patient.38 Brett and colleagues34 evaluated the usefulness of FAST performed by experienced sonographers in a setting of a blunt abdominal trauma, compar- ing hypotensive and normotensive patients. They found a statistically significant difference between hypotensive and normotensive patients with small amounts of free fluid, which reflects the greater significance of small amounts of fluid in hypoten- sive patients and the higher associated therapeu- tic laparotomy rate. They concluded that FAST is an effective screening tool when performed by ex- perienced sonographers. In hypotensive patients, in whom a moderate to large amount of fluid is found, immediate triage to laparotomy, obviating CT, is warranted. Miller and colleagues16 evaluated 372 hemody- namically stable patients who had suspected blunt abdominal injury. FAST examination had a sensitiv- ity of 42% and a negative predictive value of 98%. They concluded that the use of FAST examination in hemodynamically stable trauma patients results in underdiagnosis of intra-abdominal injury. Thus, FAST evaluation of stable patients who have suspected abdominal injury is perhaps less accurate than for unstable patients, but still has an important role in the triage of all trauma patients. FOCUSED ASSESSMENT WITH SONOGRAPHY FOR TRAUMA AS ATRIAGE TOOL IN MULTIPLE-CASUALTY INCIDENTS In war zones and regions of political conflict, civil- ians and military personnel are exposed to serious injuries due to explosives and firearms. Injuries may be blunt or penetrating, often combined in a single patient.39–41 Effective initial triage, defined as the art of sort- ing patients according to the severity of their injury, Focused Assessment with Sonography for Trauma 27
  • 6. is the key to dealing successfully with a multiple- casualty incident. To proceed to further triage and patient manage- ment, a quick and efficient imaging diagnosing test is needed. FAST can be performed rapidly in the ad- mission area and is repeatable, noninvasive, nonir- radiating, and inexpensive. It is widely accepted as an effective initial tool to evaluate trauma victims with suspected blunt abdominal injuries.42 FAST may play an important role in the work-up of trauma patients in a multiple-casualty incident be- cause ofthecomplexityofthe injuries. Some contro- versies remain concerning the role of FAST in penetrating trauma.28 Although the role of FAST in an individual trauma casualty has been reviewed in the literature, few studies have described the role of FAST in multiple-casualty incidents. Miletic and colleagues43 described US screen- ing of mass war casualties as an efficient and effective means for detection and on-site triage of abdominal injuries that were mostly penetrating (90%), with a similar sensitivity and specificity in war and civil conditions. Sarkisian and colleagues44 described a suc- cessful application of US after a catastrophic earthquake in Armenia, which involved mostly crush injuries. In war conflict and in terror-related injuries, pa- tients comprise a heterogeneous group of blunt and penetrating injuries, hemodynamically stable and unstable patients, adults and children. The level of care for each casualty in a multiple-casual- ty incident is less than that provided under regular circumstances. Attention is given to the moder- ately to severely injured, because these will benefit the most from optimal care. In a study the authors conducted on 102 soldiers and civilians during the second Lebanon war, they reported a sensitivity of 75% for hemo- peritoneum detection. Injuries encountered were blunt and penetrating combined. Their results show that FAST, as the first imaging examination during continuous arrival phase in a setting of a war conflict–related multiple-casualty incident, enabled immediate triage of casualties to laparotomy, CT, or clinical observation. Because of its moderate sensitivity and limita- tion in diagnosing solid organs or hollow viscous injury, a negative FAST in the presence of a strong clinical suspicion must be followed by CT or laparotomy, according to clinical judgment.45 ROLE OF FOCUSED ASSESSMENT WITH SONOGRAPHY FOR TRAUMA IN FOLLOW-UP One of US’s main advantages is the fact that no ionizing radiation is involved; thus, the examination can be repeated when needed. Blackbourne and colleagues46 aimed to evaluate whether delayed, repeat US study can reveal additional intra- abdominal injuries and hemoperitoneum. They found that secondary US of the abdomen signifi- cantly increases the sensitivity of US to detecting intra-abdominal injury. The sensitivity of US to detecting intraperitoneal injury is directly related to the fact that US relies on the existence of free intraperitoneal blood and does not routinely in- clude parenchymal imaging. Studies have shown that the sensitivity to detecting intraperitoneal fluid is relatively proportional to the amount of fluid in the peritoneal cavity, especially for inexperienced US operators.47,48 The limited intraperitoneal blood on admission, combined with the necessity for a significant amount of intraperitoneal blood (200 mL) for most surgical US operators to be able to detect hemoperitoneum, may limit the sensitivity of US in stable blunt trauma patients.49 A secondary abdominal US may allow for the duration necessary to accumulate the prerequisite amount of blood for detection by most surgical US operators. Although FAST has shown lower sensi- tivity for penetrating trauma,28 a secondary US in cases of such injuries may give better results for the same reason. In the case of a multiple-casualty incident, when resources are overwhelmed, par- ticularly CT, a secondary US can be helpful, especially when an initially stable patient who was left on clinical observation is deteriorating and CT is not yet available. A secondary US can be beneficial in cases of a known trauma to parenchymal organs, in most cases initially diagnosed by CT. The secondary US can evaluate the parenchymal injuries and the amount of free fluid over time. The pediatric population is more sensitive to ionizing radiation damage and CT should be limited; a follow-up US examination is most useful. In addition, treat- ment of such injuries takes a more conservative approach in children than in adults. PITFALLS AND LIMITATIONS US is first and foremost an operator-dependent examination; thus, experience plays an important role and sensitivity drops with little experience. US showed a low sensitivity of 44% in detecting free fluid associated with bowel or mesenteric injury,50 US has a low sensitivity for parenchymal injuries, injuries to the diaphragm and the pan- creas, and vascular injuries. These specific limita- tions must be kept in mind when one performs the FAST examination, so that the only question that can be answered with high accuracy is the presence or absence of free fluid. Beck-Razi Gaitini28
  • 7. Without a full bladder, free fluid may be missed, because a full bladder creates an acoustic window that helps detect small amounts of fluid in the pelvis and displaces bowel loops.17 On the other hand, false-positive results can be due to physio- logic pelvic fluid in female patients of reproductive ages. The mechanism of fluid accumulation is unclear and is probably multifactorial.51–53 With transabdominal imaging, physiologic fluid has been described during all stages of the menstrual cycle in up to 30% to 40% of healthy volunteers.53 In the obstetric literature, numerous investigators have quantified the volume of fluid found surgically in the cul-de-sac and have estimated the upper limit of physiologic fluid to be about 45 mL. Although these investigators described the fluid as ranging from clear to blood tinged, physiologic fluid is generally anechoic on sonographic imag- ing. When fluid in the cul-de-sac contains internal echoes, it is unlikely to be physiologic. And in a pa- tient with trauma, this fluid likely represents hemo- peritoneum.54 Because the cul-de-sac is the most dependent recess in the peritoneum in both supine and upright positions, pathologic fluid tends to collect within it.55 Sirlin and colleagues54 reported in their study that fluid in the cul-de-sac was never the sole manifestation of a solid organ or enteric injury. They concluded that in a female patient of repro- ductive age with blunt abdominal trauma, small amounts of anechoic fluid isolated to the cul-de- sac or adjacent pelvic recesses should be consid- ered physiologic, and further evaluation is not needed in the absence of other radiologic or clinical findings. They emphasized that if the fluid measures at least 3 cm in depth, has internal echoes, and extends into the supravesical space or anterior to the bladder, or if the patient is past her reproduc- tive years or her reproductive status is unknown, fluid is regarded with suspicion. US is an opera- tor-dependent examination, which is a limitation of the examination in itself. Thus, when the exam- ination is performed by a resident with less experi- ence, under the stressful environment of a trauma room, his or her tendency is to overcall the findings when in doubt. A similar dilemma occurs when small amounts of fluid are found in the pelvis in children. Rathaus and colleagues56 aimed to eval- uate the significance of the US finding of pelvis fluid after blunt abdominal trauma in children as a predictor of an abdominal injury. They concluded that a normal US examination or the presence of pelvic fluid is associated with a low probability of an organ injury, but the presence of peritoneal fluid outside the pelvis indicates that the probability of an organ injury is high. Despite this conclusion, the residence tendency is again to overcall. Last but not least, the medical history of a trauma patient arriving in the trauma room is not known; thus, if the patient has ascites for any number of reasons, the examination will be positive. In addi- tion, even if the patient’s condition is known, one cannot be sure if there is hemoperitoneum on top of the known ascites. SUMMARY The US examination in the trauma room is brief and focused and should answer a single relevant question: ‘‘Is there a hemoperitoneum?’’ The pres- ence of hemopericardium is evaluated also, as is the presence of pneumothorax. The answer to this question enables the attend- ing staff to perform better triage, whether dealing with an individual trauma patient or in the case of a multiple-casualty incident, thus improving patient prognosis. Because no ionizing radiation is involved, FAST can be performed consecutively and can spare the patient from CT, an important fact to remember, especially when dealing with pediatric trauma patients. In the authors’ institution, it is acceptable that the FAST examination be performed on all trauma patients, keeping in mind the examination’s limita- tions, including its lower sensitivity in cases of penetrating trauma and stable patients. REFERENCES 1. Kristensen JK, Buemann B, Kuehl E. Ultrasonic scanning in the diagnosis of splenic haematomas. Acta Chir Scand 1971;137:653–7. 2. Asher WM, Parvin S, Virgilo RW. Echographic evalu- ation of splenic injury after blunt trauma. Radiology 1976;118:411–5. 3. Kimura A, Otsuka T. Emergency center ultrasonog- raphy in the evaluation of hemoperitoneum: a pro- spective study. J Trauma 1991;31:20–3. 4. McGahan, Lianyi W, Richards JR, et al. From the RSNA refresher courses: focused abdominal US for trauma. Radiographics 2001;21:S191–9. 5. Scalea TM, Rodrquez A, Chiu WC, et al. Focused assessment with sonography for trauma (FAST). Results from an international consensus conference. J Trauma 1999;46(3):466–72. 6. Lingawi SS, Buckley AR. 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