1) FAST (Focused Assessment with Sonography for Trauma) is an ultrasound technique used to rapidly detect free fluid in the abdomen or chest as a marker of injury from blunt trauma. It can identify hemoperitoneum, hemothorax, or hemopericardium.
2) The standard FAST exam involves scanning four areas of the abdomen and chest to detect free fluid. Additional views of the liver, spleen, and other organs may also be included.
3) Accuracy of FAST depends on the experience and training of the provider. Studies show higher sensitivity when performed by radiologists compared to other clinicians. Maintaining skills through a sufficient case volume is important for competency.
M tor inhibitors for management of encapsulating peritoneal sclerosisPediatric Nephrology
EPS is a rare complication of PD that is characterized :
intraperitoneal inflammation
Fibrosis
EPS causes ultrafiltration failure and bowel obstruction and is associated with significant morbidity and a high mortality.
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An analysis of the evidence about Transhiatal or Transthoracic approach for cancer of the oesophagogastric junction. Invited presentation at the 27th National Congress of the Italian Society of Young Surgeons SPIGC
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M tor inhibitors for management of encapsulating peritoneal sclerosisPediatric Nephrology
EPS is a rare complication of PD that is characterized :
intraperitoneal inflammation
Fibrosis
EPS causes ultrafiltration failure and bowel obstruction and is associated with significant morbidity and a high mortality.
Lotti Marco MD - Cancer of the Oesophago-Gastric JunctionMarco Lotti
An analysis of the evidence about Transhiatal or Transthoracic approach for cancer of the oesophagogastric junction. Invited presentation at the 27th National Congress of the Italian Society of Young Surgeons SPIGC
Brand YOU: Identify before You Amplify (Strategies for the solopreneur to easily leverage and amplify their brand message, plus Q&A on your branding questions)
Branding is Your Social Currency, Kathy Bass, Ladies Who Brand, TechPHXKathy Bass
Branding is Your Social Currency talk at TechPHX on November 11, 2012. Comes with a handout -- if you would like a copy, email request here:
Info@LadiesWhoBrand.com
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Pharynx and Clinical Correlations BY Dr.Rabia Inam Gandapore.pptx
Fast 1
1. Focused Assessment with
Sonography forTrauma
Nira Beck-Razi, MD*, Diana Gaitini, MD
The use of ultrasound (US) in trauma to detect
abdominal parenchymal injuries, specifically
traumatic splenic hematomas, was described by
Kristensen and colleagues1
back in 1971. In
1976, Asher and colleagues2
reported a sensitivity
of 80% for the detection of splenic injury from
blunt abdominal injuries. US for trauma evaluation
was then abandoned but resurfaced in 1990,
especially for blunt abdominal injuries.3
SONOGRAPHIC TECHNIQUE
The US examination in the emergency room
differs from the examination conducted in the US
suite. The emergency examination is brief
and highly focused, and typically seeks to answer
a single clinically relevant question: ‘‘Is there
a hemoperitoneum?’’
The protocol of the focused assessment with
sonography for trauma (FAST) examination in-
cludes evaluation of the right upper quadrant, the
left upper quadrant, and the pelvis for free fluid.
It is desirable that the bladder be filled, thus creat-
ing an acoustic window, needed to detect small
amounts of hemoperitoneum and to displace
bowel loops.4
The rest of the protocol may differ between insti-
tutions. McGahan and colleagues4
report that their
protocol includes scanning the right upper quad-
rant; the hepatorenal fossa, including the right
kidney, checking the liver for parenchymal anoma-
lies; the right flank; and the pelvis; and evaluation
of the epigastrium; the left upper quadrant; the
spleen; the left kidney; and the left flank. They in-
corporated a subxiphoid view, to check the heart
for pericardial fluid, and pleural views. These addi-
tions to the classic protocol are part of the
extended FAST.
The authors’ protocol includes scanning of the
right (Morison’s pouch) and left upper quadrants,
the right and left gutters, and the pelvis for the
evaluation of free fluid, in transverse and longitudi-
nal planes; a subxiphoid or transthoracic view of
the pericardium for the evaluation of hemopericar-
dium; and an evaluation of the pleurae for pneu-
mothorax (Figs. 1–4).
Although FAST was defined by international
consensus as ‘‘an examination to detect free intra
peritoneal fluid as a marker of injury’’,5
the role of
FAST has been extended to the diagnosis of
hemopericardium and, lately, to pneumothorax
(extended FAST). FAST is not expected to detect
injuries to abdominal organs, associated or not
with intraperitoneal fluid, such as hollow viscous
tear, mesenteric tear, intraparenchymal or sub-
capsular bleeding, and retroperitoneal injuries.6,7
Free fluid will usually appear anechogenic to
homogenously hypoechogenic, sometimes with
low-level echoes. At the site of an injured solid
organ, one may find echogenic blood forming
a subcapsular hematoma, which may be less
obvious than the hypoechoic free fluid.
Richards and colleagues8
evaluated the US
appearance of blunt liver injuries. Parenchymal
injuries were documented in only 12% of patients,
and three different patterns were observed. The
most common pattern was a discrete hyperecho-
genic area; other patterns included a diffuse
hyperechogenic pattern or a discrete hypoechoic
pattern (Fig. 5). An echogenic clot was often
Unit of Ultrasound, Department of Medical Imaging, Rambam Medical Center, Ha’aliya Hashniya 8, 31096,
POB 9602, Haifa, Israel
* Corresponding author.
E-mail address: n_beck_razi@rambam.health.gov.il (N. Beck-Razi).
KEYWORDS
Focused assessment with sonography for trauma
Multiple casualty incidents Diagnosis Triage
Ultrasonography
Ultrasound Clin 3 (2008) 23–31
doi:10.1016/j.cult.2007.12.009
1556-858X/08/$ – see front matter ª 2008 Elsevier Inc. All rights reserved.
ultrasound.theclinics.com
2. seen surrounding the liver. Of course, hypoecho-
genic fluid may be seen in other portions of the ab-
domen. The appearance of hepatic lacerations
changes with time, as is the case in other solid
organs. The laceration may be difficult to recog-
nize or may appear slightly echogenic. Hepatic
lacerations appear more hypoechoic or cystic
when scanned days after the initial injury.4
Ri-
chards and colleagues9
identified parenchymal in-
juries of the spleen in 31 of 162 patients. The most
common pattern was a diffuse heterogeneous ap-
pearance, a pattern that may be difficult to recog-
nize (Fig. 6).
McGahan and associates10
found that US
discovered only 8 injured kidneys from a total of
37. If a kidney was severely injured, the sono-
graphic appearance was that of a large, mixed,
anechogenic renal fossa with loss of normal renal
shape. Mild renal lacerations were difficult to
detect with US.
WHOSE TURF IS IT?
Accurate training and experience are crucial to
accurate US evaluation.
US is first and foremost an operator-dependent
examination; this fact should be especially empha-
sized when surgeons or emergency physicians with
Fig. 1. Components of the modified assessment with
sonography for trauma, including a subxiphoid view
to evaluate possible pericardial blood (1); a right
upper quadrant view to evaluate Morison’s pouch
(2); a right paracolic gutter view (3); a left upper
quadrant view to evaluate the splenorenal recess (4);
a left paracolic gutter view (5); a suprapubic view of
the pouch of Douglas/retrovesical pouch (6). (From
Yen K, Gorelick MH. Ultrasound applications for the
pediatric emergency department: a review of the
current literature. Pediatr Emerg Care 2002;18(3):
226–34; with permission.)
Fig. 2. A longitudinal view of the hepatorenal space
(Morrison’s pouch), illustrating free fluid (short
arrow). Perihepatic fluid (long arrow) is also shown,
as is an appreciable amount of pleural effusion (PE).
Fig. 3. A longitudinal view of the splenorenal space,
illustrating free fluid (short arrow). A diffuse heteroge-
neous area is shown (long arrow) at the lower pole of
the spleen, representing a parenchymal traumatic injury.
Fig. 4. A longitudinal view of the pelvis, illustrating
free fluid in the retrovesical space (arrow).
Beck-Razi Gaitini24
3. limited training perform the examination.11
The re-
ported sensitivities for FAST examination vary
among institutions and studies, and among studies
in which the examiners were either radiologists/so-
nographers or nonradiologists. This variability can
be attributed to the differences in methods and pa-
tient population. Some studies screen not only for
fluid but also for abdominal injuries, a fact that
lowers sensitivity (Table 1).
Brown and colleagues11
reported an 84% sensi-
tivity and a negative predictive value of 99%. The
FAST examinations were performed by a staff or
resident radiologist. In this study, it must be
emphasized that US findings were considered
Fig. 5. A transverse view of the right lobe of the liver,
showing a hypoechogenic round area, representing
a posttraumatic hematoma (arrow).
Fig. 6. A longitudinal view of the spleen, showing
a heterogeneous diffuse appearance of the spleen
parenchyma, representing a parenchymal traumatic
injury (arrow).
Table1
Sensitivityofthefocusedassessmentwithsonographyfortraumaexamination,indifferentstudies,comparingradiologistsandnonradiologists
SensitivityOperator
IncludingParenchymal
InjuriesPediatricPatientsOnlyStablePatientsOnly
Brownetal84%Radiologists1ÀÀ
Nuraletal86%Radiologists1ÀÀ
Soudacketal92%RadiologistsÀ1À
Brenchleyetal78%Emergencyphysicians
afterabrieftraining
period
ÀÀÀ
Brooksetal100%TrainednonradiologistsÀÀÀ
Milleretal42%AttendingtraumastaffÀÀ1
Focused Assessment with Sonography for Trauma 25
4. false-negative if a subsequent study revealed
either free fluid (hemoperitoneum) or any visceral
abdominal injury, also a fact lowering sensitivity.
Nural and colleagues12
reported a sensitivity of
86%. The examinations were performed by radiol-
ogy residents and, again, the sensitivity calculated
was that of intra-abdominal fluid or organ damage
in detecting intra-abdominal injury.
Soudack and colleagues13
reported a sensitivity
of 92% for a pediatric population; false-negative
results were considered to pertain to free fluid
alone, and not parenchymal injuries.
Brenchleyandcolleagues14
reportedasensitivity
of 78% for free fluid. In this study, emergency phy-
sicians performed the FAST after a brief training pe-
riod. Books and colleagues15
reported a sensitivity
of 100% for free fluid; the FAST examinations were
performed by trained nonradiologists. Miller and
colleagues16
evaluated 372 hemodynamically sta-
ble patients who had suspected blunt abdominal
injury. FAST examination had a sensitivity of 42%
for free fluid. The examination was performed by
attending trauma staff.
McGahan and colleagues17
suggested that
trauma sonography has a definite learning curve
and this examination should be performed only
by US technologists with more than 3 years of
experience, and interpreted only by radiologists
with more than 3 years of training in sonographic
techniques.
The American Institute of Ultrasound in Medicine
has recommended that at least 500 abdominal US
examinations be performed with supervision be-
fore physicians are allowed to perform sonography
independently.18
Smith and colleagues19
concluded that senior
surgical residents are capable of performing the
focused US examination for trauma with a high
level of skill after a concise introductory course.
A learning curve was not apparent in their study,
indicating that the criteria for being permitted to
perform trauma sonography that include the
requirement of a large number of examinations or
extensive proctoring should be reassessed. They
reported a sensitivity of 73% for detecting free
fluid, commenting that they believe that it appears
that many recommendations are influenced by
emotional ‘‘turf battles’’ and fear of lost practice
domain.
The authors believe that because one of sonog-
raphy’s main limitations is experience and
operator dependency, it cannot be ignored that
sonographers and radiologists are capable, in
principle, of achieving higher accuracies.
The authors’ radiology department is able to give
24-hour coverage of FAST examination in the
trauma room. They believe that 24-hour coverage
should be the case if a radiology department in
a specific institution can give such service.
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA IN THE ADULTAND PEDIATRIC
POPULATION
In the pediatric patient, physical examination is fre-
quently unreliable and imaging studies are
required.20
Because children differ from adults not
only in size but also in their physiologic response
to trauma,theeffectiveness of FAST in children can-
not be extrapolated from studies in adults.13
The management of solid visceral abdominal
injuries in children differs from that of adults. In
children, parenchymal injury generally does not
require surgery. Surgical treatment of hepatic in-
juries in children is associated with high morbidity
and mortality. Splenectomy is associated with
sepsis and thus, a high risk of fatality.13
According
to Taylor and Sivit,21
abdominal injury was not
associated with free peritoneal fluid in 37% of
children, compared with 22% in the adult popula-
tion.22
Furthermore, sonography is repeatable;
thus, serial follow-up scans can be performed in
cases of conservative management or when
a case is not conclusive.
Several reports on the usefulness of FAST in
children have been published, with conflicting
results.23–25
In the literature, reported sensitivity
ranges from 33%,24
to 81%,26
to 97%.13
Soudack
and colleagues’13
results showed a sensitivity of
92.5% and a specificity of 97.2%, thus concluding
that FAST can be used in pediatric patients as an
effective screening tool adjunct to the clinical
evaluation. In contrast to this study, Richards
and colleagues27
showed a sensitivity of 56% for
the detection of abdominal injuries (hemoperito-
neum and solid organ injury) in pediatric blunt
abdominal trauma.
In contrast to sonography, CT involves ionizing
radiation, which is potentially harmful, especially
to pediatric patients. Sonography produces no
ionizing radiation, is quick and relatively inexpen-
sive, and thus is appropriate as a screening test.
Sonography is a valuable tool as an adjunct to
physical examination in cases of pediatric blunt
abdominal trauma.13
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA IN BLUNTAND PENETRATING
TRAUMA
FAST is rapidly establishing its place in the evalu-
ation of blunt abdominal trauma. However, few
articles have been published concerning its role
in penetrating abdominal trauma. Udobi and
colleagues28
concluded in their study that FAST
Beck-Razi Gaitini26
5. can be a useful initial diagnostic study after
penetrating abdominal trauma; furthermore, they
concluded that a positive FAST is a strong predic-
tor of injury, and these patients should proceed
directly to laparotomy. If negative, additional
diagnostic studies should be performed to rule
out occult injury, because their results showed
a low sensitivity of 46%.
Rapid diagnosis and treatment of abdominal
injury is an important factor in decreasing mortality
in patients who have blunt abdominal trauma.
Physical examination is frequently unreliable in
the setting of acute trauma.29
Diagnostic peritoneal lavage has been used
successfully to aid in the diagnosis of
abdominal injury and to determine the need for
laparotomy.30
When CT emerged in clinical practice, it allowed
a more accurate decision-making process and
a better triage of these patients.31,32
Today, US
is used in many centers of the world in the evalua-
tion of blunt abdominal trauma.33–35
Most studies in the literature report a high sensi-
tivity and a high negative predictive value for FAST
in blunt abdominal injury, thus making the exami-
nation an excellent screening test.
Lingawi and colleagues reported a sensitivity of
94%, and a 100% negative predictive value in
blunt abdominal injuries.6
Rothlin and associates 36
reviewed the European literature about US of
blunt abdominal trauma and cited reports of sensi-
tivities of 85% to 100% and specificities of 98% to
100%. Their study showed an overall sensitivity
and specificity of the US examination of 90%
and 99.5%, respectively.
Brown and colleagues11
reported a slightly
lower sensitivity of 84%, probably because they
screened patients for abdominal injury and not
for free fluid alone. US in the emergency room is
not expected to detect abdominal injuries not
associated with free fluid, such as hollow viscous
injuries or parenchymal injuries.
McGahan and colleagues17
reported a low sen-
sitivity of 63% of US in detecting free fluid, in com-
parison to CT, diagnostic peritoneal lavage and
surgery. They explained their results by the fact
that the bladder was not filled during the examina-
tion and small amounts of fluid in the pelvis were
undetected.
The authors believe that FAST plays an impor-
tant part in the evaluation of all trauma injuries,
whether blunt or penetrating, and should be
performed on all of them during the resuscitation
phase. US is fast and noninvasive, does not in-
volve radiation, is portable, and can be integrated
into the resuscitation process in the trauma bay
without disrupting it.
A negative FAST should be received with
caution, especially in penetrating abdominal injury,
because in such injuries it takes time to develop
appreciable hemoperitoneum that can be de-
tected by US.
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA IN STABLE AND UNSTABLE
PATIENTS
In a setting of a blunt abdominal trauma, determin-
ing which patients should be triaged to laparotomy
is important, even more so when these patients
are unstable; rapid and accurate triage is crucial
because delayed treatment is associated with
increased morbidity and mortality.37
In such a set-
ting, clinical history, laboratory test, and a physical
examination are often not reliable in the evaluation
of the patient.38
Brett and colleagues34
evaluated the usefulness
of FAST performed by experienced sonographers
in a setting of a blunt abdominal trauma, compar-
ing hypotensive and normotensive patients. They
found a statistically significant difference between
hypotensive and normotensive patients with small
amounts of free fluid, which reflects the greater
significance of small amounts of fluid in hypoten-
sive patients and the higher associated therapeu-
tic laparotomy rate. They concluded that FAST is
an effective screening tool when performed by ex-
perienced sonographers. In hypotensive patients,
in whom a moderate to large amount of fluid is
found, immediate triage to laparotomy, obviating
CT, is warranted.
Miller and colleagues16
evaluated 372 hemody-
namically stable patients who had suspected blunt
abdominal injury. FAST examination had a sensitiv-
ity of 42% and a negative predictive value of 98%.
They concluded that the use of FAST examination
in hemodynamically stable trauma patients results
in underdiagnosis of intra-abdominal injury.
Thus, FAST evaluation of stable patients who
have suspected abdominal injury is perhaps less
accurate than for unstable patients, but still has
an important role in the triage of all trauma patients.
FOCUSED ASSESSMENT WITH SONOGRAPHY
FOR TRAUMA AS ATRIAGE TOOL
IN MULTIPLE-CASUALTY INCIDENTS
In war zones and regions of political conflict, civil-
ians and military personnel are exposed to serious
injuries due to explosives and firearms. Injuries
may be blunt or penetrating, often combined in
a single patient.39–41
Effective initial triage, defined as the art of sort-
ing patients according to the severity of their injury,
Focused Assessment with Sonography for Trauma 27
6. is the key to dealing successfully with a multiple-
casualty incident.
To proceed to further triage and patient manage-
ment, a quick and efficient imaging diagnosing test
is needed. FAST can be performed rapidly in the ad-
mission area and is repeatable, noninvasive, nonir-
radiating, and inexpensive. It is widely accepted as
an effective initial tool to evaluate trauma victims
with suspected blunt abdominal injuries.42
FAST may play an important role in the work-up of
trauma patients in a multiple-casualty incident be-
cause ofthecomplexityofthe injuries. Some contro-
versies remain concerning the role of FAST in
penetrating trauma.28
Although the role of FAST in
an individual trauma casualty has been reviewed
in the literature, few studies have described the
role of FAST in multiple-casualty incidents.
Miletic and colleagues43
described US screen-
ing of mass war casualties as an efficient and
effective means for detection and on-site triage
of abdominal injuries that were mostly penetrating
(90%), with a similar sensitivity and specificity in
war and civil conditions.
Sarkisian and colleagues44
described a suc-
cessful application of US after a catastrophic
earthquake in Armenia, which involved mostly
crush injuries.
In war conflict and in terror-related injuries, pa-
tients comprise a heterogeneous group of blunt
and penetrating injuries, hemodynamically stable
and unstable patients, adults and children. The
level of care for each casualty in a multiple-casual-
ty incident is less than that provided under regular
circumstances. Attention is given to the moder-
ately to severely injured, because these will benefit
the most from optimal care.
In a study the authors conducted on 102
soldiers and civilians during the second Lebanon
war, they reported a sensitivity of 75% for hemo-
peritoneum detection. Injuries encountered were
blunt and penetrating combined. Their results
show that FAST, as the first imaging examination
during continuous arrival phase in a setting of
a war conflict–related multiple-casualty incident,
enabled immediate triage of casualties to
laparotomy, CT, or clinical observation.
Because of its moderate sensitivity and limita-
tion in diagnosing solid organs or hollow viscous
injury, a negative FAST in the presence of a strong
clinical suspicion must be followed by CT or
laparotomy, according to clinical judgment.45
ROLE OF FOCUSED ASSESSMENT WITH
SONOGRAPHY FOR TRAUMA IN FOLLOW-UP
One of US’s main advantages is the fact that no
ionizing radiation is involved; thus, the examination
can be repeated when needed. Blackbourne and
colleagues46
aimed to evaluate whether delayed,
repeat US study can reveal additional intra-
abdominal injuries and hemoperitoneum. They
found that secondary US of the abdomen signifi-
cantly increases the sensitivity of US to detecting
intra-abdominal injury. The sensitivity of US to
detecting intraperitoneal injury is directly related
to the fact that US relies on the existence of free
intraperitoneal blood and does not routinely in-
clude parenchymal imaging. Studies have shown
that the sensitivity to detecting intraperitoneal fluid
is relatively proportional to the amount of fluid in
the peritoneal cavity, especially for inexperienced
US operators.47,48
The limited intraperitoneal
blood on admission, combined with the necessity
for a significant amount of intraperitoneal blood
(200 mL) for most surgical US operators to be
able to detect hemoperitoneum, may limit the
sensitivity of US in stable blunt trauma patients.49
A secondary abdominal US may allow for the
duration necessary to accumulate the prerequisite
amount of blood for detection by most surgical US
operators. Although FAST has shown lower sensi-
tivity for penetrating trauma,28
a secondary US in
cases of such injuries may give better results for
the same reason. In the case of a multiple-casualty
incident, when resources are overwhelmed, par-
ticularly CT, a secondary US can be helpful,
especially when an initially stable patient who
was left on clinical observation is deteriorating
and CT is not yet available.
A secondary US can be beneficial in cases of
a known trauma to parenchymal organs, in most
cases initially diagnosed by CT. The secondary
US can evaluate the parenchymal injuries and
the amount of free fluid over time. The pediatric
population is more sensitive to ionizing radiation
damage and CT should be limited; a follow-up
US examination is most useful. In addition, treat-
ment of such injuries takes a more conservative
approach in children than in adults.
PITFALLS AND LIMITATIONS
US is first and foremost an operator-dependent
examination; thus, experience plays an important
role and sensitivity drops with little experience.
US showed a low sensitivity of 44% in detecting
free fluid associated with bowel or mesenteric
injury,50
US has a low sensitivity for parenchymal
injuries, injuries to the diaphragm and the pan-
creas, and vascular injuries. These specific limita-
tions must be kept in mind when one performs the
FAST examination, so that the only question that
can be answered with high accuracy is the
presence or absence of free fluid.
Beck-Razi Gaitini28
7. Without a full bladder, free fluid may be missed,
because a full bladder creates an acoustic window
that helps detect small amounts of fluid in the
pelvis and displaces bowel loops.17
On the other
hand, false-positive results can be due to physio-
logic pelvic fluid in female patients of reproductive
ages. The mechanism of fluid accumulation is
unclear and is probably multifactorial.51–53
With
transabdominal imaging, physiologic fluid has
been described during all stages of the menstrual
cycle in up to 30% to 40% of healthy volunteers.53
In the obstetric literature, numerous investigators
have quantified the volume of fluid found surgically
in the cul-de-sac and have estimated the upper
limit of physiologic fluid to be about 45 mL.
Although these investigators described the fluid
as ranging from clear to blood tinged, physiologic
fluid is generally anechoic on sonographic imag-
ing. When fluid in the cul-de-sac contains internal
echoes, it is unlikely to be physiologic. And in a pa-
tient with trauma, this fluid likely represents hemo-
peritoneum.54
Because the cul-de-sac is the most
dependent recess in the peritoneum in both supine
and upright positions, pathologic fluid tends to
collect within it.55
Sirlin and colleagues54
reported in their study
that fluid in the cul-de-sac was never the sole
manifestation of a solid organ or enteric injury.
They concluded that in a female patient of repro-
ductive age with blunt abdominal trauma, small
amounts of anechoic fluid isolated to the cul-de-
sac or adjacent pelvic recesses should be consid-
ered physiologic, and further evaluation is not
needed in the absence of other radiologic or
clinical findings.
They emphasized that if the fluid measures at
least 3 cm in depth, has internal echoes, and
extends into the supravesical space or anterior to
the bladder, or if the patient is past her reproduc-
tive years or her reproductive status is unknown,
fluid is regarded with suspicion. US is an opera-
tor-dependent examination, which is a limitation
of the examination in itself. Thus, when the exam-
ination is performed by a resident with less experi-
ence, under the stressful environment of a trauma
room, his or her tendency is to overcall the findings
when in doubt. A similar dilemma occurs when
small amounts of fluid are found in the pelvis in
children. Rathaus and colleagues56
aimed to eval-
uate the significance of the US finding of pelvis
fluid after blunt abdominal trauma in children as
a predictor of an abdominal injury. They concluded
that a normal US examination or the presence of
pelvic fluid is associated with a low probability of
an organ injury, but the presence of peritoneal fluid
outside the pelvis indicates that the probability of
an organ injury is high. Despite this conclusion,
the residence tendency is again to overcall. Last
but not least, the medical history of a trauma
patient arriving in the trauma room is not known;
thus, if the patient has ascites for any number of
reasons, the examination will be positive. In addi-
tion, even if the patient’s condition is known, one
cannot be sure if there is hemoperitoneum on
top of the known ascites.
SUMMARY
The US examination in the trauma room is brief
and focused and should answer a single relevant
question: ‘‘Is there a hemoperitoneum?’’ The pres-
ence of hemopericardium is evaluated also, as is
the presence of pneumothorax.
The answer to this question enables the attend-
ing staff to perform better triage, whether dealing
with an individual trauma patient or in the case
of a multiple-casualty incident, thus improving
patient prognosis.
Because no ionizing radiation is involved, FAST
can be performed consecutively and can spare the
patient from CT, an important fact to remember,
especially when dealing with pediatric trauma
patients.
In the authors’ institution, it is acceptable that
the FAST examination be performed on all trauma
patients, keeping in mind the examination’s limita-
tions, including its lower sensitivity in cases of
penetrating trauma and stable patients.
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Focused Assessment with Sonography for Trauma 31