The document summarizes key landmark breast cancer trials that helped establish modern standards of care. The NSABP B-04 trial showed that modified radical mastectomy was as effective as radical mastectomy. The NSABP B-06 and Milan trials established breast-conserving surgery plus radiation as an equivalent alternative to mastectomy. The NSABP B-32 trial demonstrated sentinel node biopsy alone had similar outcomes as axillary dissection for node-negative cancer. Subsequent trials like ALMANAC and Z011 found sentinel node biopsy reduced arm morbidity without compromising survival. These trials provided critical evidence supporting less invasive surgical approaches for breast cancer.
This document provides an overview of carcinoma of the esophagus, including epidemiology, etiology, classification, diagnosis, staging, and management. It discusses the different types of esophageal cancer, risk factors, pre-malignant conditions, patterns of spread, diagnostic tools such as endoscopy and imaging, and the AJCC staging system. Treatment options are covered for early stage disease including endoscopic resection and ablation methods, as well as surgical approaches for localized and advanced disease, including transhiatal esophagectomy, Ivor-Lewis esophagectomy, and McKeown esophagectomy. Post-operative complications are also reviewed.
Laparoscopic gastrectomy is being compared to open gastrectomy for gastric cancer treatment. Several studies show that laparoscopic and open approaches have comparable short-term surgical outcomes in terms of complication rates. Regarding long-term oncologic outcomes, multiple studies found no differences in the number of retrieved lymph nodes or disease-free and overall survival rates between the two approaches. While the laparoscopic approach has a learning curve of around 20 cases, it provides better post-operative quality of life measures like less pain and earlier return of bowel function.
This randomized controlled trial compared neoadjuvant chemoradiotherapy plus surgery to surgery alone in 368 patients with resectable esophageal or junctional cancer. Patients receiving neoadjuvant treatment had significantly improved overall survival (48.6 vs 24 months) and progression-free survival (37.7 vs 16.2 months). R0 resection rates were also higher in the neoadjuvant group (92% vs 69%). The trial demonstrated that preoperative chemoradiotherapy improves long-term outcomes for esophageal cancer patients.
Role of radiation in carcinoma rectum and colon Bharti Devnani
1. Radiation therapy has been shown to decrease rates of local recurrence in rectal cancer when used preoperatively or postoperatively.
2. Studies have demonstrated benefits of preoperative chemoradiation over postoperative chemoradiation, including lower rates of local recurrence, reduced toxicity, and increased rates of sphincter preservation.
3. Techniques such as prone positioning, abdominal compression, and bladder filling can help displace small bowel out of the radiation field and decrease toxicity.
This document discusses carcinoma of the esophagus. It covers the embryology, anatomy, epidemiology and risk factors. It describes Barrett's esophagus and the hereditary cancer predisposition syndromes associated with esophageal cancer. The clinical features, diagnosis, staging and tumor markers are outlined. The principles of endoscopic staging and therapy are discussed. The management of esophageal cancer including surgery, chemotherapy and radiation are reviewed. Specific surgical approaches like Ivor Lewis and transhiatal are described. Principles of postoperative surveillance are also mentioned.
- Recurrent retroperitoneal sarcoma is common, occurring in 50% of patients within 5 years of primary resection. Late recurrences beyond 5 years are also possible, requiring long-term follow-up.
- Patterns of recurrence vary depending on histological subtype. Well-differentiated liposarcoma often recurs locally, which can sometimes be managed with additional surgery. Leiomyosarcoma commonly spreads to distant sites, with 50% of patients experiencing metastases.
- Complete surgical resection remains the main treatment for recurrent retroperitoneal sarcoma when possible. Management decisions must consider the likelihood and implications of local versus distant failure based on histological factors.
1) The document discusses various treatment options for esophageal cancer including surgery, radiation therapy, and chemotherapy.
2) Key trials evaluated preoperative chemoradiation, which resulted in improved overall survival rates compared to surgery alone. The CROSS trial showed a 5-year survival rate of 47% with preoperative chemoradiation versus 34% with surgery alone.
3) For locally advanced disease, concurrent chemoradiation is the standard treatment approach based on trials showing improved outcomes compared to radiation alone. The optimal radiation dose when combined with chemotherapy is 50-50.4 Gy.
The document summarizes key landmark breast cancer trials that helped establish modern standards of care. The NSABP B-04 trial showed that modified radical mastectomy was as effective as radical mastectomy. The NSABP B-06 and Milan trials established breast-conserving surgery plus radiation as an equivalent alternative to mastectomy. The NSABP B-32 trial demonstrated sentinel node biopsy alone had similar outcomes as axillary dissection for node-negative cancer. Subsequent trials like ALMANAC and Z011 found sentinel node biopsy reduced arm morbidity without compromising survival. These trials provided critical evidence supporting less invasive surgical approaches for breast cancer.
This document provides an overview of carcinoma of the esophagus, including epidemiology, etiology, classification, diagnosis, staging, and management. It discusses the different types of esophageal cancer, risk factors, pre-malignant conditions, patterns of spread, diagnostic tools such as endoscopy and imaging, and the AJCC staging system. Treatment options are covered for early stage disease including endoscopic resection and ablation methods, as well as surgical approaches for localized and advanced disease, including transhiatal esophagectomy, Ivor-Lewis esophagectomy, and McKeown esophagectomy. Post-operative complications are also reviewed.
Laparoscopic gastrectomy is being compared to open gastrectomy for gastric cancer treatment. Several studies show that laparoscopic and open approaches have comparable short-term surgical outcomes in terms of complication rates. Regarding long-term oncologic outcomes, multiple studies found no differences in the number of retrieved lymph nodes or disease-free and overall survival rates between the two approaches. While the laparoscopic approach has a learning curve of around 20 cases, it provides better post-operative quality of life measures like less pain and earlier return of bowel function.
This randomized controlled trial compared neoadjuvant chemoradiotherapy plus surgery to surgery alone in 368 patients with resectable esophageal or junctional cancer. Patients receiving neoadjuvant treatment had significantly improved overall survival (48.6 vs 24 months) and progression-free survival (37.7 vs 16.2 months). R0 resection rates were also higher in the neoadjuvant group (92% vs 69%). The trial demonstrated that preoperative chemoradiotherapy improves long-term outcomes for esophageal cancer patients.
Role of radiation in carcinoma rectum and colon Bharti Devnani
1. Radiation therapy has been shown to decrease rates of local recurrence in rectal cancer when used preoperatively or postoperatively.
2. Studies have demonstrated benefits of preoperative chemoradiation over postoperative chemoradiation, including lower rates of local recurrence, reduced toxicity, and increased rates of sphincter preservation.
3. Techniques such as prone positioning, abdominal compression, and bladder filling can help displace small bowel out of the radiation field and decrease toxicity.
This document discusses carcinoma of the esophagus. It covers the embryology, anatomy, epidemiology and risk factors. It describes Barrett's esophagus and the hereditary cancer predisposition syndromes associated with esophageal cancer. The clinical features, diagnosis, staging and tumor markers are outlined. The principles of endoscopic staging and therapy are discussed. The management of esophageal cancer including surgery, chemotherapy and radiation are reviewed. Specific surgical approaches like Ivor Lewis and transhiatal are described. Principles of postoperative surveillance are also mentioned.
- Recurrent retroperitoneal sarcoma is common, occurring in 50% of patients within 5 years of primary resection. Late recurrences beyond 5 years are also possible, requiring long-term follow-up.
- Patterns of recurrence vary depending on histological subtype. Well-differentiated liposarcoma often recurs locally, which can sometimes be managed with additional surgery. Leiomyosarcoma commonly spreads to distant sites, with 50% of patients experiencing metastases.
- Complete surgical resection remains the main treatment for recurrent retroperitoneal sarcoma when possible. Management decisions must consider the likelihood and implications of local versus distant failure based on histological factors.
1) The document discusses various treatment options for esophageal cancer including surgery, radiation therapy, and chemotherapy.
2) Key trials evaluated preoperative chemoradiation, which resulted in improved overall survival rates compared to surgery alone. The CROSS trial showed a 5-year survival rate of 47% with preoperative chemoradiation versus 34% with surgery alone.
3) For locally advanced disease, concurrent chemoradiation is the standard treatment approach based on trials showing improved outcomes compared to radiation alone. The optimal radiation dose when combined with chemotherapy is 50-50.4 Gy.
This document summarizes findings from a study examining the oncologic safety of nipple-sparing mastectomy (NSM) in patients with a tumor-to-nipple distance (TND) of less than 1 cm. The study retrospectively analyzed 1,369 patients who underwent NSM at a medical center in Seoul, Korea between 2003-2015. The primary endpoint was locoregional recurrence and secondary endpoints included recurrence-free and disease-free survival rates. The study found that a short TND of less than 1 cm did not compromise long-term oncologic safety as long as the nipple-areolar complex was clinically and radiologically negative and retroareolar margins were clear of tumor cells
Gastric cancer discussion slides final version.pptnew.pptzoezettemarc
1) Peri-operative chemotherapy with ECX before and after surgery improves overall survival compared to surgery alone in resectable gastric cancer based on the MAGIC trial.
2) The ACTS-GT trial showed adjuvant S-1 chemotherapy improves 3-year survival compared to observation alone after D2 gastrectomy for stage II-III gastric cancer.
3) Combination chemotherapy improves survival over best supportive care alone in advanced gastric cancer, with regimens including anthracyclines and cisplatin or oxaliplatin showing better efficacy.
Endoscopic submucosal dissection of gastric neoplastic12Taisir Shahriar
1) A systematic review was conducted of studies reporting on ESD of gastric neoplastic lesions in patients with liver cirrhosis. The review identified 68 ESD procedures in 61 cirrhotic patients reported in 3 studies.
2) En bloc resection was successful in 88.2% of cases and complete (R0) resection in 89.7% of cases. Post-procedure bleeding occurred in 13.1% of patients and was managed endoscopically.
3) Patients with more advanced cirrhosis (Child-Pugh class B/C) had a higher risk of bleeding compared to those with less severe disease (Child-Pugh class A). No procedure-related deaths occurred.
This study compared total neoadjuvant therapy (TNT), consisting of a minimum of 4 months of chemotherapy followed by chemoradiation, to shorter course neoadjuvant therapy (SNT) for resectable and borderline resectable pancreatic cancer. The study found that patients receiving TNT were more likely to complete at least 5 months of nonsurgical therapy without negatively impacting surgery completion rates. TNT patients did not reach median overall survival while SNT patients had a median OS of 25.1 months. Receiving at least 5 months of nonsurgical therapy decreased the risk of death by 40% compared to those receiving less therapy.
This document discusses treatment options for cancer of the esophagus. It covers staging, endoscopic resection options for early stage cancers, preoperative chemoradiation followed by surgery as standard treatment for locally advanced cancers, and types of surgery and postoperative care. Chemotherapy regimens including cisplatin and fluorouracil provide response rates of 20-30% for metastatic cancers. Overall, the document provides an overview of current guidelines and evidence for endoscopic, surgical, radiation, and chemotherapy approaches to esophageal cancer treatment based on tumor stage.
Lung cancer is the leading cause of cancer mortality worldwide. Smoking is the most common risk factor, responsible for 90% of lung cancer cases. The document discusses the classification, staging, symptoms, investigations, and treatment of lung cancer. Lung cancers are classified as small cell lung cancer and non-small cell lung cancer. Physiotherapy can play an important role in lung cancer management by improving pulmonary function and physical activity levels before, during, and after treatment through exercises and pulmonary rehabilitation.
Low Ligation of Inferior Mesenteric Artery in Laparoscopic Anterior Resection...King Hussien Cancer Center
This randomized controlled trial compared low ligation versus high ligation of the inferior mesenteric artery during laparoscopic anterior resection for rectal cancer. The primary outcome was genitourinary dysfunction assessed through validated questionnaires and uroflowmetry at 1 and 9 months postoperatively. Results showed that both techniques resulted in impaired genitourinary function, though low ligation led to less worsening of symptoms over time. There were no significant differences in secondary outcomes like complications or oncological adequacy between the groups. In summary, low ligation of the inferior mesenteric artery better preserved genitourinary function after surgery without compromising other outcomes.
This study compared clinical examination to examination under anesthesia (EUA) for staging locally advanced cervical cancer in 62 patients. There was significant variation between the two methods. Upstaging occurred in 14 patients and downstaging in 12 patients after EUA. Staging changed in 26 patients overall. Parametrial assessment showed the highest discordance. EUA is recommended for staging, especially for parametrial assessment, as it reduces bias and variability compared to clinical examination alone. The authors conclude that EUA or other objective staging methods should be considered mandatory for accurate staging of locally advanced cervical cancer in India given its high prevalence.
The document discusses adjuvant radiation therapy for gallbladder carcinoma based on available literature. It summarizes several retrospective studies that found improved survival outcomes with adjuvant radiation or chemoradiation after surgical resection compared to surgery alone, especially for node-positive or advanced-stage disease. However, it notes the evidence is limited due to the rarity of the disease and lack of large randomized controlled trials. While adjuvant therapy appears logical, more research is still needed to better define its role and optimal use.
This document summarizes the management of carcinoma of the oesophagus. It discusses the AJCC TNM classification and staging for squamous cell carcinoma and adenocarcinoma. It also describes surgical options like esophagectomy and conservative procedures. Non-surgical treatments including chemotherapy regimens, radiotherapy alone or with chemotherapy are mentioned. Several studies evaluating the role of neoadjuvant chemoradiotherapy and chemotherapy prior to surgery are summarized. Meta-analyses demonstrating improved survival with neoadjuvant therapy are also highlighted.
- Microinvasive breast cancer (MIBC) has a low but measurable risk of lymph node metastasis. Several studies found positive lymph nodes in 3.7-7.5% of MIBC patients who underwent sentinel lymph node biopsy (SLNB).
- Factors like lymphatic invasion and positive estrogen receptor status predict higher risk of lymph node metastases in MIBC. However, routine SLNB is not warranted for all MIBC patients. Careful selection based on risk factors is needed to avoid overtreatment.
- Studies of patients with DCIS found lymph node micrometastases in 21-34% of those undergoing SLNB for high-risk features like palpable mass or suspicious imaging. However, the clinical significance
The document discusses pancreatic ductal adenocarcinoma (PDA) and different treatment approaches. It summarizes several key trials evaluating neoadjuvant therapy, adjuvant therapy, and chemotherapy for resectable, borderline resectable, locally advanced, and metastatic PDA. The take home message is that more randomized controlled trials are needed to determine the optimal treatment approach for different PDA stages, but neoadjuvant therapy appears beneficial for locally advanced and borderline resectable disease, while gemcitabine + nab-paclitaxel or FOLFIRINOX chemotherapy provide good outcomes for metastatic PDA.
Esophageal cancer is often diagnosed when a person experiences difficulty swallowing. A physician will typically perform an endoscopy to examine the esophagus. Common treatments include chemotherapy, radiation, and surgery, but survival rates are modest at 5-20% after 5 years even with surgery. A study of 304 patients receiving chemotherapy and radiation before possible surgery found a 25.7% complete response rate and 45.9% partial response rate. For patients who underwent surgery after responding to treatment, the 5-year survival rate was 40% compared to 25% for non-surgical patients. The authors conclude that aggressive pre-operative chemoradiation may improve outcomes but also increase toxicity, and recommend intensifying post-operative treatment instead.
This document discusses treatment options for gastric cancer, including surgery, chemotherapy, and radiation therapy. It covers various lymph node dissection classifications (D0-D2) and their roles in different stages of disease. Adjuvant therapies like chemotherapy and chemoradiation are recommended after surgery to improve survival outcomes. Perioperative and postoperative chemotherapy are supported by clinical trials to be beneficial in resectable gastric cancer.
This document provides an overview of carcinoma of the esophagus. It discusses the epidemiology, etiology, pathological classification, clinical features, staging, diagnosis and management of esophageal cancer. Esophageal cancer is the 8th most common cancer worldwide and has a poor 5-year survival rate of less than 18%. Risk factors and types of esophageal cancer vary globally. The document outlines the various diagnostic tests and staging systems used to evaluate esophageal cancer as well as endoscopic, surgical and non-surgical treatment options.
COMPOSITE GRAFT: ANTROPYLORUS TRANSPOSITION AND GLUTEUS MAXIMUS WRAPDr Amit Dangi
THIS PRESENTATION DESCRIBES THE NOVEL SURGICAL TECHNIQUE OF TOTAL ANORECTAL RECONSTRUCTION WITH ANTROPYLORUS TRANSPOSITION AND GLUTEOPLASTY AND ITS RESULTS.
The document discusses the anatomy and clinical presentation of colorectal cancer. It notes that 80% of patients present electively with symptoms like altered bowel habits, bleeding, abdominal pain, or anemia. Physical examination often finds a rectal or abdominal mass. Diagnosis relies on colonoscopy and barium enema imaging. Treatment involves surgical resection with chemotherapy and radiation also playing a role depending on cancer stage. Early detection improves prognosis but 55% of patients still present with late stage or metastatic disease.
This document presents a case report of a 42-year-old male patient with an atypical choroid plexus papilloma located in the foramen magnum. The patient presented with dizziness, hearing loss, and gait disturbance. Imaging showed a large mass in the foramen magnum that was partially removed via suboccipital craniotomy. Histological examination found the tumor to be a grade II atypical choroid plexus papilloma. The patient developed post-operative meningitis but otherwise recovered well. The report reviews other cases of atypical choroid plexus papillomas in the posterior fossa and discusses treatment approaches.
This document discusses the management of gastric cancer. It outlines the treatment approaches for localized (stage I-III) and metastatic (stage IV) disease. For localized disease, options include endoscopic mucosal resection, limited surgical resection, or gastrectomy depending on the stage, followed by lymph node dissection and adjuvant chemoradiation or chemotherapy. For metastatic disease, chemotherapy is the standard treatment approach. The document provides details on surgical procedures, lymph node dissection approaches, radiotherapy techniques, and the role of perioperative and adjuvant chemotherapy based on clinical trials.
Early esophageal cancer refers to Tis, T1a, and T1b lesions. The main treatment options are esophagectomy and endoscopic resection. Esophagectomy provides accurate staging but higher morbidity and mortality, while endoscopic resection has lower risk but requires close surveillance. The choice depends on risk factors for lymph node metastasis like depth of invasion, lymphovascular invasion, and tumor size. Minimally invasive esophagectomy techniques aim to reduce complications while achieving equivalent oncologic outcomes.
This document summarizes the treatment of anal canal cancer. It discusses:
1. The treatment has evolved from radical surgery (abdominoperineal resection) to nonsurgical chemoradiotherapy using 5-fluorouracil and mitomycin C, allowing for organ preservation in most patients.
2. Definitive chemoradiotherapy is now the standard of care, using a dose of 50.4 Gy radiation with concurrent 5-fluorouracil and mitomycin C. This approach provides high rates of pathologic complete response and survival compared to radiation alone.
3. Ongoing research is exploring modifying the chemoradiotherapy regimen by replacing mitomycin C with cisplatin, 5-fluoroura
This document summarizes findings from a study examining the oncologic safety of nipple-sparing mastectomy (NSM) in patients with a tumor-to-nipple distance (TND) of less than 1 cm. The study retrospectively analyzed 1,369 patients who underwent NSM at a medical center in Seoul, Korea between 2003-2015. The primary endpoint was locoregional recurrence and secondary endpoints included recurrence-free and disease-free survival rates. The study found that a short TND of less than 1 cm did not compromise long-term oncologic safety as long as the nipple-areolar complex was clinically and radiologically negative and retroareolar margins were clear of tumor cells
Gastric cancer discussion slides final version.pptnew.pptzoezettemarc
1) Peri-operative chemotherapy with ECX before and after surgery improves overall survival compared to surgery alone in resectable gastric cancer based on the MAGIC trial.
2) The ACTS-GT trial showed adjuvant S-1 chemotherapy improves 3-year survival compared to observation alone after D2 gastrectomy for stage II-III gastric cancer.
3) Combination chemotherapy improves survival over best supportive care alone in advanced gastric cancer, with regimens including anthracyclines and cisplatin or oxaliplatin showing better efficacy.
Endoscopic submucosal dissection of gastric neoplastic12Taisir Shahriar
1) A systematic review was conducted of studies reporting on ESD of gastric neoplastic lesions in patients with liver cirrhosis. The review identified 68 ESD procedures in 61 cirrhotic patients reported in 3 studies.
2) En bloc resection was successful in 88.2% of cases and complete (R0) resection in 89.7% of cases. Post-procedure bleeding occurred in 13.1% of patients and was managed endoscopically.
3) Patients with more advanced cirrhosis (Child-Pugh class B/C) had a higher risk of bleeding compared to those with less severe disease (Child-Pugh class A). No procedure-related deaths occurred.
This study compared total neoadjuvant therapy (TNT), consisting of a minimum of 4 months of chemotherapy followed by chemoradiation, to shorter course neoadjuvant therapy (SNT) for resectable and borderline resectable pancreatic cancer. The study found that patients receiving TNT were more likely to complete at least 5 months of nonsurgical therapy without negatively impacting surgery completion rates. TNT patients did not reach median overall survival while SNT patients had a median OS of 25.1 months. Receiving at least 5 months of nonsurgical therapy decreased the risk of death by 40% compared to those receiving less therapy.
This document discusses treatment options for cancer of the esophagus. It covers staging, endoscopic resection options for early stage cancers, preoperative chemoradiation followed by surgery as standard treatment for locally advanced cancers, and types of surgery and postoperative care. Chemotherapy regimens including cisplatin and fluorouracil provide response rates of 20-30% for metastatic cancers. Overall, the document provides an overview of current guidelines and evidence for endoscopic, surgical, radiation, and chemotherapy approaches to esophageal cancer treatment based on tumor stage.
Lung cancer is the leading cause of cancer mortality worldwide. Smoking is the most common risk factor, responsible for 90% of lung cancer cases. The document discusses the classification, staging, symptoms, investigations, and treatment of lung cancer. Lung cancers are classified as small cell lung cancer and non-small cell lung cancer. Physiotherapy can play an important role in lung cancer management by improving pulmonary function and physical activity levels before, during, and after treatment through exercises and pulmonary rehabilitation.
Low Ligation of Inferior Mesenteric Artery in Laparoscopic Anterior Resection...King Hussien Cancer Center
This randomized controlled trial compared low ligation versus high ligation of the inferior mesenteric artery during laparoscopic anterior resection for rectal cancer. The primary outcome was genitourinary dysfunction assessed through validated questionnaires and uroflowmetry at 1 and 9 months postoperatively. Results showed that both techniques resulted in impaired genitourinary function, though low ligation led to less worsening of symptoms over time. There were no significant differences in secondary outcomes like complications or oncological adequacy between the groups. In summary, low ligation of the inferior mesenteric artery better preserved genitourinary function after surgery without compromising other outcomes.
This study compared clinical examination to examination under anesthesia (EUA) for staging locally advanced cervical cancer in 62 patients. There was significant variation between the two methods. Upstaging occurred in 14 patients and downstaging in 12 patients after EUA. Staging changed in 26 patients overall. Parametrial assessment showed the highest discordance. EUA is recommended for staging, especially for parametrial assessment, as it reduces bias and variability compared to clinical examination alone. The authors conclude that EUA or other objective staging methods should be considered mandatory for accurate staging of locally advanced cervical cancer in India given its high prevalence.
The document discusses adjuvant radiation therapy for gallbladder carcinoma based on available literature. It summarizes several retrospective studies that found improved survival outcomes with adjuvant radiation or chemoradiation after surgical resection compared to surgery alone, especially for node-positive or advanced-stage disease. However, it notes the evidence is limited due to the rarity of the disease and lack of large randomized controlled trials. While adjuvant therapy appears logical, more research is still needed to better define its role and optimal use.
This document summarizes the management of carcinoma of the oesophagus. It discusses the AJCC TNM classification and staging for squamous cell carcinoma and adenocarcinoma. It also describes surgical options like esophagectomy and conservative procedures. Non-surgical treatments including chemotherapy regimens, radiotherapy alone or with chemotherapy are mentioned. Several studies evaluating the role of neoadjuvant chemoradiotherapy and chemotherapy prior to surgery are summarized. Meta-analyses demonstrating improved survival with neoadjuvant therapy are also highlighted.
- Microinvasive breast cancer (MIBC) has a low but measurable risk of lymph node metastasis. Several studies found positive lymph nodes in 3.7-7.5% of MIBC patients who underwent sentinel lymph node biopsy (SLNB).
- Factors like lymphatic invasion and positive estrogen receptor status predict higher risk of lymph node metastases in MIBC. However, routine SLNB is not warranted for all MIBC patients. Careful selection based on risk factors is needed to avoid overtreatment.
- Studies of patients with DCIS found lymph node micrometastases in 21-34% of those undergoing SLNB for high-risk features like palpable mass or suspicious imaging. However, the clinical significance
The document discusses pancreatic ductal adenocarcinoma (PDA) and different treatment approaches. It summarizes several key trials evaluating neoadjuvant therapy, adjuvant therapy, and chemotherapy for resectable, borderline resectable, locally advanced, and metastatic PDA. The take home message is that more randomized controlled trials are needed to determine the optimal treatment approach for different PDA stages, but neoadjuvant therapy appears beneficial for locally advanced and borderline resectable disease, while gemcitabine + nab-paclitaxel or FOLFIRINOX chemotherapy provide good outcomes for metastatic PDA.
Esophageal cancer is often diagnosed when a person experiences difficulty swallowing. A physician will typically perform an endoscopy to examine the esophagus. Common treatments include chemotherapy, radiation, and surgery, but survival rates are modest at 5-20% after 5 years even with surgery. A study of 304 patients receiving chemotherapy and radiation before possible surgery found a 25.7% complete response rate and 45.9% partial response rate. For patients who underwent surgery after responding to treatment, the 5-year survival rate was 40% compared to 25% for non-surgical patients. The authors conclude that aggressive pre-operative chemoradiation may improve outcomes but also increase toxicity, and recommend intensifying post-operative treatment instead.
This document discusses treatment options for gastric cancer, including surgery, chemotherapy, and radiation therapy. It covers various lymph node dissection classifications (D0-D2) and their roles in different stages of disease. Adjuvant therapies like chemotherapy and chemoradiation are recommended after surgery to improve survival outcomes. Perioperative and postoperative chemotherapy are supported by clinical trials to be beneficial in resectable gastric cancer.
This document provides an overview of carcinoma of the esophagus. It discusses the epidemiology, etiology, pathological classification, clinical features, staging, diagnosis and management of esophageal cancer. Esophageal cancer is the 8th most common cancer worldwide and has a poor 5-year survival rate of less than 18%. Risk factors and types of esophageal cancer vary globally. The document outlines the various diagnostic tests and staging systems used to evaluate esophageal cancer as well as endoscopic, surgical and non-surgical treatment options.
COMPOSITE GRAFT: ANTROPYLORUS TRANSPOSITION AND GLUTEUS MAXIMUS WRAPDr Amit Dangi
THIS PRESENTATION DESCRIBES THE NOVEL SURGICAL TECHNIQUE OF TOTAL ANORECTAL RECONSTRUCTION WITH ANTROPYLORUS TRANSPOSITION AND GLUTEOPLASTY AND ITS RESULTS.
The document discusses the anatomy and clinical presentation of colorectal cancer. It notes that 80% of patients present electively with symptoms like altered bowel habits, bleeding, abdominal pain, or anemia. Physical examination often finds a rectal or abdominal mass. Diagnosis relies on colonoscopy and barium enema imaging. Treatment involves surgical resection with chemotherapy and radiation also playing a role depending on cancer stage. Early detection improves prognosis but 55% of patients still present with late stage or metastatic disease.
This document presents a case report of a 42-year-old male patient with an atypical choroid plexus papilloma located in the foramen magnum. The patient presented with dizziness, hearing loss, and gait disturbance. Imaging showed a large mass in the foramen magnum that was partially removed via suboccipital craniotomy. Histological examination found the tumor to be a grade II atypical choroid plexus papilloma. The patient developed post-operative meningitis but otherwise recovered well. The report reviews other cases of atypical choroid plexus papillomas in the posterior fossa and discusses treatment approaches.
This document discusses the management of gastric cancer. It outlines the treatment approaches for localized (stage I-III) and metastatic (stage IV) disease. For localized disease, options include endoscopic mucosal resection, limited surgical resection, or gastrectomy depending on the stage, followed by lymph node dissection and adjuvant chemoradiation or chemotherapy. For metastatic disease, chemotherapy is the standard treatment approach. The document provides details on surgical procedures, lymph node dissection approaches, radiotherapy techniques, and the role of perioperative and adjuvant chemotherapy based on clinical trials.
Early esophageal cancer refers to Tis, T1a, and T1b lesions. The main treatment options are esophagectomy and endoscopic resection. Esophagectomy provides accurate staging but higher morbidity and mortality, while endoscopic resection has lower risk but requires close surveillance. The choice depends on risk factors for lymph node metastasis like depth of invasion, lymphovascular invasion, and tumor size. Minimally invasive esophagectomy techniques aim to reduce complications while achieving equivalent oncologic outcomes.
This document summarizes the treatment of anal canal cancer. It discusses:
1. The treatment has evolved from radical surgery (abdominoperineal resection) to nonsurgical chemoradiotherapy using 5-fluorouracil and mitomycin C, allowing for organ preservation in most patients.
2. Definitive chemoradiotherapy is now the standard of care, using a dose of 50.4 Gy radiation with concurrent 5-fluorouracil and mitomycin C. This approach provides high rates of pathologic complete response and survival compared to radiation alone.
3. Ongoing research is exploring modifying the chemoradiotherapy regimen by replacing mitomycin C with cisplatin, 5-fluoroura
Rectal Cancer and Radiotherapy:What is the Clinical Implication of a Complet...ensteve
1) The document discusses complete response rates for patients with advanced rectal cancer receiving pre-operative chemoradiotherapy. It reports a complete pathological response rate of 17.5% in its study.
2) Patients who had a complete pathological response were found to have excellent long-term survival and no recurrence of cancer, with a median follow-up time of over 5 years.
3) A complete clinical response seen before surgery does not guarantee there is no remaining cancer, as viable tumor cells may still be present. The nature of the surgery should not be determined based on clinical response alone.
Intersphincteric resection is a technique that allows for sphincter-preserving surgery for rectal cancers located 1-2 cm from the anal verge. The procedure involves partial resection of the internal anal sphincter while completely preserving the external anal sphincter. A study of 90 patients who underwent this surgery found that 82% had 5-year overall survival and 75% had 5-year disease-free survival. While 41% had perfect post-operative continence, 76% reported overall subjective satisfaction with functional results. Preoperative radiotherapy was associated with worse functional outcomes.
Evaluation and management of Stage III Non-Small Cell Carcinoma Lung including Radiotherapy planning. On a Radiation Oncologist Perspective. MD Radiotherapy discussion - CMC, Vellore
This multicenter study analyzed 111 elderly patients (age 80-89) who underwent radical cystectomy for bladder cancer. The complication rate was high, with 50.4% experiencing early complications and 32% late complications. The perioperative mortality rate was 7.2% and 27.2% of patients were readmitted to the hospital. Tumor progression-free survival at 12 months was lower for patients with ≥pT3 disease (36%) compared to ≤pT1 disease (83.9%). Radical cystectomy in elderly patients carries significant risks given high complication rates, mortality, and readmission rates. Careful patient selection is important to minimize risks and balance benefits against life expectancy.
This study analyzed regional nodal failure patterns in 1031 breast cancer patients treated with mastectomy and chemotherapy without radiation. The chest wall was the most common site of recurrence (67%). Regional nodal recurrences occurred in 53% of patients. Failure in the low-mid axilla was rare (3% rate), suggesting axillary radiation is not needed for most patients. Failure in the supraclavicular fossa/axillary apex was more common (8% rate) and was associated with factors like >3 positive nodes, lymphovascular invasion, and >20% positive nodes, identifying subgroups that may benefit from regional nodal radiation.
Carcinoma vagina surgery radiotherapy managementParag Roy
This document summarizes the management of carcinoma vagina including surgery, radiation therapy, and chemoradiation. It discusses prognostic factors, patterns of failure, survival rates, and management approaches for different stages of disease. For early stage disease, radiation therapy is preferred while surgery may be considered for superficial lesions. Later stages are best managed with external beam radiation and brachytherapy, with chemoradiation potentially playing a role but requiring further study. Outcomes depend strongly on stage, with stage I disease having 5-year survival rates of 60-85% with radiation alone.
This document summarizes information about acoustic neuromas, also known as vestibular schwannomas. It discusses the incidence, growth patterns, clinical presentation, evaluation, and management options for these tumors, including conservative management, microsurgery, and stereotactic radiosurgery. Key points include that acoustic neuromas are usually benign and slow-growing tumors originating in the internal auditory canal. Surgical removal aims to completely excise the tumor while preserving hearing and facial nerve function when possible. The appropriate treatment depends on factors like tumor size, growth rate, hearing status, and patient age and preferences.
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with rapid growth and early metastasis. SCLC is usually responsive to initial chemotherapy but often relapses within two years. The standard first-line treatment is platinum-based chemotherapy such as etoposide plus cisplatin or carboplatin. Adding thoracic radiotherapy to chemotherapy improves survival for limited-stage disease. Many clinical trials have evaluated additional agents or alternative regimens but no significant improvements in outcomes have been achieved compared to standard etoposide plus platinum chemotherapy.
This document summarizes a study of 62 patients with squamous cell carcinoma of the maxillary sinus treated at a single institution between 1994-1999. The majority of patients presented with locally advanced disease. 40 patients (65%) underwent surgery followed by radiation therapy. The 3 and 5-year overall survival rates were 38% and 35% respectively. The most common site of recurrence was at the primary site, occurring in 28 patients (45%). The study concludes that new treatment approaches are needed given the poor outcomes with conventional therapies and high rates of local recurrence.
This document provides information on the management of small cell lung cancer (SCLC). It begins with defining SCLC and describing its typical clinical presentation and features. It then discusses the epidemiology and etiology of SCLC, noting that it is caused primarily by tobacco smoking. The document outlines the recommended workup, staging, and prognostic factors for SCLC. It provides details on the evidence-based management of limited-stage and extensive-stage SCLC, including the use of chemotherapy, radiotherapy, surgery, and protocols for concurrent and sequential chemo-radiotherapy treatment.
Hypofractionated radiotherapy regimens are being re-explored for their potential logistical benefits compared to conventionally fractionated radiotherapy. Several studies have evaluated hypofractionation for prostate cancer, finding comparable rates of tumor control and acceptable toxicity profiles. The CHHiP trial directly compared 57Gy in 19 fractions to 74Gy in 37 fractions for prostate cancer, finding no significant differences in patient-reported bowel symptoms up to 2 years post-treatment.
Hypofractionated radiotherapy regimens provide comparable tumour control to conventional fractionation for several cancer types based on multiple studies. For prostate cancer, studies found hypofractionated regimens of 57Gy in 19 fractions and 60Gy in 20 fractions resulted in similar biochemical control and toxicity outcomes as 74Gy in 37 fractions at median follow ups of 5 years. However, a larger study found 64.6Gy in 19 fractions significantly increased grade 3 gastrointestinal toxicity compared to 78Gy in 39 fractions for intermediate-high risk prostate cancer. Estimated alpha/beta ratios from studies on breast and other cancers support hypofractionation for tissues with low alpha/beta ratios.
Sino Nasal malignancy & Anterior skull base surgery, Endoscopy is the best ???Ajay Manickam
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2) A review of studies found no difference in margins or survival between the two approaches. Endoscopic surgery was associated with significantly shorter hospital stays.
3) Complications were also lower with endoscopic surgery. While open surgery remains necessary in some complex cases, endoscopic surgery is presented as a valid alternative for most sinonasal and anterior skull base malignancies.
This document discusses the management of non-small cell lung carcinoma. It begins by outlining the lymph node staging system for NSCLC. It then discusses the main treatment modalities of surgery, radiation, and chemotherapy. For early stage disease, surgery is the primary treatment discussed. The document outlines criteria for determining operability and details on surgical procedures. It also discusses the role of radiation and chemoradiation for various stages. Post-operative radiation is discussed for high risk patients. The document provides guidance on chemotherapy regimens and timing for different stages.
This study examined factors associated with the timing of death due to cancer recurrence after esophagectomy for adenocarcinoma. The study found:
- Of 351 patients who underwent esophagectomy, 191 (54%) died of cancer recurrence. The majority (97%) of these patients died within 5 years.
- Factors independently associated with earlier death due to recurrence included higher T-stage, lymph node ratio over 0.2, and presence of extracapsular lymph node involvement.
- Among patients who died of recurrence, earlier death was also associated with experiencing postoperative complications. This suggests complications may disturb the immune system and allow faster growth of residual cancer.
- The occurrence of complications was not directly
esophageal cancer surgery types and complicationsved sah
Background-Anatomy & Staging
Surgical Candicate
Contraindication of sx
Assessment of patients for surgery
Approaches of esophagectomies
Esophageal reconstruction
Complications of esophagectomy
Transanal Endoscopic Microsurgery in Young Patients: A Retrospective Studysemualkaira
Local excision of rectal lesions is considered an acceptable choice for elderly and high-risk patients, yet data is scarce regarding its application in young adults
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
Are you looking for a long-lasting solution to your missing tooth?
Dental implants are the most common type of method for replacing the missing tooth. Unlike dentures or bridges, implants are surgically placed in the jawbone. In layman’s terms, a dental implant is similar to the natural root of the tooth. It offers a stable foundation for the artificial tooth giving it the look, feel, and function similar to the natural tooth.
The biomechanics of running involves the study of the mechanical principles underlying running movements. It includes the analysis of the running gait cycle, which consists of the stance phase (foot contact to push-off) and the swing phase (foot lift-off to next contact). Key aspects include kinematics (joint angles and movements, stride length and frequency) and kinetics (forces involved in running, including ground reaction and muscle forces). Understanding these factors helps in improving running performance, optimizing technique, and preventing injuries.
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These lecture slides, by Dr Sidra Arshad, offer a simplified look into the mechanisms involved in the regulation of respiration:
Learning objectives:
1. Describe the organisation of respiratory center
2. Describe the nervous control of inspiration and respiratory rhythm
3. Describe the functions of the dorsal and respiratory groups of neurons
4. Describe the influences of the Pneumotaxic and Apneustic centers
5. Explain the role of Hering-Breur inflation reflex in regulation of inspiration
6. Explain the role of central chemoreceptors in regulation of respiration
7. Explain the role of peripheral chemoreceptors in regulation of respiration
8. Explain the regulation of respiration during exercise
9. Integrate the respiratory regulatory mechanisms
10. Describe the Cheyne-Stokes breathing
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1. Chapter 42, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 36, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 13, Human Physiology by Lauralee Sherwood, 9th edition
Travel vaccination in Manchester offers comprehensive immunization services for individuals planning international trips. Expert healthcare providers administer vaccines tailored to your destination, ensuring you stay protected against various diseases. Conveniently located clinics and flexible appointment options make it easy to get the necessary shots before your journey. Stay healthy and travel with confidence by getting vaccinated in Manchester. Visit us: www.nxhealthcare.co.uk
5. Feature Squamous Cell Adenoid Cystic Others
Carcinoma Carcinoma
52: 17 41:39 26:22
Sex (M:F ratio) Similar to lung ca
Risk factor Smoking in all pt Incidental smoking Incidental smoking
hx hx
Age (yr) of highest 50-69 (6-7 decade) 30-59(slight peak at 11-39 (children and
incidence 5th decade) young adults)
Carinal 25% 50%
involvement
6. 66% (147) of the lesions
were resected
132 resection and
reconstruction
7 removal of larynx and
trachea
8 had staged
reconstruction
7. Detailed description on surgical approach
Cervical collar incision
Median sternotomy with transpericardial trap
door incision
Right thoracotomy
Carinal resection
+/- Pneumonectomy
+/- Laryngeal/hilar release
9. 135 out of 147
patients survived
tumour resection
70% are still alive
without tumour
Disease specific
▪ 49% SCC
▪ 75% ACC
▪ 83% others
10. Recurrence
SCC 1st recurrence noted after
3 years of resection
▪ One patient was resected 3
times, 81, 85, 89
▪ All patient who died of SCC did
so within 4 years of resection
Long term outlook less clear
with ACC
▪ Ist patient had suture line
recurrence 17 years after
resection (postop not radiated)
▪ Dis free for many yrs but late
recurrence typical
11. All patients with positive nodes or
margins were radiated (4500 to
6500 rads)
Positive nodes and positive
margins were frequently found in
patients who later died with SCC
ACC, submucosal and perineural
invasion was common hence most
often resection margins are
compromised for safe
anastomosis, nodal or margins
positive was rampant even in
survived subgroup of patients
Irradiation in unresected ACC is
uniformly characterized by local
recurrence within 3-5 years
12. In both groups of
patients with SCC and
ACC patients who
underwent resection as
primary treatment had
better survival
compared to those who
had primary irradiation
Resection combined
with irradiation
provided tripled survival
time for SCC and ACC
13. Largest series, however with least mortality
comparatively
Recommendations:
Benign and intermediate aggressiveness are best
treated by surgical resection and reconstruction of
the airway
Primary SCC and ACC of the trachea are best
treated by surgical resection only when primary
reconstruction can be safely accomplished
▪ High mortality with staged procedure
14. Title: appropriate,more informative to mention single
centre experience of 26 years
Material and Methods
Long term follow up with large amount of patients
Mean/ median follow up not mentioned, good amounts
>10 years in table
No mention of subgroup of patient that did not undergo
surgical resection primarily. ? Anatomical
contraindications or extensive disease, hence difficult to
intepret results in terms of survival and disease free years
Results
Authors mention in detail regarding various types of
surgeries performed and their learning experiences
15. Result
All study questions were addressed by subjective
comparison and no statistical analysis were offered to
conclude results.
Effect on survival, adjunct chemo or radio not properly
mentioned
Conclusion
A good study that address different types of primary
tracheal tumours in terms of clinical features and
characteristic clinical progression
Treatment options and survival: biased to surgical
resection (single centre experience)
Limitations to study were not mentioned
16. 2:
Journal of the Chinese Medical
Association
October 2006
Vol 69, No 10
Impact factor: 0.678
17. Spindle Cell Carcinoma (SpCC) is also known as
sarcomatoid carcinoma, rare
Sites:
Larynx (1%)
Nasal cavity, hypopharynx, oral
cavity, esophagus, trachea, skin, breast
Gender predilection to men
SpCC is an unusual form of poorly differentiated SCC
Microscopic feature akin to sarcoma (elongated spindle
cells)
Immunohistologic feature: CK, EMA (Epithelial Membrane
Antigen) positive, Vimentin negativity
18. Retrospective analysis of patient’s records
1994 to 2005
18 lesions (SpCC oral cavity and oropharynx) in 17
patients
Criteria for diagnosis:
Identification of carcinoma with squamoid feature
Spindle cells positive for CK and negative for Vimentin
Presence of SCC in situ
Statistical analyses
The Kaplan–Meier model with log rank test was performed for survival analysis.
Fisher’s exact test and Student’s t test were used to determine the relationship between the
variables and recurrent pattern.
The Mann–Whitney test was used to compare the relationship between time to recurrence
and salvage operation.
A p value< 0.05 was considered statistically significant.
19. Male preponderance
94% to 6%
Age of onset
Median 51 years, range 32-76 years
Mean follow up time 14.2 months
Common primary sites:
Tongue (28%)
Buccal mucosa (22%)
20.
21. 15 patients underwent
WLE of tumour with a safety margin of about 1–2
cm
and neck dissection for possible neck disease
▪ 11 developed local recurrence (73%)
▪ 4 with nodal recurrence too
▪ 5 with distant mets then subseq died
▪ Even so in negative margins and early stage
1 received chemotherapy alone
1 refused treatment
22. The median overall survival time was
8.9 months.
The 1-year overall survival rate was 36.7%
3-year overall survival rate was 27.5%.
In the early stage group (stages I and
II), the 3-year survival rate was100%.
In the late stage group (stages III and
IV), the 1-year survival rate was only
9%, and the 3-year survival rate was 0%
The following factors did not
statistically significantly influence
survival:
gender, age, tumor site, previous existence
of SCC, cigarette smoking, alcohol
drinking, betel nut chewing, positive
surgical margin, distance of safe
margin, nerve invasion, muscular
invasion, tumor
necrosis, radiotherapy, chemotherapy, com
bined treatment of surgery and
radiotherapy, and local recurrence.
23. The median overall recurrence
time was 5.2 months.
In the early stage group was
10.5 months,
versus 4.0 months in the late
stage group (p = 0.03).
The median recurrence time in
patients managed with
salvage operation was 8
months, whereas it was 2
months in patients who did
not receive salvage operation
(p = 0.014).
24. No patient with recurrence had positive margin
The significant factor for local recurrence was
alcohol consumption (p = 0.03).
There were no significant factors for regional
recurrence, but muscular invasion (p=0.05) was
noteworthy.
The significant factors for distant metastasis
were age < 50 years (p = 0.03), T stage > T2 (p
=0.03), and nerve invasion (p = 0.007).
25. Survival and reaction to treatment of SpCC still
controversial
Ellis (oral) 36% survival
Olsen (larynx) 56% survival
This series show lower survival rates compared to SCC of oral
cavity and oropharynx
The recurrence rate was very high, even in the early stage
patients. The metastatic rate was high in the advanced-
stage patients.
More aggressive behaviour
None of the patients with local recurrence had positive
margin
a much wider safety margin (> 2 cm) for SpCC would be helpful.
26. SpCC in the oral cavity and oropharynx is potentially
aggressive and seems to recur easily and to metastasize.
Those with early-stage tumors usually have an excellent
prognosis.
If local recurrence occurs, salvage operation should be
performed and will be beneficial to patients.
27. Title: appropriate to content,more
informative to mention single centre
experience of 10 years
Methods
No mention of 1 patient with two lesions ?
Synchronous, recurrence; even though 1 patient
but this series has small number of patient and
statistical analysis might be affected
Statistical analyses well mentioned, appropriately
used for given study objectives
28. Methods
Descriptive data well presented, summarized well
in table
One data mistakenly represented in table
▪ median recurrence time in patients managed with
salvage operation was 8 months, whereas it was 2
months in patients who did not receive salvage
operation (p = 0.014). Table <0.01
Study well concluded and limitations were
mentioned
30. Endoscopic surgery plays a central role in the treatment of
inverted papilloma (IP) of the nose and paranasal sinuses
and both its safety and its efficacy have been established
The goal of surgical treatment is complete removal of the
lesion under direct visual control with minimal morbidity.
Many authors advocate extended endoscopic medial
maxillectomy (include removal of nasolacrimal duct and IT
even though not involved)
The IT warms, cleans, moistens inhaled air and regains
water during exhalation.
Novel technique for performing EEMM with preservation
of IT
31. Retrospective series of patients who
underwent EEMM with preservation of IT
15 operated sides
5 with primary IP of the MS
7 with recurrent IP of the MS
2 patients with 3 mucoceles of the MS
12 patients (5 women and 7 men, aged 26-77
years)
Endoscopic follow up 3/12 1st year, 6/12 next
yr and then once a year
32. A 45° endoscope was used for most parts of the
operation. Additionally, 0° and 70° telescope
was used.
In IP, the tumor is first debulked intranasally and
then followed into the MS to look for the
attachment.
An uncinectomy is necessary to do this. If the
tumor can not be sufficiently removed via a
middle meatal antrostomy and the IT is not
involved in the tumor, the decision to perform an
EEMM with preservation of the IT is made
33. Schematic drawing: 2:
Continued dissection opened maxillary sinus;
Characteristic After reinsertion of IT at
Cutting of the anterior slightly lateral along the 3: opened lacrimal sac; 1:
endoscopic appearance the original attachment
attachment of IT attachment, preserving IT sutured at its anterior
of an inverted papilloma site end
posterior part
5: ground lamella
34. Nose is occluded for 2-4 weeks by taping
nose with sticking plaster
To prevent dryness, which may cause impaired
healing and increased risk of dehiscence
Gentle after care toileting to prevent
mechanical trauma
35. Postoperative endoscopy
revealed no recurrence of the
tumor in any of the cases after a
follow-up period of 12–80
months (28 months on average)
All ITs survived dissection and
reinsertion, showed normal
appearance endoscopically
Both patients with
mucoceles, the marsupialized
cavities were patent 12 month
post op.
36. No specific additional pain, postoperative
bleeding and occlusion was well tolerated
One has persistent crusting but is also a
heavy smoker with recurrent infection of the
residual MS
Two patients with IP developed mucoceles in
the MS but remained asymptomatic
37. In all cases of EEMM authors recommend
attempting to preserve the IT
With permanent occlusion for at least 2
weeks, preservation of the IT is possible in all
cases.
Aftercare should focus on not pulling off the
healing turbinate
38. Title: appropriate to content
Methods
Small number of patients
Limited literature review on clinical significance of
preserving the IT in whole length as opposed to
current practise of preserving anterior 1 cm
2 different pathologies were lumped into same
group ? Not appropriate
39. Operative technique
Discuss in detail with beautiful pictures to
facilitate understanding
Occlusion of the nose not elaborated
much, unclear
Results
No mention on additional patient’s benefit on
preserving the IT
Editor's Notes
Dr Hermes Grillo, father of tracheal surgery. Even though he has passed away from a car accident in 2006, I had to choose his work as this is the largest series of primary tracheal tumours ever collected with longest long term followup
None of the SCC were secondary to other common primaries in the lungs, bronchus, larynx or esophagusAdenoid cystic radiosensitive hence not all were resectedPapillomas treated with cryo, laserPleomorphic adenoma: had salivary PA 10 years beforeRhabdomyosarcoma: pedunculated isolated tracheal lesion; cervical rhabdomyosarcoma treated with RND and RT 6 years agoPlexiformneurofibroma and paraganglioma: primary trachea
Give a detailed description on patients who had resection and primary reconstruction
HsingHao Su from ENT department in Kaohsiung Veterans GH, not much is known, only has 6 published articles on Research Gate, all of them published in Chinese journals, none internationalDespite decreases in subsidies, VGH-KS, the only public medical center in the southern area, continues to serve the public. We coordinate with the official health authorities to implement policies and serve as a leader of medical service improvement standards throughout the community and the region. The continuance of our role as a veterans hospital to protect and care for our veterans and their families.
25 years ago series by Ellis et al: 10 patients; this series 18 patients
Rainer K. Weber, MD university of Marburg Germany, Karlsruhe ospitalProfessor and Head Division of Paranasal Sinus and Skull Base Surgery