This document presents an analysis of orthotropic reinforced concrete slabs with long side openings using the affine theorem and yield line method. Ten possible yield line failure patterns are considered for slabs with continuous, simply supported, two long sides continuous, and two short sides continuous edge conditions. Virtual work equations are formulated for each failure pattern. Numerical examples are provided to illustrate the governing failure patterns for different slab geometries and support conditions. The affine theorem is used to transform orthotropic slab properties into equivalent isotropic properties to simplify the analysis.