This document discusses extensions of Mendelian genetics including incomplete dominance, codominance, multiple alleles, and gene interactions. It provides examples of incomplete dominance in flowers where the heterozygote has an intermediate phenotype. Codominance is explained using blood types where both alleles are expressed in the heterozygote. Multiple alleles are exemplified by the ABO blood group system which has three alleles. Gene interactions like epistasis can alter expected phenotypes when genes act together.
INTRODUCTION TO GENETICS AND PRINCIPLES OF BREEDING_final.pptSenyongaEmmanuel
Introduction to Genetics:
Definition and significance of genetics.
Historical milestones in the field of genetics.
Central Dogma of Molecular Biology:
DNA replication.
Transcription and RNA synthesis.
Translation and protein synthesis.
Genetic Material:
Structure of DNA and RNA.
Genetic code and codons.
Mendelian Genetics:
Principles of inheritance (laws of segregation and independent assortment).
Punnett squares and genetic crosses.
Terms: genotype, phenotype, homozygous, heterozygous.
Non-Mendelian Inheritance:
Incomplete dominance.
Codominance.
Polygenic inheritance.
Chromosomes and Cell Division:
Overview of mitosis and meiosis.
Chromosome structure and organization.
Sex chromosomes and sex determination.
Genetic Variation:
Mutation types (point mutations, insertions, deletions).
Causes of mutations (chemical, radiation, genetic).
Genetic Disorders:
Single gene disorders (e.g., cystic fibrosis, sickle cell anemia).
Chromosomal disorders (e.g., Down syndrome, Turner syndrome).
Multifactorial disorders and gene-environment interactions.
Human Genome Project:
Purpose and goals.
Achievements and implications for medicine.
Molecular Genetics:
DNA sequencing techniques.
Recombinant DNA technology and genetic engineering.
Genetic Counseling and Testing:
Purpose and process of genetic counseling.
Genetics: The study of heredity.
Heredity is the relations between successive generations.
Why do children look a little bit like their parents but also different?What is responsible for these similarities and differences? this slides try to explain why these things are happening.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
INTRODUCTION TO GENETICS AND PRINCIPLES OF BREEDING_final.pptSenyongaEmmanuel
Introduction to Genetics:
Definition and significance of genetics.
Historical milestones in the field of genetics.
Central Dogma of Molecular Biology:
DNA replication.
Transcription and RNA synthesis.
Translation and protein synthesis.
Genetic Material:
Structure of DNA and RNA.
Genetic code and codons.
Mendelian Genetics:
Principles of inheritance (laws of segregation and independent assortment).
Punnett squares and genetic crosses.
Terms: genotype, phenotype, homozygous, heterozygous.
Non-Mendelian Inheritance:
Incomplete dominance.
Codominance.
Polygenic inheritance.
Chromosomes and Cell Division:
Overview of mitosis and meiosis.
Chromosome structure and organization.
Sex chromosomes and sex determination.
Genetic Variation:
Mutation types (point mutations, insertions, deletions).
Causes of mutations (chemical, radiation, genetic).
Genetic Disorders:
Single gene disorders (e.g., cystic fibrosis, sickle cell anemia).
Chromosomal disorders (e.g., Down syndrome, Turner syndrome).
Multifactorial disorders and gene-environment interactions.
Human Genome Project:
Purpose and goals.
Achievements and implications for medicine.
Molecular Genetics:
DNA sequencing techniques.
Recombinant DNA technology and genetic engineering.
Genetic Counseling and Testing:
Purpose and process of genetic counseling.
Genetics: The study of heredity.
Heredity is the relations between successive generations.
Why do children look a little bit like their parents but also different?What is responsible for these similarities and differences? this slides try to explain why these things are happening.
Safalta Digital marketing institute in Noida, provide complete applications that encompass a huge range of virtual advertising and marketing additives, which includes search engine optimization, virtual communication advertising, pay-per-click on marketing, content material advertising, internet analytics, and greater. These university courses are designed for students who possess a comprehensive understanding of virtual marketing strategies and attributes.Safalta Digital Marketing Institute in Noida is a first choice for young individuals or students who are looking to start their careers in the field of digital advertising. The institute gives specialized courses designed and certification.
for beginners, providing thorough training in areas such as SEO, digital communication marketing, and PPC training in Noida. After finishing the program, students receive the certifications recognised by top different universitie, setting a strong foundation for a successful career in digital marketing.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Introduction to AI for Nonprofits with Tapp NetworkTechSoup
Dive into the world of AI! Experts Jon Hill and Tareq Monaur will guide you through AI's role in enhancing nonprofit websites and basic marketing strategies, making it easy to understand and apply.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
2. Allele Variation and Gene Function
Mendel’s
Experiments
gene can exist
in alternate
forms (one
dominant, the
other recessive
Simple
functional
dichotomy
between alleles
Research in
early 20th
century genes
can exist in
more than two
allelic state
Each allele have
different effect on
the phenotype in
different ways
3. Incomplete Dominance
• An allele is dominant same phenotypic effect both in heterozygotes &
homozygotes (Mendelian crosses)
• Unlike Mendelian crosses, a cross between parents with contrasting traits may
sometimes generate offspring with an intermediate phenotype
• Ex: a four-o’clock or a snapdragon plant (Antirrhinum majus) with red flowers is
crossed with a white-flowered plant, the offspring have pink flowers. Because some
red pigment is produced in the F1 intermediate-colored plant, neither the red nor
white flower color is dominant
• White and red varieties are homozygous for different alleles of a color-
determining gen; when crossed, they produce heterozygous that have pink flowers
• The allele for red color (W) is therefore said to be incomplete, or partial,
dominance over the allele for white color (w)
4. Incomplete Dominance
• The intensity of pigmentation in
this species depends on the
amount of a product specified by
the color gene
• If the W allele specifies this
product and the w allele does
not, WW homozygotes will have
twice as much of the product as
Ww heterozygotes do and will
therefore show deeper color
6. The most accurate way is to consider gene expression in a quantitative
way
In the case of flower color above, the mutation causing white flowers is
most likely one where complete “loss of function” occurs. In this case, it is
likely that the gene product of the wild-type allele (R1) is an enzyme that
participates in a reaction leading to the synthesis of a red pigment.
The mutant allele (R2) produces an enzyme that cannot catalyze the
reaction leading to pigment. The end result is that the heterozygote
produces only about half the pigment of the red-flowered plant and the
phenotype is pink
How are we interpret lack of dominance whereby an
intermediate phenotype characterizes heterozygotes?
7. Incomplete dominance in human disease
• Clear-cut cases of incomplete dominance are relatively rare
• However, even when one allele seems to have complete dominance
over the other, careful examination of the gene product, rather than the
phenotype, often reveals an intermediate level of gene exprssion
• Ex: human biochemical disorder Tay-Sachs disease, in which
homozygous recessive individuals are severely affected with a fatal
lipid-storage disorder and neonates die during their first one to three
years of life
• In afflicted individuals, there is almost no activity of the enzyme
hexosaminidase A, an enzyme normally involved in lipid metabolism.
• Heterozygotes, with only a single copy of the mutaant gene, are
phenotypically normal, but with only about 50% of the enzyme activity
found in homozygous normal individuals
8. Incomplete dominance in human disease
• Fortunately, this level of enzyme activity is adequate to
achieve normal biochemical function. This situation is not
uncommon in enzyme disorders and illustrates the concept
of the threshold effect, whereby normal phenotypic
expression occurs anytime a certain level of gene product is
attained.
• Most often, and in particular in Tay-Sachs disease the
threshold is less than 50 percent
9. Codominance
• Another exception to the principle of simple dominance arises when a heterozygote shows characteristics
found in each of the associated homozygotes
• This occurs with human blood types, which are identified by testing for special cellular products called
antigen. These factors, which are produced by the immune system, recognize antigens quite specifically
• The ability to produce the M and N antigens is determined by a gene with two alleles. One allele allows the
M antigen to be produced; the other allows the N antigen to be produced
• Homozygotes for the M allele produce only the M antigen, and homozygotes for the N allele produce only
the N antigen. However, heterozygotes for these two alleles produce both kinds of antigens
• Because the two alleles appear to contribute independently to the phenotype of the heterozygotes, they are
said to be codominant
• Codominance implies that there is an independence of allele function
• Codominant inheritance is characterized by distinc expression of the gene products of both alleles. This
characteristic distinguishes codominance from incomplete dominance, where heterozygotes express an
intermediate blended, phenotype.
• For codominance to be studied, both products must be phenotypically detectable.
• ABO blood-type system is another example of codominance when we examine the ABO blood-type system
10.
11. Multiple Alleles of a Gene May Exist in a Population
• The information stored in any gene is extensive, and mutations can modify this
information in many ways. Each change produces a different allele. Therefore, for
any gene, the number of alleles within members of a population need not to be
restricted to two.
• When three or more alleles of the same gene-which we designate as multiple
alleles-are present in a population, the resulting mode of inheritance may be
unique.
• It is important to realize that multiple alleles can be studied only in populations.
• Any individual diploid organism has, at most, two homologous gene loci that may
be occupied by different alleles of the same gene. However, among members of
a species, numerous alternative forms of the same gene can exist
12. Multiple Alleles of a Gene May Exist in a Population
• Example:
1. The ABO Blood Groups
• the simplest case of multiple alleles occurs when three alternative alleles of one
gene exist. This situation is illustrated in the inheritance of the ABO blood groups
in humans
• The ABO system, like the MN blood types, is characterized by the presence of
antigens on the surface of red blood cells
• The A and B antigens are distinct from the MN antigens and are under the control
of a different gene located on chromosome 9
• One combination of alleles in the ABO system exhibits a codominant mode of
inheritance
13. Multiple Alleles of a Gene May Exist in a Population
• Example:
1. The ABO Blood Groups
• The ABO phenotype of any individual is scertained by mixing a blood sample with
an antiserum containing type A or type B antibodies. If an antigen is present on
the surface of the person’s red blood cells, it will react with the corresponding
antibody and cause clumping, or agglutination, of the red blood cells.
• When an individual is tested in this way, one of four phenotypes may be revealed.
Each individual has either the A antigen (A phenotype), the B antigen (B
phenotype), the A and B antigen (B phenotype), the A and B antigens (AB
phenotype), or neither antigen (O phenotype). These phenotypes were inherited
as the result of three alleles of a single gene.
• To distinguish these three alleles, we’ll use the symbols IA, IB and i. The I
designation stands for isoagglutinogen, another term for antigen.
14. Multiple Alleles of a Gene May Exist in a Population
• Example:
1.The ABO Blood Groups
In these assignments, the IA and IB, alleles are
dominant to the i allele, but codominant to each other
15. Multiple Alleles of a Gene May Exist in a Population
• Example:
2. The white Locus in
Drosophila
• many other
phenotypes in plants
and animals are
influenced by multiple
allelic inheritance
16. Multiple Alleles of a Gene May Exist in a Population
• Example:
3. The gene that controls
coat color in rabbits
• the color-determining
gene, denoted by a c
(albino), cb (himalayan),
ccb (chinchilla), and c+
(wild-type). z
17. GENE INTERACTIONS (ATAVISME)
Two independently assorting genes can affect a trait (due to the interactions between gene products at
biochemical/ cellular levels based on Bateson & Punnett’s breeding experiments with chickens (domestic
breeds of chickens have different comb shapes)
Rose,
Wyandottes
(RRpp)
Pea, Brahmas
(rrPP)
Walnut (hybrid
crosses
between Rose
& pea
(RrPp)
Single,
Leghorns
(rrpp)
If F1 hybrids RrPp intercrossed with
each other all 4 types of combs
appear in the progeny
9/16 walnut (R-P-)
3/16 rose (R-pp)
3/16 pea (rr P-)
1/16 single (rr pp)
20. GENE INTERACTION (Kriptomeri faktor dominan yang baru tampak pengaruhnya
apabila bertemu dengan faktor dominan lain yang bukan alelnya )
Linaria maroccana.
A+B bunga ungu
A tanpa B bunga merah
Rasio fenotip Ungu: Merah
: Putih = 9:3:4
21. EPISTASIS-HIPOSTASIS gen dominan lain yang bukan alelnya menutupi gen dominan
lainnya )
H epistasis terhadap K
K hipostasis terhadap H
12:3:1
22. GEN KOMPLEMENTER interaksi antara dua gen dominan, jika terdapat bersama-sama akan saling
melengkapi sehingga muncul suatu fenotip )
Interaksi antara dua gen dominan, jika
terdapat bersama-sama akan saling
melengkapi sehingga muncul suatu fenotip.
Jika salah satu gennya tidak ada, maka
pemunculan sifat terhalang.
9:7