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Shima’a Jaffer Al-Amer
211504748
ERYTHEMA NODOSUM
What is Erythema Nodosum?
• A painful inflammatory
disorder in which crops of
tender nodules occur in
response to antigenic stimuli.
• Usually it is limited to the
extensor aspects of the lower
legs.
Causes:
• Hypersensitivity reaction
1- Infection:
Streptcoccus, Mycoplasma pneumoniae
2- certain medication:
• Antibiotic e.g. amoxicillin
• Sulfonamides
• Birth control pills
3- pregnancy
4- sarcoidosis
5- leukemia
6- Ulcerative colitis
Clinical presentation:
1- At the beginning:
* red tender nodules ,
* poorly Defined border,
* vary from 2-6 cm.
2- During the first week:
lesions become tense, hard, and painful
3- During the second week:
they may become fluctuant, as in an abscess, but do not suppurate
or ulcerate.
4- Aching legs and swelling ankles may persist for weeks.
Investigations:
• 1- Throat culture  for streptococcus
• 2- Chest X-ray  sarcoidosis and TB
• 3- Skin biopsy  for difficult cases
Treatment:
self-limited disease
symptomatic relief using :
• ROXBURGH’S, Common Skin
Disease, R. MARKS
• Medscape
• DermNet NZ
REFRANCES

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