Introduction to Epidemiology
At the end of this session the participants will be able to:
Discuss the historical evolution of epidemiology
Explain the usage of epidemiology
List the core epidemiological functions
Explain types of epidemiological studies
“The study of the distribution and determinants of health-related states or events in specified population and the application of the study to control of health problems.”
Natural history of disease is a very important concept in Community Medicine. I had prepared this presentation in a very short duration for my class presentaton. There is not a lot of text in the presentation but there is a really good collection of images.
Uploading it in the hope that atleast someone out there will find it useful.
EVENTS IN NATURAL HISTORY OF DISEASE
1.Pre-Pathogenesis phase
•This period is preliminary to the onset of disease.
•Disease agent not entered man but factor which favour its interaction with the human host are always existing in the environment.
2.Pathogenesis phase
•This period begins with the entry of disease agent in the susceptible human host.
FACTORS OF EPIDEMIOLOGICAL TRAID
1.Agent Factor: -
•First link in the chain of disease transmission.
•Agent defined as substances living or non-living or a force the excessive presence or relative lack of which may initiate or perpetuate a disease process.
•A disease may have single agent a number or a complex of two or more agent.
•Disease agents are: -
a)Biological agent:
•These are living agent of disease.
•This agent exhibits certain “host” related biological properties such as,
i.Infectivity –
oability of infectious agent to invade and multiply.
ii.Pathogenicity –
ability to induce clinically aperantt illness.
iii.Virulence –
opreparation of clinical cases resulting in severe clinical manifestation
b)Nutrient agent:
•These are proteins, fat, carbohydrate, vitamins, minerals and water.
•Any excess or deficiency results in nutritional disorder.
c)Physical agent:
•Exposure to excessive heat, cold, humidity, pressure, radiation, electricity, sound may result in illness
d)Chemical agent:
i.Endogenous –
Chemical produced in the body due to derangement of function serum bilirubin.
ii. Exogenous –
arising outside of human host. E.g.- allergen, metals, dust, etc
e)Mechanical agent:
•Exposure to chronic friction and other mechanical forces may result in crushing, tearing, sprains, dislocation or even death.
f)Absence or insufficiency or excess of a factor necessary to health:
•Chemical factor - hormones. E.g. – insulin
•Nutrient factor
•Lack of structure e.g.- thymus
•Lack of parts of structure e.g. – cardiac defect
•Chromosomal factor e.g. – magnolia
•Immunological factor
g)Social agent:
•These are poverty, smoking, abuse of drugs and alcohol
2.Host Factor (Intrinsic): -
•It plays a major role in determining the outcome of an individual’s exposure to infection. e.g. – tuberculosis
•Human host is referred to soil to the disease.
•Host factors are –
i.Demographic characteristics –
age, sex, ethnicity
ii.Biological characteristics –
genetic factors, biochemical levels of blood.
iii.Social and economic characteristics –
socio-economic status, education, occupation, stress, housing, etc
iv.Lifestyle factor –
personality traits, living habits, nutrition, physical exercise
3.Environmental Factor (Extrinsic): -
•Environment is the reservoir for the agents of disease.
•It helps in transmission of agents to host bringing about their contact and interaction.
•The environment of man is of two types: -
External Environment –
oIt is all that which is external to the individual human host.
Macro-environment is another term used to denote external environment.
Micro-environment is the term used to denote one’
Introduction to Epidemiology
At the end of this session the participants will be able to:
Discuss the historical evolution of epidemiology
Explain the usage of epidemiology
List the core epidemiological functions
Explain types of epidemiological studies
“The study of the distribution and determinants of health-related states or events in specified population and the application of the study to control of health problems.”
Natural history of disease is a very important concept in Community Medicine. I had prepared this presentation in a very short duration for my class presentaton. There is not a lot of text in the presentation but there is a really good collection of images.
Uploading it in the hope that atleast someone out there will find it useful.
EVENTS IN NATURAL HISTORY OF DISEASE
1.Pre-Pathogenesis phase
•This period is preliminary to the onset of disease.
•Disease agent not entered man but factor which favour its interaction with the human host are always existing in the environment.
2.Pathogenesis phase
•This period begins with the entry of disease agent in the susceptible human host.
FACTORS OF EPIDEMIOLOGICAL TRAID
1.Agent Factor: -
•First link in the chain of disease transmission.
•Agent defined as substances living or non-living or a force the excessive presence or relative lack of which may initiate or perpetuate a disease process.
•A disease may have single agent a number or a complex of two or more agent.
•Disease agents are: -
a)Biological agent:
•These are living agent of disease.
•This agent exhibits certain “host” related biological properties such as,
i.Infectivity –
oability of infectious agent to invade and multiply.
ii.Pathogenicity –
ability to induce clinically aperantt illness.
iii.Virulence –
opreparation of clinical cases resulting in severe clinical manifestation
b)Nutrient agent:
•These are proteins, fat, carbohydrate, vitamins, minerals and water.
•Any excess or deficiency results in nutritional disorder.
c)Physical agent:
•Exposure to excessive heat, cold, humidity, pressure, radiation, electricity, sound may result in illness
d)Chemical agent:
i.Endogenous –
Chemical produced in the body due to derangement of function serum bilirubin.
ii. Exogenous –
arising outside of human host. E.g.- allergen, metals, dust, etc
e)Mechanical agent:
•Exposure to chronic friction and other mechanical forces may result in crushing, tearing, sprains, dislocation or even death.
f)Absence or insufficiency or excess of a factor necessary to health:
•Chemical factor - hormones. E.g. – insulin
•Nutrient factor
•Lack of structure e.g.- thymus
•Lack of parts of structure e.g. – cardiac defect
•Chromosomal factor e.g. – magnolia
•Immunological factor
g)Social agent:
•These are poverty, smoking, abuse of drugs and alcohol
2.Host Factor (Intrinsic): -
•It plays a major role in determining the outcome of an individual’s exposure to infection. e.g. – tuberculosis
•Human host is referred to soil to the disease.
•Host factors are –
i.Demographic characteristics –
age, sex, ethnicity
ii.Biological characteristics –
genetic factors, biochemical levels of blood.
iii.Social and economic characteristics –
socio-economic status, education, occupation, stress, housing, etc
iv.Lifestyle factor –
personality traits, living habits, nutrition, physical exercise
3.Environmental Factor (Extrinsic): -
•Environment is the reservoir for the agents of disease.
•It helps in transmission of agents to host bringing about their contact and interaction.
•The environment of man is of two types: -
External Environment –
oIt is all that which is external to the individual human host.
Macro-environment is another term used to denote external environment.
Micro-environment is the term used to denote one’
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
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the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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2. • Disease results from a complex interaction between man,
an agent (or cause of disease) and the environment.
• The term epidemiological triad is a key concept in
epidemiology.
• Each disease has its own unique natural history of causes,
which is not necessarily the same in all individuals.
EPIDEMIOLOGICAL TRIAD contd.,
2
5. AGENT FACTORS
• The first link in the chain of disease transmission is a disease
agent.
• The disease agent is defined as a substance, living or non-
living or a force, tangible or intangible, the excessive
presence or relative lack of which may initiate or perpetuate a
disease process
• A disease may have a single agent, a number of independent
alternative agents or a complex of two or more facts whose
combined presence is essential for the development of the
disease 5
6. BIOLOGICAL AGENTS
NUTRIENT AGENTS
PHYSICAL AGENTS
CHEMICAL AGENTS
MECHANICAL AGENTS
ABSENCE OR
INSUFFICIENCY OR
EXCESS OF A
FACTOR
NECESSARY TO
HEALTH
SOCIAL AGENTS
AGENT FACTORS contd.,
6
7. 1. BIOLOGICAL AGENTS: These are living agents of disease.
viz, viruses, rickettsiae, fungi, bacteria, protozoa and metazoa.
These agents having certain biological properties such as
Infectivity, pathogenecity and virulence
• Infectivity is the ability of an infectious agent to invade and
multiply in a host
• Pathogenecity is the ability to induce clinically apparent
illness
• Virulence is the proportion of clinical cases resulting in severe
clinical manifestations
AGENT FACTORS contd.,
7
8. 2. NUTRIENT AGENTS: These are proteins, fats,
carbohydrates, vitamins, minerals and water. Any
excess or deficiency of the intake of nutritive elements
may result in nutritional disorders.
Eg: Protein Energy Malnutrition, Anaemia, Goitre,
Obesity and Vitamin deficiencies are the some of the
current nutritional problems.
AGENT FACTORS contd.,
8
9. 3. PHYSICAL AGENTS :Exposure to excessive heat, cold,
humidity, pressure, radiation, electricity, sound etc may
result in illness
4. CHEMICAL AGENTS:
(i) Endogenous : Some of the chemicals may be produced in
the body as a result of derangement of function eg. bilirubin
(jaundice)
(ii) Exogenous: Agents arising outside of human host.
eg.allergens, metals, fumes and gases
AGENT FACTORS contd.,
9
10. 5. MECHANICAL: Exposure to chronic friction and other
mechanical may result in crushing, tearing, sprains,
dislocations and even death.
6. ABSENCE OR INSUFFICIENCY OR EXCESS OF A
FACTOR NECESSARY TO HEALTH: These may be
(i) Chemical Factors eg. Hormones (ii) Nutrient factors
(iii) Lack of structure (iv) Lack of part of structure
(v) Chromosal factors (vi) Immunological factors
AGENT FACTORS contd.,
10
11. 7. SOCIAL AGENTS: It is also necessary to consider
social agents of disease. These are poverty, smoking,
abuse of drugs and alcohol, unhealthy lifestyles, social
isolation, maternal deprivation etc.
AGENT FACTORS contd.,
11
12. HOST FACTORS
• The human host is referred to as “soil” and the disease
agent as “seed”.
• In some situations, host factors play a major role in
determining the outcome of an individual’s exposure to
infection. Eg. Tuberculosis
12
13. 1.
Demographic
Characteristics
such as age,
sex, ethnicity
etc
2. Biological
characteristics
such as genetic
factors, blood
groups and
enzymes,
immunological
factors, etc
3. Social and
economic
characteristics
such as socio-
economic
status,
education,
occupation,
stress, marital
status,
housing, etc
4. Life style
factors such as
personality
traits, living
habits,
nutrition,
physical
exercise and
use of alcohol,
drugs and
smoking etc.
HOST FACTORS contd.,
13
14. ENVIRONMENTAL FACTORS
• The external or macro environment is defined as all that
which is external to the individual human host, living and
non-living, and with which he is in constant interaction.
This includes all of man’s external surroundings such as
air, water, food housing, etc.
• For human beings the environment is not limited, as it
normally is for plants and animals, to a set of climatic
factors
14
16. • PHYSICAL ENVIRONMENT: Its apply to non living things
and Physical factors such as Air,Water,Soil,Housing Etc
With Which man is in constant interaction.
• Man has altered practically every thing in his physical
environment to is advantage which has created new
health problems such as air, water & noise pollution,
Urbanization and Radiation hazards.
ENVIRONMENTAL FACTORS contd.,
16
17. • BIOLOGICAL ENVIRONMENT: It’s the universe of living
things which surrounds man including man himself. The
living things are the viruses, and other microbial agents,
insects, rodents, animals and plants
• For the most part, the parties manage to effect a
harmonious inter-relationship, to achieve a state of
peaceful co-existence, even though this may not be
always enduring. When for any reason this harmonious
relationship is disturbed, ill health results
ENVIRONMENTAL FACTORS contd.,
17
18. • PSYCHO SOCIAL ENVIRONMENT: It includes a
complex of psycho social factors which are defined as
“those factors affecting personal health, health care and
community, well-being that stem from the psychosocial
make-up of individuals and the structures and functions
of social groups”,
ENVIRONMENTAL FACTORS contd.,
18
19. • They include cultural values, customs, habits, beliefs,
attitudes, morals, religion, education, life styles, community
life, health services, social and political organization.
• The impact of social environment has both positive and
negative aspects on the health of individuals and
communities.
• A favourable social environment can improve health, provide
opportunities for man to achieve a sense of fulfilment, and
add to the quality of life.
ENVIRONMENTAL FACTORS contd.,
19
20. • It can also affect negatively man’s health and well-being.
For eg, poverty, urbanisation, migration, loss of
employment etc may produce feelings of anxiety,
depression, anger which may affect the physical health
manifested by physical symptoms like headache,
palpitations and sweating.
ENVIRONMENTAL FACTORS contd.,
20
22. • Man today is viewed as an agent of his own
diseases, his state of health is determined more
by what he does to himself than what some
outside germ or infectious agent does to him.
• The epidemiologist are so much concerned with
psychosocial environment as with physical or
biological environment in search of etiological
causes of disease
22
SUMMARY
23. REFERENCES
• K.PARK, “Essentials of Community Health
Nursing” Banarsidas Bhanot Publishers, 20th
edition
• Prof.Dr.E. Vijay, “Textbook of Community
Medicine” 2nd edition, Beacon zen publishers
• Kasthuri Sundar Rao, “Introduction to community
Health Nursing”, 4th edition B.I. Publications
23
24. EXPECTED QUESTIONS
Essay: (15 marks)
• Describe about the Epidemiological triad in detail
Short Notes: ( 5 marks)
• Explain about the approaches of epidemiology
• Discuss the Physical agents in detail
Short Answers:(2 marks)
• Draw epidemiological triad
• Mention the factors of environment
•State about the psycho social environment
24
24