EWMA 2014 - EP463 MANAGEMENT OF LYEEL SYNDROME (TEN)

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This document reports on a study of 5 cases of toxic epidermal necrolysis (TEN). TEN is a severe drug reaction that affects 1.8 people per million per year and has a high mortality rate of 25-70%. The study aimed to describe the interventions for 5 patients who developed TEN and were transferred to the intensive care unit. The patients' ages, triggering drugs, primary diagnoses, and body surface area affected are reported. The dressings were changed in the operating room using soft silicone dressings with silver to prevent infection. Linoleic acid and dermal matrices were also used. The average hospitalization was 33 days. The conclusion is that TEN is severe and early diagnosis is important, and new

Health & Medicine

Dr Luiz Gustavo Balaguer Cruz
Hospital 9 de Julho – São Paulo – Brazil
Dra Vania Declair Cohen
V.Declair Asses Tec Cient em Dermatol
MANAGEMENT OF LYEEL
SYNDROME (TEN)

 Introduction: TEN it is a severe idiosyncratic
drug reaction that affects overall 1.8 cases
per million people per year. Its mortality
rate is very high, reaching between 25 and
70% according to various authors.
 Aim: The aim of this study is to report 5
cases of TEN and describe the interventions
for each of these patients.
 Method: We follow five patients developed
TEN and all of them were transferred to
Intensive Care Unit with special care.
MANAGEMENT OF LYEEL
SYNDROME (TEN)

MANAGEMENT OF LYEEL
SYNDROME (TEN)
Age Drug Primary DH BSA
18 Antiretroviral HIV + 79%
4 Dipirone Mielomeningocele 88%
14 Metocloropramida BCP 70%
55 Alupurinol Reumatic / Cardiologic
disease
85%
60 ATB Leukemia 59%

 Result: The dressings were changed in the
operating room and soft silicone dressing
with silver was to prevent infection. Linoleic
acid was associated with silicone screen and
was applied to stimulate the granulation
tissue. Two patients received dermal matrix
in prime areas like hands, eyelids and
nipples. The average hospitalization was 33
days.
 Conclusion: The TEN is a severe disease and
early diagnosis is extremely important. The
use of new technologies is essential to the
survival of the patient.
MANAGEMENT OF LYEEL
SYNDROME (TEN)

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