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Lecture - 54
Endocrine System
Dr Shamshad
Majamaah University
KSA
Objectives
1. Define hormones and list the general functions of hormones in the body.
2. Classify hormones according to their chemical nature.
3. Outline the endocrine glands and exemplify some of their hormones.
4. Describe briefly the major mechanisms for hormone actions.
GUYTON & HALL Textbook of Medical Physiology, 12th ed. page: 881-882 & 886-891.
Definition
Hormone is a chemical substance secreted by ductless gland into the blood.
2: Neuroendocrine hormones are secreted by neurons into the circulating blood & influence
the function of target cells at another location in the body.
Ex: Thyroid, Insulin, Parathyroid ,Vasopressin, Steroids ,Estrogen Testosterone
Vasopressin, Oxytocin Growth hormone …etc.
1: Endocrine hormones are released by glands or specialized cells into the circulating blood
& influence the function of target cells at another location in the body.
1. Hypothalamus
2. Pineal gland
3. Pituitary gland
4. Thyroid gland
5. Parathyroid gland
6. Thymus
7. Adrenal glands
8. Pancreas
9. Kidneys
10. Stomach
11. Small intestine
12. Adipose tissue
13. Ovaries
14. Testis
15. Placenta
1
2
3
45
6
7
9
10
12
1113
1415
8
Endocrine glands
 Maintain Internal Homeostasis
 Support Cell Growth
 Coordinate Development
 Coordinate Reproduction
 Facilitate Responses to External Stimuli
Functions of Endocrine hormones
Main function: To integrate with Neural system of the body and thus
maintain the homeostasis of the body function
Hormone Source Action
Thyroid hormone Thyroid gland Controls basal metabolism in most tissues
Cortisol Adrenal cortex Energy metabolism, permissive action for other
hormones
Mineralocorticoids Adrenal cortex Regulate plasma volume via effects on serum
electrolytes
Vasopressin Posterior pituitary Regulate plasma osmolality via effects on
water excretion
Parathyroid hormone Parathyroid Regulates calcium and phosphorous levels
Major hormonal contributors to homeostasis
1: Proteins and polypeptides: Ant. pituitary hormone( GH,TSH etc.), post. Pituitary(ADH
Oxytocin), Pancreas :Insulin & glucagon and parathyroid gland:PTH.
2: Steroids: Adrenal cortex :cortisol & aldosterone,
Ovaries & placenta: estrogen and progesterone,
Testes :testosterone.
3. Derivatives of the amino acid tyrosine:
Thyroid gland: Thyroxine & triiodothyronine
Adrenal medullae :Epinephrine & norepinephrine.
Classification of hormones according to their chemical nature
1:Paracrines: are secreted by cells into the extracellular fluid and affect neighboring
target cells of a different type.
2: Autocrines: are secreted by cells into the extracellular fluid and affect the function of
the same cells that produced them.
3.Intracrine:
Based on distance of target cells
Mechanism of action of hormones
Mechanism of action of hormones
HORMONES THAT ACT MAINLY ON THE GENETIC MACHINERY OF THE CELL
Steroid Hormones Increase Protein Synthesis in the target cells.
These proteins then function as enzymes, transport proteins, or structural proteins,
which in turn provide other functions of the cells.
Full action of the steroid hormone is
delayed for at least 45 minutes—up
to several hours or even days.
Thyroid Hormones Increase Gene
Transcription in the Cell Nucleus
The cell membrane phospholipid
second messenger system by
which some hormones exert
their control of cell function.
Ex: DAG (diacylglycerol),
IP3(inositol triphosphate).
Water-soluble hormones:
Ex: peptides & catecholamines are dissolved in the plasma
Transported from their sites of synthesis to target tissues, where they diffuse out of the
capillaries, into the interstitial fluid, and ultimately to target cells.
TRANSPORT OF HORMONES IN THE BLOOD
Lipid-soluble hormones:
Ex: Steroid and thyroid hormones circulate in the blood mainly bound to plasma proteins.
Usually <10 % of steroid or thyroid hormones exists free form in the plasma .
Protein bound hormones cannot easily diffuse across the capillaries therefore biologically
inactive until they dissociate from plasma proteins.
Hormones bound to proteins serve as reservoirs, replenishing the concentration of free
hormones when they are bound to target receptors or lost from the circulation.
Binding of hormones to plasma proteins greatly slows their clearance from the plasma
Hormones are “cleared” from the plasma in several ways,
(1) Metabolic destruction by the tissues,
(2) Binding with the tissues,
(3) Excretion by the liver into the bile, and
(4) Excretion by the kidneys into the urine.
FEEDBACK CONTROL OF HORMONE SECRETION
Negative Feedback Prevents Over activity of Hormone Systems
Surges of Hormones Can Occur With Positive Feedback
Negative feedback Positive feedback

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Endocrine gland lecture

  • 1. Lecture - 54 Endocrine System Dr Shamshad Majamaah University KSA
  • 2. Objectives 1. Define hormones and list the general functions of hormones in the body. 2. Classify hormones according to their chemical nature. 3. Outline the endocrine glands and exemplify some of their hormones. 4. Describe briefly the major mechanisms for hormone actions. GUYTON & HALL Textbook of Medical Physiology, 12th ed. page: 881-882 & 886-891.
  • 3. Definition Hormone is a chemical substance secreted by ductless gland into the blood. 2: Neuroendocrine hormones are secreted by neurons into the circulating blood & influence the function of target cells at another location in the body. Ex: Thyroid, Insulin, Parathyroid ,Vasopressin, Steroids ,Estrogen Testosterone Vasopressin, Oxytocin Growth hormone …etc. 1: Endocrine hormones are released by glands or specialized cells into the circulating blood & influence the function of target cells at another location in the body.
  • 4. 1. Hypothalamus 2. Pineal gland 3. Pituitary gland 4. Thyroid gland 5. Parathyroid gland 6. Thymus 7. Adrenal glands 8. Pancreas 9. Kidneys 10. Stomach 11. Small intestine 12. Adipose tissue 13. Ovaries 14. Testis 15. Placenta 1 2 3 45 6 7 9 10 12 1113 1415 8 Endocrine glands
  • 5.  Maintain Internal Homeostasis  Support Cell Growth  Coordinate Development  Coordinate Reproduction  Facilitate Responses to External Stimuli Functions of Endocrine hormones Main function: To integrate with Neural system of the body and thus maintain the homeostasis of the body function
  • 6. Hormone Source Action Thyroid hormone Thyroid gland Controls basal metabolism in most tissues Cortisol Adrenal cortex Energy metabolism, permissive action for other hormones Mineralocorticoids Adrenal cortex Regulate plasma volume via effects on serum electrolytes Vasopressin Posterior pituitary Regulate plasma osmolality via effects on water excretion Parathyroid hormone Parathyroid Regulates calcium and phosphorous levels Major hormonal contributors to homeostasis
  • 7. 1: Proteins and polypeptides: Ant. pituitary hormone( GH,TSH etc.), post. Pituitary(ADH Oxytocin), Pancreas :Insulin & glucagon and parathyroid gland:PTH. 2: Steroids: Adrenal cortex :cortisol & aldosterone, Ovaries & placenta: estrogen and progesterone, Testes :testosterone. 3. Derivatives of the amino acid tyrosine: Thyroid gland: Thyroxine & triiodothyronine Adrenal medullae :Epinephrine & norepinephrine. Classification of hormones according to their chemical nature
  • 8. 1:Paracrines: are secreted by cells into the extracellular fluid and affect neighboring target cells of a different type. 2: Autocrines: are secreted by cells into the extracellular fluid and affect the function of the same cells that produced them. 3.Intracrine: Based on distance of target cells
  • 9.
  • 10.
  • 11.
  • 12. Mechanism of action of hormones
  • 13. Mechanism of action of hormones
  • 14. HORMONES THAT ACT MAINLY ON THE GENETIC MACHINERY OF THE CELL Steroid Hormones Increase Protein Synthesis in the target cells. These proteins then function as enzymes, transport proteins, or structural proteins, which in turn provide other functions of the cells. Full action of the steroid hormone is delayed for at least 45 minutes—up to several hours or even days.
  • 15. Thyroid Hormones Increase Gene Transcription in the Cell Nucleus
  • 16. The cell membrane phospholipid second messenger system by which some hormones exert their control of cell function. Ex: DAG (diacylglycerol), IP3(inositol triphosphate).
  • 17. Water-soluble hormones: Ex: peptides & catecholamines are dissolved in the plasma Transported from their sites of synthesis to target tissues, where they diffuse out of the capillaries, into the interstitial fluid, and ultimately to target cells. TRANSPORT OF HORMONES IN THE BLOOD
  • 18. Lipid-soluble hormones: Ex: Steroid and thyroid hormones circulate in the blood mainly bound to plasma proteins. Usually <10 % of steroid or thyroid hormones exists free form in the plasma . Protein bound hormones cannot easily diffuse across the capillaries therefore biologically inactive until they dissociate from plasma proteins. Hormones bound to proteins serve as reservoirs, replenishing the concentration of free hormones when they are bound to target receptors or lost from the circulation. Binding of hormones to plasma proteins greatly slows their clearance from the plasma
  • 19. Hormones are “cleared” from the plasma in several ways, (1) Metabolic destruction by the tissues, (2) Binding with the tissues, (3) Excretion by the liver into the bile, and (4) Excretion by the kidneys into the urine.
  • 20. FEEDBACK CONTROL OF HORMONE SECRETION Negative Feedback Prevents Over activity of Hormone Systems Surges of Hormones Can Occur With Positive Feedback Negative feedback Positive feedback