The endocrine system consists of glands that secrete hormones directly into the bloodstream to regulate distant target organs and tissues. The pituitary gland is called the "master gland" as it controls other endocrine glands by producing hormones that stimulate or inhibit their secretions. Disorders of the endocrine system can result from too little or too much hormone production and can have wide-ranging effects on the body if left untreated.
The thyroid and parathyroid glands are important endocrine glands located in the neck. The thyroid gland secretes thyroxine and calcitonin which regulate metabolism and calcium levels. Disorders can result from too little or too much secretion. The parathyroid glands secrete parathyroid hormone which regulates calcium levels in the blood by increasing calcium absorption and mobilizing calcium from bones. Disorders include hypocalcemia from low secretion or bone issues from high secretion.
Endocrine system & disorders, gland by glandjugafoce
The document discusses the endocrine system, which regulates body functions through hormones secreted into the bloodstream. It describes the major endocrine glands like the hypothalamus, pituitary gland, thyroid gland, parathyroid gland, thymus, adrenal gland, pancreas, testes and ovaries. It also discusses other tissues that contain endocrine cells like the kidneys, heart, digestive tract and placenta. The roles and hormones of each gland are explained in detail. Common endocrine disorders and the feedback control of hormone release are also summarized.
Hyperthyroidism and hypothyroidism are abnormalities in thyroid hormone secretion. Hyperthyroidism occurs when there is increased secretion of thyroid hormones from the thyroid gland. Common causes include Graves' disease, toxic goiter, and thyroid adenomas. Hypothyroidism occurs when there is decreased secretion of thyroid hormones. Cretinism refers to hypothyroidism in infants while myxedema refers to hypothyroidism in adults. Both can be caused by autoimmune disorders, iodine deficiency, or genetic defects. Signs and symptoms vary depending on the age of onset but include changes to metabolism, growth, and development.
The thyroid gland is located in the neck region and controls metabolism. It secretes the hormones thyroxine and triiodothyronine, which regulate functions like basal metabolic rate, protein synthesis, and development. Hypersecretion of thyroid hormones increases metabolism and weight loss, while hyposecretion decreases metabolism and causes weight gain. Conditions that result from thyroid hormone imbalances include hypothyroidism, which causes slowed functions, and hyperthyroidism like Graves' disease, which increases metabolic rate.
The document summarizes the thyroid gland and its hormone production. It discusses:
- The thyroid gland's location in the neck and its lobes/isthmus.
- The three hormones it produces: thyroxine, triiodothyronine, and calcitonin.
- The process of hormone biosynthesis, including iodine trapping, oxidation, thyroglobulin synthesis, iodination of tyrosine, and coupling reactions to form T3 and T4.
- Storage of hormones in thyroglobulin vesicles and their release into blood circulation.
This document summarizes various disorders of the endocrine system, including disorders of the anterior and posterior pituitary gland. It discusses conditions such as dwarfism, gigantism, diabetes insipidus, and Syndrome of Inappropriate ADH Secretion (SIADH). It provides information on causes, clinical features, diagnostic evaluations, and management approaches for each condition.
Hyperthyroidism is a condition where the thyroid gland is overactive and produces too much thyroid hormone, leading to accelerated metabolism. It can be caused by Graves' disease in most cases. Symptoms include nervousness, rapid heartbeat, weight loss, and eye problems. Treatment involves anti-thyroid medications, radioactive iodine, surgery or beta blockers to reduce thyroid hormone levels and symptoms.
The pituitary gland, also known as the hypophysis, acts as the control center for the endocrine system. It has an anterior and posterior lobe. The anterior lobe is controlled by hormones from the hypothalamus that stimulate or inhibit the release of hormones like growth hormone, thyroid stimulating hormone, and adrenocorticotropic hormone. These hormones target organs like the thyroid, adrenals, and liver. The posterior lobe stores and releases oxytocin and antidiuretic hormone which are produced in the hypothalamus. Pituitary tumors can cause hyperpituitarism by overproducing hormones or compressing the pituitary and decreasing hormone production.
The thyroid and parathyroid glands are important endocrine glands located in the neck. The thyroid gland secretes thyroxine and calcitonin which regulate metabolism and calcium levels. Disorders can result from too little or too much secretion. The parathyroid glands secrete parathyroid hormone which regulates calcium levels in the blood by increasing calcium absorption and mobilizing calcium from bones. Disorders include hypocalcemia from low secretion or bone issues from high secretion.
Endocrine system & disorders, gland by glandjugafoce
The document discusses the endocrine system, which regulates body functions through hormones secreted into the bloodstream. It describes the major endocrine glands like the hypothalamus, pituitary gland, thyroid gland, parathyroid gland, thymus, adrenal gland, pancreas, testes and ovaries. It also discusses other tissues that contain endocrine cells like the kidneys, heart, digestive tract and placenta. The roles and hormones of each gland are explained in detail. Common endocrine disorders and the feedback control of hormone release are also summarized.
Hyperthyroidism and hypothyroidism are abnormalities in thyroid hormone secretion. Hyperthyroidism occurs when there is increased secretion of thyroid hormones from the thyroid gland. Common causes include Graves' disease, toxic goiter, and thyroid adenomas. Hypothyroidism occurs when there is decreased secretion of thyroid hormones. Cretinism refers to hypothyroidism in infants while myxedema refers to hypothyroidism in adults. Both can be caused by autoimmune disorders, iodine deficiency, or genetic defects. Signs and symptoms vary depending on the age of onset but include changes to metabolism, growth, and development.
The thyroid gland is located in the neck region and controls metabolism. It secretes the hormones thyroxine and triiodothyronine, which regulate functions like basal metabolic rate, protein synthesis, and development. Hypersecretion of thyroid hormones increases metabolism and weight loss, while hyposecretion decreases metabolism and causes weight gain. Conditions that result from thyroid hormone imbalances include hypothyroidism, which causes slowed functions, and hyperthyroidism like Graves' disease, which increases metabolic rate.
The document summarizes the thyroid gland and its hormone production. It discusses:
- The thyroid gland's location in the neck and its lobes/isthmus.
- The three hormones it produces: thyroxine, triiodothyronine, and calcitonin.
- The process of hormone biosynthesis, including iodine trapping, oxidation, thyroglobulin synthesis, iodination of tyrosine, and coupling reactions to form T3 and T4.
- Storage of hormones in thyroglobulin vesicles and their release into blood circulation.
This document summarizes various disorders of the endocrine system, including disorders of the anterior and posterior pituitary gland. It discusses conditions such as dwarfism, gigantism, diabetes insipidus, and Syndrome of Inappropriate ADH Secretion (SIADH). It provides information on causes, clinical features, diagnostic evaluations, and management approaches for each condition.
Hyperthyroidism is a condition where the thyroid gland is overactive and produces too much thyroid hormone, leading to accelerated metabolism. It can be caused by Graves' disease in most cases. Symptoms include nervousness, rapid heartbeat, weight loss, and eye problems. Treatment involves anti-thyroid medications, radioactive iodine, surgery or beta blockers to reduce thyroid hormone levels and symptoms.
The pituitary gland, also known as the hypophysis, acts as the control center for the endocrine system. It has an anterior and posterior lobe. The anterior lobe is controlled by hormones from the hypothalamus that stimulate or inhibit the release of hormones like growth hormone, thyroid stimulating hormone, and adrenocorticotropic hormone. These hormones target organs like the thyroid, adrenals, and liver. The posterior lobe stores and releases oxytocin and antidiuretic hormone which are produced in the hypothalamus. Pituitary tumors can cause hyperpituitarism by overproducing hormones or compressing the pituitary and decreasing hormone production.
The document discusses several disorders of the pituitary gland including gigantism, acromegaly, Cushing's disease, dwarfism, acromicria, Simmond's disease, syndrome of inappropriate antidiuretic hormone secretion, diabetes insipidus, and dystrophia adiposogenitalis. It describes the causes, signs and symptoms, and characteristics of each disorder. The disorders result from hyperactivity or hypoactivity of the pituitary gland and can be caused by tumors, injuries, or genetic factors that impact hormone production and regulation.
The document provides information on thyroid disorders including:
- The thyroid gland regulates metabolism by producing thyroid hormones. Common disorders include hyperthyroidism (overactive thyroid), hypothyroidism (underactive thyroid), goiter (enlarged thyroid), and thyroid nodules.
- Hyperthyroidism causes an overactive thyroid and symptoms of rapid heartbeat. Common causes include Graves' disease and toxic nodules. Hypothyroidism is an underactive thyroid with symptoms like fatigue. Hashimoto's disease and thyroid removal commonly cause it.
- Goiter is an enlarged thyroid often due to iodine deficiency or inflammation. Thyroid nodules are abnormal growths that may be cancerous
This document summarizes several common heart disorders:
- Coronary heart disease is caused by plaque buildup in the coronary arteries, reducing blood flow to the heart. Atherosclerosis is a similar condition where plaques develop inside arterial walls.
- Chest pain called angina occurs due to insufficient blood supply to the heart. Arrhythmias happen when the heart's electrical system malfunctions, causing irregular heartbeats.
- Congestive heart failure occurs when the heart cannot pump enough blood to meet the body's needs. Other disorders discussed include stroke, myocardial infarction, hypotension, hypertension, rheumatic heart disease, and congenital heart disease. Risk factors and treatments are also outlined.
The thyroid gland is located in the neck below the larynx. It produces hormones that regulate metabolism. The document discusses hyperthyroidism and hypothyroidism, which are excess and insufficient thyroid hormone production respectively. Graves' disease is an autoimmune cause of hyperthyroidism where antibodies stimulate the thyroid gland to produce too much hormone. Symptoms of Graves' disease include weight loss, rapid heartbeat, anxiety, and bulging eyes. Treatment options include antithyroid medications, beta blockers, radioactive iodine therapy, or surgery to remove the thyroid gland.
This document outlines learning objectives and content for a lecture on endocrine glands and hormones. The objectives are to describe endocrine gland functions and hormones, diagnostic tests, and compare conditions affecting the thyroid, parathyroid, adrenal glands, and their management and nursing care. Key content covers the hypothalamus and pituitary glands, hormone chemistry and regulation, and conditions involving the thyroid, parathyroid and adrenal glands like hypothyroidism, Cushing's syndrome, and diabetes insipidus.
The document summarizes the key aspects of the endocrine system. It discusses the two main control systems - the nervous system and the endocrine system. It then focuses on the endocrine system, describing the endocrine glands and hormones. The mechanisms of hormone action and classifications of hormones are explained. Finally, it provides overviews of specific endocrine glands including the pituitary gland, thyroid gland, parathyroid glands, and adrenal glands.
The document summarizes the physiology of the thyroid gland. It discusses the anatomy of the thyroid gland, the synthesis and secretion of thyroid hormones, and the regulation of thyroid hormone secretion. It describes the major actions of thyroid hormones on metabolism, body systems, and growth. It also discusses diseases associated with underactivity and overactivity of the thyroid gland, such as hypothyroidism (underactivity) and hyperthyroidism (overactivity).
The document provides an overview of several endocrine system diseases. It discusses pituitary gland diseases like acromegaly which results in GH hypersecretion in adulthood causing disfiguring bone and tissue overgrowth. It also discusses thyroid diseases including Graves' disease, a common cause of hyperthyroidism, and hypothyroidism. The document also summarizes parathyroid diseases, adrenal diseases like Cushing's syndrome, diabetes mellitus, and diabetic emergencies.
Blood transports oxygen and carbon dioxide between the lungs and tissues. Oxygen is transported bound to hemoglobin as oxyhemoglobin (97%) and dissolved in plasma (3%). Carbon dioxide is transported as bicarbonates (70%) and carbamino compounds (23%). The binding of oxygen to hemoglobin depends on partial pressure of oxygen and is influenced by factors like carbon dioxide, pH, temperature and 2,3-BPG. The respiratory center in the brain stem regulates breathing in response to changes in carbon dioxide and hydrogen ion levels detected by central and peripheral chemoreceptors. Common respiratory disorders include asthma, emphysema, bronchitis, pneumonia and occupational lung diseases.
This document discusses disorders of the endocrine system, focusing on disorders of the pituitary gland, thyroid gland, parathyroid gland, adrenal cortex, and pancreatic islets. Key points covered include:
- Disorders of the anterior pituitary gland include acromegaly, gigantism, dwarfism, hyperprolactinemia, and Simmond's disease.
- Disorders of the thyroid gland include hyperthyroidism (Graves' disease and hypothyroidism (cretinism, myxedema). Goiter is also discussed.
- Disorders of the parathyroid glands include hyperparathyroidism and hypoparathyroidism.
- Disorders of the adren
The renin-angiotensin system (RAS) plays a key role in hypertension and other cardiovascular diseases. It involves renin cleaving angiotensinogen to form angiotensin I, which is then cleaved by ACE to form the active peptide angiotensin II. Angiotensin II causes vasoconstriction and sodium retention. RAS inhibitors like ACE inhibitors, ARBs, and direct renin inhibitors are used to treat hypertension and related conditions by blocking the formation or effects of angiotensin II. These drugs effectively lower blood pressure and protect organs but can cause side effects like cough, hypotension, and hyperkalemia.
A closed system of the heart and blood vessels
The heart pumps blood
Blood vessels allow blood to circulate to all parts of the body
The function of the cardiovascular system is to deliver oxygen and nutrients and to remove carbon dioxide and other waste products
A closed system of the heart and blood vessels
The heart pumps blood
Blood vessels allow blood to circulate to all parts of the body
The function of the cardiovascular system is to deliver oxygen and nutrients and to remove carbon dioxide and other waste products
Disorders of the pituitary gland can cause hyperpituitarism or hypopituitarism. Hyperpituitarism results from overproduction of hormones and can lead to gigantism, acromegaly, Cushing's syndrome, or inappropriate release of ADH. Hypopituitarism is caused by underproduction of hormones and can cause Sheehan's syndrome, dwarfism, or diabetes insipidus. Gigantism occurs in children and causes excessive growth, while acromegaly occurs after growth plates close and causes enlargement of extremities. Dwarfism is growth hormone deficiency in children leading to short stature. Diabetes insipidus is caused by ADH deficiency resulting in excessive ur
Blood pressure (BP) is the pressure exerted by circulating blood upon the walls of blood vessels and is one of the principal vital signs. When used without further specification, "blood pressure" usually refers to the arterial pressure of the systemic circulation, usually measured at a person's upper arm. A person’s blood pressure is usually expressed in terms of the systolic pressure over diastolic pressure and is measured in millimeters of mercury (mm Hg). Normal resting blood pressure for an adult is approximately 120/80 mm Hg.
The prostaglandins are lipids produced during tissue damage or infection that regulate processes like inflammation, blood flow, blood clotting, and childbirth. They act as vasodilators to lower blood pressure, cause inflammation at sites of injury to initiate healing, regulate contraction of gastrointestinal and respiratory muscles, and influence immune function, renal function, metabolism, and female reproduction such as ovulation and inducing labor. High or low levels of prostaglandins can impact health, so herbs, drugs, and hormones are used to regulate their levels.
Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age where the ovaries may develop numerous small fluid collections and fail to regularly release eggs. Women with PCOS often have irregular or prolonged menstrual periods and excess male hormone levels, which can cause irregular periods, excess facial/body hair growth, acne, and enlarged ovaries with cysts. The exact causes are unknown but may include excess insulin, low-grade inflammation, heredity, and excess androgen production. Complications can include infertility, gestational diabetes, miscarriage, nonalcoholic steatohepatitis, metabolic syndrome, type 2 diabetes, sleep apnea, depression, abnormal uterine bleeding, and obesity
The document summarizes the structure and function of blood vessels. It describes the three layers (tunics) that make up arteries and veins, as well as the single-layered endothelium of capillaries. It then compares different types of blood vessels, including elastic and muscular arteries, arterioles, venules and veins. It discusses the roles of each in conducting blood away from the heart in arteries and returning it to the heart in veins. It also describes the structure of capillaries and their role in exchanging materials with tissues.
Gestational diabetes (GDM) is glucose intolerance first identified during pregnancy. Risk factors include BMI over 30, previous large or diabetic baby, family history of diabetes. GDM is identified through a 75g oral glucose tolerance test. It is associated with risks like large baby, shoulder dystocia, preeclampsia. Treatment like insulin lowers risks. Other types of diabetes may present as GDM and require identification. Mild maternal hyperglycemia increases risks incrementally without a clear threshold.
A 22-year-old university student presents with symptoms of excessive thirst, drinking 20-25 glasses of water per day and waking up 5-6 times per night to pass urine. She is constipated but has a normal appetite and weight. The differential diagnoses are psychogenic polydipsia, diabetes mellitus, and diabetes insipidus. Diabetes insipidus is defined as the excretion of large volumes of dilute urine and can be central or nephrogenic in origin. Central diabetes insipidus results from a decreased secretion of antidiuretic hormone due to conditions affecting the hypothalamus or pituitary gland.
The document discusses several disorders of the pituitary gland including gigantism, acromegaly, Cushing's disease, dwarfism, acromicria, Simmond's disease, syndrome of inappropriate antidiuretic hormone secretion, diabetes insipidus, and dystrophia adiposogenitalis. It describes the causes, signs and symptoms, and characteristics of each disorder. The disorders result from hyperactivity or hypoactivity of the pituitary gland and can be caused by tumors, injuries, or genetic factors that impact hormone production and regulation.
The document provides information on thyroid disorders including:
- The thyroid gland regulates metabolism by producing thyroid hormones. Common disorders include hyperthyroidism (overactive thyroid), hypothyroidism (underactive thyroid), goiter (enlarged thyroid), and thyroid nodules.
- Hyperthyroidism causes an overactive thyroid and symptoms of rapid heartbeat. Common causes include Graves' disease and toxic nodules. Hypothyroidism is an underactive thyroid with symptoms like fatigue. Hashimoto's disease and thyroid removal commonly cause it.
- Goiter is an enlarged thyroid often due to iodine deficiency or inflammation. Thyroid nodules are abnormal growths that may be cancerous
This document summarizes several common heart disorders:
- Coronary heart disease is caused by plaque buildup in the coronary arteries, reducing blood flow to the heart. Atherosclerosis is a similar condition where plaques develop inside arterial walls.
- Chest pain called angina occurs due to insufficient blood supply to the heart. Arrhythmias happen when the heart's electrical system malfunctions, causing irregular heartbeats.
- Congestive heart failure occurs when the heart cannot pump enough blood to meet the body's needs. Other disorders discussed include stroke, myocardial infarction, hypotension, hypertension, rheumatic heart disease, and congenital heart disease. Risk factors and treatments are also outlined.
The thyroid gland is located in the neck below the larynx. It produces hormones that regulate metabolism. The document discusses hyperthyroidism and hypothyroidism, which are excess and insufficient thyroid hormone production respectively. Graves' disease is an autoimmune cause of hyperthyroidism where antibodies stimulate the thyroid gland to produce too much hormone. Symptoms of Graves' disease include weight loss, rapid heartbeat, anxiety, and bulging eyes. Treatment options include antithyroid medications, beta blockers, radioactive iodine therapy, or surgery to remove the thyroid gland.
This document outlines learning objectives and content for a lecture on endocrine glands and hormones. The objectives are to describe endocrine gland functions and hormones, diagnostic tests, and compare conditions affecting the thyroid, parathyroid, adrenal glands, and their management and nursing care. Key content covers the hypothalamus and pituitary glands, hormone chemistry and regulation, and conditions involving the thyroid, parathyroid and adrenal glands like hypothyroidism, Cushing's syndrome, and diabetes insipidus.
The document summarizes the key aspects of the endocrine system. It discusses the two main control systems - the nervous system and the endocrine system. It then focuses on the endocrine system, describing the endocrine glands and hormones. The mechanisms of hormone action and classifications of hormones are explained. Finally, it provides overviews of specific endocrine glands including the pituitary gland, thyroid gland, parathyroid glands, and adrenal glands.
The document summarizes the physiology of the thyroid gland. It discusses the anatomy of the thyroid gland, the synthesis and secretion of thyroid hormones, and the regulation of thyroid hormone secretion. It describes the major actions of thyroid hormones on metabolism, body systems, and growth. It also discusses diseases associated with underactivity and overactivity of the thyroid gland, such as hypothyroidism (underactivity) and hyperthyroidism (overactivity).
The document provides an overview of several endocrine system diseases. It discusses pituitary gland diseases like acromegaly which results in GH hypersecretion in adulthood causing disfiguring bone and tissue overgrowth. It also discusses thyroid diseases including Graves' disease, a common cause of hyperthyroidism, and hypothyroidism. The document also summarizes parathyroid diseases, adrenal diseases like Cushing's syndrome, diabetes mellitus, and diabetic emergencies.
Blood transports oxygen and carbon dioxide between the lungs and tissues. Oxygen is transported bound to hemoglobin as oxyhemoglobin (97%) and dissolved in plasma (3%). Carbon dioxide is transported as bicarbonates (70%) and carbamino compounds (23%). The binding of oxygen to hemoglobin depends on partial pressure of oxygen and is influenced by factors like carbon dioxide, pH, temperature and 2,3-BPG. The respiratory center in the brain stem regulates breathing in response to changes in carbon dioxide and hydrogen ion levels detected by central and peripheral chemoreceptors. Common respiratory disorders include asthma, emphysema, bronchitis, pneumonia and occupational lung diseases.
This document discusses disorders of the endocrine system, focusing on disorders of the pituitary gland, thyroid gland, parathyroid gland, adrenal cortex, and pancreatic islets. Key points covered include:
- Disorders of the anterior pituitary gland include acromegaly, gigantism, dwarfism, hyperprolactinemia, and Simmond's disease.
- Disorders of the thyroid gland include hyperthyroidism (Graves' disease and hypothyroidism (cretinism, myxedema). Goiter is also discussed.
- Disorders of the parathyroid glands include hyperparathyroidism and hypoparathyroidism.
- Disorders of the adren
The renin-angiotensin system (RAS) plays a key role in hypertension and other cardiovascular diseases. It involves renin cleaving angiotensinogen to form angiotensin I, which is then cleaved by ACE to form the active peptide angiotensin II. Angiotensin II causes vasoconstriction and sodium retention. RAS inhibitors like ACE inhibitors, ARBs, and direct renin inhibitors are used to treat hypertension and related conditions by blocking the formation or effects of angiotensin II. These drugs effectively lower blood pressure and protect organs but can cause side effects like cough, hypotension, and hyperkalemia.
A closed system of the heart and blood vessels
The heart pumps blood
Blood vessels allow blood to circulate to all parts of the body
The function of the cardiovascular system is to deliver oxygen and nutrients and to remove carbon dioxide and other waste products
A closed system of the heart and blood vessels
The heart pumps blood
Blood vessels allow blood to circulate to all parts of the body
The function of the cardiovascular system is to deliver oxygen and nutrients and to remove carbon dioxide and other waste products
Disorders of the pituitary gland can cause hyperpituitarism or hypopituitarism. Hyperpituitarism results from overproduction of hormones and can lead to gigantism, acromegaly, Cushing's syndrome, or inappropriate release of ADH. Hypopituitarism is caused by underproduction of hormones and can cause Sheehan's syndrome, dwarfism, or diabetes insipidus. Gigantism occurs in children and causes excessive growth, while acromegaly occurs after growth plates close and causes enlargement of extremities. Dwarfism is growth hormone deficiency in children leading to short stature. Diabetes insipidus is caused by ADH deficiency resulting in excessive ur
Blood pressure (BP) is the pressure exerted by circulating blood upon the walls of blood vessels and is one of the principal vital signs. When used without further specification, "blood pressure" usually refers to the arterial pressure of the systemic circulation, usually measured at a person's upper arm. A person’s blood pressure is usually expressed in terms of the systolic pressure over diastolic pressure and is measured in millimeters of mercury (mm Hg). Normal resting blood pressure for an adult is approximately 120/80 mm Hg.
The prostaglandins are lipids produced during tissue damage or infection that regulate processes like inflammation, blood flow, blood clotting, and childbirth. They act as vasodilators to lower blood pressure, cause inflammation at sites of injury to initiate healing, regulate contraction of gastrointestinal and respiratory muscles, and influence immune function, renal function, metabolism, and female reproduction such as ovulation and inducing labor. High or low levels of prostaglandins can impact health, so herbs, drugs, and hormones are used to regulate their levels.
Polycystic ovary syndrome (PCOS) is a hormonal disorder common among women of reproductive age where the ovaries may develop numerous small fluid collections and fail to regularly release eggs. Women with PCOS often have irregular or prolonged menstrual periods and excess male hormone levels, which can cause irregular periods, excess facial/body hair growth, acne, and enlarged ovaries with cysts. The exact causes are unknown but may include excess insulin, low-grade inflammation, heredity, and excess androgen production. Complications can include infertility, gestational diabetes, miscarriage, nonalcoholic steatohepatitis, metabolic syndrome, type 2 diabetes, sleep apnea, depression, abnormal uterine bleeding, and obesity
The document summarizes the structure and function of blood vessels. It describes the three layers (tunics) that make up arteries and veins, as well as the single-layered endothelium of capillaries. It then compares different types of blood vessels, including elastic and muscular arteries, arterioles, venules and veins. It discusses the roles of each in conducting blood away from the heart in arteries and returning it to the heart in veins. It also describes the structure of capillaries and their role in exchanging materials with tissues.
Gestational diabetes (GDM) is glucose intolerance first identified during pregnancy. Risk factors include BMI over 30, previous large or diabetic baby, family history of diabetes. GDM is identified through a 75g oral glucose tolerance test. It is associated with risks like large baby, shoulder dystocia, preeclampsia. Treatment like insulin lowers risks. Other types of diabetes may present as GDM and require identification. Mild maternal hyperglycemia increases risks incrementally without a clear threshold.
A 22-year-old university student presents with symptoms of excessive thirst, drinking 20-25 glasses of water per day and waking up 5-6 times per night to pass urine. She is constipated but has a normal appetite and weight. The differential diagnoses are psychogenic polydipsia, diabetes mellitus, and diabetes insipidus. Diabetes insipidus is defined as the excretion of large volumes of dilute urine and can be central or nephrogenic in origin. Central diabetes insipidus results from a decreased secretion of antidiuretic hormone due to conditions affecting the hypothalamus or pituitary gland.
This document discusses the management of various endocrine diseases in pregnancy, including hypothyroidism, hyperthyroidism, prolactinoma, and Addison's disease. It provides guidance on treatment, monitoring, risks of under-treatment, and complications for each condition. Case examples are presented and management strategies are outlined, emphasizing the importance of optimizing treatment to reduce risks while minimizing harm to the mother and fetus. Close monitoring is recommended for conditions like Graves' disease and prolactinoma.
This document provides information on endocrine disorders complicating pregnancy, focusing on gestational diabetes mellitus (GDM). It discusses the pathophysiology of GDM, risk factors, screening and diagnostic criteria, management including medical nutrition therapy, exercise, and insulin therapy if needed. Potential maternal and fetal complications of GDM are also outlined. The document emphasizes maintaining appropriate glycemic control during pregnancy, labor, and postpartum to minimize risks. Screening for and management of thyroid disorders during pregnancy are also briefly covered.
This document discusses endocrine disorders that can occur during pregnancy, including thyroid disorders, parathyroid disorders, adrenal disorders, and pituitary disorders. Some key points discussed include:
- Thyroid disorders are the most common endocrine disorders in pregnancy, with hypothyroidism and hyperthyroidism posing risks to maternal and fetal health if not properly treated.
- Gestational diabetes is the most common endocrinopathy in pregnancy overall.
- Parathyroid, adrenal, and pituitary disorders are less frequently encountered but can impact the mother and fetus if not managed appropriately.
- Physiologic changes during pregnancy can also impact the endocrine system and complicate diagnosis and treatment of disorders.
- Close
This document discusses various medical conditions that can complicate pregnancy, including diabetes mellitus, gestational diabetes, urinary tract infections, tuberculosis, thyroid disorders, and pulmonary disorders. It provides definitions, classifications, diagnostic criteria, management guidelines, and effects on pregnancy for each condition. Key points include screening and treatment recommendations for diabetes, criteria for diagnosing overt diabetes versus gestational diabetes, management of urinary tract infections and tuberculosis with antibiotics, and use of antithyroid medications like propylthiouracil to treat Graves disease during pregnancy.
The document discusses various physiological changes that occur in pregnancy across multiple body systems. The uterus increases dramatically in size from 70g and 10mL non-pregnant to approximately 1100g and 5L by the end of pregnancy. Hormonal changes include increased estrogen, progesterone, hCG, hPL, prolactin, IGF, and decreased hGH levels. This leads to adaptations in various organ systems like increased blood volume by 45%, enlarged heart and increased cardiac output, mild anemia and thrombocytopenia, immunosuppression to tolerate the fetus, and metabolic changes in carbohydrate and fat metabolism. Respiration is also altered to support higher oxygen demands.
The document discusses several endocrine disorders and conditions involving hormone imbalances. It covers disorders of the pituitary gland like gigantism and acromegaly caused by excess growth hormone, as well as diabetes insipidus caused by excess antidiuretic hormone. Disorders of the thyroid like Graves' disease, and of the adrenal glands like Cushing's syndrome and Addison's disease are also outlined. The effects and roles of various hormones produced by these and other endocrine glands like the pancreas and gonads are described.
The endocrine system controls homeostasis through hormone production and negative feedback loops. The major endocrine glands are the pituitary, thyroid, parathyroid, adrenals, pancreas, testes/ovaries. The pituitary regulates other glands and produces growth hormone, prolactin, TSH, ACTH, FSH, LH, and MSH. Thyroid hormones regulate metabolism. The adrenals produce corticosteroids and adrenaline. Gonadal and pancreatic hormones regulate reproduction and metabolism.
The document discusses the pituitary gland and pituitary diseases. It begins by providing an overview of the pituitary gland, noting that it is located at the base of the brain and controls other endocrine glands by releasing hormones into the bloodstream. It then discusses specific pituitary diseases including anterior and posterior pituitary hypofunction, as well as pituitary hyperfunction. Anterior pituitary hypofunction can be caused by tumors, vascular issues, or trauma/infection and results in hormone deficiencies. Posterior pituitary hypofunction impacts antidiuretic hormone and causes diabetes insipidus. Pituitary hyperfunction includes excess secretion of hormones like prolactin, growth hormone, ACTH, and TSH, leading to conditions such as acromegaly, Cushing
The document provides an overview of the endocrine system, including:
- The endocrine system uses hormones to regulate bodily functions through slower chemical signaling compared to the nervous system.
- Major endocrine glands include the pituitary, thyroid, parathyroid, adrenal, pancreas, ovaries/testes, thymus, placenta, and pineal glands.
- Hormone secretion is regulated by negative and positive feedback loops to maintain homeostasis. Endocrine disorders can result from too much or too little hormone production.
The document summarizes the endocrine system and its major glands. It discusses how the hypothalamus and posterior pituitary gland work together to secrete antidiuretic hormone and oxytocin. It also explains how the hypothalamus and anterior pituitary gland interact via releasing and inhibiting hormones to regulate hormones like ACTH, TSH, FSH, LH and prolactin. Additionally, it describes the pancreatic islets of Langerhans and how they secrete insulin and glucagon to regulate blood sugar levels. Finally, it provides overviews of the adrenal glands, thyroid gland, parathyroid glands, testes and ovaries and their key hormonal functions.
The endocrine system controls many body functions through hormones secreted by endocrine glands. The major glands include the hypothalamus, pituitary, thyroid, parathyroids, adrenals, pancreas, ovaries and testes. The hypothalamus and pituitary gland work together to regulate other glands. The pituitary gland, located at the base of the brain, is called the "master gland" as it controls other glands by producing hormones that stimulate or inhibit their secretions. Hormones travel through the bloodstream to target organs, where they control processes like metabolism, growth, development, and stress response. Hormone levels are regulated through a negative feedback system to prevent over or under secretion.
The adrenal glands are paired organs that sit atop the kidneys. Each consists of an outer adrenal cortex and inner adrenal medulla. The cortex secretes corticosteroids like aldosterone and cortisol to regulate electrolytes and metabolism. The medulla secretes epinephrine and norepinephrine to increase heart rate and metabolism during stress. The thyroid gland regulates metabolism through thyroxine (T4) and triiodothyronine (T3) production. Hypothyroidism causes low metabolism while hyperthyroidism elevates it. The parathyroid glands secrete parathyroid hormone to regulate blood calcium levels.
The endocrine system uses glands and hormones to regulate processes in the body through chemical messages released into the bloodstream. Major glands include the pituitary, thyroid, parathyroid, adrenal, pancreas, gonads and reproductive organs. Endocrine disorders occur when glands under-produce or over-produce hormones, or grow abnormally, and can cause issues like hypothyroidism, polycystic ovary syndrome, or non-toxic goiter.
The document discusses the endocrine system in humans and other chordates. It describes the major endocrine glands and hormones, including the hypothalamus, pituitary gland, thyroid gland, parathyroid gland, adrenal glands, gonads, and others. It explains how the hypothalamus controls the pituitary gland to regulate hormone release, and the functions of key hormones like growth hormone, thyroid hormones, insulin, estrogen, and testosterone.
The document summarizes the key roles and functions of the endocrine system. It explains that the hypothalamus monitors body conditions and signals the pituitary gland if changes are needed. The pituitary gland is the "master gland" that then signals other endocrine glands to produce hormones in response. The hormones travel through the bloodstream and target specific cells and tissues to regulate processes like metabolism, growth, reproduction, and stress response. The document provides details on the hormones produced by the pituitary gland, thyroid gland, parathyroid glands, pancreas, ovaries, testes, adrenal glands, and pineal gland and their functions in controlling processes such as blood sugar levels, calcium regulation, sexual development, and the fight
The document summarizes key aspects of the endocrine system. It describes how the endocrine system is composed of glands that secrete hormones directly into the bloodstream to regulate distant target tissues. It provides details about major endocrine glands like the pituitary gland, thyroid gland, parathyroid glands, adrenal glands, and how they regulate important body functions through negative feedback loops and secretion of hormones like thyroid hormones, growth hormone, cortisol, and others. It also explains the different types of stimuli that regulate hormone release and the chemical nature of hormones.
Anatomy and physiology of endocrine system by Simhachalam K L VLVSimhachalam
The endocrine system is comprised of glands that secrete hormones directly into the bloodstream to regulate functions in target organs. The major endocrine glands include the hypothalamus, pituitary gland, pineal gland, thyroid gland, parathyroid glands, thymus gland, adrenal glands, pancreas, ovaries, and testes. Hormones control metabolism, growth and development, reproduction, and the body's response to stress. Imbalances in hormone levels can lead to disorders that may be treated by controlling hormone production or utilization.
The endocrine system coordinates activities through chemical messengers called hormones. It consists of endocrine glands that secrete hormones directly into the bloodstream. The hypothalamus and pituitary gland regulate many other endocrine glands. The thyroid gland regulates metabolism through thyroxine and calcitonin regulates calcium levels. The parathyroid glands work with the thyroid to maintain calcium homeostasis through PTH. The adrenal glands produce hormones like adrenaline for the fight-or-flight response. The pancreas regulates blood sugar through insulin and glucagon. The gonads produce sex hormones like testosterone and estrogen.
The document summarizes the key endocrine glands and hormones in the human body. It describes the endocrine system and its role in producing hormones that regulate important bodily functions like growth, metabolism, mood, and reproduction. It provides details on the primary glands - the pituitary, thyroid, parathyroids, adrenals, pancreas, ovaries/testes - and their hormone products like growth hormone, thyroid hormones, insulin, estrogen/progesterone, and testosterone.
Anatomy and Physiology of Endocrine Systemiffat aisha
The document provides an overview of the endocrine system, including:
1) It describes the endocrine system as made up of glands that secrete hormones like the pituitary, thyroid, parathyroid, adrenals and reproductive organs.
2) It explains hormones regulate important bodily functions such as growth, metabolism, mood, and reproduction. Disruptions in hormone levels can cause disorders.
3) Key glands and their hormone secretions involved in growth, calcium regulation, metabolism, stress response, and sexual development/functioning are detailed.
The endocrine system helps regulate body activities through hormones. The hypothalamus and pituitary gland control other endocrine glands like the thyroid, parathyroid, adrenals, pancreas, gonads, thymus and pineal gland. The hypothalamus secretes hormones that signal the pituitary gland, which then secretes hormones that signal other glands. These glands secrete hormones like insulin, glucagon, thyroid hormones, estrogen and testosterone to regulate processes in the body including metabolism, growth, reproduction and behavior. Hormone levels are regulated through feedback mechanisms to maintain homeostasis.
The document discusses the endocrine system and hormone-secreting glands. It describes the major endocrine glands including the hypothalamus and pituitary gland, thyroid gland, pancreas, adrenal glands, gonads, and pineal gland. It also discusses the suffixes -crine, meaning to secrete, and -dipsia, meaning thirst, as well as hormones and their roles in regulating processes like metabolism, growth, sexual development, and blood sugar levels.
This document discusses the endocrine system. It begins by defining hormones and describing their roles in regulating metabolism, growth, development, and homeostasis. It describes the mechanisms of hormone secretion and action, including negative and positive feedback loops. It provides details on the major endocrine glands - the hypothalamus, pituitary gland, thyroid gland, parathyroid glands, adrenal glands, and pancreas. It discusses hormone classification, disorders of hormone imbalance, and regulation of hormone production and release in the body.
Similar to Endocrine basic and advanced by dr ashvini jakhar (20)
Chapter wise All Notes of First year Basic Civil Engineering.pptxDenish Jangid
Chapter wise All Notes of First year Basic Civil Engineering
Syllabus
Chapter-1
Introduction to objective, scope and outcome the subject
Chapter 2
Introduction: Scope and Specialization of Civil Engineering, Role of civil Engineer in Society, Impact of infrastructural development on economy of country.
Chapter 3
Surveying: Object Principles & Types of Surveying; Site Plans, Plans & Maps; Scales & Unit of different Measurements.
Linear Measurements: Instruments used. Linear Measurement by Tape, Ranging out Survey Lines and overcoming Obstructions; Measurements on sloping ground; Tape corrections, conventional symbols. Angular Measurements: Instruments used; Introduction to Compass Surveying, Bearings and Longitude & Latitude of a Line, Introduction to total station.
Levelling: Instrument used Object of levelling, Methods of levelling in brief, and Contour maps.
Chapter 4
Buildings: Selection of site for Buildings, Layout of Building Plan, Types of buildings, Plinth area, carpet area, floor space index, Introduction to building byelaws, concept of sun light & ventilation. Components of Buildings & their functions, Basic concept of R.C.C., Introduction to types of foundation
Chapter 5
Transportation: Introduction to Transportation Engineering; Traffic and Road Safety: Types and Characteristics of Various Modes of Transportation; Various Road Traffic Signs, Causes of Accidents and Road Safety Measures.
Chapter 6
Environmental Engineering: Environmental Pollution, Environmental Acts and Regulations, Functional Concepts of Ecology, Basics of Species, Biodiversity, Ecosystem, Hydrological Cycle; Chemical Cycles: Carbon, Nitrogen & Phosphorus; Energy Flow in Ecosystems.
Water Pollution: Water Quality standards, Introduction to Treatment & Disposal of Waste Water. Reuse and Saving of Water, Rain Water Harvesting. Solid Waste Management: Classification of Solid Waste, Collection, Transportation and Disposal of Solid. Recycling of Solid Waste: Energy Recovery, Sanitary Landfill, On-Site Sanitation. Air & Noise Pollution: Primary and Secondary air pollutants, Harmful effects of Air Pollution, Control of Air Pollution. . Noise Pollution Harmful Effects of noise pollution, control of noise pollution, Global warming & Climate Change, Ozone depletion, Greenhouse effect
Text Books:
1. Palancharmy, Basic Civil Engineering, McGraw Hill publishers.
2. Satheesh Gopi, Basic Civil Engineering, Pearson Publishers.
3. Ketki Rangwala Dalal, Essentials of Civil Engineering, Charotar Publishing House.
4. BCP, Surveying volume 1
Philippine Edukasyong Pantahanan at Pangkabuhayan (EPP) CurriculumMJDuyan
(𝐓𝐋𝐄 𝟏𝟎𝟎) (𝐋𝐞𝐬𝐬𝐨𝐧 𝟏)-𝐏𝐫𝐞𝐥𝐢𝐦𝐬
𝐃𝐢𝐬𝐜𝐮𝐬𝐬 𝐭𝐡𝐞 𝐄𝐏𝐏 𝐂𝐮𝐫𝐫𝐢𝐜𝐮𝐥𝐮𝐦 𝐢𝐧 𝐭𝐡𝐞 𝐏𝐡𝐢𝐥𝐢𝐩𝐩𝐢𝐧𝐞𝐬:
- Understand the goals and objectives of the Edukasyong Pantahanan at Pangkabuhayan (EPP) curriculum, recognizing its importance in fostering practical life skills and values among students. Students will also be able to identify the key components and subjects covered, such as agriculture, home economics, industrial arts, and information and communication technology.
𝐄𝐱𝐩𝐥𝐚𝐢𝐧 𝐭𝐡𝐞 𝐍𝐚𝐭𝐮𝐫𝐞 𝐚𝐧𝐝 𝐒𝐜𝐨𝐩𝐞 𝐨𝐟 𝐚𝐧 𝐄𝐧𝐭𝐫𝐞𝐩𝐫𝐞𝐧𝐞𝐮𝐫:
-Define entrepreneurship, distinguishing it from general business activities by emphasizing its focus on innovation, risk-taking, and value creation. Students will describe the characteristics and traits of successful entrepreneurs, including their roles and responsibilities, and discuss the broader economic and social impacts of entrepreneurial activities on both local and global scales.
Leveraging Generative AI to Drive Nonprofit InnovationTechSoup
In this webinar, participants learned how to utilize Generative AI to streamline operations and elevate member engagement. Amazon Web Service experts provided a customer specific use cases and dived into low/no-code tools that are quick and easy to deploy through Amazon Web Service (AWS.)
Elevate Your Nonprofit's Online Presence_ A Guide to Effective SEO Strategies...TechSoup
Whether you're new to SEO or looking to refine your existing strategies, this webinar will provide you with actionable insights and practical tips to elevate your nonprofit's online presence.
Andreas Schleicher presents PISA 2022 Volume III - Creative Thinking - 18 Jun...EduSkills OECD
Andreas Schleicher, Director of Education and Skills at the OECD presents at the launch of PISA 2022 Volume III - Creative Minds, Creative Schools on 18 June 2024.
2. Endocrine Glands Controls many body functions exerts control by releasing special chemical substances into the blood called hormones Hormones affect other endocrine glands or body systems Ductless glands Secrete hormones directly into bloodstream Hormones are quickly distributed by bloodstream throughout the body
3. Hormones Chemicals produced by endocrine glands Act on target organs elsewhere in body Control/coordinate widespread processes: Homeostasis Reproduction Growth & Development Metabolism Response to stress Overlaps with the Sympathetic Nervous System
4. Hormones Hormones are classified as: Proteins Polypeptides (amino acid derivatives) Lipids (fatty acid derivatives or steroids)
5. Hormones Amount of hormone reaching target tissue directly correlates with concentration of hormone in blood. Constant level hormones Thyroid hormones Variable level hormones Epinephrine (adrenaline) release Cyclic level hormones Reproductive hormones
6. The Endocrine System Consists of several glands located in various parts of the body Specific Glands Hypothalamus Pituitary Thyroid Parathyroid Adrenal Kidneys Pancreatic Islets Ovaries Testes
7. Pituitary Gland Small gland located on stalk hanging from base of brain - AKA “The Master Gland” Primary function is to control other glands. Produces many hormones. Secretion is controlled by hypothalamus in base of brain.
8. Pituitary Gland Two areas Anterior Pituitary Posterior Pituitary Structurally, functionally different
9. Pituitary Gland Anterior Pituitary Thyroid-Stimulating Hormone (TSH) stimulates release of hormones from Thyroid thyroxine (T4) and triiodothyronine (T3): stimulate metabolism of all cells calcitonin: lowers the amount of calcium in the blood by inhibiting breakdown of bone released when stimulated by TSH or cold abnormal conditions hyperthyroidism: too much TSH release hypothyroidism: too little TSH release
10. Pituitary Gland Anterior Pituitary Growth Hormone (GH) stimulates growth of all organs and increases blood glucose concentration decreases glucose usage increases consumption of fats as an energy source Adreno-Corticotrophic Hormone (ACTH) stimulates the release of adrenal cortex hormones
11. Pituitary Gland Anterior Pituitary Follicle Stimulating Hormone (FSH) females - stimulates maturation of ova; release of estrogen males - stimulates testes to grow; produce sperm Luteinizing Hormone (LH) females - stimulates ovulation; growth of corpus luteum males - stimulates testes to secrete testosterone
12. Pituitary Gland Anterior Pituitary Prolactin stimulates breast development during pregnancy; milk production after delivery Melanocyte Stimulating Hormone (MSH) stimulates synthesis, dispersion of melanin pigment in skin
13. Pituitary Gland Posterior Pituitary Stores, releases two hormones produced in hypothalamus Antidiuretic hormone (ADH) Oxytocin
14. Pituitary Gland Posterior Pituitary Antidiuretic hormone (ADH) Stimulates water retention by kidneys reabsorb sodium and water Abnormal conditions Undersecretion: diabetes insipidus (“water diabetes”) Oversecretion: Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Oxytocin Stimulates contraction of uterus at end of pregnancy (Pitocin®); release of milk from breast
15. Hypothalamus Produces several releasing and inhibiting factors that stimulate or inhibit anterior pituitary’s secretion of hormones. Produces hormones that are stored in and released from posterior pituitary What are these two hormones?
16. Hypothalamus Also responsible for: Regulation of water balance Esophageal swallowing Body temperature regulation (shivering) Food/water intake (appetite) Sleep-wake cycle Autonomic functions
17. Pineal Gland Located within the Diencephalon Melatonin Inhibits ovarian hormones May regulate the body’s internal clock
18. Thyroid Located below larynx and low in neck Not over the thyroid cartilage Thyroxine (T4) and Triiodothyronine (T3) Stimulate metabolism of all cells Calcitonin Decreases blood calcium concentration by inhibiting breakdown of bone
19. Parathyroids Located on posterior surface of thyroid Frequently damaged during thyroid surgery Parathyroid hormone (PTH) Stimulates Ca2+ release from bone Promotes intestinal absorption and renal tubular reabsorption of calcium
22. Thymus Gland Located in anterior chest Normally absent by ~ age 4 Promotes development of immune-system cells (T-lymphocytes)
23. Adrenal Glands Small glands located near (ad) the kidneys (renals) Consists of: outer cortex inner medulla
24. Adrenal Glands Adrenal Medulla the Adrenal Medulla secretes the catecholamine hormones norepinephrine and epinephrine Epinephrine and Norepinephrine Prolong and intensify the sympathetic nervous system response during stress
25. Adrenal Glands Adrenal Cortex Aldosterone (Mineralocorticoid) Regulates electrolyte (potassium, sodium) and fluid homeostasis Cortisol (Glucocorticoids) Antiinflammatory, anti-immunity, and anti-allergy effects. Increases blood glucose concentrations Androgens (Sex Hormones) Stimulate sexual drive in females
26. Adrenal Glands Adrenal Cortex Glucocorticoids accounts for 95% of adrenal cortex hormone production the level of glucose in the blood Released in response to stress, injury, or serious infection - like the hormones from the adrenal medulla
27. Adrenal Glands Adrenal Cortex Mineralcorticoids work to regulate the concentration of potassium and sodium in the body
28. Ovaries Located in the abdominal cavity adjacent to the uterus Under the control of LH and FSH from the anterior pituitary Produce eggs for reproduction Produce hormones estrogen progesterone Functions include sexual development and preparation of the uterus for implantation of the egg
29. Ovaries Estrogen Development of female secondary sexual characteristics Development of endometrium Progesterone Promotes conditions required for pregnancy Stabilization of endometrium
30. Testes Located in the scrotum Controlled by anterior pituitary hormones FSH and LH Produce sperm for reproduction Produce testosterone - promotes male growth and masculinization promotes development and maintenance of male sexual characteristics
31. Pancreas Located in retroperitoneal space between duodenum and spleen Has both endocrine and exocrine functions Exocrine Pancreas Secretes key digestive enzymes Endocrine Pancreas Alpha Cells - glucagon production Beta Cells - insulin production Delta Cells - somatostatin production
42. Abnormal Thyroid Function Hypothyroidism Too little thyroid hormone Hyperthyroidism(Thyrotoxicosis / Thyroid Storm) Too much thyroid hormone
43. Hypothyroidism Thyroid hormone deficiency causing a decrease in the basal metabolic rate Person is “slowed down” Causes of Hypothyroidism: Radioactive iodine ablation Non-compliance with levothyroxine Hashimoto’s thyroiditis - autoimmune destruction
44. Hypothyroidism Confusion, drowsiness, coma Cold intolerant Hypotension, Bradycardia Muscle weakness Decreased respirations Weight gain, Constipation Non-pitting peripheral edema Depression Facial edema, loss of hair Dry, coarse skin Appearance of Myxedema
64. Thyroid Storm/Thyrotoxicosis Severe form of hyperthyroidism that can be fatal Acute life-threatening hyperthyroidism Cause Increased physiological stress in hyperthyroid patients
65. Thyroid Storm/Thyrotoxicosis Severe tachycardia Heart Failure Dysrhythmias Shock Hyperthermia Abdominal pain Restlessness, Agitation, Delirium, Coma
78. Hyperadrenalism Adrenogenital syndrome “Bearded Lady” Group of disorders caused by adrenocortical hyperplasia or malignant tumors Excessive secretion of adrenocortical steroids especially those with androgenic or estrogenic effects Characterized by masculinization of women feminization of men premature sexual development of children
79. Hyperadrenalism Cushing’s Syndrome Results from increased adrenocortical secretion of cortisol Causes include: ACTH-secreting tumor of the pituitary (Cushing’s disease) excess secretion of ACTH by a neoplasm within the adrenal cortex excess secretion of ACTH by a malignant growth outside the adrenal gland excessive or prolonged administration of steroids
81. Hyperadrenalism Cushing’s Disease Too much adrenal hormone production adrenal hyperplasia caused by an ACTH secreting adenoma of the pituitary “Cushingoid features” striae on extremities or abdomen moon face buffalo hump weight gain with truncal obesity personality changes, irritable
82. Hyperadrenalism Cushing’s Syndrome Management Airway/Ventilation/Oxygen Supportive care Assess for cardiovascular event requiring treatment severe hypertension myocardial ischemia
84. Hyperadrenalism Pheochromocytoma Management Supportive care based upon presentation Airway/Ventilation/Oxygen Calm/Reassure Assess blood glucose Consider beta blocking agent - Labetalol Consider benzodiazepines
85. Hypoadrenalism Adrenal Insufficiency decrease production of glucocorticoids, mineralcorticoids and androgens Causes Primary adrenal failure (Addison’s Disease) Infection (TB, fungal, Meningococcal) AIDS Prolonged steroid use
86. Hypoadrenalism Presentation Hypotension, Shock Hyponatremia, Hyperkalemia Progressive Muscle weakness Progressive weight loss and anorexia Skin hyperpigmentation areas exposed to sun, pressure points, joints and creases Arrhythmias Hypoglycemia N/V/D
87. Hypoadrenalism Management Airway/Ventilation/Oxygen ECG monitor IV fluids Assess blood glucose - D50 if hypoglycemic Steroids hydrocortisone or dexamethasone florinef (mineralcorticoid) Vasopressors if unresponsive to IV fluids
89. Diabetes Mellitus Chronic metabolic disease One of the most common diseases in North America Affects 5% of USA population (12 million people) Results in insulin secretion by the Beta () cells of the islets of Langerhans in the pancreas, AND/OR Defects in insulin receptors on cell membranes leading to cellular resistance to insulin Leads to an risk for significant cardiovascular, renal and ophthalmic disease
90. Regulation of Glucose Dietary Intake Components of food: Carbohydrates Fats Proteins Vitamins Minerals
91. Regulation of Glucose The other 3 major food sources for glucose are carbohydrates proteins fats Most sugars in the human diet are complex and must be broken down into simple sugars: glucose, galactose and fructose - before use
92. Regulation of Glucose Carbohydrates Found in sugary, starchy foods Ready source of near-instant energy If not “burned” immediately by body, stored in liver and skeletal muscle as glycogen (short-term energy) or as fat (long-term energy needs) After normal meal, approximately 60% of the glucose is stored in liver as glycogen
93. Regulation of Glucose Fats Broken down into fatty acids and glycerol by enzymes Excess fat stored in liver or in fat cells (under the skin)
94. Regulation of Glucose Pancreatic hormones are required to regulate blood glucose level glucagon released by Alpha () cells insulin released by Beta Cells () somatostatin released by Delta Cells ()
95. Regulation of Glucose Alpha () cells release glucagon to control blood glucose level When blood glucose levels fall, cells the amount of glucagon in the blood The surge of glucagon stimulates liver to release glucose stores by the breakdown of glycogen into glucose (glycogenolysis) Also, glucagon stimulates the liver to produce glucose (gluconeogenesis)
96. Regulation of Glucose Beta Cells () release insulin (antagonistic to glucagon) to control blood glucose level Insulin the rate at which various body cells take up glucose insulin lowers the blood glucose level Promotes glycogenesis - storage of glycogen in the liver Insulin is rapidly broken down by the liver and must be secreted constantly
97. Regulation of Glucose Delta Cells () produce somatostatin, which inhibits both glucagon and insulin inhibits insulin and glucagon secretion by the pancreas inhibits digestion by inhibiting secretion of digestive enzymes inhibits gastric motility inhibits absorption of glucose in the intestine
98. Regulation of Glucose Breakdown of sugars carried out by enzymes in the GI system As simple sugars, they are absorbed from the GI system into the body To be converted into energy, glucose must first be transmitted through the cell membrane Glucose molecule is too large and does not readily diffuse
99. Regulation of Glucose Glucose must pass into the cell by binding to a special carrier protein on the cell’s surface. Facilitated diffusion - carrier protein binds with the glucose and carries it into the cell. The rate at which glucose can enter the cell is dependent upon insulin levels Insulin serves as the messenger - travels via blood to target tissues Combines with specific insulin receptors on the surface of the cell membrane
100. Regulation of Glucose Body strives to maintain blood glucose between 60 mg/dl and 120 mg/dl. Glucose brain is the biggest user of glucose in the body sole energy source for brain brain does not require insulin to utilize glucose
101. Regulation of Glucose Insulin Glucagon Glucagon and Insulin are opposites (antagonists) of each other.
102. Regulation of Glucose Glucagon Released in response to: Sympathetic stimulation Decreasing blood glucose concentration Acts primarily on liver to increase rate of glycogen breakdown Increasing blood glucose levels have inhibitory effect on glucagon secretion
103. Regulation of Glucose Insulin Released in response to: Increasing blood glucose concentration Parasympathetic innervation Acts on cell membranes to increase glucose uptake from blood stream Promotes facilitated diffusion of glucose into cells
104. Diabetes Mellitus 2 Types historically based on age of onset (NOT insulin vs. non-insulin) Type I juvenile onset insulin dependent Type II historically adult onset now some morbidly obese children are developing Type II diabetes non-insulin dependent may progress to insulin dependency
106. Pathophysiology of Type I Diabetes Mellitus Characterized by inadequate or absent production of insulin by pancreas Usually presents by age 25 Strong genetic component Autoimmune features body destroys own insulin-producing cells in pancreas may follow severe viral illness or injury Requires lifelong treatment with insulin replacement
107. Pathophysiology of Type II Diabetes Mellitus Pancreas continues to produce some insulin however disease results from combination of: Relative insulin deficiency Decreased sensitivity of insulin receptors Onset usually after age 25 in overweight adults Some morbidly obese children develop Type II diabetes Familial component Usually controlled with diet, weight loss, oral hypoglycemic agents Insulin may be needed at some point in life
109. Gestational Diabetes Mellitus Occurs during pregnancy Usually resolves after delivery Occurs rarely in non-pregnant women on BCPs Increased estrogen, progesterone antagonize insulin
110. Presentation of New Onset Diabetes Mellitus 3 Ps Polyuria Polydipsia Polyphagia Blurred vision, dizziness, altered mental status Rapid weight loss Warm dry skin, Weakness, Tachycardia, Dehydration
111. Long Term Treatment of Diabetes Mellitus Diet regulation e.g. 1400 calorie ADA diet Exercise increase patient’s glucose metabolism Oral hypoglycemic agents Sulfonylureas Insulin Historically produced from pigs (porcine insulin) Currently genetic engineering has lead to human insulin (Humulin)
112. Long Term Treatment ofDiabetes Mellitus Insulin Available in various forms distinguished on onset and duration of action Onset rapid (Regular, Semilente, Novolin 70/30) intermediate (Novolin N, Lente) slow (Ultralente) Duration short, 5-7 hrs (Regular) intermediate, 18-24 hrs (Semilente, Novolin N, Lente, NPH) long-acting, 24 - 36+ hrs (Novolin 70/30, Ultralente)
113. Long Term Treatment ofDiabetes Mellitus Insulin Must be given by injection as insulin is protein which would be digested if given orally extremely compliant patients may use an insulin pump which provides a continuous dose current research studying inhaled insulin form
114. Long Term Treatment of Diabetes Mellitus Oral Hypoglycemic Agents Stimulate the release of insulin from the pancreas, thus patient must still have intact beta cells in the pancreas. Common agents include: Glucotrol® (glipizide) Micronase® or Diabeta® (glyburide) Glucophage® (metformin) [Not a sulfonylurea]
116. Hyperglycemia Defined as blood glucose > 200 mg/dl Causes Failure to take medication (insulin) Increased dietary intake Stress (surgery, MI, CVA, trauma) Fever Infection Pregnancy (gestational diabetes)
117. Hyperglycemia Two hyperglycemic diabetic states may occur Diabetic Ketoacidosis (DKA) Hyperglycemic Hyperosmolar Non-ketotic Coma (HHNC)
118. Diabetic Ketoacidosis (DKA) Occurs in Type I diabetics (insulin dependency) Usually associated with blood glucose level in the range of 200 - 600 mg/dl No insulin availability results in ketoacidosis
119. Diabetic Ketoacidosis (DKA) Pathophysiology Results from absence of insulin prevents glucose from entering the cells leads to glucose accumulation in the blood Cells become starved for glucose and begin to use other energy sources (primarily fats) Fat metabolism generates fatty acids Further metabolized into ketoacids (ketone bodies)
120. Diabetic Ketoacidosis (DKA) Pathophysiology (cont) Blood sugar rises above renal threshold for reabsorption (blood glucose > 180 mg/dl) glucose “spills” into the urine Loss of glucose in urine causes osmotic diuresis Results in dehydration acidosis electrolyte imbalances (especially K+)
121. Diabetic Ketoacidosis (DKA) Presentation Gradual onset with progression Warm, pink, dry skin Dry mucous membranes (dehydrated) Tachycardia, weak peripheral pulses Weight loss Polyuria, polydipsia Abdominal pain with nausea/vomiting Altered mental status Kussmaul respirations with acetone (fruity) odor
123. Management of DKA Airway/Ventilation/Oxygen NRB mask Assess blood glucose level & ECG IV access, large bore NS normal saline bolus and reassess often requires several liters Assess for underlying cause of DKA Transport How does fluid treat DKA?
124. Hyperosmolar Hyperglycemic Nonketotic Coma (HHNC) Usually occurs in type II diabetics Typically very high blood sugar (>600mg/dl) Some insulin available Higher mortality than DKA
125. Hyperosmolar Hyperglycemic Nonketotic Coma (HHNC) Pathophysiology Some minimal insulin production enough insulin available to allow glucose to enter the cells and prevent ketogenesis not enough to decrease gluconeogenesis by liver no ketosis Extreme hyperglycemia produces hyperosmolar state causing diuresis severe dehydration electrolyte disturbances
127. Hyperosmolar Hyperglycemic Nonketotic Coma (HHNC) Presentation Same as DKA but with greater severity Higher blood glucose level Non-insulin dependent diabetes Greater degree of dehydration
128. Management of HHNC Secure airway and assess ventilation Consider need to assist ventilation Consider need to intubate High concentration oxygen Assess blood glucose level & ECG IV access, large bore NS normal saline bolus and reassess often requires several liters Assess for underlying cause of HHNC Transport
129. Further Management of Hyperglycemia Insulin (regular) Correct hyperglycemia Correction of acid/base imbalances Bicarbonate (severe cases documented by ABG) Normalization of electrolyte balance DKA may result in hyperkalemia 2o to acidosis H+ shifts intracellularly, K+ moves to extracellular space Urinary K+ losses may lead to hypokalemia once therapy is started
130. Hypoglycemia True hypoglycemia defined as blood sugar < 60 mg/dl ALL hypoglycemia is NOT caused by diabetes Can occur in non-diabetic patients thin young females alcoholics with liver disease alcohol consumption on empty stomach will block glucose synthesis in liver (gluconeogenesis) Hypoglycemia causes impaired functioning of brain which relies on constant supply of glucose
131. Hypoglycemia Causes of hypoglycemia in diabetics Too much insulin Too much oral hypoglycemic agent Long half-life requires hospitalization Decreased dietary intake (took insulin and missed meal) Vigorous physical activity Pathophysiology Inadequate blood glucose available to brain and other cells resulting from one of the above causes
132. Hypoglycemia Presentation Hunger (initially), Headache Weakness, Incoordination (mimics a stroke) Confusion, Unusual behavior may appear intoxicated Seizures Coma Weak, rapid pulse Cold, clammy skin Nervousness, trembling, irritability
135. Management of Hypoglycemia Secure airway manually suction prn Ventilate prn High concentration oxygen Vascular access Large bore IV catheter Saline lock, D5W or NS Large proximal vein preferred Assess blood glucose level
136. Management of Hypoglycemia Oral glucose ONLY if intact gag reflex, awake & able to sit up 15gm-30gm of packaged glucose, or May use sugar-containing drink or food Oral route often slower Intravenous glucose Adult: Dextrose 50% (D50) 25gms IV in patent, free-flowing vein, may repeat Children: Dextrose 25% (D25) @ 2 - 4 cc/kg (0.5 - 1 gm/kg) [Infants - may choose Dextrose 10% @ 0.5 - 1 gm/kg or 5 - 10 cc/kg]
137. Management of Hypoglycemia Glucagon Used if unable to obtain IV access 1 mg IM Requires glycogen stores slower onset of action than IV route What persons are likely to have inadequate glycogen stores?
138. Management of Hypoglycemia Have patient eat high-carbohydrate meal Transport? Patient Refusal Policy Contact medical control Leave only with responsible family/friend for 6 hours Must educate family/friend to hypoglycemic signs/symptoms Advise to contact personal physician Transport Hypoglycemic patients on oral agents (long half life) Unknown, atypical or untreated cause of hypoglycemia
139. Long-term Complications of Diabetes Mellitus Blindness Retinal hemorrhages Renal Disease Peripheral Neuropathy Numbness in “stocking glove” distribution (hands and feet) Heart Disease and Stroke Chronic state of Hyperglycemia leads to early atherosclerosis Complications in Pregnancy
140. Long-term Complications of Diabetes Mellitus Diffuse Atherosclerois AMI CVA PVD Hypertension Renal failure Diabetic retinopathy/blindness Gangrene
141. Long-term Complications of Diabetes Mellitus Diabetics are up to 4 times more likely to have heart disease and up to 6 times more likely to have a stroke than a non-diabetic 10% of all diabetics develop renal disease usually resulting in dialysis
142. Long-term Complications of Diabetes Mellitus Peripheral Neuropathy Silent MI Vague, poorly-defined symptom complex Weakness Dizziness Malaise Confusion Suspect MI in any diabetic with MI signs/symptoms with or without CP
143. Diabetes in Pregnancy Early pregnancy (<24 weeks) Rapid embryo growth Decrease in maternal blood glucose Episodes of hypoglycemia
144. Diabetes in Pregnancy Late pregnancy (>24 weeks) Increased resistance to insulin effects Increased blood glucose Ketoacidosis
146. Diabetes in Pregnancy Increased fetal risk for: High birth weight Hypoglycemia Liver dysfunction-hyperbilirubinemia Hypocalcemia
147. Assessment of the Diabetic Patient Maintain high-degree of suspicion Assess blood glucose level in all patients with seizure, neurologic S/S, altered mental status vague history or chief complaint Blood glucose assessment IS NOT necessary in all patients with diabetes mellitus!!
148. Assessment of the Diabetic Patient History and Physical Exam includes Look for insulin syringes, medical alert tag, glucometer, or insulin (usually kept in refrigerator) Last meal and last insulin dose Missed med or missed meal? Signs of infection Foot cellulitis / ulcers Recent illness or physiologic stressors
149. Blood Glucose Assessment Capillary vs. venous blood sample Depends on glucometer model Usually capillary preferred Dextrostick vs Glucometer Dextrostick - colorimetric assessment of blood provides glucose estimate Glucometer - quantitative glucose measurement Neonatal blood Many glucometers are not accurate for neonates