EM propulsion drive technology road map. Matter in motion exhibits internal Lorentz-contracted moving standing waves (de Broglie matter waves). The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz-Doppler waves in a phase conjugate four-wave mixing process modulating a standing wave signal to generate a matter wave producing self-induced motion of a wave system without expulsion of reaction mass. A simplified impulse drive may be constructed with a standing wave cavity resonator excited by two-counter-propagating traveling waves with independent phase and frequency control.
EM propulsion drive technology road map. Matter in motion exhibits internal Lorentz-contracted moving standing waves (de Broglie matter waves). The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz-Doppler waves in a phase conjugate four-wave mixing process modulating a standing wave signal to generate a matter wave producing self-induced motion of a wave system without expulsion of reaction mass. A simplified impulse drive may be constructed with a standing wave cavity resonator excited by two-counter-propagating traveling waves with independent phase and frequency control.
A dimensionless quantity described as a fundamental physical constant characterizing the coupling strength of the electromagnetic interaction. Introduced by Sommerfeld in 1916 to describe the spacing of splitting of spectral lines in multi-electron atoms, it is formed from four physical constants: electric charge, speed of light in vacuo, Planck's constant and electric permittivity of free space.
The inverse fine structure constant (=137.035999...) represents the spin precession whirl no. of the electron. The electron exhibits a slight precession due to an imbalance of electrostatic and magnetostatic energy levels. Electric charge is a result of this spin precession and represents a loop closure failure (torsion defect) similar to topological charge.
Rest mass results from quantum wave interference due to precession. Hence, electric charge, rest mass and the fine structure constant are interrelated and directly calculable.
A photon is a self-sustaining electromagnetic traveling spin wave disturbance is a polarizable vacuum. A photon is described as a spin 1 boson with helical geometry. A graviton represents a momentary resonance superposition of a photon and counter-propagating phase conjugate photon with additive spins. A graviton is described as a spin 2 boson with helicoid geometry with net zero linear momentum. Phase conjugation reflection occurs at EM wave front interference anti-nodes at Fresnel zone boundaries.
A geometrical model of the electron is illustrated. Pair production and annihilation processes is described. Origin of electric charge and the the fine structure constant reviewed. Quantum mechanical description of electric and magnetic field lines at the Planck scale is depicted
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic energy as stored energy in standing wave resonances.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
Einstein's General Theory of Relativity interpreted in terms of a polarizable quantum vacuum. Electromagnetic wavelength increase corresponds to apparent time dilation while a frequency increase corresponds to an apparent space contraction as a result of a spectral energy density gradient. Matter in motion generates a de Broglie matter wave (contracted moving standing wave). An inverse effect of induced motion of matter by matter wave synthesis is predicted.
Matter in motion exhibits internal Lorentz-contracted moving standing waves (de Broglie matter waves). Rest mass and inertia result from confinement of electromagnetic radiation in the form of a standing wave within a cavity resonator. Mass results from wave function interference obstructing energy flow. The de Broglie matter wave frequency equals the difference in red- and blue-shifted, counter-propagating traveling waves.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted, counter-propagating Lorentz-Doppler shifted traveling waves within a standing wave resonator by independent phase and frequency-controlled signal oscillators. Wave system velocity is proportional to wave phase difference while acceleration is proportional to frequency difference. Imbalance of internal radiation pressure provides the ponderomotive force without expulsion of reaction mass. Contracted moving standing waves may likewise be generated in a four-way mixing process using parametrically amplified synthesized Lorentz-Doppler pump beams interacting with a signal beam and phase conjugate. Kinetic energy of motion is provided by direct conversion of EM pump beam energy.using phase conjugation.
(This presentation is in .pptx format, and will display well when embedded improperly, such as on the SlideShare site. Please download at your discretion, and be sure to cite your source)
Review of the Hartree-Fock algorithm for the Self-Consistent Field solution of the electronic Schroedinger equation. This talk also serves to highlight some basic points in Quantum Mechanics and Computational Chemistry.
March 21st, 2012
EM propulsion drive technology road map. Matter in motion exhibits internal Lorentz-contracted moving standing waves (de Broglie matter waves). The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz-Doppler waves in a phase conjugate four-wave mixing process modulating a standing wave signal to generate a matter wave producing self-induced motion of a wave system without expulsion of reaction mass. A simplified impulse drive may be constructed with a standing wave cavity resonator excited by two-counter-propagating traveling waves with independent phase and frequency control.
A dimensionless quantity described as a fundamental physical constant characterizing the coupling strength of the electromagnetic interaction. Introduced by Sommerfeld in 1916 to describe the spacing of splitting of spectral lines in multi-electron atoms, it is formed from four physical constants: electric charge, speed of light in vacuo, Planck's constant and electric permittivity of free space.
The inverse fine structure constant (=137.035999...) represents the spin precession whirl no. of the electron. The electron exhibits a slight precession due to an imbalance of electrostatic and magnetostatic energy levels. Electric charge is a result of this spin precession and represents a loop closure failure (torsion defect) similar to topological charge.
Rest mass results from quantum wave interference due to precession. Hence, electric charge, rest mass and the fine structure constant are interrelated and directly calculable.
A photon is a self-sustaining electromagnetic traveling spin wave disturbance is a polarizable vacuum. A photon is described as a spin 1 boson with helical geometry. A graviton represents a momentary resonance superposition of a photon and counter-propagating phase conjugate photon with additive spins. A graviton is described as a spin 2 boson with helicoid geometry with net zero linear momentum. Phase conjugation reflection occurs at EM wave front interference anti-nodes at Fresnel zone boundaries.
A geometrical model of the electron is illustrated. Pair production and annihilation processes is described. Origin of electric charge and the the fine structure constant reviewed. Quantum mechanical description of electric and magnetic field lines at the Planck scale is depicted
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic energy as stored energy in standing wave resonances.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
Einstein's General Theory of Relativity interpreted in terms of a polarizable quantum vacuum. Electromagnetic wavelength increase corresponds to apparent time dilation while a frequency increase corresponds to an apparent space contraction as a result of a spectral energy density gradient. Matter in motion generates a de Broglie matter wave (contracted moving standing wave). An inverse effect of induced motion of matter by matter wave synthesis is predicted.
Matter in motion exhibits internal Lorentz-contracted moving standing waves (de Broglie matter waves). Rest mass and inertia result from confinement of electromagnetic radiation in the form of a standing wave within a cavity resonator. Mass results from wave function interference obstructing energy flow. The de Broglie matter wave frequency equals the difference in red- and blue-shifted, counter-propagating traveling waves.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted, counter-propagating Lorentz-Doppler shifted traveling waves within a standing wave resonator by independent phase and frequency-controlled signal oscillators. Wave system velocity is proportional to wave phase difference while acceleration is proportional to frequency difference. Imbalance of internal radiation pressure provides the ponderomotive force without expulsion of reaction mass. Contracted moving standing waves may likewise be generated in a four-way mixing process using parametrically amplified synthesized Lorentz-Doppler pump beams interacting with a signal beam and phase conjugate. Kinetic energy of motion is provided by direct conversion of EM pump beam energy.using phase conjugation.
(This presentation is in .pptx format, and will display well when embedded improperly, such as on the SlideShare site. Please download at your discretion, and be sure to cite your source)
Review of the Hartree-Fock algorithm for the Self-Consistent Field solution of the electronic Schroedinger equation. This talk also serves to highlight some basic points in Quantum Mechanics and Computational Chemistry.
March 21st, 2012
A photon is a self-sustaining, electromagnetic traveling spin wave disturbance in a polarizable vacuum. A photon is described as a spin 1 boson with helical geometry. A graviton represents a momentary resonance superposition of a photon and counter-propagating phase conjugate photon with net zero linear momentum. A graviton is described as a spin 2 boson with helicoid geometry with additive spins. Phase conjugation reflection occurs at EM wave front interference anti-nodes at Fresnel zone boundaries.
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving stationary standing waves (de Broglie waves). Rest mass and inertia result from confinement of electromagnetic radiation as stored energy in standing wave resonances.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
Traveling EM waves represent freely propagating energy. Standing waves represent stored energy. Light is a traveling wave disturbance in a polarizable vacuum. Matter consists of standing wave resonances. Matter in motion with respect to an inertial frame generates Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic radiation.
Lecture 8: Introduction to Quantum Chemical Simulation graduate course taught at MIT in Fall 2014 by Heather Kulik. This course covers: wavefunction theory, density functional theory, force fields and molecular dynamics and sampling.
A geometrical model of the electron is shown as a closed-loop standing wave. The charge path is in the form of rotating Hopf link generating a toroidal swept surface with circumference equal to the Compton wavelength. A precessing epitrochoid charge path composed of two orthogonal spinors with toroidal & poloidal current loop components of 2:1 rotary octave resulting in observed 1/2 spin. Electric charge arises a result of a slight precession due to imbalance of electrostatic & magnetostatic energy characterized by a whirl no. equal to the inverse fine structure constant. Quantum mechanical description of electric & magnetic field lines at the Planck scale is depicted.
CHAPTER 6 Quantum Mechanics II
6.0 Partial differentials
6.1 The Schrödinger Wave Equation
6.2 Expectation Values
6.3 Infinite Square-Well Potential
6.4 Finite Square-Well Potential
6.5 Three-Dimensional Infinite-Potential Well
6.6 Simple Harmonic Oscillator
6.7 Barriers and Tunneling in some books an extra chapter due to its technical importance
In this talk I will discuss different approximations in DFT: pseduo-potentials, exchange correlation functions.
The presentation can be downloaded here:
http://www.attaccalite.com/wp-content/uploads/2022/03/dft_approximations.odp
A freely-propagating photon in empty space (gravity-free, zero curvature vacuum) is described as a self-sustaining, helical, traveling wavepacket of quantized spin angular momentum moving at the speed of light. A photon is categorized as a stable, massless boson, having no electrical charge with spin angular momentum s = +/- hbar. The spin axis s is aligned with the direction of wave vector k in either the forward or backward direction depending on helicity.
The observed EM frequency spectrum spans more than 140 octaves or ~24 orders of magnitude. The cutoff frequency of the vacuum is taken as the Planck frequency fsubP = 1.855E43 Hz
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving standing waves (de Broglie matter waves). Rest mass and inertia result from confinement of electromagnetic radiation as stored energy in standing wave resonances.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic radiation in standing wave resonances as stored energy.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
A photon is a self-sustaining, electromagnetic traveling spin wave disturbance in a polarizable vacuum. A photon is described as a spin 1 boson with helical geometry. A graviton represents a momentary resonance superposition of a photon and counter-propagating phase conjugate photon with net zero linear momentum. A graviton is described as a spin 2 boson with helicoid geometry with additive spins. Phase conjugation reflection occurs at EM wave front interference anti-nodes at Fresnel zone boundaries.
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving stationary standing waves (de Broglie waves). Rest mass and inertia result from confinement of electromagnetic radiation as stored energy in standing wave resonances.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
Traveling EM waves represent freely propagating energy. Standing waves represent stored energy. Light is a traveling wave disturbance in a polarizable vacuum. Matter consists of standing wave resonances. Matter in motion with respect to an inertial frame generates Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic radiation.
Lecture 8: Introduction to Quantum Chemical Simulation graduate course taught at MIT in Fall 2014 by Heather Kulik. This course covers: wavefunction theory, density functional theory, force fields and molecular dynamics and sampling.
A geometrical model of the electron is shown as a closed-loop standing wave. The charge path is in the form of rotating Hopf link generating a toroidal swept surface with circumference equal to the Compton wavelength. A precessing epitrochoid charge path composed of two orthogonal spinors with toroidal & poloidal current loop components of 2:1 rotary octave resulting in observed 1/2 spin. Electric charge arises a result of a slight precession due to imbalance of electrostatic & magnetostatic energy characterized by a whirl no. equal to the inverse fine structure constant. Quantum mechanical description of electric & magnetic field lines at the Planck scale is depicted.
CHAPTER 6 Quantum Mechanics II
6.0 Partial differentials
6.1 The Schrödinger Wave Equation
6.2 Expectation Values
6.3 Infinite Square-Well Potential
6.4 Finite Square-Well Potential
6.5 Three-Dimensional Infinite-Potential Well
6.6 Simple Harmonic Oscillator
6.7 Barriers and Tunneling in some books an extra chapter due to its technical importance
In this talk I will discuss different approximations in DFT: pseduo-potentials, exchange correlation functions.
The presentation can be downloaded here:
http://www.attaccalite.com/wp-content/uploads/2022/03/dft_approximations.odp
A freely-propagating photon in empty space (gravity-free, zero curvature vacuum) is described as a self-sustaining, helical, traveling wavepacket of quantized spin angular momentum moving at the speed of light. A photon is categorized as a stable, massless boson, having no electrical charge with spin angular momentum s = +/- hbar. The spin axis s is aligned with the direction of wave vector k in either the forward or backward direction depending on helicity.
The observed EM frequency spectrum spans more than 140 octaves or ~24 orders of magnitude. The cutoff frequency of the vacuum is taken as the Planck frequency fsubP = 1.855E43 Hz
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving standing waves (de Broglie matter waves). Rest mass and inertia result from confinement of electromagnetic radiation as stored energy in standing wave resonances.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
Matter in motion with respect to an inertial frame exhibits internal Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic radiation in standing wave resonances as stored energy.
The inverse effect of self-induced motion of matter may be potentially realized by utilizing synthesized red- and blue-shifted Lorentz Doppler waves in a phase conjugate four-way mixing process using parametrically amplified Lorentz Doppler pump beams to modulate a standing wave generating a matter wave producing self-induced motivided by direct conversion of EM pump energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force to induce motion of matter is not required. on of a wave system without expulsion of reaction mass. Kinetic energy of motion is provided by direct conversion of pump beam EM energy into the contracted moving standing wave formed within a phase-locked cavity resonator. The imbalance of internal radiation pressure provides the ponderomotive force acting on the resonator. In this inverse effect, application of an external force or expulsion of reaction mass is not required to induce motion of matter.
Electromagnetic radiation consists of photons, the quanta of electromagnetic fields. A freely-propagating photon in empty space (gravity-free, zero curvature vacuum) is described as a self-sustaining, helical traveling wave packet of quantized spin angular momentum moving at the speed of light. A photon is categorized as a stable, massless boson having no electric charge with spin angular momentum s = +/- hbar. The spin axis is aligned with the direction of wave vector k in either the forward or backward direction depending on helicity.
The observed EM frequency spectrum spans more than 140 octaves or ~24 orders of magnitude. The cutoff frequency of the vacuum is taken as the Planck frequency fsubP = 1.855E43 Hz.
Light consists of photons, the quanta of electromagnetic fields, A freely-propagating photon in empty space (gravity-free, zero curvature vacuum) is described as a self-sustaining, helical traveling electromagnetic wave packet of quantized spin angular momentum moving at the speed of light. A photon is categorized as a stable, massless boson having no electrical charge with spin angular momentum s = +/-hbar. The spin axis is aligned with direction of the wave vector k in either the forward or backward direction depending on helicity.
The observed EM frequency spectrum spans more than 140 octaves or ~24 orders of magnitude. The cutoff frequency of the vacuum is taken as the Planck frequency fsubP = 1.855E43 Hz.
Explaining all the difficult concepts with precise and accurate points, 3D models, animations and smart art graphics.
Principle
The NMR phenomenon
Theory
Precessional frequency (ν)
Chemical shift
Spin-spin interactions
Interpretation of NMR
Chemical shift (δ)
Multiplicity of the signal
Coupling constant
Instrumentation
Fourier NMR
Continuous wave NMR
Applications
Identification testing
Assay of drugs
Traveling EM waves represent freely-propagating energy. Standing waves represent bottled-up energy. Light is a traveling wave disturbance in a polarizable vacuum. Matter consists of standing waves resonances.
Matter in motion with respect to an inertial frame generates Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic radiation.
Traveling EM waves represent freely propagating energy. Standing waves represent stored energy. Light is a traveling wave disturbance in a polarizable vacuum in the form of spin 1 bosons (photons). Matter consists of standing wave resonances in the form of spin 1/2 fermions created from energetic photons. Matter in motion with respect to an inertial frame generates Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic radiation.
Traveling EM waves represent freely propagating energy. Standing waves represent bottled-up energy. Light is a traveling wave disturbance in a polarizable vacuum. Matter consists of standing wave resonances.
Matter in motion with respect to an inertial frame generates de Broglie matter waves (contracted moving standing waves). Rest mass and inertia result from confinement of electromagnetic radiation.
Traveling EM waves represent freely propagating energy. Standing waves represent stored energy. Light is a traveling wave disturbance made of quantized photons (spin 1 bosons). in a polarizable vacuum. Matter consists of standing wave resonances in the form of spin 1/2 fermions created from energetic photons.. Matter in motion with respect to an inertial frame generates Lorentz contracted moving standing waves. Rest mass and inertia result from confinement of electromagnetic radiation.
A geometrical model of the electron is illustrated. Pair production and annihilation processes is described. Origin of electric charge and the fine structure constant reviewed. Quantum mechanical description of electric and magnetic field lines at the Planck scale is depicted.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
5. Wave system resonator at constant velocity
• Displacement of phase triggers shifting of standing wave nodes.
• Mass transport is a result of node displacement of contracted
moving standing waves.
6. EM drive & Inertia control
Electromagnetic propulsion without repulsion of reaction mass has yet to be realized. Do we
not understand the physics of force fields and wave mechanics to set forth some notional
theoretical concepts? What sort of energy conversion is required? Energy is a measure of
wavefront curvature and may be conveyed in waves. Consider what sort of energy transfor-
mation is required. Waves occur in any of several forms including:
Description Example Remarks
traveling wave photon wave train Freely propagating with zero rest mass in
vacuo. Wave velocity depends on the
energy density of the wave medium.
standing wave electron Confined travelling wave within a cavity
resonator. Stored energy exhibits rest
mass & inertia.
transverse waves electromagnetic waves electric & magnetic fields orthogonal to
direction of propagation.
longitudinal waves sound waves, scalar EM waves Compression & rarefaction pressure
pulsations
partial standing waves mufflers, organ pipes, Helmholtz
resonators
A mixture of a standing wave & travelling
wave. Leaky resonator.
contracted moving standing waves Matter waves (de Broglie waves) Matter in motion with respect to an
observer. Modulated standing wave.
coherent waves lasers, masers Frequency & phase-locked overlapping
waves
soliton waves water waves topologically confined in a
wave guide; optical soliton waves
Nondispersive wave
19. Confinement of traveling EM waves
• Confinement of traveling electromagnetic waves within a phase-locked
cavity resonator creates rest mass and inertia.
22. Lorentz contraction of a standing wave
resonator in motion
• Stored energy in a resonator is in the
form of standing waves while released
energy is in the form of traveling waves.
• Matter in motion undergoes a Lorentz
contraction in the direction of motion
as a result of increased EM flux density
• Inertial mass and gravitation mass are
equivalent as both arise from the same
causal mechanism: accelerated motion
into regions of increased energy density.
• Rest mass and relativistic mass have a
common origin – both are a measure
of EM wave interaction in regions of
increased spectral energy density.
23. Wave motion represented as Riemann
sphere projections onto a complex plane
• Mappings on the complex plane in the form of Möbius transformations
correspond to Lorentz transformations.
25. Constant wave energy phasor
Traveling wave, standing wave and contracted moving standing waves
26. Contracted moving wave diagram for an
electron moving @ 0.5 c
Compton, Lorentz Doppler and de Broglie wave components
27. EM cavity resonator equivalent LC circuit
• A lossless electromagnetic cavity resonator and equivalent LC circuit.
• The electric and magnetic energy are in phase quadrature.
• A resonant system must contain at least one element in which kinetic
energy is stored and another element in which potential energy is stored.
28. Impedance and energy triangle comparison
• Mass and electrical impedance are measures of resistance to energy flow.
29. Resonator velocity staircase
A Minkowski spacetime diagram illustrating a phased-locked
standing wave resonator in motion with oscillatory sequence
of accelerative jumps and constant velocity intervals
31. EM wave reflection/diffraction from
Bragg planes formed by EM wave interference
• Phase conjugate beam formation in four-way mixing of signal & pump beams
32. Irradiated phase-locked phase conjugate resonator
• Conceptual diagram for induced motion of a phase-locked resonator with
a phase conjugate reflector irradiated by amplified Lorentz-Doppler shifted
pump beams modulating a standing wave generating a ponderomotive force.
33. Phase-locked phase conjugate resonator
induced motion
• Simulated Lorentz-Doppler effect results in a contracted moving standing wave.
• The internal radiation pressure imbalance results in a net ponderomotive force.
• Pump beam energy input provides the kinetic energy of motion.
34. Induced motion of wave system resonator
• Contracted moving standing waves created by superposition
of Lorentz-Doppler shifted modulated standing waves.
35. Self-induced motion of wave system resonator
• Velocity v is proportional to
phase difference (= Df·c/p)
• Acceleration a is proportional
to frequency difference (= 2c·Dn)
• Energy flow is in the direction of
the frequency gradient. Pump
beam energy is converted directly
into kinetic energy of motion.
• Very high velocity and acceleration
possible with no expulsion of
reaction mass
• Electromagnetic energy contained
within resonator(s). Low external
observables.
37. Push-pull cavity phase conjugate resonator
• Direction of motion may be rapidly changed by redirecting the vector
orientation of the incident and phased array conjugation beams enabling
levitation and high acceleration, darting, zigzag motion without expulsion
of reaction mass. Amplified pump beams provide energy of motion.
38. Broad band frequency phase conjugate
resonator system
• High internal radiation pressure
provided by high frequency
standing wave modulation over
a wide frequency range.
• Amplified synthesized Lorentz-
Doppler shifted pump beams
modulates a standing wave in
a phase conjugate resonator to
generate a matter wave inducing
motion of the wave system.
• Energy of motion is proportional
to the number of frequency pairs
DEi = nhDni.
39. Gravitational spectral energy density gradient
subject to electronic augmentation and control
• Acceleration is proportional to the frequency differential Dn.
40. Paired overlapping multi-band swept frequencies
with discrete frequency differential
• Available energy is proportional to the number of frequency pairs (DEi = nhDni)
• Acceleration induced inertial strains are reduced by minimizing jerk (Da/Dt)
41. Inverse Lorentz-Doppler effect
Negative EM susceptibility
Lorentz-Doppler effect
Positive EM susceptibility
va-
a
zero-g NIM whispering
gallery resonator
encapsulating
internal cavity
resonator
Internal acceleration neutralization
42. Negative Index Metamaterial external shell
whispering gallery resonator
Increasing magnetic permeability of a Negative Index Metamaterial (NIM)
reduces local velocity of light and results in an inverse Lorentz-Doppler effect
44. External resonator buffer zone
In the case of collision with an immovable object, the excess linear momentum may be
converted and temporarily stored as angular momentum and released over a longer interval
as in a conventional inerter or convert the energy into mechanical deformation and heat as in
a conventional shock absorber. An alternative approach may be to convert linear momentum
into angular momentum as EM waves in a whispering gallery resonator, for example.
In order to avoid dissipative losses such as formation of drag votices or shock waves, etc, the
surrounding media must be uniformly accelerated around the moving resonator. How might
such an external influence zone be established? If the external emission is sufficient to ionize
the surrounding air, such as ball lightning, we may create an external microwave cavity
resonator enveloping the internal standing wave resonator. To reduce energy requirements,
observable signatures and deleterious biologic effects, we might imagine instead, a phase
conjugate reflector formed by synthesized Lorentz-Doppler pump beams focused ahead of the
resonator in direction of motion and bounce a signal beam off the the wave interference zone
to create external contracted moving standing waves acting on the surrounding medium. An
omnidirectional outward flux of matter waves in a surrounding spherical irradiation zone may
serve to offset compressive forces during submergence in a dense liquid medium. A negative
index metamaterial may be used to generate an inverse Lorentz-Doppler effect which when
superimposed with the Lorentz-Doppler radiation pattern allows create of a net neutral
acceleration zone in the overlap region.
45. Inertial damper
• Linear momentum converted
to rotary momentum in a
whispering gallery mode (WGM)
resonator.
• Electro-optic analog of a
mechanical rack & pinion
or shock absorber. Electro-
magnetic wave energy is
temporarily stored in the
resonator and released.
48. Acceleration induced thermal spectrum
• Intensity of observed EM spectrum is greater in an accelerated frame than
one at rest and is proportional to the cube of frequency.
49. Phase conjugate simulated Doppler shift
• Phase conjugate by degenerate
four-wave mixing requires a
signal, phase conjugate and two
pump beams.
• Pump waves at simulated Doppler
red- and blue-shifted frequencies
acting on a phase conjugate
reflector in a nonlinear medium
may be used to modulate a signal
beam standing wave to generate
a matter wave to induce motion
of a resonator.
• Synthesis of de Broglie matter
waves to induce motion is the
inverse effect of motion of matter
inducing matter waves.
50. Phase conjugate phased array antenna
EM energy density gradient creates radiation pressure differential
generating a lift force acting over the antenna disc
51. Tractor/repulsor beam operation
• Phase conjugate standing wave levitation with multi-phase, multi-frequency
oscillator array.
• Levitation is accomplished by neutralization of the gravitational frequency
differential Dn = g/2c.
52. Synthesized Doppler frequency
phased array antenna
• Synthesized Doppler phased
emitter array antenna disc
with agile beam steering and
focusing.
53. Tractor/repulsor beam generated by
phase conjugate phased array antenna
• Attraction and repulsion is
determined by direction of
contracted moving standing
wave vectors.
• Direction is controlled by
relative phase and frequency
of the synthesized Doppler
signals fed to the emitter
array.
• The phased array allows
control of the beam boresight
direction, focus length,
intensity, and wave front
contour.
54. Tilt-edge suspension modes
• Tilt-edge & on-edge suspension
hover modes enabled with
opposed, contracted moving
standing waves in a
tractor/repulsor, tractor/tractor
or repulsor/repulsor mode
configuration.
• Chromatic focusing results in a
frequency gradient along the
boresight augmenting tractor/
repulsor beam effect.
55. Triangular plan form vehicle
concept
• Phase conjugate push-pull
cavity resonators and phased
array push-pull phase conjugate
grappler beam
58. Phase array beam operating modes
• Horizontal and vertical flight
accomplished with either
repulsor or tractor beams or
in combination.
• Sustained hover accomplished
with a combination of tractor
or repulsor beams, dual
repulsor or dual tractor beams.
• Near the ground, intensity of
phase conjugate beam is
augmented by reflected ground
return.
• Objects located within the beam
focus will tend to attracted or
repelled with the tractor/repulsor
engaged.
59. Augmented spectral energy density profile
• Modification of naturally occurring spectral energy density enables alteration
of local acceleration of gravity
60. Phase conjugate cavity resonator cell
• Double-ended phase conjugate
cavity resonator includes a
nonlinear, high K, polarizable,
phase conjugate medium.
• EM radiation may be confined
within a dielectric resonator by
abrupt change in permittivity
and reflected by the large
change in conductivity by the
walls of a metallic cavity
resonator.
• Nonlinearity may be augmented
if the energy input interval is on
the order of the system critical
reaction time.
61. Horizontal motion – level flight
• Planar array wave system
composed of n-element
phase conjugate, phase-
locked resonators.
• Horizontal velocity is
controlled by varying the
relative phase of two
counter-propagating
moving standing waves.
• Horizontal acceleration
is controlled by varying
the frequency difference.
63. Induced gravitomagnetic field
• Radially outward directed EM
waves creating a synthesized
gravity-Poynting energy flow
Sig (= - gi x Hg) opposing the
gravito-Poynting energy influx
Sg (= - g x Hg).
• Angular rotation of a standing
wave corresponds to a mass
current loop gravitomagnetic
field. Result torsion field is
equivalent to a co-gravitational
field K inducing an acceleration
in the axial direction perpendicular
to the disc plane. K = (g x v)/c2 =
(2cDn x c)/c2 = 2Dn
65. Gravitational dipole self-induced motion
• Hypothetical gravitational
dipole of positive and
negative mass accelerates
in the direction of the field
gradient from negative and
positive mass.
• A changing gravitomagnetic
mass current loop generates
a net acceleration from the
virtual negative mass pole
towards the virtual positive
mass pole.
• Two coupled, coaxial,
gravito-magnetic loops
generates a net acceleration
in the direction of the
inertial moment.
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Mechanics-Larry-Reed/
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