Lack of socialization can have negative effects on both mental and physical health, including poor self-esteem, increased risk of depression, higher tumor risk, body chills, loss of reality when immersed in media, decreased ability to learn, decreased empathy, inflammation, shorter life span, increased risk of dementia, and reduced resilience. Studies have shown that social connections are important for cognitive function, well-being, and longevity, while isolation is linked to stress, depression, and health issues.