Innovations:
VR surgeries and studying
Food delivery robots
Gaming
Infrastructure
People didn’t really have to worry about staying covered up after leaving the house
Generations were not at odds with each other, yet the younger generations would still joke around
Everyone in the US was worrying about the election
Social Interaction, Loneliness and Quality of Life in Healthcare and Older Ad...Innovations2Solutions
The purpose of this report is to increase understanding of loneliness and social interaction to improve the quality of life of patients, older adults and carers, so they can progress and the organisations near them can perform better.
2018-04-18 المؤتمر العلمي الثاني للمعهد القومي لعلوم المسنين جامعة بني سويف بعنوان" التحديات والمستجدات العالمية في رعاية المسنين"
http://www.bsu.edu.eg/ShowConfDetails.aspx?conf_id=217
Innovations:
VR surgeries and studying
Food delivery robots
Gaming
Infrastructure
People didn’t really have to worry about staying covered up after leaving the house
Generations were not at odds with each other, yet the younger generations would still joke around
Everyone in the US was worrying about the election
Social Interaction, Loneliness and Quality of Life in Healthcare and Older Ad...Innovations2Solutions
The purpose of this report is to increase understanding of loneliness and social interaction to improve the quality of life of patients, older adults and carers, so they can progress and the organisations near them can perform better.
2018-04-18 المؤتمر العلمي الثاني للمعهد القومي لعلوم المسنين جامعة بني سويف بعنوان" التحديات والمستجدات العالمية في رعاية المسنين"
http://www.bsu.edu.eg/ShowConfDetails.aspx?conf_id=217
How technology is actually affecting your brain what we actually knowCharityComms
Sylwia Korsak, digital wellbeing consultant and social media community champion, OTR Bristol
Visit the CharityComms website to view slides from past events, see what events we have coming up and to check out what else we do: www.charitycomms.org.uk
Social Media a Revolutionary Tool with Psychological ImpactThe Sprouts
Social media dependency is an alarming trend in today's fast-paced world, with an increasing number of individuals relying heavily on it for their daily existence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
2. What is Social Isolation?
- The state of complete lack of contact between a person and
the rest of society
- Social isolation is NOT ‘loneliness’
- Social isolation is willfully avoiding contact with other
humans for a long period of time
- Socially Isolating ones self can mean staying at home for
days on end, not communicating with relatives or friends
- Any form of contact is likely to be limited and very brief
- Can be a result of depression, or low self worth
- Is associated with social anxiety
3. Causes of Social Isolation
- Voluntarily choosing to isolate themselves
- Can be caused by physical disabilities or illness such as
cancer or muscular dystrophy
- Social Isolation is very common in individuals who suffer
from conditions that are stigmatized, HIV/AIDS
- Advanced age can also lead to social isolation
- Depression and anxiety can also be leading factor in a person
developing social isolation
- A person having a lack of social interaction as a child,
therefore growing up with a lack of social interest
- Advancement in technology making human interactions
unnecessary (eg. internet, online shopping)
4. What is Neurosis?
- “A relatively mild mental illness that is not caused by organic disease, involving symptoms
of stress (depression, anxiety, obsessive behavior, hypochondria) but not a radical loss of
touch with reality. Compare with psychosis”
- “Also called psychoneurosis a functional disorder in which feelings of anxiety, obsessional
thoughts, compulsive acts, and physical complaints without objective evidence of disease, in
various degrees and patterns, dominate the personality” (Dictionary.com, 2017)
Various types of nervous system disorders can be extremely diverse core and associated
symptoms. The main or mental symptoms of neuroses include:
- anxiety, fear and depression;
- crying, fear of communication and resentment;
- isolation, confusion and significant memory impairment;
- indecision, despair and despondency;
- irritability and aggressiveness.
5. Causes of Neurosis
- “The failure of the stability of the nervous system occurs on a background
of personal predisposition to such a disease, a result of hereditary or
acquired factors. Trauma refers to the direct causes of neurosis. In
addition, alcohol dependence, nervous exhaustion of the human body on
the background of mental and physical exhaustion, depression, chronic
fatigue are some of the common causes of disorders of the nervous
system” (Medicineinfo, 2017).
6. Social Media’s Impact
- It is possible that increased social media use could help alleviate feelings
of social isolation, it is a fast and simple way to stay connected to friends
and relatives. But it could also have the opposite effect in young adults
by limiting in-person interactions.
- People purposefully craft an image of themselves that they want the
world to see. This can cause a lack of openness in relationships which
can lead to bonds not being fully formed.
- People start to compare themselves to others socially, which then creates
feelings of envy, loneliness and depression.
- Its addictive; A study from Swansea University found that people
experienced the psychological symptoms of withdrawal when they
stopped using (this went for all internet use, not just social media
Positive or Negative?
7. Distraction From Real Life
- Social media has changed our ability to stay focused on what is
going on immediately around us
- Resorting to social media lets people instantly escape into
another world
Question: Have you ever used your social media to get
out of an awkward situation?
- Often when people are introduced to awkward situations they
look at social media instead of dealing with the feelings right in
front of them
8. - Social media gives us a false sense of friends and
family
- There is emotional distance
“A study conducted by Ethan Kross, from the University of
Michigan, found that the more time a person spent using
Facebook, the lonelier and more depressed they became
over time” (The New Yorker, 2013).
- Carnegie Mellon University, in Pittsburgh, discovered that when people interacted directly with
friends on Facebook, they become more content.
- If their interaction on Facebook was passive, they began to feel isolated and unhappy.
Illusion of Companionship
9. Social Media and Self Image
- Social media can give people the impression that others are leading better and
happier lives by portraying themselves unrealistically online, (work, meals,
vacations, friends etc..)
- Social media gives the illusion that the average joe is living an amazing, exciting
successful life. Giving the viewers/followers a low self image when their life
doesn’t lead up like someone else's
10. Reduced Intimacy
- “People have a tendency to give precedence to others who aren’t present over people who
are present” (Activebeat, 2016).
For example, going out for dinner with friends and tweeting about the experience while it's
happening right in front of you or someone checking their texts and missing their son or
daughter's game winning goal.
- Social media is interrupting quality time with friends and family.
- Being present in the moment has been proved to be much better for your health in the
long run
12. Conclusion
Social media is a key factor in the development of Social Isolation and Neurosis. While social
networks can be a positive way to interact and stay in touch with friends and family, it can also cause
loneliness and depression in teens and young adults. Advancement in technology has allowed people
to limit social interactions and relationships, and in turn no real emotional bonds are made. When this
persist it can lead to voluntary social isolation with is very unhealthy for our mental growth and
stability. Going long periods of time without social interaction can lead to lack of social interest and a
lack of wanting to create intimate relationships.
13. References
Dictionary.com. (2017). Neurosis. Retrieved from: http://www.dictionary.com/browse/neurosis?s=t
GoodTherapy. (July, 2015). Isolation. Retrieved from: https://www.goodtherapy.org/learn-about-therapy/issues/isolation
Medicineinfo. (October, 2014). Causes, Symptoms and Treatment of Neurosis. Retrieved from: http://medicineinfo.net/causes-
symptoms-and-treatment-of-neurosis.html
Konnikova, M. (September, 2013). How Facebook Makes Us Happy. Retrieved from:
https://www.newyorker.com/tech/elements/how-facebook-makes-us-unhappy
McGauran, D. (September, 2016). Social Isolation. Retreived from: http://www.activebeat.com/your-health/women/5-ways-
social-media-contributes-to-social-isolation/
Miller, G. (March, 2017). Too Much Social Media Use Linked to Feelings of Isolation. Retrieved from:
https://www.livescience.com/58121-social-media-use-perceived-isolation.html
Walton, A. (June, 2017). 6 Ways Social Media Affects Our Mental Health. Retrieved from:
https://www.forbes.com/sites/alicegwalton/2017/06/30/a-run-down-of-social-medias-effects-on-our-mental-
health/#437abf8e2e5a