Rice bran is fabricated from the rice milling enterprise and contains about 10% of the entire weight of rough rice. It is especially composed of aleurone, pericarp, subaleurone layer, and germ. Rice bran is a fertile supply of nutrients, minerals, vital fatty acids, dietary fiber, and different sterols. The quantification of γ-oryzanol in rice bran can be conducted by many methods that require drawing out of rice bran oil (RBO) from the bran, accompanied by way of evaluation of the quantity of γ-oryzanol in the RBO with the aid of high-performance liquid chromatography. RBO is the oil drain out of the outer rigid surface of rice called chaff (rice husk). It is identified for its excessive smoke factor of 232°C (450°F) and soft taste, making it pleasant for excessive-temperature cooking strategies such as blend and deep frying. It is healthy for human expenditure, which is employed in the system of vegetable ghee. Wax was drawn out of RBO and palpanese extract, which is employed for carnauba wax in makeup, confectionery, shoe lotions, and sharpening compounds. It is accepted as a food preparation oil in numerous Asian countries, along with Bangladesh, Japan, India, and China. Regarding the importance of RBO, this overview intends to pay attention at the phytochemistry and therapeutic functions of RBO.
DIETARY INTAKE AND NUTRITIONAL STATUS IN HEMODIALYSIS PATIENTSNeeleshkumar Maurya
This study was conducted on 50 CKD-5 patients during the year 2016-17, considered stable from, 3 months of regular dialysis at least 2 times in a week dialysis centre in MLB, Medical College Jhansi. Dietary intake was estimated by 24-hour recall and analysed after 30 days three times the average dietary intake of 1580.5±164 kcal/day; carbohydrate 204.3±19.0 gm/day; lipid, 49.0±4.6 gm/day, protein 54.0±4.8 gm/day. The significant prevalence was observed for the inadequacy of calories intake and other nutrients. Hemodialysis patients had a lower intake of fruit (77%), vegetable (56%) and dairy products (70%) exchange whereas they had normal intake of oils/fats (95%) and sugars/sweets (97%). This study the reveals that the patient suffered from CKD with dialysis phase were observed loss of appetite and inadequate dietary intake than the recommended, lead to malnutrition, susceptible to various life style diseases and high risk of morbidity.
Keywords: Dialysis, inadequate, dietary intake, malnutrition, morbidity.
THERAPEUTIC EFFECT OF SOYA BEAN CHUNKS SUPPLEMENTION DURING HEMODIALYSISNeeleshkumar Maurya
The present study was conducted during the year 2016-17 on 30 ckd-5 patients on hemodialysis admitted in various medical wards of the MLB, Medical College, Jhansi (U.P.) India. The primary data were obtained from all CKD patients 30 days intervals and three times first time proper medication with hemodialysis therapy and second time same condition patients with additional dietary counseling. The data was collected in all the patients, thorough anthropometric measurement, dietary history and blood are collected for analysis of Hb, serum albumin, blood urea, cholesterol and cretonne. The Proper dietary counseling along with high biological protein (20 gm) given during hemodialysis superior the nutritional value of undernourished chronic kidney disease patient. About proper diet counseling of the patients showed significant statistical positive (<0.005) response in a various nutritional factor like BMI, MUAC, Serum Albumin, hemoglobin, total calorie intake while the only medication and dialysis therapy showed an undergoing undernourished in their nutritional value. The patients undergoing hemodialysis often develop protein-energy malnutrition which is related to mortality and morbidity rate increases. Special nutritional care is required for the dialysis patient to improve the net protein anabolism. The nutritional value of soya bean chunks in patients on HD requirements more attention providing one-to-one nutrition psychotherapy could be improvements in the patients. Key words : Dialysis, malnutrition, soybean chunks, high biological protein.
Anaemia in Chronic Renal Failure Patients Undergoing Haemodialysis: A across ...Neeleshkumar Maurya
ABSTRACT Chronic renal failure disease is frequently associated with anaemia and the level of anaemia correlates with the stage of chronic kidney disease (CKD). A cross-sectional study was conducted in 44 chronic kidney disease patients in the department of medicine, M.L.B. Medical College, Jhansi during the period January to June, 2018. The study was evaluating the profile of anaemia and to find the association between the severity of anaemia and ckd-5 patients time period of taking on haemodialysis. Haemoglobin, blood urea, serum albumin, serum creatinine levels were examined using standard techniques. There was a significant difference in the haemoglobin of CKD patients taking 30 days regular interval 3 times values (P <0.05). All 44 patients (100%) were anaemic there was no significant correlation between the severity of anaemia and serum creatinine levels (P > 0.82) the most frequent anaemia in chronic kidney disease patients was a malnourished type of a moderate degree anaemic (7 10mg/dl). A significant correlation was not found between the severity of anomie and serum creatinine levels 30 day interval of CKD of patients on haemodialysis. Keywords: - haemodialysis, anomie, serum creatinine, haemoglobin, malnutrition.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
DIETARY INTAKE AND NUTRITIONAL STATUS IN HEMODIALYSIS PATIENTSNeeleshkumar Maurya
This study was conducted on 50 CKD-5 patients during the year 2016-17, considered stable from, 3 months of regular dialysis at least 2 times in a week dialysis centre in MLB, Medical College Jhansi. Dietary intake was estimated by 24-hour recall and analysed after 30 days three times the average dietary intake of 1580.5±164 kcal/day; carbohydrate 204.3±19.0 gm/day; lipid, 49.0±4.6 gm/day, protein 54.0±4.8 gm/day. The significant prevalence was observed for the inadequacy of calories intake and other nutrients. Hemodialysis patients had a lower intake of fruit (77%), vegetable (56%) and dairy products (70%) exchange whereas they had normal intake of oils/fats (95%) and sugars/sweets (97%). This study the reveals that the patient suffered from CKD with dialysis phase were observed loss of appetite and inadequate dietary intake than the recommended, lead to malnutrition, susceptible to various life style diseases and high risk of morbidity.
Keywords: Dialysis, inadequate, dietary intake, malnutrition, morbidity.
THERAPEUTIC EFFECT OF SOYA BEAN CHUNKS SUPPLEMENTION DURING HEMODIALYSISNeeleshkumar Maurya
The present study was conducted during the year 2016-17 on 30 ckd-5 patients on hemodialysis admitted in various medical wards of the MLB, Medical College, Jhansi (U.P.) India. The primary data were obtained from all CKD patients 30 days intervals and three times first time proper medication with hemodialysis therapy and second time same condition patients with additional dietary counseling. The data was collected in all the patients, thorough anthropometric measurement, dietary history and blood are collected for analysis of Hb, serum albumin, blood urea, cholesterol and cretonne. The Proper dietary counseling along with high biological protein (20 gm) given during hemodialysis superior the nutritional value of undernourished chronic kidney disease patient. About proper diet counseling of the patients showed significant statistical positive (<0.005) response in a various nutritional factor like BMI, MUAC, Serum Albumin, hemoglobin, total calorie intake while the only medication and dialysis therapy showed an undergoing undernourished in their nutritional value. The patients undergoing hemodialysis often develop protein-energy malnutrition which is related to mortality and morbidity rate increases. Special nutritional care is required for the dialysis patient to improve the net protein anabolism. The nutritional value of soya bean chunks in patients on HD requirements more attention providing one-to-one nutrition psychotherapy could be improvements in the patients. Key words : Dialysis, malnutrition, soybean chunks, high biological protein.
Anaemia in Chronic Renal Failure Patients Undergoing Haemodialysis: A across ...Neeleshkumar Maurya
ABSTRACT Chronic renal failure disease is frequently associated with anaemia and the level of anaemia correlates with the stage of chronic kidney disease (CKD). A cross-sectional study was conducted in 44 chronic kidney disease patients in the department of medicine, M.L.B. Medical College, Jhansi during the period January to June, 2018. The study was evaluating the profile of anaemia and to find the association between the severity of anaemia and ckd-5 patients time period of taking on haemodialysis. Haemoglobin, blood urea, serum albumin, serum creatinine levels were examined using standard techniques. There was a significant difference in the haemoglobin of CKD patients taking 30 days regular interval 3 times values (P <0.05). All 44 patients (100%) were anaemic there was no significant correlation between the severity of anaemia and serum creatinine levels (P > 0.82) the most frequent anaemia in chronic kidney disease patients was a malnourished type of a moderate degree anaemic (7 10mg/dl). A significant correlation was not found between the severity of anomie and serum creatinine levels 30 day interval of CKD of patients on haemodialysis. Keywords: - haemodialysis, anomie, serum creatinine, haemoglobin, malnutrition.
Transplantation of Autologous Bone Marrow- Derived Stromal Cells in Type 2 Di...CrimsonpublishersITERM
Type 2 Diabetes is a debilitating metabolic disorder which is also the seventh leading cause of death worldwide. Current therapeutic regimes to date have failed to achieve significant long-term glycemic control even with intensive insulin therapy as revealed by deregulated Hb1Ac and C-peptides levels. In the current study, we have evaluated the effect of regenerative cellular therapy for functional recovery from Diabetic pathophysiology. 10 patients with a median age of 51 years were selected for the study and subjected to bone marrow isolation. These samples were processed under sterile conditions for the enrichment of mononuclear cells (BM MNCs) from bone marrow. After strict quality control and characterization of cells, 2 x 106 cells/kg of BM MNCs were infused back into the patient through the anterior pancreaticoduodenal artery. We performed an evaluation of clinical parameters like Body Mass Index, Fasting Plasma Glucose, Fasting Plasma Insulin, HbA1c and C-peptide levels, and followed up the patients for 12 months. Our study showed a reduction in insulin dependency by ≥ 50%.
Obesity and hyperlipidemia is international /worldwide problem causing heart disease leading to major predisposing factor for morbidity and death. Conventional medicine used in allopathy include statins, fibrates, niacin and resins but are going to defame due to their adverse effects. Herbal medicine ginger has proved itself as one of the potent anti hyperlipidemic and anti obesity herb with least adverse effects. We did try to compare its hypolipidemic effects with placebo effects when used in mild to moderate hyperlipidemic patients. It was placebo-controlled single blind research study. Research was conducted at National hospital, Lahore, from July to November 2016. Consent was taken from sixty hyperlipidemic patients age range from 25 to 60 years. Both gender male and female patients were enrolled. Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly.
International Journal of Medical Science in Clinical Research and Review Vol 03, Issue 02,April – 2020 Page |
229
When duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values. Three months treatment with 5 grams of ginger decreased total cholesterol from 233.11±1.53 mg/dl to 198.44±1.23 mg/dl, LDL cholesterol reduced from 202.21±1.88 mg/dl to 187.72± 1.98 mg/dl, reduced body weight from 76.01±2.66 kg to 72.80±1.87 kg. Both plasma total cholesterol and LDL cholesterol reduction was statistically significant, but body weight decrease was non-significant when analyzed biostatistically.
Heart diseases due to hyperlipidemia (primary or secondary) can lead to cause chest pain, heart attacks,
strokes, cardiac arrhythmias, cardiac failure. Because of these risks, treatment is often recommended for people with
hyperlipidemia, because it is well known factor to increase incidence of heart diseases. This may lead to
development of atherosclerotic plaques which is major etiological factor for establishing coronary artery disease
(CAD). Hypolipidemic drugs used in allopathy include Statins, Fibric acids, Niacin, and Resins but all have their
low compliance due to frequent side effects. Medicinal herbs like Onion and Ginger are hypolipidemic agents
commonly used as flavoring agents and making foods spicy and tasty. We have compared hypolipidemic potential
between these two medicinal herbs. The study was conducted at Ghurki Trust teaching hospital, Lahore from
January to June 2018. Eighty secondary hyperlipidemic patients were enrolled after getting written consent which
was approved by Ethics committee of the hospital. They were divided in two equal groups comprising 40 patients in
each group. Group-I was treated by Ginger 10 grams daily in three divided doses for 2 months. Group-II was
advised to take Onion 200 grams daily in divided amount with each meal i.e.; breakfast, lunch, and dinner for two
months. After two months therapy it was observed by statistical analysis that 10 grams ginger reduced TC (total
cholesterol) of 38 hyperlipidemic patients 12.4 gm/dl and LDL-C (low density lipoprotein cholesterol) 27.3 mg/dl.
In group-II, onion reduced TC in 35 patients 17.9 mg/dl and LDL-C 14.8 mg/dl. Changes in tested parameters are
significant biostatistically with p-values <0.01 to <0.001. We concluded from this research work that Onion and
Ginger reduces risk of CAD by decreasing plasma total cholesterol and LDL cholesterol.
The effects of dietary fats on the risk of coronary artery disease (CAD) have traditionally
been estimated from their effects on LDL cholesterol. Fats, however, also affect HDL
cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is
LDL cholesterol. Hypolipidemic drugs and fruits can play a part to reduce LDL particles
decreasing chances of CAD development. This study was conducted to compare
hypolipidemic effects of Niacin and Jujube fruit in primary as well as secondary
hyperlipidemic patients. Study was conducted from November 2018 to February 2019 at
Jinnah Hospital Lahore. Sixty participants were enrolled of both gender male and female
patients age range from 20 to 70 years. Consent was taken from all patients. They were
divided in two groups. Group-I was advised to take 2 grams Niacin in divided doses for the
period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the
period of two months. Their baseline LDL and HDL cholesterol was determined by
conventional method of measuring Lipid Profile. After two months therapy, their post
treatment lipid profile was measured and mean values with ± SEM were analyzed
biostatistically. Group-I which was on Niacin their LDL cholesterol decreased significantly and
HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was
decreased significantly but HDL increase was not significant with p-value of >0.05. It was
concluded from the research work that Niacin is potent in lowering LDL and increasing HDL
cholesterol, while Jujube has significant effect as LDL cholesterol lowering potential, but it
does not increase HDL cholesterol significantly.
ABSTRACT- Previous studies have suggested an association between vegetarian persons and non-vegetarian persons, although this relationship
positive correlation significant. The present study was designed to investigate comparative study of lipid profile levels in vegetarian and nonvegetarian
person. The lipid profile is used to determine the risk of obesity, heart disease in myocardial infarction, atherosclerosis and help in deciding
treatment has borderline or high risk. the present study was undertaken to compare case and control produce effect on individuals lipid profile, the
parameters of lipid metabolism i.e. cholesterol, tri-glyceride, high density lipoprotein, low density lipoprotein of the age of 20-85 years and early
aged 50 years and above males and females, divided categories i.e. vegetarian and non- vegetarian persons. the study was done on 20 cases in 10
control (non-vegetarians) and 10 cases (vegetarians) diet was significantly found to reduce the values of all the parameter lipid metabolism except
HDL-Cholesterol(45.02± 9.595; p<0.0001).when><0.0001 ) from this study, it can be concluded
that along with diet, sex and age factor also influence parameters of lipid metabolism.
Key words- Vegetarian persons, non-Vegetarian, Lipid profile
Transglucosidase improves the gut microbiota profile of type 2 diabetes melli...Enrique Moreno Gonzalez
Recently, the relationship between gut microbiota and obesity has been highlighted. The
present randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy of
transglucosidase (TGD) in modulating blood glucose levels and body weight gain in patients
with type 2 diabetes mellitus (T2DM) and to clarify the underlying mechanism by analyzing
the gut microbiota of T2DM patients.
DOI:10.21276/ijlssr.2016.2.4.22
ABSTRACT- Diabetes mellitus, an impaired blood glucose status is a major cause for loss of valuable human life. The
important risk factors include: High familial aggregation, insulin resistance, lifestyle changes due to rapid urbanization
and obesity specially central one. This study was carried out in diabetics (study group) & non-diabetic (control group)
women of 30-50 years age. They were subjected to anthropometric measurement and body composition assessment by
bioelectrical impedance analysis. This include waist circumference (WC), hip circumference (HC), waist hip ratio (WHR),
body mass index (BMI), body fat % (BF %) and lean body mass % (LBM %). It was found that the BMI of study group
was significantly higher as compared to that of controls. Values of WC and WHR were significantly higher in Type 2 DM
women than control. This shows that there is association of abdominal obesity (WC and WHR) with Type 2 DM. BF %
gives the relative percentage of fat in human body. BF% was significantly high in diabetic women than in control. Mean
value of body fat % in study group was 35.67±3.03% while that of controls was 28.29±2.66%. This shows that Asians
having higher BF % at low BMI values and also individuals with a similar BMI can vary considerably in their abdominal
fat mass. In such a situation, body fat would constitute the only true measure of obesity. Key-words- Body Composition, Bioelectrical impedance, Type 2 Diabetes Mellitus
Metabolic effects of bariatric surgery in patients with moderate obesity and ...Apollo Hospitals
Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: Analysis of a randomized control trial comparing surgery with intensive medical treatment
Effects of souvenaid on plasma micronutrient levels and fatty acid profiles i...Nutricia
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
Obesity and hyperlipidemia is international /worldwide problem causing heart disease leading to major predisposing factor for morbidity and death. Conventional medicine used in allopathy include statins, fibrates, niacin and resins but are going to defame due to their adverse effects. Herbal medicine ginger has proved itself as one of the potent anti hyperlipidemic and anti obesity herb with least adverse effects. We did try to compare its hypolipidemic effects with placebo effects when used in mild to moderate hyperlipidemic patients. It was placebo-controlled single blind research study. Research was conducted at National hospital, Lahore, from July to November 2016. Consent was taken from sixty hyperlipidemic patients age range from 25 to 60 years. Both gender male and female patients were enrolled. Patients were randomly divided in two groups, 30 patients were on drug ginger pasted-powder advised to take 5 grams in divided doses with their normal diet for the period of three months. Thirty patients were on placebo pasted-wheat powder, with same color as of ginger powder, advised to take 5 grams in divided doses with their normal diet for the period of three months. Their base line lipid profile and body weight was recorded at start of treatment and were advised to come for check-up, fortnightly.
International Journal of Medical Science in Clinical Research and Review Vol 03, Issue 02,April – 2020 Page |
229
When duration of study was over, their lipid profile and body weight was measured and compared statistically with pre-treatment values. Three months treatment with 5 grams of ginger decreased total cholesterol from 233.11±1.53 mg/dl to 198.44±1.23 mg/dl, LDL cholesterol reduced from 202.21±1.88 mg/dl to 187.72± 1.98 mg/dl, reduced body weight from 76.01±2.66 kg to 72.80±1.87 kg. Both plasma total cholesterol and LDL cholesterol reduction was statistically significant, but body weight decrease was non-significant when analyzed biostatistically.
Heart diseases due to hyperlipidemia (primary or secondary) can lead to cause chest pain, heart attacks,
strokes, cardiac arrhythmias, cardiac failure. Because of these risks, treatment is often recommended for people with
hyperlipidemia, because it is well known factor to increase incidence of heart diseases. This may lead to
development of atherosclerotic plaques which is major etiological factor for establishing coronary artery disease
(CAD). Hypolipidemic drugs used in allopathy include Statins, Fibric acids, Niacin, and Resins but all have their
low compliance due to frequent side effects. Medicinal herbs like Onion and Ginger are hypolipidemic agents
commonly used as flavoring agents and making foods spicy and tasty. We have compared hypolipidemic potential
between these two medicinal herbs. The study was conducted at Ghurki Trust teaching hospital, Lahore from
January to June 2018. Eighty secondary hyperlipidemic patients were enrolled after getting written consent which
was approved by Ethics committee of the hospital. They were divided in two equal groups comprising 40 patients in
each group. Group-I was treated by Ginger 10 grams daily in three divided doses for 2 months. Group-II was
advised to take Onion 200 grams daily in divided amount with each meal i.e.; breakfast, lunch, and dinner for two
months. After two months therapy it was observed by statistical analysis that 10 grams ginger reduced TC (total
cholesterol) of 38 hyperlipidemic patients 12.4 gm/dl and LDL-C (low density lipoprotein cholesterol) 27.3 mg/dl.
In group-II, onion reduced TC in 35 patients 17.9 mg/dl and LDL-C 14.8 mg/dl. Changes in tested parameters are
significant biostatistically with p-values <0.01 to <0.001. We concluded from this research work that Onion and
Ginger reduces risk of CAD by decreasing plasma total cholesterol and LDL cholesterol.
The effects of dietary fats on the risk of coronary artery disease (CAD) have traditionally
been estimated from their effects on LDL cholesterol. Fats, however, also affect HDL
cholesterol, and the ratio of total to HDL cholesterol is a more specific marker of CAD than is
LDL cholesterol. Hypolipidemic drugs and fruits can play a part to reduce LDL particles
decreasing chances of CAD development. This study was conducted to compare
hypolipidemic effects of Niacin and Jujube fruit in primary as well as secondary
hyperlipidemic patients. Study was conducted from November 2018 to February 2019 at
Jinnah Hospital Lahore. Sixty participants were enrolled of both gender male and female
patients age range from 20 to 70 years. Consent was taken from all patients. They were
divided in two groups. Group-I was advised to take 2 grams Niacin in divided doses for the
period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the
period of two months. Their baseline LDL and HDL cholesterol was determined by
conventional method of measuring Lipid Profile. After two months therapy, their post
treatment lipid profile was measured and mean values with ± SEM were analyzed
biostatistically. Group-I which was on Niacin their LDL cholesterol decreased significantly and
HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was
decreased significantly but HDL increase was not significant with p-value of >0.05. It was
concluded from the research work that Niacin is potent in lowering LDL and increasing HDL
cholesterol, while Jujube has significant effect as LDL cholesterol lowering potential, but it
does not increase HDL cholesterol significantly.
ABSTRACT- Previous studies have suggested an association between vegetarian persons and non-vegetarian persons, although this relationship
positive correlation significant. The present study was designed to investigate comparative study of lipid profile levels in vegetarian and nonvegetarian
person. The lipid profile is used to determine the risk of obesity, heart disease in myocardial infarction, atherosclerosis and help in deciding
treatment has borderline or high risk. the present study was undertaken to compare case and control produce effect on individuals lipid profile, the
parameters of lipid metabolism i.e. cholesterol, tri-glyceride, high density lipoprotein, low density lipoprotein of the age of 20-85 years and early
aged 50 years and above males and females, divided categories i.e. vegetarian and non- vegetarian persons. the study was done on 20 cases in 10
control (non-vegetarians) and 10 cases (vegetarians) diet was significantly found to reduce the values of all the parameter lipid metabolism except
HDL-Cholesterol(45.02± 9.595; p<0.0001).when><0.0001 ) from this study, it can be concluded
that along with diet, sex and age factor also influence parameters of lipid metabolism.
Key words- Vegetarian persons, non-Vegetarian, Lipid profile
Transglucosidase improves the gut microbiota profile of type 2 diabetes melli...Enrique Moreno Gonzalez
Recently, the relationship between gut microbiota and obesity has been highlighted. The
present randomized, double-blind, placebo-controlled study aimed to evaluate the efficacy of
transglucosidase (TGD) in modulating blood glucose levels and body weight gain in patients
with type 2 diabetes mellitus (T2DM) and to clarify the underlying mechanism by analyzing
the gut microbiota of T2DM patients.
DOI:10.21276/ijlssr.2016.2.4.22
ABSTRACT- Diabetes mellitus, an impaired blood glucose status is a major cause for loss of valuable human life. The
important risk factors include: High familial aggregation, insulin resistance, lifestyle changes due to rapid urbanization
and obesity specially central one. This study was carried out in diabetics (study group) & non-diabetic (control group)
women of 30-50 years age. They were subjected to anthropometric measurement and body composition assessment by
bioelectrical impedance analysis. This include waist circumference (WC), hip circumference (HC), waist hip ratio (WHR),
body mass index (BMI), body fat % (BF %) and lean body mass % (LBM %). It was found that the BMI of study group
was significantly higher as compared to that of controls. Values of WC and WHR were significantly higher in Type 2 DM
women than control. This shows that there is association of abdominal obesity (WC and WHR) with Type 2 DM. BF %
gives the relative percentage of fat in human body. BF% was significantly high in diabetic women than in control. Mean
value of body fat % in study group was 35.67±3.03% while that of controls was 28.29±2.66%. This shows that Asians
having higher BF % at low BMI values and also individuals with a similar BMI can vary considerably in their abdominal
fat mass. In such a situation, body fat would constitute the only true measure of obesity. Key-words- Body Composition, Bioelectrical impedance, Type 2 Diabetes Mellitus
Metabolic effects of bariatric surgery in patients with moderate obesity and ...Apollo Hospitals
Metabolic effects of bariatric surgery in patients with moderate obesity and type 2 diabetes: Analysis of a randomized control trial comparing surgery with intensive medical treatment
Effects of souvenaid on plasma micronutrient levels and fatty acid profiles i...Nutricia
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial
In Pakistan, the overall prevalence of dyslipidemia in adolescents aged 10–18 years is 21.7~25.2%; prevalence is reported to be two times higher (53.1~56.1%) in obese adolescents. However, few studies have been conducted on the relationship between height and blood lipid concentrations in children and adolescents The recent emphasis on treatment of the dyslipidemia of the metabolic syndrome (hypertriglyceridemia, reduced high-density lipoprotein, and increased small, dense low-density lipoprotein particle number) has compelled practitioners to consider lipid-lowering therapy in a greater number of their patients, as one in two individuals over age 50 has the metabolic syndrome. Individuals with the metabolic syndrome typically have normal low-density lipoprotein cholesterol levels, and current lipid-lowering guidelines may underestimate their cardiovascular risk. Two subgroups of patients with the metabolic syndrome are at particularly high risk for premature CAD. One, individuals with type 2 diabetes, accounts for 20-30% of early cardiovascular disease. The second, familial combined hyperlipidemia, accounts for an additional 10-20% of premature CAD. Familial combined hyperlipidemia is characterized by the metabolic syndrome in addition to a disproportionate elevation of apolipoprotein B levels. The measurement of fasting glucose and apolipoprotein B, in addition to the fasting lipid profile, can help to estimate CAD risk in patients with the metabolic syndrome. In this research we compared allopathic medication and medicinal herb in treating hyperlipidemia.
פירוט הרכיבים הטבעיים שנמצאים ב Cane תוסף תזונה טבעי המסייע לחולי סוכרת להגיע לאיזון ברמות הסוכר שלהם. Cane הוא תוסף תזונה מבית קיורהלייף, חברה הדואגת לאיכות חייהם של החולים במחלות כרוניות.
http://www.cane-curalife.com/
Moringa is a plantfood of high nutritional value, ecologically and economically beneficial and readily available in the countries hardest hit by the food crisis. http://miracletrees.org/ http://moringatrees.org/
Diabetes is a rapidly and serious health problem in Pakistan. This chronic condition is associated with serious long-term complications, including higher risk of heart disease and stroke. Aggressive treatment of hypertension and hyperlipideamia can result in a substantial reduction in cardiovascular events in patients with diabetes 1. Consequently pharmacist-led diabetes cardiovascular risk (DCVR) clinics have been established in both primary and secondary care sites in NHS Lothian during the past five years. An audit of the pharmaceutical care delivery at the clinics was conducted in order to evaluate practice and to standardize the pharmacists’ documentation of outcomes. Pharmaceutical care issues (PCI) and patient details were collected both prospectively and retrospectively from three DCVR clinics. The PCI`s were categorized according to a triangularised system consisting of multiple categories. These were ‘checks’, ‘changes’ (‘change in drug therapy process’ and ‘change in drug therapy’), ‘drug therapy problems’ and ‘quality assurance descriptors’ (‘timer perspective’ and ‘degree of change’). A verified medication assessment tool (MAT) for patients with chronic cardiovascular disease was applied to the patients from one of the clinics. The tool was used to quantify PCI`s and pharmacist actions that were centered on implementing or enforcing clinical guideline standards. A database was developed to be used as an assessment tool and to standardize the documentation of achievement of outcomes. Feedback on the audit of the pharmaceutical care delivery and the database was received from the DCVR clinic pharmacist at a focus group meeting.
Amino acid is monomer of protein
Proteins are organic nitrogenous compounds formed of C H O & “N”
Proteins are the polymers of 20 naturally occurring amino acids
Amino acids are organic acids in which one H is replaced by NH3 usually at α carbon (next to COOH group)
All amino acids have in common
central α carbon to which COOH & H & NH2 are attached
They also attached α carbon to a side chain called R group which is different for each
The present time encourages herbal supplements that
provide immune boosters, but they should thoroughly understand
herbal supplements, pharmacodynamics, and pharmacokinetics.
Citation: Neelesh Kumar Maurya. “Using the Herb to Treat COVID-19 by Self-medication”. Acta Scientific Pharmaceutical Sciences 5.1 (2020):.In this pandemic of COVID 19, herbs in pharmacopeia should be
revised, and all contraindications should be indicated. Therefore,
it is crucial for governments and agencies involved in the health
sector to take urgent action, such as policy-making and programs,
to raise public awareness of the health hazards of self-medication
with herbal medicines (especially without standardized products)
Studies showed that RBO has important hypocholesterolemic effects. RBO
incorporates a healthy diet and fitness regimen to improve cardiac health
and other health conditions. It is important to remind everyone that RBO is
not a drug, even with minor changes in your lipid profile. This concept
could be beneficial. It is a convenient and cost-effective approach to a well-balanced life and better quality of life.
Studies on Vegetarian and Non- vegetarian food habits during pregnancy periodNeeleshkumar Maurya
The study was conducted on 35 pregnant women who were pregnant at in Attarsuiya at Allahabad (U.P.), India during in the year 2017-18. Anaemia in pregnancy is associated with increased rates of maternal and prenatal mortality, premature delivery, low birth weight, and other adverse outcomes. Hemoglobin is expected to drop during pregnancy. It is normal for hemoglobin to drop to 10.5g/dl during pregnancy. Micronutrients like Iron, copper, pyridoxine, Vitamin-C, Vitamin-B12, the deficiency is may cause of low hemoglobin that is become a reason for Anaemia. The blood was collected from all the subjects to measure the hemoglobin (Hb) during 16-18 weeks, 22-24 weeks, and 34-35 weeks of gestation. According to food habits, it is divided into 2 groups. The first group was vegetarian and the second group was non-vegetarian both groups were taken proper routine check-ups by the gynecologist and consult a nutritionist. Result founded that BMI Mean± SD of vegetarian pregnant women is 23.1±4.1 and on vegetarians was 22.8 ±2.9. Hemoglobin Mean± SD of a vegetarian pregnant lady is 11.9±0.4 and on non-vegetarians was 11.3±1.3. There is no significant difference (p <0.05) was observed value of BMI and hemoglobin in both groups.
Keywords: vegetarian diets, nutrition; pregnancy, anaemia, balanced diet.
Renewable Energy: An Assessment of Public Awareness in Jhansi Neeleshkumar Maurya
India is one of the countries with the largest production of energy from renewable sources (solar light, bio gas, hydro, bio diesel, wind etc). Jhansi city has a very good scope to generate renewable energy due to their geographical situation and environmental factors. Diffusion methods are a key factor in promoting renewable energy production. Present time Indian government uses different types of effective extension education and diffusion method a deep gap which needs to be addressed in the area of energy education and awareness in India. This study aims to address the awareness of renewable energy and running Indian government different subsidy scheme like Jawaharlal Nehru National Solar Mission (JNNSM), Government Yojana: Solar Energy Subsidy Scheme, UDAY Scheme, SECI scheme, ROOFTOP scheme. Methodology used sample size was 250 respondents from Jhansi three different local area were chosen Shiva Ji Nagar, Veerangana, Kochha Bhanwar its duration from November 2018 to February 2019. Questionnaire based on self-structured questionnaires including demographic data that includes gender, age, income, education, area of residence, life quality, and interest of implementation. The statistical analysis used percentage and ratio, stated that middle class and rural respondents were more (76%)interested to use renewable energy, government launched different schemes but 96 % respondent had no knowledge. The government needs to improve its diffusion method that changes Indian people’s view of renewable energy not only economically but eco-friendly and helpful in various type of health issues. Keywords: Awareness -Renewable Energy, Diffusion method, government subsidy, eco-friendly
India is the second rank in population and developing in the world. It leads to other countries by own Scio-economic, cultural way. Any country health affects growth in their average expectancy and various socioeconomic indicators like Human Development Index, Multidimensional Poverty Index, and Gross Domestic Product per capita other way reducing the burden of disease. Children, pregnant and lactating women are the most affected with a reduction in cognitive and physical growth and prone to unhealthy which directly affect the productivity of the country. After independence in Indian constitute have a provision in part -IV (Article -45, 47) development of nutritional strategies and intervention in the five-year plans. Hence Government has devised several nutrition programmes like National Nutritional Anaemia Prophylaxis Programme, National Goitre Control Programme, National, Iodine Deficiency Disorders Control Programme, Midday Meal Programme, Applied nutrition Programme, Akshaya Patra Program. The activities in each program have been seen and its impact assessed by various evaluation programs and it was found that these programmes helped the nation. They helped to provide the proper nutrition to the children and women. The implementation of these principles, together with intensification of public health and primary care services, offers an approach to ensure more equitable health care for India’s population. Keywords: India, nutritional programs, Article-45, 47
Novel Protein Foods: Alternative Sources of Protein for Human Consumption Neeleshkumar Maurya
Proteins are a major macronutrient of the human diet needed for survival. Its crucial function in nourishment is to provide sufficient amounts of amino acids to the body as these amino acids work as anaplerotic substrates in the building block of the body. As the growth of population increases continuously, the demand for protein also increases over the next decades, and it is very important to search alternative sources of protein for human consumption. The present food industrialists aim to develop a cheaper, protein rich that have almost essential amino acids with highest bioavailability and more convenient food products. Single cell protein from algae and fungi, leaf protein extract and many insects could be an alternative of protein, because they have almost all the essential amino acids required for the human body for the survival.
ABSTRACT Emblica officinalis commonly known as Indian gooseberry or Amla, is perhaps the most important medicinal plant in the Indian traditional system of medicine, the Ayurveda.Vitamin C, tannins and flavonoidspresent in amla have powerful antioxidant activities. Due to rich Vitamin C content, amla is successfully used in the treatment of diabetes mellitus.It is one of the oldest Indian fruits and considered as “wonder fruit for health”. Amla pulp of fresh fruit contains 200–900 mg/100 g of vitamin C.Ascorbic acid retention was found to be decreased with increase in temperature. The fruit is highly perishable in nature and is available for short period from October to January. Theamla fruit possess excellent nutritive and therapeutic value. Processed forms of Amla fruit are murabbas, candy, dried chips, jelly, sauce, pickle, squash and syrup. Therefore, present study was undertaken to develop a value addedamla products.Amlabhujiawas prepared from gram flour, amla pulp or amla powder with spices.Amlawas incorporated at different forms (powder and pulp).Amlabhujia was prepared by using nine point hedonic scale. The Comparison of three samples B1 (Gram flour with amla pulp), B2 (Gram flour, amla powder, spices, oil with citric acid) and B3 (Gram flour,amla powder, without citric acid).The result of study revealed that according to sensory evaluation of amlabhujia, sample B1 (gram flour with aonla pulp) was found to be highly acceptable by the judges. Keywords:Amla, Medicinal uses,Diseases, Vitamin C,Sensory evaluation
Proper handling, treatment and disposal of biomedical wastes are important elements of health care office infection control programme. Pyperharin treatment and disposal of biomedical waste play a vital role in the hospital infection control programme. Objectives of BMW (Biomedical waste) management mainly involves preventing transmission of disease from patient to patient, from patient to health worker and vice versa to present injury to the healthcare worker and workers in support services, while handling biomedical waste, to prevent genital exposure to the harmful effects of the cytotoxic, genotoxic ,Anatomical Waste, Bio Technology Waste and chemical biomedical waste generated in hospitals. If properly designed and applied, waste management can be a relatively effective and effective compliance related practice. This review article discusses the collection situation, treatment and disposal of biomedical waste and its various types Hospital are one of the complex institutions which are frequently visited by people from every standard of life without any distinction between age, sex, race and religion. Most of these hospitals and health clinics produce waste which is increasing in its amount and type and leading to risk for patients and personnel who handle their wastes and the low threat to public health and environment.
KEYWORDS: Awareness, biomedical waste management, hospital waste management, anatomical waste, chemical waste, bio Technology Waste.
Impact of Malnutrition on Lipid Profile in Chronic Kidney Disease Patients in...Neeleshkumar Maurya
The present study was carried out to identify the role of malnutrition and its relationship for the development of cardiovascular disease (CVD) in chronic kidney disease (CKD) patients taking hemodialysis. We conducted an analytical study with 100 patients. It was carried out over one-year period, from February 25, 2017 to March 30, 2018. The inclusion criteria were the patients who have been on hemodialysis for at least past three months period and at least more than 18-year-old. All the patients were divided into two groups: first group of patients have both CVD and CKD and other group of patients have only CKD. Patients were subjected to biochemical and anthropometric parameters. Out of hundred patients, about 60 followed the inclusion and exclusion criteria. Eight women and 52 men with the age range from 18 to 80 years with 49±10.2years as mean age. We found that higher level of cholesterol, triglyceride, low protein intake and low energy conception in CKD alone patients is directly associated with malnutrition. The association between cholesterol levels and CKD would be altered by the presence of malnutrition. Low level of protein and total energy intake also confirms the presence of malnutrition in CKD patient developed the CVD.
Keywords: Malnutrition, hemodialysis patients, chronic kidney disease (CKD), cardiovascular disease (CVD)
PATIENT-GENERATED SUBJECTIVE GLOBAL ASSESSMENT (PG-SGA): A REVIEW Neeleshkumar Maurya
The present investigation, Subjective Global Assessment (SGA) and its different variants are being widely used as a nutritional status or risk assessment tool in clinical and hospital practice for myriads of disease including life-threatening one such as cancer, chronic kidney diseases. SGA is based on measurement and observation of several parameters such as weight change, dietary intake change, gastrointestinal symptoms, functional capacity, co morbidities related to nutritional condition and physical examination. However, the tool is not devoid of limitation and is being constantly improved for the optimization of its use in various other diseases. Therefore, clinicians need an easy to use and interpret, low cost, reliable tool to assess nutritional status. The PG-SGA is a more sensitive tool than other versions of SGA and is successfully being used as a screening tool in diseases like cancer, tuberculosis, HIV and chronic kidney disease (CKD) etc. According to the theory of “reverse epidemiology”, a patient with better nutritional status is supposed to have increased scope of survival. Therefore, it is increasingly being used patients who are at the pre-dialysis stage or being treated with dialysis. The review will summarize the basics of the nutritional assessment tool, its indications, and limitation of use in clinical practice etc. Moreover, the review will summarize the recommendations for use of PG-SGA in CKD and a brief review of existing literature to understand the scope of use and future perspective of the application of this tool for using in CKD patient population. Key Words: SGA, PG-SGA, Chronic kidney disease, Dialysis, nutrition
Human health has many aspects, we need to feed the diet which provides better nutrition and gives good health, an absence of disease and good behaviour. There are many health-related problems and conditions are responsible for the weak health and sometimes death causing illness, in which cancer is one most common health risk in human healthcare. Cancer is the state in which cell division is uncontrolled which damage the cells and in the last stage, if incurable caused death. There are many reasons why cell got infected due to cancerous infections, in which food habits and quality of foodstuffs are also increased the risk of cancer, like mycotoxins contamination in the food. MSG additives, taste enhancer, food colouring etc. done by the chemical processing which produces toxins inside the during the oxidation process of food. Cancer is causes of death rate higher than other health risks all over the world. The number of cancer cases is likely to rise up to 24 million by 2035. Several studies were performed in the last years in order to explore and analyze associations between diet and risk of cancer. The risk of cancer is depending on the degree of exposure to contaminated food, availability of nutrients in the body, dietary pattern and lifestyle as well as food behaviour. Research from a number of sources provides information that some vegetables, fruits, and whole grains, dietary fibre, certain micronutrients, few fatty acids and physical activity protect against cancers. Whereas poor dietary intake, imbalanced nutrition, less physical activity trances fatty acids, food processing and cooking method may increase risks.
Keywords: Cancer, death, nutrition, fruits and vegetable
Renewable Energy: An Assessment of Public Awareness in Jhansi Neeleshkumar Maurya
ABSTRACT India is one of the countries with the largest production of energy from renewable sources (solar light, bio gas, hydro, bio diesel, wind etc). Jhansi city has a very good scope to generate renewable energy due to their geographical situation and environmental factors. Diffusion methods are a key factor in promoting renewable energy production. Present time Indian government uses different types of effective extension education and diffusion method a deep gap which needs to be addressed in the area of energy education and awareness in India. This study aims to address the awareness of renewable energy and running Indian government different subsidy scheme like Jawaharlal Nehru National Solar Mission (JNNSM), Government Yojana: Solar Energy Subsidy Scheme, UDAY Scheme, SECI scheme, ROOFTOP scheme. Methodology used sample size was 250 respondents from Jhansi three different local area were chosen Shiva Ji Nagar, Veerangana, Kochha Bhanwar its duration from November 2018 to February 2019. Questionnaire based on self-structured questionnaires including demographic data that includes gender, age, income, education, area of residence, life quality, and interest of implementation. The statistical analysis used percentage and ratio, stated that middle class and rural respondents were more (76%)interested to use renewable energy, government launched different schemes but 96 % respondent had no knowledge. The government needs to improve its diffusion method that changes Indian people’s view of renewable energy not only economically but eco-friendly and helpful in various type of health issues. Keywords: Awareness -Renewable Energy, Diffusion method, government subsidy, eco-friendly.
Prevalence of infertility gravitates to increase due to different factors. Causes of male infertility could be varicocele, idiopathic infertility, testicular insufficiency, obstruction, ejaculation disorder, medicineradiation effect, undescended testis, immunological mechanisms, endocrine dysfunction such as diabetes, excessive taking of alcohol, smoking and environmental toxins such as pesticides, mercury and lead. It is furthermore understood that person, obesity, be deficient in of nutrition and habits of utilizing time for example too much use of, laptop, mobile phones, computers and sauna, etc., as for women, age, smoking, too much consumption of alcohol, having a skinny or overweight body and having been exposed to physical or mental stress fruition in amenorrhea might be the causes of infertility. The progress in infertility prevalence draws attention to the effects of factors such as lifestyle, dietetic habits and environmental factors. Male infertility originates from mostly as a result of the association between oxidative stress and antioxidants. A review of these areas will provide researchers with a more noteworthy understanding of the compulsory participation of these nutrients in male reproductive processes. This review also caustic out gaps in recent studies which will require further investigations.
Keywords: Nutrition; spermatogenesis, oligospermia, infertility, antioxidants, reproductive
End-stage renal disease (ESRD) can result from a wide variety of different kidney diseases. Currently, 90% of patients reaching CKD have chronic diabetes mellitus, glomerulonephritis or hypertension. With CKD comes a myriad of problems related to the kidney's inability to excrete waste products leads to symptoms of uraemia. The treatments of CKD require dialysis or kidney transplantation. In this review, an attempt has been made to explain the nutritional management of CKD along with various dialysis treatment and the complications related to the dialysis method. It is important to maintain optimal nutritional status so that the patient will be a good candidate to respond to the treatment effectively.Kidney Patients necessitate following a blanced diet plan to retain normal protein stores and to avoid metabolic complications. This article deals with the therapeutic aspects of nutrition in CKD patients and will improve the quality of life Keywords: ESRD, CKD, Dialysis, Nutritional management.
FORMULATION OF VALUE ADDED LOW-CALORIE, HIGH FIBRE BISCUITS USING FLAX SEEDS ...Neeleshkumar Maurya
Worldwide scientists are focusing on developing functional food products which are healthy and low in calories. The possibility of incorporating roasted flax seeds flour (RFF) and substituting sugar with Stevia rebaudiana leaves powder (SLP) for developing nutritious, healthier and high quality biscuits has been investigated. Overall six biscuit formulations were designed besides control. SLP was used as a natural sweetener and RFF was used as a source of dietary fibre. Standardisation was done by evaluating the sensory quality of the formulated biscuits prepared from a mixture of blends. As soon as standardisation of blends was completed, the standardised flour mix was used to formulate biscuits by substituting sucrose with SLP at levels of 5.5%, 6%, 6.5%, 7%, 7.5% and 8%. The treatment (T4) was found to be the best among different variations on the basis of sensory evaluation with incorporation of 8% (RFF) and 7% (SLP) resulted in increased moisture (7.57%), ash (3.69%), protein (18.88 g/100g), fat (10.97 g/100g), fibre (4.52 g/100g), calcium (408.23 mg/100g), phosphorus (445.03 mg/100g) and iron (10.01 mg/100g) content in comparison to control (T0) which was high in calories (384 Kcal/100g) and carbohydrate (62.34g/100g) content. Thus, results signify that incorporation of RFF at 8% and SLF at 7% enhance the functional properties of developed biscuits by reducing the calorie density and improving the health benefits.
Impact of Hemodialysis on lipid profile among chronic renal failure patients ...Neeleshkumar Maurya
Chronic Renal Failure (CRF) patients are at risk of cardiovascular diseases due to the elevation of various forms of lipids. Many a time CRF patients live on hemodialysis on regular basis. Chronic renal failure (CRF) is complicated by characteristic dyslipidemias. We sought to evaluate the pattern of lipid profile in CRF patients with and without hemodialysis. Study were divided into 2 groups, Group-I: CRF patients who never undergone hemodialysis (24) and Group-II: CRF patients on hemodialysis (24). We obtained serum samples from patients in the morning after an overnight fast and were analyzed for total cholesterol (TC), triglycerides (TGs), HDL, LDL and VLDL. Significant change (p<0.05) was found in Total cholesterol (TC), HDL-C, VLDL-C, HDL-C(level) between first and second group.
Keywords: Chronic renal failure, cardiovascular disease, Haemodialysis, CKD stage – 5
Amaranth grain is extremely nutritional pseudocereal with a higher amount of proteins when compared to true cereals. It is a reasonably well-balanced food with functional properties that have been shown to provide medicinal benefits. The health benefits credited include decreasing plasma cholesterol levels, exerting an antitumor activity, reducing blood glucose levels and anemia. The current article provides a comprehensive idea of amaranth grain that focuses on recent research reporting its use in the clinical practice and its possible profit to human health.
Keywords: grain amaranth, nutritive value, clinical studies
Memory booster herb (natural cognitive enhancers): An overview Neeleshkumar Maurya
Abstract The main important aspect to differentiate from one individual to other human beings is Memory as it is important to recognize individual self. There are three basic forms of memory which allow the brain to encode, store, and retrieve. Without these basic forms of memory, individual even fails to build personal rapport, to acquire new knowledge, and unable to do basic functions of daily life. From last decades, Indian and Chinese cultures took interest for natural remedies by developing various traditional medicines from herbs for the declining activity of cognition, reverse memory loss and to increase learning power. Neotropic herbs are famous for brain acting herbs and smart drugs called from its isolated constituents as it helps to enhance circulation of blood in the brain. This Review focuses on natural agents and Herbs which act as memory boosters.
Keywords: Memory, herbs, Cognitive, enhancers, Memory enhancing herbs, improving memory, Brain booster
Roti Bank Hyderabad: A Beacon of Hope and NourishmentRoti Bank
One of the top cities of India, Hyderabad is the capital of Telangana and home to some of the biggest companies. But the other aspect of the city is a huge chunk of population that is even deprived of the food and shelter. There are many people in Hyderabad that are not having access to
Ang Chong Yi Navigating Singaporean Flavors: A Journey from Cultural Heritage...Ang Chong Yi
In the heart of Singapore, where tradition meets modernity, He embarks on a culinary adventure that transcends borders. His mission? Ang Chong Yi Exploring the Cultural Heritage and Identity in Singaporean Cuisine. To explore the rich tapestry of flavours that define Singaporean cuisine while embracing innovative plant-based approaches. Join us as we follow his footsteps through bustling markets, hidden hawker stalls, and vibrant street corners.
At Taste Of Middle East, we believe that food is not just about satisfying hunger, it's about experiencing different cultures and traditions. Our restaurant concept is based on selecting famous dishes from Iran, Turkey, Afghanistan, and other Arabic countries to give our customers an authentic taste of the Middle East
Piccola Cucina is regarded as the best restaurant in Brooklyn and as the best Italian restaurant in NYC. We offer authentic Italian cuisine with a Sicilian touch that elevates the entire fine dining experience. We’re the first result when someone searches for where to eat in Brooklyn or the best restaurant near me.
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Filomena, a renowned Italian restaurant, is renowned for its authentic cuisine, warm environment, and exceptional service. Recognized for its homemade pasta, traditional dishes, and extensive wine selection, we provide a true taste of Italy. Its commitment to quality ingredients and classic recipes has made it a adored dining destination for Italian food enthusiasts.
1. Asian Journal of Pharmaceutics • Jan-Mar 2019 • 13 (1) | 33
Effect of Dietary Counseling in Chronic
Renal Failure Patients on Hemodialysis
Neelesh Kumar Maurya1
, Pratibha Arya1
, N. S. Sengar2
1
Department of Food and Nutrition, Institute of Home Science, Bundelkhand University, Jhansi, Uttar Pradesh,
India, 2
Department of Medicine, MLB Medical College, Jhansi, Uttar Pradesh, India
Abstract
Objective: The present study was conducted with the aim to assess and analyze the effect of dietary counseling
the nutritional status of patients (>19 years) undergoing hemodialysis (HD) at least 3 months and in chronic
kidney disease (CKD)-5 stage for the past 3 months. Materials and Methods: A total of 60 subjects were
enrolled in the study (48 males and 12 females) in two groups; the first group taken proper medication and
dialysis therapy and the second one additional diet counseling we suggested soy and paneer-like high biological
protein. Different biochemical parameters such as blood urea, creatinine, and albumin along with the amount of
calorie and protein intake were compared pre-nutritional counseling and post-nutritional counseling and protein
dietary recommendation for 60 days during ongoing HD. Results: Short-term suggestion resulted in a significant
statistically difference in the biochemical parameters. Proper dietary counseling along with high biological protein
(1.2 gm/kg/ideal body weight) is given during HD superior the nutritional status of undernourished CKD patient.
About proper diet counseling of the patients showed a positive response (<0.005) while the only medication
and dialysis therapy showed an undergoing undernourished in their nutritional status. Conclusion: Patients
undergoing HD frequently develop protein-energy malnutrition which is related to morbidity and mortality rate
increases. Special nutritional care is required for the dialysis patient to improve the net protein anabolism.
Key words: Chronic kidney disease, hemodialysis, high biological protein, malnutrition, nutritional status
Address for correspondence:
Neelesh Kumar Maurya, Institute of Home Science,
Bundelkhand University, Jhansi, Uttar Pradesh, India.
E-mail: id-neeleshkumar.maurya@gmail.com
Received: 25-12-2018
Revised: 24-01-2019
Accepted: 05-02-2019
INTRODUCTION
K
idney is the vital human organ which
is responsible for the filtration of
nitrogenous and other metabolic waste
products from the body through the urinary
system and maintains the volume of biochemical,
especially hemostatics fluid, electrolyte, and
acid-base balance kidney also help to maintain
blood pressure, activate Vitamin D, and produce
erythropoietininthehumanbody.[1]
Theefficiency
of kidney declined when its basic unit damaged by
disease or factors, chronic renal failure (CRF) is
the cause of uremia that is a drastically increased
level of urea in blood serum in progressive and
uncontrolled condition become is responsible
for the development of acute glomerulonephritis
and nephrotic syndrome.[2,3]
CRF is a slowly
progressive decline of renal function over a period
of month or year consequential in unusually
low glomerular filtration rate (GFR) which is
frequently determined the indirectly increased
level of creatinine in the blood serum.[4,5]
Patients who suffer from chronic kidney disease
(CKD stage 4) have sophisticated kidney
damage with a rigorous decline in the GFR to 15–30 ml/min.[6]
Dialysis therapy (both peritoneal dialysis and hemodialysis
[HD]) is not cures for end-stage renal disease (ESRD) but will
help CKD patients feel improved and live longer. Dialysis is
an artificial process by which nitrogenous waste products are
isolated from the blood in the occurrence of kidney failure.[7,8]
Adsorption is a specific characteristic that isolates nitrogenous
waste in peritoneal and HD procedures [Table 1].[10,11]
It is found very commonly in a patient of CKD during the
period when the GFR falls <10 ml/min;this clinical condition
is called kidney renal failure (CRF). Dialysis patient needs
a much privileged intake of high biological protein than
the normal person. HD patients often suffering protein-
energy malnutrition due to low intake of protein-energy
malnutrition.[9,10]
ORIGINALARTICLE
2. Maurya, et al.: Dietary counseling in HD patients
Asian Journal of Pharmaceutics • Jan-Mar 2019 • 13 (1) | 34
MATERIALS AND METHODS
This study was conducted on 60 selected CKD patients of
consecutive CKD stage-5 patients in MLB Medical College,
Jhansi, India, from February 25, 2016, to March 30, 2017,
aged between 19 and 65 years and undergone HD at least
3 months before. All the included patients have regular HD
for minimum 2 times a week for CKD patients, who suffering
5 stage from the past 3 months.
The observational study was continued after approval from
the Institutional Review Board (Human Ethics Committee),
MLB Medical College, Jhansi. The Human Ethical
Committee approval number is NO-838/SURGERY/15.
Informed written consent was obtained from the patients
before enrolment whose fulfilling the inclusion and exclusion
criteria taken in this study. The patients were taken into two
groups; both were suffering from CRF with the CKD-5 stage
in the past 3 months. 30 patients were taken in each group.
In this study, the 30 patients in the group first undergo with
HD at regular compulsory 2 times interval in a week. In
group second, all patients were having the same condition
as like group first but additional counseling proper diet soy
and cheese-like high biological protein (1.2 g/kg/ideal body
weight).
The blood samples of patients (5 ml of intravenous) were
collected in EDTA/without EDTA tubes after an overnight
fast. After collection, the blood samples were allowed to clot
for the ½ h following which the samples were centrifuged
and serum was analyzed. Serum total cholesterol, high-
density lipoprotein cholesterol (HDL-C), triglycerides (TGs),
and low-density lipoprotein cholesterol (LDL-C) were
measured calorimetrically using commercially available kits
on fully autoanalyzer of Clinical Biochemistry Laboratory.
Very LDL-C (VLDL-C) concentration was calculated using
Friedewald’s formula.[11,12]
Nutritional assessment is done by
24 dietary recall methods.[13]
All data collected 30-day interval
2 timesinthisstudy.StatisticaldatawererecordedonMicrosoft
Excel program. The comparison between two groups was done
by paired t-testin GraphPad Prism 7 software.[14,15]
RESULTS
A total of 60 patients were enrolled in this longitudinal study.
Group 1 had 27 males and 3 females, whereas Group 2 had
25 males and 5 females that CKD patients undergone HD
were taken dietary counseling. Table 1 is presented lipid
profile, blood sugar, and urea.
InGroup 1,meanbaselinecholesterolwas173.37±33.01(mg/dl)
and in Group 2 was 163.95 ± 29.35 (mg/dl). TGs, LDL-C, and
VLD-C in Group 1 mean baseline was 157.22 ± 28.85, 97.5 ±
32.8, and 32.27 ± 7.25 (mg/dl) and in Group 2 was 137.9 ± 37.72,
99.71 ± 26.33, and 27.5 ± 6.79 (mg/dl). HDL-C mean baseline
value in the group was 47.06 ± 06 (mg/dl) and in Group 2 was
50.7 ± 7.0 (mg/dl). Blood urea mean baseline in Group 1 was
146.42 ± 34.5 (mg/dl) and in Group 2 was 142.5 ± 36.16 (mg/dl).
RandombloodsugarmeanbaselinevaluewasinGroup 1,110.86
± 15.02 (mg/dl) and in Group 2 was 111.28 ± 12.02 (mg/dl).
Hemoglobin baseline value in Group 1 was 7.68 ± 1.38 (mg/dl)
and in Group 2 was 8.63 ± 1.4 (mg/dl) [Table 2].
Table 2 is presented anthropometrics measurements such as
weights,bodymassindex(BMI),midupperarmcircumference
(MUAC), micronutrients (energy and protein), and serum
albumin, weight mean baseline in Group 1 was 56.8 ± 6.7
and in Group 2 was 58.04 ± 6.11, BMI mean baseline in
Group 1 was 21.41 ± 1.7 and in Group 2 was 21.95 ± 1.22.
MUAC mean baseline in Group 1 was 22.18 ± 1.47 (cm)
and in Group 2 was 24.1 ± 1.14 (cm), macronutrients energy
Table 1: Recommended dietary nutrient intake for hemodialysis patients (Alpers et al., 2008, Richards, 2011)
Nutrients Recommended intake
DPI 1.2 g/kg/day for clinically stable patients (at least 50% should be of high biological value)
DEI 35 kcal/kg/day if<60 years 30–35 kcal/kg/day if 60 years or older
Total fat 25–35% of total energy intake
Saturated fat <7% of total energy intake
Polyunsaturated fatty acids Up to 10% of total calories
Carbohydrate Rest of calories (complex carbohydrates preferred)
Total fiber >20–25 g/day
Sodium 750–2000 mg/day
Potassium 2000–2750 mg/day
Phosphorus 800–1000 mg/day
Calcium <1000 mg/day
Iron 10–18 mg/day
Water Usually 750–1500 ml/day
DPI: Dietary protein intake, DEI: Daily energy intake, HD: Hemodialysis
3. Maurya, et al.: Dietary counseling in HD patients
Asian Journal of Pharmaceutics • Jan-Mar 2019 • 13 (1) | 35
(kcal) and protein mean baseline in Group 1 were 1580.5 ±
164 (kcal) and 58.1 ± 6.0 (g/day) and in Group 2 were 1644.0
± 96.93 (kcal) and 60.15 ± 3.68 (g/day), and serum albumin
mean baseline in Group 1 was 3.49 ± 0.4 (mg/dl) and in
Group 2 was 3.5 ± 0.4 (mg/dl).
DISCUSSION
It is revealed from Tables 2 and 3 the foods intake was
recorded at the past week of the month and after calculation
to analyze the changes in the energy (calories) and protein
intake. The CRF patients are at prone for cardiovascular
disease (CVD), and they are more likely to die of CVD
than to develop ESRD. The patients CRF is associated
with premature atherosclerosis and an increased incidence
of cardiovascular morbidity and mortality.[16]
These several
factors contribute to atherogenesis and CVD in patients with
CRF, the notably among all is dyslipidemias.[17]
CRF primarily affects the metabolism of HDL and TG-rich
lipoproteins.[10,18,19]
The protein-energy is high prevalence
(25–50%) among dialysis patients and is linked with increased
morbidity and mortality. The prevalence of CKD has been
increasing day by day and it is well known that patients are
more likely to die than to progress to ESRD. The presence of
multiple classical and novel risk factors influences this group
of patients, and in fact, patient with premature cardiovascular
mortality is due to ESRD.[20,21]
CONCLUSION
In this study, the result was concluded a high prevalence of
malnutrition in HD subjects. The role of high biological protein
source (soya and cheese nutritional value) in subjective patients
on HD needs to be more attention in the management of CKD.
The nutritional condition of CKD and ESRD patients remains
a considerable cause for concern. Multimodal therapeutic
strategies should be considered the better understanding of
the pathophysiologic mechanisms of urea malnutrition and
the improvements made in nutritional support. We hereby
recommend that the assessment of nutritional status should be
a part of routine evaluation of all CKD patients.
Table 2: Biochemical tests of lipid profiles, rbs, blood urea, and Hb, in CKD patients
Biochemical tests
of CKD patients
Mean±SD of CKD
patients undergone
hemodialysis
without dietary
counseling
P value Statistically
significant
(P<0.05)
Mean±SD of
CKD patients
undergone
hemodialysis with
dietary counseling
P value Statistically
significant
(P<0.05)
Urea (mg/dl) 146.42±34.5 <0.346 No 142.5±36.16 <0.0001 Yes
RBS (mg/dl) 110.86±15.02 <0.553 No 111.28±12.02 <0.6484 No
Cholesterol (mg/dl) 173.37±33.01 <0.0003 Yes 163.95±29.35 <0.0145 Yes
HDL‑C (mg/dl) 47.06±06 <0.2984 No 50.7±7.0 <0.0001 Yes
VLDL‑C (mg/dl) 32.27±7.25 <0.0001 Yes 27.5±6.79 <0.1762 Yes
TGs (mg/dl) 157.22±28.85 <0.0001 Yes 137.9±37.72 <0.37 N0
LDL‑C (mg/dl) 97.5±32.8 <0.0001 Yes 99.71±26.33 <0.0017 Yes
Serum creatine (mg/dl) 10.05±2.7 <0.57 No 12.81±3.55 <0.0001 Yes
Hb (mg/dl) 7.68±1.38 <0.015 Yes 8.63±1.4 <0.86 No
HDL: High‑density lipoprotein, VLDL: Very low‑density lipoprotein, LDL: Low‑density lipoprotein, Hb: Hemoglobin, SD: Standard deviation,
CKD: Chronic kidney disease, RBS: Random blood sugar
Table 3: Nutritional assessments of CKD patients on hemodialysis
Nutritional
assessment tests
of CKD patients
Mean±SD of CKD
patients undergone
hemodialysis without
dietary counseling
P value Statistically
significant
(P<0.05)
Mean±SD of CKD
patients undergone
hemodialysis with
dietary counseling
P value Statistically
significant
(P<0.05)
Weight (Kg) 56.8±6.7 <0.0001 Yes 58.04±6.11 <0.0001 Yes
BMI 21.41±1.7 <0.0145 Yes 21.95±1.22 <0.0001 Yes
MUAC (cm) 22.18±1.47 <0.0001 Yes 24.1±1.14 <0.0067 Yes
S. albumin (mg/dl) 3.49±0.4 <0.03 Yes 3.5±0.4 <0.187 No
Energy (Kcal) 1580.5±164 <0.0001 Yes 1644.0±96.93 <0.357 No
Protein (gm/day) 58.1±6.0 <0.0001 Yes 60.15±3.68 <0.0001 Yes
S. albumin: Serum albumin, MUAC: Midupper arm circumference, Kcal: Kilocalorie, SD: Standard deviation, CKD: Chronic kidney disease
4. Maurya, et al.: Dietary counseling in HD patients
Asian Journal of Pharmaceutics • Jan-Mar 2019 • 13 (1) | 36
Recommendation
The conclusion of the present experimental study is the HD
therapy that is very useful to counsel for other high-risk
populations for operative intervention, dieticians should
present a guide for instruct HD patients about individual
nutritional needs. This guide should provide appropriate
information about food nutrients sources, nutrients data and
usage of exchange food, and avoidable foods.
ACKNOWLEDGMENT
We acknowledge the support and cooperation of the patients
registered in the study and we also thankful to the employees
of the Department of Medicine and Dialysis Unit of MLB
Medical College, Jhansi, for their valuable help and support.
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Source of Support: Nil. Conflict of Interest: None declared.