The document summarizes two studies on the impact of an intensive lifestyle change program on coronary artery disease (CAD) and related risk factors. Both studies found statistically significant improvements in biomarkers and clinical measurements like blood pressure and cholesterol levels in patients who underwent lifestyle changes including a plant-based diet, exercise, stress reduction, and social support, compared to standard medical care. Specifically, the lifestyle changes were associated with reduced inflammation, improved endothelial function, lower BMI and waist-hip ratio, and better quality of life. The results provide further evidence that comprehensive lifestyle interventions can positively impact CAD.