The document discusses the nature and causes of autocorrelation in regression models. Autocorrelation occurs when the error terms are correlated over time or between observations, violating the independence assumption of classical linear regression models. It can be caused by inertia in time series, omitted variables, incorrect functional forms, lags between dependent and independent variables, and data manipulation or transformation. Addressing autocorrelation is important as it can invalidate statistical tests and estimates in regression analysis.