The keynote discusses how companies can maintain a startup culture and mentality even as they grow in order to reap the benefits of an agile and innovative approach. Some of the benefits mentioned include higher learning and focus on priorities, nimbleness in decision making, and keeping a culture that attracts talent. However, there are also pitfalls like a lack of processes that can lead startups to fail. The keynote provides tips for companies to operate like startups such as using small cross-functional teams, empowering employees, and continually learning through the build-measure-learn process. Overall, it argues that more established companies should seek to emulate the culture of startups.