Drugs acting on ANS

1. Drugs acting
on
the Autonomic Nervous System
Dr. Manoj R. Kumbhare
SMBT College of Pharmacy,
Nandi Hills, Dhamangaon, Nasik
422403

2. Learning outcomes
• After watching this presentation student able
to explain-
• Neurotransmitter release
• Differentiate sympathetic and parasympathetic
nervous system.
• Describe the cholinergic drug effects on major
body systems.
• Classify cholinergic drugs

3. Neurotransmitter release

4. Neurotransmitter release

5. Parasympathetic and Smpathetic System

7. Classification of Cholinergic Drugs
• Direct-acting cholinergic agonists
– Bind to cholinergic receptors, activating them
a. Acetylcholine and related compounds
e.g. Acetylcholine, Methacholine, Carbamylcholine
b. Cholinomimetic alkaloids
e.g. Pilocarpine, Muscarine
• Indirect-acting cholinergic agonists
– Inhibit the enzyme acetylcholinesterase - preventing, which
breaks down ACh - more ACh is available at the receptors
– Reversible - Bind to cholinesterase for a period of minutes to
hours e.g. Physostigmine, Neostigmine
– Irreversible - Bind to cholinesterase and form a permanent
covalent bond e.g. Parathion, Malathion
• The body must make new cholinesterase to break these bonds