An Overview of Antimicrobial Use - Dr. Kurt Stevenson, The Ohio State University Medical Center, from the 2012 NIAA One Health Approach to Antimicrobial Resistance and Use Symposium, October 26-27, 2012, Columbus, OH, USA.
More presentations at:
http://www.trufflemedia.com/agmedia/conference/2012-one-health-to-approach-antimicrobial-resistance-and-use
Prescribing practices of antibiotics in outpatient setting of a tertiary care...SriramNagarajan19
Antibiotic resistance is a form of drug resistance whereby certain sub-populations of a microorganism, usually a bacterial species, are able to survive after exposure to one or more antibiotics; pathogens resistant to multiple antibiotics are considered multidrug resistant (MDR) and the issue is the subject of ongoing investigation these days. The present study observed the rationality of antibiotics prescribed in an outpatient setting in a tertiary care hospital.
A prospective cohort study was conducted for 2 months on the patients who were prescribed antibiotics in a tertiary care hospital in outpatient setting. The prescriptions of patients were evaluated with respect to the medical condition of the patient. A total of 500 prescriptions were evaluated for rationality out of which 240 prescriptions (48%) were rational and 260 prescriptions (52%) were found to be irrational. The misuse of antibiotics continues to haunt the health care system of Pakistan and pose a threat of pandemic of bacterial resistance due to irrational use. Interventions by clinical pharmacists in the given situation are the need of the hour.
Journal club presentation: by RxVichuZ!! ;)RxVichuZ
My 97th powerpoint... deals with the comparative study of efficacy of piperacillin-tazobactam, as compared to meropenem in the treatment of ESBL(Extended spectrum beta-lactamases) infections.
A summarized insight has been provided, using research article from JAMA.
Webinar: Defeating Superbugs: Hospitals on the Front Lines Modern Healthcare
About the Webinar: Defeating Superbugs: Hospitals on the Front Lines
http://www.modernhealthcare.com/article/20140917/INFO/309179926
Hospitals across the country are facing a grim reality in which some of the most deadly healthcare-associated infections they encounter are untreatable with first- or even second-line antibiotics. These “superbugs” affect at least 2 million Americans each year and lead to 23,000 deaths. And their threat is growing, public health officials warn. This editorial webinar and “Defeating Superbugs” white paper will explore the steps providers must take to ramp up surveillance efforts, promote appropriate antibiotic use and control outbreaks. Our panel of experts will share their organizations' experiences as well as proven strategies for success.
Registration for this webinar includes Modern Healthcare's “Defeating Superbugs” white paper, with proven tips and strategies for promoting appropriate antibiotic use, improving infection surveillance, identifying drug-resistant infections and dealing with outbreaks.
KEY TAKEAWAYS
- Best practices for effective antimicrobial stewardship
- Real-world examples of effective interventions, including universal rapid testing for drug-resistant MRSA
- Tips for engaging senior leadership
- Aggressive strategies for controlling outbreaks
PANELISTS
Lance Peterson
Director of the Clinical Microbiology and Infectious Disease Research Division
NorthShore University HealthSystem, Evanston, Ill.
Anurag Malani
Medical Director for the Infection Prevention and Antimicrobial Stewardship Programs
St. Joseph Mercy Hospital, Ann Arbor, Mich.
Robert Weinstein
Chief Medical Officer for Population Health
Chairman of the Department of Medicine, Cook County Health and Hospitals System; Professor, Rush University Medical Center, Chicago
MODERATOR
Maureen McKinney
Editorial Programs Manager
Modern Healthcare
Prescribing practices of antibiotics in outpatient setting of a tertiary care...SriramNagarajan19
Antibiotic resistance is a form of drug resistance whereby certain sub-populations of a microorganism, usually a bacterial species, are able to survive after exposure to one or more antibiotics; pathogens resistant to multiple antibiotics are considered multidrug resistant (MDR) and the issue is the subject of ongoing investigation these days. The present study observed the rationality of antibiotics prescribed in an outpatient setting in a tertiary care hospital.
A prospective cohort study was conducted for 2 months on the patients who were prescribed antibiotics in a tertiary care hospital in outpatient setting. The prescriptions of patients were evaluated with respect to the medical condition of the patient. A total of 500 prescriptions were evaluated for rationality out of which 240 prescriptions (48%) were rational and 260 prescriptions (52%) were found to be irrational. The misuse of antibiotics continues to haunt the health care system of Pakistan and pose a threat of pandemic of bacterial resistance due to irrational use. Interventions by clinical pharmacists in the given situation are the need of the hour.
Journal club presentation: by RxVichuZ!! ;)RxVichuZ
My 97th powerpoint... deals with the comparative study of efficacy of piperacillin-tazobactam, as compared to meropenem in the treatment of ESBL(Extended spectrum beta-lactamases) infections.
A summarized insight has been provided, using research article from JAMA.
Webinar: Defeating Superbugs: Hospitals on the Front Lines Modern Healthcare
About the Webinar: Defeating Superbugs: Hospitals on the Front Lines
http://www.modernhealthcare.com/article/20140917/INFO/309179926
Hospitals across the country are facing a grim reality in which some of the most deadly healthcare-associated infections they encounter are untreatable with first- or even second-line antibiotics. These “superbugs” affect at least 2 million Americans each year and lead to 23,000 deaths. And their threat is growing, public health officials warn. This editorial webinar and “Defeating Superbugs” white paper will explore the steps providers must take to ramp up surveillance efforts, promote appropriate antibiotic use and control outbreaks. Our panel of experts will share their organizations' experiences as well as proven strategies for success.
Registration for this webinar includes Modern Healthcare's “Defeating Superbugs” white paper, with proven tips and strategies for promoting appropriate antibiotic use, improving infection surveillance, identifying drug-resistant infections and dealing with outbreaks.
KEY TAKEAWAYS
- Best practices for effective antimicrobial stewardship
- Real-world examples of effective interventions, including universal rapid testing for drug-resistant MRSA
- Tips for engaging senior leadership
- Aggressive strategies for controlling outbreaks
PANELISTS
Lance Peterson
Director of the Clinical Microbiology and Infectious Disease Research Division
NorthShore University HealthSystem, Evanston, Ill.
Anurag Malani
Medical Director for the Infection Prevention and Antimicrobial Stewardship Programs
St. Joseph Mercy Hospital, Ann Arbor, Mich.
Robert Weinstein
Chief Medical Officer for Population Health
Chairman of the Department of Medicine, Cook County Health and Hospitals System; Professor, Rush University Medical Center, Chicago
MODERATOR
Maureen McKinney
Editorial Programs Manager
Modern Healthcare
Global & Malaysia data has consistently shown that after 2 doses of Sinovac, a Pfizer/AstraZeneca booster is more effective than a 3rd dose of Sinovac, especially Omicron. And despite a third dose of Sinovac, levels of ‘neutralizing’ antibodies, tend to remain low.
Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea ...Utai Sukviwatsirikul
Saccharomyces boulardii in the prevention of antibiotic-associated
diarrhoea in children: a randomized double-blind placebo-controlled
trial
M. KOTOWSKA, P. ALBRECHT & H. SZAJEWSKA
Department of Pediatric Gastroenterology and Nutrition, The Medical University of Warsaw, Warsaw, Poland
Accepted for publication 24 November 2004
Jessica Maria Atrio, MD, has demonstrated that a safe but less-frequently prescribed birth control "mini-pill" is effective for women taking HIV medications. Study title: Effect of protease inhibitors on pharmacokinetics of oral norethindrone contraception in hiv+ women
Read the full story: http://sc-ctsi.org/index.php/news/sc-ctsi-supported-research-drives-global-health-policy#.Ut2b6WTTktU
Fluoroquinolone resistant rectal colonization predicts risk of infectious com...TC İÜ İTF Üroloji AD
Fluoroquinolone resistant rectal colonization predicts risk of infectious complications after transrectal prostate biopsy. Evidence based on journal club by Samed Verep
Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions
Dr. Theoklis Zaoutis - Antimicrobial Use and Stewardship in the Pediatric Out...John Blue
Antimicrobial Use and Stewardship in the Pediatric Outpatient Setting - Dr. Theoklis Zaoutis, Chief, Division of Infectious Diseases, Professor of Pediatrics and Epidemiology of the University of Pennsylvania, from the 2014 NIAA Symposium on Antibiotics Use and Resistance: Moving Forward Through Shared Stewardship, November 12-14, 2014, Atlanta, Georgia, USA.
More presentations at http://www.swinecast.com/2014-niaa-antibiotics-moving-forward-through-shared-stewardship
Dr.sherin elsherbiny
Senior registrar clinical microbiology
AMR coordinator
Infection control auditor
Riyadh region
Meeqat General Hospital ,Madina,KSA
Global & Malaysia data has consistently shown that after 2 doses of Sinovac, a Pfizer/AstraZeneca booster is more effective than a 3rd dose of Sinovac, especially Omicron. And despite a third dose of Sinovac, levels of ‘neutralizing’ antibodies, tend to remain low.
Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea ...Utai Sukviwatsirikul
Saccharomyces boulardii in the prevention of antibiotic-associated
diarrhoea in children: a randomized double-blind placebo-controlled
trial
M. KOTOWSKA, P. ALBRECHT & H. SZAJEWSKA
Department of Pediatric Gastroenterology and Nutrition, The Medical University of Warsaw, Warsaw, Poland
Accepted for publication 24 November 2004
Jessica Maria Atrio, MD, has demonstrated that a safe but less-frequently prescribed birth control "mini-pill" is effective for women taking HIV medications. Study title: Effect of protease inhibitors on pharmacokinetics of oral norethindrone contraception in hiv+ women
Read the full story: http://sc-ctsi.org/index.php/news/sc-ctsi-supported-research-drives-global-health-policy#.Ut2b6WTTktU
Fluoroquinolone resistant rectal colonization predicts risk of infectious com...TC İÜ İTF Üroloji AD
Fluoroquinolone resistant rectal colonization predicts risk of infectious complications after transrectal prostate biopsy. Evidence based on journal club by Samed Verep
Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions
Dr. Theoklis Zaoutis - Antimicrobial Use and Stewardship in the Pediatric Out...John Blue
Antimicrobial Use and Stewardship in the Pediatric Outpatient Setting - Dr. Theoklis Zaoutis, Chief, Division of Infectious Diseases, Professor of Pediatrics and Epidemiology of the University of Pennsylvania, from the 2014 NIAA Symposium on Antibiotics Use and Resistance: Moving Forward Through Shared Stewardship, November 12-14, 2014, Atlanta, Georgia, USA.
More presentations at http://www.swinecast.com/2014-niaa-antibiotics-moving-forward-through-shared-stewardship
Dr.sherin elsherbiny
Senior registrar clinical microbiology
AMR coordinator
Infection control auditor
Riyadh region
Meeqat General Hospital ,Madina,KSA
Antibiotic Stewardship: Current status and implications in IndiaJindal Chest Clinic
Antibiotic Stewardship: Current status and implications in India. This presentation gives an overview of Antibiotics: components, prescription, selection etc.
Antibiotics are most common therapeutic agents used in hospitals across world, however, microbial world is becoming resistant day by day, posing special challenges to clinicians specially working in ICU set ups. There are multiple ways to curb this menace, if approached together in antibiotic stewardship way, can bring about wonders and retain therapeutic potentials of these drugs.
Evaluation of Prescribing Patterns of Antibiotics in General Medicine Ward in...ijtsrd
Knowledge about antibiotic utilization and resistance patterns of most common microorganisms are unavailable in tertiary care hospitals. To assess the pattern of antibiotic utilization and outcome of patients in a General Medical Ward, all positive blood cultures BC over a 4 month period from July 2019 to October 2019 were retrospectively reviewed. Sixty five positive BC were recorded in which patients 43 males and 22 females . 72 of the patients received antibiotics before or soon after obtaining the BC, and ceftriaxone was the most frequently prescribed antibiotic 41.93 , either alone or in combination with other antibiotics. The bacteraemia was due to gram positive cocci in 60.46 of cases, gram negative rods in 30.23 , and gram positive rods in 9.30 . Positive BC due to contamination was not included. The most common gram positive cocci were Staphylococcus epidermidis, followed by S. aureus, while the most common gram negative bacilli were Brucella species, Proteus mirabilis, and Klebsiella sp. The suspected sources of the bacteraemia were respiratory 21.2 , urinary 19.2 , or skin 19.2 . A subsequent change in the antibiotics regimen was done in 69.76 cases after BC results became available with no apparent effect on the outcome. Adding Cefotaxime, Amoxicillin clavulonic acid, piperacillintazobactum, vancomycin and clindamycin was the most frequent change done 19.4 for each equally . Complications developed in 69.76 of patients, with 88.66 of them suffering from sepsis shock. 69.23 of the patients improved and 30.77 expired death was related to infection in 87.5 of cases. In conclusion, most bacteremia in the medical ward of the hospital were due to gram positive cocci, which should be considered in antibiotic selection prior to BC. Vageeshwari Devuni | Debabrata Chaudhary "Evaluation of Prescribing Patterns of Antibiotics in General Medicine Ward in a Tertiary Care Hospital" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29618.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmacology-/29618/evaluation-of-prescribing-patterns-of-antibiotics-in-general-medicine-ward-in-a-tertiary-care-hospital/vageeshwari-devuni
Tackling the U.S. Healthcare System’s Infectious Disease Management ProblemViewics
The United States healthcare system has a serious infectious disease management problem. The antibiotic resistance crisis is widespread, serious, costly, and deadly. Delays in pathogen identification lead to poor clinical outcomes, including increased mortality risk. And, optimally managing outbreaks is critical to health systems whose reimbursement is tied to the health of a population, such as ACOs.
Eleanor Herriman, MD, MBA, Chief Medical Informatics Officer at Viewics led an informative panel discussion with industry leaders on the issues surrounding the infectious disease management crisis. Margret Oethinger, MD, Ph.D., Medical Director of Providence Health & Services, and Susan E. Sharp, Ph.D., DABMM, FAAM, Regional Director of Microbiology and the Molecular Infectious Disease Laboratories, Department of Pathology, Kaiser Permanente and President-Elect, American Society for Microbiology cover the current state of infectious disease management in the U.S., and what can be done to improve it.
You’ll learn about:
• The magnitude of the U.S. health system’s infectious disease management problem
• The most serious concerns and trends for healthcare institutions and communities across the nation
• The most promising solutions to health systems’ most urgent infectious disease management challenges
Jordan Hoewischer - OACI Farmer Certification ProgramJohn Blue
OACI Farmer Certification Program - Jordan Hoewischer, Ohio Farm Bureau, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Fred Yoder - No-till and Climate Change: Fact, Fiction, and IgnoranceJohn Blue
No-till and Climate Change: Fact, Fiction, and Ignorance - Fred Yoder, Former President, National Corn Growers Association, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. John Grove - Fifty Years Of No-till Research In KentuckyJohn Blue
Fifty Years Of No-till Research In Kentucky - Dr. John Grove, Univerity of Kentucky, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Warren Dick - Pioneering No-till Research Since 1962John Blue
Pioneering No-till Research Since 1962 - Dr. Warren Dick, OSU-OARDC (retired), from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Christine Sprunger - The role that roots play in building soil organic ma...John Blue
The role that roots play in building soil organic matter and soil health - Dr. Christine Sprunger, OSU - SENR, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Leonardo Deiss - Stratification, the Role of Roots, and Yield Trends afte...John Blue
Stratification, the Role of Roots, and Yield Trends after 60 years of No-till - Dr. Leonardo Deiss, OSU, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Steve Culman - No-Till Yield Data AnalysisJohn Blue
No-Till Yield Data Analysis - Dr. Steve Culman, OSU Soil Fertility Extension Specialist, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Alan Sundermeier and Dr. Vinayak Shedekar - Soil biological Response to BMPs John Blue
Soil biological Response to BMPs - Alan Sundermeier, OSU Extension, and Dr. Vinayak Shedekar, USDA-ARS, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Curtis Young - Attracting And Protecting PollinatorsJohn Blue
Attracting And Protecting Pollinators - Dr. Curtis Young, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Sarah Noggle - Cover Crop Decision Tool SelectorJohn Blue
Cover Crop Decision Tool Selector - Sarah Noggle, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Hemp Regulations - Jim Belt, ODA, Head of Hemp for Ohio, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
John Barker - UAVs: Where Are We And What's NextJohn Blue
UAVs: Where Are We And What's Next - John Barker, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Rajbir Bajwa - Medical uses of MarijuanaJohn Blue
Medical uses of Marijuana - Dr. Rajbir Bajwa, Coordinator of legal medical marijuana sales, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Jeff Stachler - Setting up a Corn and Soybean Herbicide Program with Cove...John Blue
Setting up a Corn and Soybean Herbicide Program with Cover Crops - Dr. Jeff Stachler, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Chad Penn - Developing A New Approach To Soil Phosphorus Testing And Reco...John Blue
Developing A New Approach To Soil Phosphorus Testing And Recommendations - Dr. Chad Penn, USDA-ARS, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Jim Hoorman - Dealing with Cover Crops after Preventative PlantingJohn Blue
Dealing with Cover Crops after Preventative Planting - Jim Hoorman, Hoorman Soil Health Services, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Sjoerd Duiker - Dealing with Poor Soil Structure and Soil Compaction John Blue
Dealing with Poor Soil Structure and Soil Compaction - Dr. Sjoerd Duiker, Extension Agronomist, Penn State University, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Christine Brown - Canadian Livestock Producers Efforts to Improve Water QualityJohn Blue
Canadian Livestock Producers Efforts to Improve Water Quality - Christine Brown, Ontario Ministry of Agriculture, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Lee Briese - Details Matter (includes details about soil, equipment, cove...John Blue
Details Matter (includes details about soil, equipment, cover crops...) - Dr. Lee Briese, North Dakota, 2017 International Crop Adviser of the Year, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Dr. Kurt Stevenson - An Overview of Antimicrobial Use
1. An Overview of Antimicrobial Use
Kurt B. Stevenson MD MPH
Division of Infectious Diseases
November 13, 2012
2. Disclosures
No financial disclosures or conflicts of interest
relative to this presentation.
2
3. Antimicrobials present unique management
challenges
200-300 million antibiotics are prescribed
annually
45% for outpatient use
25-40% of hospitalized patients receive
antibiotics
10-70% are unnecessary or sub-optimal
5% of hospitalized patients who receive antibiotics experience an
adverse reaction
Antibiotics are unlike any other drugs, in that use
of the agent in one patient can compromise its
efficacy in another (“Societal Drugs”)
Slide courtesy of Sara Cosgrove, MD Johns Hopkins University
3
4. Why evaluate antimicrobial use?
Monitor precious resources
Examine the relationship of use and
development of resistance
Monitor the impact of stewardship interventions
4
8. Defined Daily Doses
Utilizes the Anatomical Therapeutic Chemical
(ATC) classification system
The DDD is defined as the average daily
maintenance dose per day for a drug for its main
indication in adults.
“Drug consumption data presented in DDDs only
give a rough estimate of consumption and not an
exact picture of actual use.”
Weight based dosing assumes 70 kg
8
9.
10. Defined daily dose examples
Cefepime= 2 grams (1 gram every 12 hours)
At OSUWMC we give 2 grams every 8 hours
Vancomycin=2 grams (1 gram every 12 hours)
At OSUWMC this would be an estimated
standard dose
Daptomycin=0.28 grams (4 mg/kg) daily
At OSUWMC we may give 6-10 mg/kg
Linezolid=1.2 grams (600 mg twice daily)
At OSUWMC this would be an estimated
standard dose
12. Methods
Antimicrobial use data from 130 hospitals
obtained from Solucient (www.solucient.com)
and examined through the Acute Care Tracker
database.
Calculated the DDD using the WHO
methodology
Calculated antimicrobials days of therapy
defined as the 1 DOT=administration of a single
antimicrobial regardless of the number of doses
administered or the dosage strength
Clin Infect Dis 2007;44:664-670
14. When the administered dose is similar to the recommended DDD
then coorelation is good between the two methods
Clin Infect Dis 2007;44:664-670
15. When the administered dose is lower than the recommended DDD
then the DDD are significantly lower than the DOT
Clin Infect Dis 2007;44:664-670
16. When the administered dose is greater than the recommended DDD
then the DDD are significantly greater than the DOT
Clin Infect Dis 2007;44:664-670
17. Other difficulties with DDD measurement
Applicable only to adults; cannot be used for
pediatric populations
Not applicable to renal failure patients with
reduced dosing.
21. European Antimicrobial Resistance Surveillance
Network (EARS-NET)
http://www.ecdc.europa.eu/en/activities/surveilla
nce/EARS-Net/Pages/index.aspx
Formerly was European Antimicrobial
Resistance Surveillance System (EARSS)
26. Methods
Accessed antimicrobial resistance data from the
CDC Active Bacterial Core (ABC) surveillance
network that tracks invasive pneumococcal
infections in 7 states
Active population based surveillance system
All isolates from sterile body sites underwent
standard susceptibility testing
Systemic antibiotic prescriptions were extracted
from the IMS Health Xponent prescription
database which contains 70% of all outpatient
prescriptions in the US
Clinical Infect Dis 2011;53:631-639
27. Results
Yearly outpatient prescriptions decreased during
the study time period from 1996-2003
37% decrease for children <5 years
42% decrease for children >5 years
Sites of high prescribing had higher number of
cases of invasive pneumococcal disease
resistant to antimicrobials than sites with low
prescribing sites
Cephalosporins and macrolides appeared to
select for penicillin and multi-drug resistant
strains
Clinical Infect Dis 2011;53:631-639
30. Methods
Surveillance and Control of Pathogens of Epidemiologic
Importance (SCOPE). SCOPE is a nosocomial
bacteremia surveillance network with about 40
participating hospitals and is coordinated by VA
Commonwealth University
MediMedia Antimicrobial Information Technology (MMIT)
Antimicrobial Monitoring Network involves about 70
nongovernmental hospitals and links drug use to hospital
and patient demographic data.
Data collected from SCOPE and MMIT partnership
Number of community prescriptions as outpatients were
obtained from IMS Health Xponent database
33. Correlation of FQ use with resistance
Clinical Infect Dis 2004;39:497-503
34. CDC Efforts
http://www.cdc.gov/hai/eip/antibiotic-use_techinfo.html
CDC’s first–ever, large–scale antimicrobial use
prevalence survey among U.S. acute care inpatients.
Phase 1:pilot survey conducted in 2009 in nine acute
care hospitals in Jacksonville, FL.
Phase 2:limited roll–out survey conducted in 2010 in 22
acute care hospitals within the catchment areas of the 10
Emerging Infection Program sites.
Phase 3: a full–scale survey conducted in 2011 in more
than 180 acute care hospitals across the 10 EIP sites.
35. Results of CDC studies
Phase 1: Antimicrobial therapy was the most
sensitive proxy indicator for HAIs
Phase 2:Antimicrobial use prevalence was
48.3% (95% CI: 46.2–50.5%). In 731 patients
receiving treatment for active infection,
vancomycin (218, 29.8%) and
piperacillin/tazobactam (139, 19.0%) were the
most commonly administered antimicrobials.
Phase 3: Results still pending.
36. CDC NHSN AU system
http://www.cdc.gov/nhsn/
The National Healthcare Safety Network (NHSN)
is a secure, internet-based surveillance system
that integrates and expands legacy patient and
healthcare personnel safety surveillance
systems managed by the Division of Healthcare
Quality Promotion (DHQP) at CDC.
Collects standardized data on healthcare-
associated infections.
Launching module for collecting antimicrobial
use and resistance data