This document summarizes the PADIT trial which tested an incremental antibiotic strategy to reduce device infections compared to conventional antibiotic prophylaxis. The trial involved over 12,000 patients across 28 centers randomized using a cluster crossover design. It found no significant reduction in device infections with the incremental antibiotic strategy of additional pre-op vancomycin, intra-op antibiotic wash, and post-op oral antibiotics compared to standard pre-op cefazolin alone. While a non-significant trend favored the incremental strategy, the overall low infection rates meant over 500 patients would need to be treated to prevent one additional infection.
Yasser's covid 19 discrepancy phenomenon-dr. yasser mohammed hassanain elsayedYasserMohammedHassan1
Yasser’s COVID-19 Discrepancy phenomenon is a novel descriptive phenomenon that is always seen in all COVID-19 pneumonia. Initial dramatic improvement of the clinical status of COVID-19 pneumonic patient, not a simultaneously after the management, not a coincide with laboratory, radiological, and electrocardiographic workup. Further larger studies for the study medical regimen with considering of “Yasser’s COVID-19 Discrepancy phenomenon” is recommended.
Dr. Rahul VC Tiwari - Fellowship In Orthognathic Surgery - Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala - 29th publication iosr jdms 3rd name
Yasser's covid 19 discrepancy phenomenon-dr. yasser mohammed hassanain elsayedYasserMohammedHassan1
Yasser’s COVID-19 Discrepancy phenomenon is a novel descriptive phenomenon that is always seen in all COVID-19 pneumonia. Initial dramatic improvement of the clinical status of COVID-19 pneumonic patient, not a simultaneously after the management, not a coincide with laboratory, radiological, and electrocardiographic workup. Further larger studies for the study medical regimen with considering of “Yasser’s COVID-19 Discrepancy phenomenon” is recommended.
Dr. Rahul VC Tiwari - Fellowship In Orthognathic Surgery - Jubilee Mission Medical College Hospital and Research Center, Thrissur, Kerala - 29th publication iosr jdms 3rd name
Presentation of Dr. Lluis Blanch at 10th Pulmonary Medicine Update Course, Cairo, Egypt. Pulmonary Medicine Update Course is organized by Scribe : www.scribeofegypt.com
The coronavirus disease outbreak has proven to be a major health crisis affecting virtually every facets of our lives.
Coronavirus disease is an ongoing pandemic disease. The disease which is caused by a new type of virus, known as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many patients hospitalized with COVID-19 will develop muscle
weakness particularly those admitted in intensive care unit (ICU). Studies have shown that muscle weakness is one of the
direct consequences of critical illness. We systematically reviewed literature that quantified changes in muscle strength and it
relationship with COVID- 19 in Intensive care unit in humans.
Observational Study on 255 Mechanically Ventilated Covid Patients at the Beginning of the USA Pandemic
This article is a preprint and has not been peer-reviewed.
Twitter: @MattisVollan
Scrub typhus manifesting with intracerebral hemorrhage: Case report and revie...Ahmad Ozair
Scrub typhus (ST), hitherto absent from many parts of India, is now recently being recognized as a significant cause of morbidity and mortality throughout the country. Its diverse clinical presentations, low of the index of suspicion by the treating physician, and lack of diagnostic testing in many parts of the country result in delayed treatment, leading to a host of complications. We here report such a complication, where ST manifested with a large intracerebral hemorrhage, of which, to the best of our knowledge, only nine cases have been reported in the English language worldwide. Family physicians, who are the often first point of contact for treatment of febrile illness, as ST typically manifests, need to be aware of this entity to prevent such catastrophic consequences.
study of hematological paremeter in sepsis patients and its prognostic implic...RahulGupta1687
The current study was a cross-sectional study with a sample size of 117 patients with sepsis. Various hematological parameters of all the patients were obtained on day of admission (day 1) and seventh day (day 7) using hemogram reports and the difference of their statistical mean and standard deviation was estimated.
Clinical course and risk factors for mortality of adult inpatients with covid...BARRY STANLEY 2 fasd
Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help
clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale
for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
The research interest of the investigator has focused on the molecular and cellular pathogenesis of sepsis. In particular, he has worked on soluble proteins involved in the innate recognition of bacteria such as soluble CD14 and MD-2, as well as in the Toll-like receptors activated by Gram-negative and Gram-positive bacteria. Another area of study is the molecular pathogenesis and cell signaling of ventilator-induced lung injury, and lung inflammation in the context of acute respiratory distress syndrome. He has also identified and tested biomarkers in the field of clinical sepsis.
Watch the presentation on Youtube: https://www.youtube.com/watch?v=CyWN7JlhlmI&
Presentation of Dr. Lluis Blanch at 10th Pulmonary Medicine Update Course, Cairo, Egypt. Pulmonary Medicine Update Course is organized by Scribe : www.scribeofegypt.com
The coronavirus disease outbreak has proven to be a major health crisis affecting virtually every facets of our lives.
Coronavirus disease is an ongoing pandemic disease. The disease which is caused by a new type of virus, known as severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Many patients hospitalized with COVID-19 will develop muscle
weakness particularly those admitted in intensive care unit (ICU). Studies have shown that muscle weakness is one of the
direct consequences of critical illness. We systematically reviewed literature that quantified changes in muscle strength and it
relationship with COVID- 19 in Intensive care unit in humans.
Observational Study on 255 Mechanically Ventilated Covid Patients at the Beginning of the USA Pandemic
This article is a preprint and has not been peer-reviewed.
Twitter: @MattisVollan
Scrub typhus manifesting with intracerebral hemorrhage: Case report and revie...Ahmad Ozair
Scrub typhus (ST), hitherto absent from many parts of India, is now recently being recognized as a significant cause of morbidity and mortality throughout the country. Its diverse clinical presentations, low of the index of suspicion by the treating physician, and lack of diagnostic testing in many parts of the country result in delayed treatment, leading to a host of complications. We here report such a complication, where ST manifested with a large intracerebral hemorrhage, of which, to the best of our knowledge, only nine cases have been reported in the English language worldwide. Family physicians, who are the often first point of contact for treatment of febrile illness, as ST typically manifests, need to be aware of this entity to prevent such catastrophic consequences.
study of hematological paremeter in sepsis patients and its prognostic implic...RahulGupta1687
The current study was a cross-sectional study with a sample size of 117 patients with sepsis. Various hematological parameters of all the patients were obtained on day of admission (day 1) and seventh day (day 7) using hemogram reports and the difference of their statistical mean and standard deviation was estimated.
Clinical course and risk factors for mortality of adult inpatients with covid...BARRY STANLEY 2 fasd
Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help
clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale
for a strategy of isolation of infected patients and optimal antiviral interventions in the future.
The research interest of the investigator has focused on the molecular and cellular pathogenesis of sepsis. In particular, he has worked on soluble proteins involved in the innate recognition of bacteria such as soluble CD14 and MD-2, as well as in the Toll-like receptors activated by Gram-negative and Gram-positive bacteria. Another area of study is the molecular pathogenesis and cell signaling of ventilator-induced lung injury, and lung inflammation in the context of acute respiratory distress syndrome. He has also identified and tested biomarkers in the field of clinical sepsis.
Watch the presentation on Youtube: https://www.youtube.com/watch?v=CyWN7JlhlmI&
Dr. Kurt Stevenson - An Overview of Antimicrobial UseJohn Blue
An Overview of Antimicrobial Use - Dr. Kurt Stevenson, The Ohio State University Medical Center, from the 2012 NIAA One Health Approach to Antimicrobial Resistance and Use Symposium, November 13-15, 2012, Columbus, OH, USA.
More presentations at:
http://www.trufflemedia.com/agmedia/conference/2012-one-health-to-approach-antimicrobial-resistance-and-use
Dr. Kurt Stevenson - An Overview of Antimicrobial UseJohn Blue
An Overview of Antimicrobial Use - Dr. Kurt Stevenson, The Ohio State University Medical Center, from the 2012 NIAA One Health Approach to Antimicrobial Resistance and Use Symposium, October 26-27, 2012, Columbus, OH, USA.
More presentations at:
http://www.trufflemedia.com/agmedia/conference/2012-one-health-to-approach-antimicrobial-resistance-and-use
Webinar: Defeating Superbugs: Hospitals on the Front Lines Modern Healthcare
About the Webinar: Defeating Superbugs: Hospitals on the Front Lines
http://www.modernhealthcare.com/article/20140917/INFO/309179926
Hospitals across the country are facing a grim reality in which some of the most deadly healthcare-associated infections they encounter are untreatable with first- or even second-line antibiotics. These “superbugs” affect at least 2 million Americans each year and lead to 23,000 deaths. And their threat is growing, public health officials warn. This editorial webinar and “Defeating Superbugs” white paper will explore the steps providers must take to ramp up surveillance efforts, promote appropriate antibiotic use and control outbreaks. Our panel of experts will share their organizations' experiences as well as proven strategies for success.
Registration for this webinar includes Modern Healthcare's “Defeating Superbugs” white paper, with proven tips and strategies for promoting appropriate antibiotic use, improving infection surveillance, identifying drug-resistant infections and dealing with outbreaks.
KEY TAKEAWAYS
- Best practices for effective antimicrobial stewardship
- Real-world examples of effective interventions, including universal rapid testing for drug-resistant MRSA
- Tips for engaging senior leadership
- Aggressive strategies for controlling outbreaks
PANELISTS
Lance Peterson
Director of the Clinical Microbiology and Infectious Disease Research Division
NorthShore University HealthSystem, Evanston, Ill.
Anurag Malani
Medical Director for the Infection Prevention and Antimicrobial Stewardship Programs
St. Joseph Mercy Hospital, Ann Arbor, Mich.
Robert Weinstein
Chief Medical Officer for Population Health
Chairman of the Department of Medicine, Cook County Health and Hospitals System; Professor, Rush University Medical Center, Chicago
MODERATOR
Maureen McKinney
Editorial Programs Manager
Modern Healthcare
Nik Nuradlina N.A,Mohd Syamir M. S. ,Noor Nashreen M.S.,Rozita M.
Pharmacy Department, National Cancer Institute, Putrajaya.
1st Clinical Audit Pharmacy Department
Objectives:
•Learn about the current of SSI prevention in Canada
•Review the updated SSI-GSK
•Compare CPSI SSI-GSK to national and international literature
HAP/VAP 2016 ATS/IDSA Guidelines. Our Data available at: https://rdcu.be/Mx8EDr Sandeep Kumar
Management of Adults With Hospital-acquired and
Ventilator-associated Pneumonia: 2016 Clinical Practice
Guidelines by the Infectious Diseases Society of America
and the American Thoracic Society.
To see our study results on HCAP and HAP, VISIT https://link.springer.com/article/10.1007/s00408-018-0117-7
Antibiotics for surgical prophylaxis.
Surgical site infections(SSIs) are a significant cause of morbidity and mortality.
Approximately 2% to 5% of patients undergoing clean extra-abdominal operations and 20%undergoing intra-abdominal operations will develop an SSI.
SSIs have become the second most common cause of nosocomial infection and these data are likely underestimated.
ABSTRACT- The treatment of carbuncle is early administration of antibiotics and surgery. The commonest surgical approach is Saucerization and Incision & Drainage (I&D). Two cases are presented here, one underwent Saucerization and then primary split thickness skin grafting. Another un-derwent I&D for her carbuncle. They were followed up for 8 weeks to assess their outcome. Saucerization produced the shortest length of hospital stay while I&D resulted in shortest wound healing. As a new modality of treatment now-a-days two new modalities gaining popularity for better cosmetic purpose: primary split thickness skin grafting & transposition of local skin/musculocutaneous flap.
Keywords: carbuncle, surgery, good glycemic control
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Strategies to reduce CIED infection, PADIT Trial by Haseeb Raza
1. Strategies to Reduce CIED
Infection
PADIT Trial
Dr. Syed Haseeb Raza
FCPS Cardiology, Clinical Cardiac Electrophysiologist
Author of ECG Book and Researcher
National Institute of Cardiovascular Diseases, Karachi, Pakistan.
21. OBJECTIVE:
This study tested the clinical effectiveness of incremental perioperative antibiotics to
reduce device infection.
22. The Conventional approach to prevention of device infection, based on several small
randomized trials, is single pre-operative infusion of cefazolin, which is supported by
guidelines.
23. Incremental antibiotic policy that included preprocedural infusion of both cefazolin and
vancomycin, plus intraprocedural bacitracin wash followed by a 2-day course of
postoperative antibiotics would reduce the 1-year risk of hospitalization for device
infection as compared with conventional cefazolin alone.
Incremental antibiotic measures are not supported by evidence from randomized
trials
24. PATIENTS:
All centers collected data on high-risk patients, and 6 centers collected data on both highrisk
and low-risk patients. The high-risk patients were defined as those with:
1) any repeat procedure on an existing pocket (generator replacement, system revision or
upgrade including any lead procedure);
or
2) any cardiac resynchronization therapy (CRT) procedure (15–18). Low-risk patients were all
other patients undergoing implantation, primarily new pacemaker and implantable
cardioverter-defibrillator (ICD) implants.
The study was performed between December 2012 and September 2016. There were 24
centers in Canada and 4 in the Netherlands
25. ANTIBIOTIC TREATMENT REGIMENS:
As per current guidelines, the conventional antibiotic strategy was a single dose of pre-operative
antibiotics: cefazolin 1 to 2 g IV 60 min before skin incision or vancomycin 1 to 1.5 g IV administered
within 120 min before skin incision in penicillin-allergic patients.
In the incremental antibiotic strategy, patients received IV cefazolin as well as pre-operative
vancomycin. Penicillin-allergic patients only received vancomycin.
The incremental antibiotic strategy also included intraoperative wound pocket wash before skin
closure (bacitracin 50,000 U diluted in 50ml of saline)
and
post-operative oral cephalexin 500 mg 4 times/day, or cephadroxil 1,000 mg twice daily for 2 days.
Penicillin-allergic patients received clindamycin 150 to 300 mg at 3 times/day. At all sites in the
Netherlands and at 1 site in Canada, bacitracin was not available, and a saline or cefazolin pocket
wash was used.
26. TRIAL DESIGN:
Cluster Randomized Crossover Trial
In this design, each institution is randomized to 1 of 2 antibiotic prophylaxis regimens,
with randomized crossover between these regimens, such that institutions would
switch randomly between the 2 antibiotic regimens every 6 months.
27. A cluster randomized 4-period crossover design was employed, with center
involvement and participant involvement.
Each participating hospital was randomized to any of 4 sequences of incremental (I)
and conventional (C) strategies (i.e., ICIC, ICCI, CICI, CIIC).
Sites were not informed of their sequence or of what regimen would be used until the
end of each period.
Each therapy period lasted for 6 months .
There was a 2- to 4-week transition phase between each of the 4 study periods.
28.
29. OUTCOMES:
The primary outcome of the trial was admission to hospital for proven CIED or
pocket infection within 1 year of the procedure. The definition of infection was
adapted from standard definitions at the start of the trial, and categorized into
pocket infection, bloodstream infection, and endocarditis.
36. DISCUSSION:
Although there was no significant reduction in the rate of hospitalization for
infection with this policy, we observed a modest trend in favor of this approach.
Testing the clinical effectiveness of new antibiotic strategies for prevention of
uncommon, but serious, infections requires a very large trial to have adequate
statistical power.
37. A cluster trial was chosen because devices are often implanted in large centers that use
standard procedures in all cases. Cluster trials, however, usually involve large loss of
statistical power due to within-cluster correlation. We mitigated this by including
crossover between treatment arms within sites. We used multiple crossovers to guard
against changes over time.
The feasibility of executing a trial of this scale was substantially enabled by the use of
the cluster crossover design because we randomized centers and not
patients, which greatly simplified execution.
38. The device infection rate in our study was much lower than anticipated. We included all
patients treated at each center, so the lower rates were not due to patient selection.
There may have been a “Hawthorne” effect, insofar as being in a research study led
centers to increase vigilance to both antibiotic adherence and surgical technique to
minimize infection rate. A nonsignificant trend of reduction in infection rate over time
was seen in both arms of the study , consistent with a health system intervention effect.
There was no statistically significant difference between treatments, although data do
provide modest support for a benefit of incremental antibiotics. However, even if a 20%
reduction in infection with incremental antibiotics is true, given the low infection rate
that we have documented, a treatment effect of this size would only result in
prevention of 1 infection for every 500 patients treated,
39. The modest possible benefit seen in the PADIT trial should be carefully weighed
against the potential risks of this intervention, such as the development of antibiotic
resistance and toxicity.
40. CONCLUSIONS:
This cluster randomized crossover trial failed to demonstrate a significant reduction
in device infection with a policy of multiple-component incremental antibiotics,
though a uniform effect across subgroups was noted.
The observed infection rate was lower than previous reports.
The cluster crossover design with patient waiver of consent was shown to be highly
efficient, practical, and inexpensive for testing changes in treatment policy, and the
design could be used in many areas of medical and surgical practice.
41. COMPETENCY IN PATIENT CARE AND PROCEDURAL SKILLS:
Compared with conventional antibiotic prophylaxis with periprocedural cefazolin in
patients undergoing implantation of electronic cardiac arrhythmia devices, a more
aggressive multicomponent antibiotic regimen provided no significant efficacy
advantage in preventing device-related infections.
cefazolin is active against most gram-positive bacteria and some gram-negative bacteria, approximately 20% of device infections are due to organisms that are resistant to cefazolin (also referred to as “methicillin-resistant” organisms) (12). Because virtually all gram-positive organisms that are implicated in CIED infection are sensitive to vancomycin, and the majority are sensitive to bacitracin
Because device procedures are most frequently performed in larger centers using standard operating procedures, we considered that a cluster randomized crossover trial would be an optimal design to test whether an institutional standard policy of incremental antibiotics would reduce device infection
A crossover study or crossover trial is a study in which individuals receive a sequence of different treatments (or exposures).
A sequence of interventions is assigned to a group, or ‘cluster’ of individuals. Each cluster receives each intervention in a separate period of time, forming ‘cluster-periods……’
The median number of patients undergoing a procedure per treatment period per site was 110. Twenty-one centers were tertiary care centers (75%).
The median number of operators per center was 5.5.
A total of 19,603 patients across 28 centers having device procedures were included in the data collection, of which 12,842 patients were high risk (Table 2). The mean age was 72.0 13.1 years, 40% of patients had a history of heart failure, and one-third were female. Most high-risk patients underwent generator change (n ¼ 7,916; 61.6%).
In high-risk patients, infection occurred in 77 (1.23%) patients receiving conventional treatment and in 66 (1.01%) receiving incremental treatment (OR: 0.82; 95% CI: 0.59 to 1.15; p ¼ 0.26). Most events were deep skin and pocket infection (86.7%). Infection requiring surgical intervention occurred in 66 patients receiving conventional treatment (1.05% overall, 86% of infections), and in 62 patients receiving incremental treatment (0.95% overall need for surgical intervention; 94% of infections; OR: 0.90; 95% CI: 0.64 to 1.28; p ¼ 0.57).
A uniform nonsignificant trend toward benefit is noted across a broad range of sites, procedures, and patient characteristics.
Infection rates analyzed by device type shows a clear gradient of risk from pacemaker to ICD to CRT, with no evidence of interaction between device type and
effect of the intervention