This document provides guidelines for adjusting diabetes medications for patients with type 2 diabetes doing intermittent fasting during Ramadan. It recommends taking most oral medications at lunch, reducing doses of short-acting insulin secretagogues and sulfonylureas, and adjusting long-acting basal and short-acting bolus insulin doses based on pre-meal blood glucose levels, reducing basal insulin by 15-30% and bolus insulin doses by 25-50% at dinner. Pre-mixed insulin dosing should also be adjusted and titrated every 3 days based on blood glucose levels.
Vanita R. Aroda, MD, prepared type 2 diabetes mellitus infographics for this CME activity titled, "Putting Basal Insulin Therapy to Work for Patients With Type 2 Diabetes Mellitus." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2kdVkuJ. CME credit will be available until September 12, 2020.
Insulin Initiation : When We should Start with Basal Insulin?mataharitimoer MT
Insulin Initiation : When We should Start with Basal Insulin?
Dr. Agus Taolin , SpPD, FINASIM | PAPDI CABANG BOGOR
Disampaikan pada acara PIT VI IDI Kota Bogor | 9 Nopember 2013
This presentation is intended to allied health professional to have a overview of different types of insulin. It is meant to be a memory refresh. It was presented as part of continuing medical education session
A presentation for the April 26, 2014 Advanced Diabetes Seminar at Texas Lions Camp. Author is my friend and colleague Nelda Rodriguez-Caceres, RN, CDE -
ADA Outpatient Diabetes Program Coordinator
Diabetes Care Coordinator - Shoreline & CHRISTUS Spohn Hospital Corpus Christi.
Insulinoterapia, Nuevos Retos - Dra. Jenny CepedaDiabetes Inden
Exposición sobre "Insulinoterapia y Nuevos Retos" a cargo de la Dra. Deysi Hernandez, en la 1 era. Jornada de Residentes INDEN "Avanzando hacia el futuro". El evento se realizó el 21 de marzo del 2015 en instalaciones de la UNIBE.
Para ver la exposición ir a: https://www.youtube.com/watch?v=p7NC4qZLpa4
Más información en: www.inden.do
This presentation was authored by Meaghan Anderson MS RD LD CDE, Senior Diabetes Clinical Manager-Houston North - Medtronic Diabetes specially for the Advanced Diabetes Seminar at TLC on April 26, 2014.
Vanita R. Aroda, MD, prepared type 2 diabetes mellitus infographics for this CME activity titled, "Putting Basal Insulin Therapy to Work for Patients With Type 2 Diabetes Mellitus." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2kdVkuJ. CME credit will be available until September 12, 2020.
Insulin Initiation : When We should Start with Basal Insulin?mataharitimoer MT
Insulin Initiation : When We should Start with Basal Insulin?
Dr. Agus Taolin , SpPD, FINASIM | PAPDI CABANG BOGOR
Disampaikan pada acara PIT VI IDI Kota Bogor | 9 Nopember 2013
This presentation is intended to allied health professional to have a overview of different types of insulin. It is meant to be a memory refresh. It was presented as part of continuing medical education session
A presentation for the April 26, 2014 Advanced Diabetes Seminar at Texas Lions Camp. Author is my friend and colleague Nelda Rodriguez-Caceres, RN, CDE -
ADA Outpatient Diabetes Program Coordinator
Diabetes Care Coordinator - Shoreline & CHRISTUS Spohn Hospital Corpus Christi.
Insulinoterapia, Nuevos Retos - Dra. Jenny CepedaDiabetes Inden
Exposición sobre "Insulinoterapia y Nuevos Retos" a cargo de la Dra. Deysi Hernandez, en la 1 era. Jornada de Residentes INDEN "Avanzando hacia el futuro". El evento se realizó el 21 de marzo del 2015 en instalaciones de la UNIBE.
Para ver la exposición ir a: https://www.youtube.com/watch?v=p7NC4qZLpa4
Más información en: www.inden.do
This presentation was authored by Meaghan Anderson MS RD LD CDE, Senior Diabetes Clinical Manager-Houston North - Medtronic Diabetes specially for the Advanced Diabetes Seminar at TLC on April 26, 2014.
This is part two of the diabetes presentation aimed for pharmacists and allied health professional who are interested in tailoring special pharmaceutical care plans for diabetic patients.
Controlling blood sugar (glucose) levels is the major goal of diabetes treatment, in order to prevent complications of the disease.
Type 1 diabetes is managed with insulin as well as dietary changes and exercise.
Type 2 diabetes may be managed with non-insulin medications, insulin, weight reduction, or dietary changes.
Medications for type 2 diabetes are designed to
increase insulin output by the pancreas,
decrease the amount of glucose released from the liver,
increase the sensitivity (response) of cells to insulin,
decrease the absorption of carbohydrates from the intestine, and
slow emptying of the stomach, thereby delaying nutrient digestion and absorption in the small intestine.
A brief description of Diabetes with management guidelines
according to different diabetes foundation and their treatment with drugs and their MOA dose and side effects
Pancreas makes a hormone called insulin. It helps your cells turn glucose, a type of sugar, from the food you eat into energy. Diabetes happens when one or more of the following occurs:
Your pancreas does not make any insulin.
Your pancreas makes very little insulin.
Your body does not respond the way it should to insulin
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. Appendix
(Based on recommendation from IDF-DAR Diabetes and Ramadan:Practical Guidelines)
This guidelines are those for T2D patients doing intermittent fasting (IF) for 16 hours (eg from 8.00
pm till 12.00 noon the next day) with 8 hours eating window (eg 12.00 noon – 8.00 pm). Simply they
are advised to skip breakfast, but can take plain water/tea/coffee without sugar
Patients usually advised to take heavier meal during lunch (60-70% of total calorie) with the
remaining taken during dinner.
The meals consist of very low carbohydrate high fat diet (5-10% carb, 70-80% fat, 20-25% protein).
Net carb (Total carb-fibre) < 50 gm/day.
Suggestions for Dose Adjusment of medications:
Oral Anti-Diabetic Agents:
1. Metformin
OD dose BD dose TDS dose Prolonged release
No dose medication
usually required
No dose medication
usually required
Combine morning dose
with dose taken at
lunch
No dose modification
usually required
Take at lunch Take at lunch & dinner Take night dose as
usual at dinner
Take at lunch
2. Acarbose – no dose modification
3. Thiazolidinediones – no dose modification
4. Short acting insulin secretagogues (repaglinide, nateglinide)-dose may be reduced or re-
distributed to two doses, according to meal size
5. Sulphonylureas – associated with higher risk of hypoglycaemia
OD dose BD dose Older drugs in the class
Take at lunch Lunch dose remains the same Older drugs eg glibenclamide
carry a higher risk of
hypoglycaemia and should be
avoided
In patients with well
controlled BG, the dose may
be reduced
In patients with well-controlled
BG, the night dose should be
reduced
2nd
gen SU (gliclazide,
glimepiride) should be used in
preference
2. 6. SGLT-2 inhibitors – no dose adjustment
7. DPP-4 inhibitors – no dose adjustment
Insulin Treatment for T2DM
This may include the use of a long acting/intermediate acting basal insulin (insulin glargine, insulin
determir or NPH insulin), possibly with a rapid or short-acting bolus/pre-meal insulin (lispro, aspart
or regular human insulin)
Changes to long and short acting insulin dose during IF
Long/intermediate-acting (basal insulin) Short acting insulin
NPH/detemir/glargine/degludec once
daily
Reduce dose by 15-30%
Take at lunch
Omit morning dose
Normal dose at lunch
Reduce dinner dose by 25-50%
NPH/determir/glargine twice-daily
Take usual morning dose at lunch
Reduce evening dose 50% and take at dinner
Dose modification based on dextrostix:
Fasting/pre-lunch/pre-dinner
dxt
Pre-lunch Pre-lunch/pre-dinner
Basal insulin Short acting insulin
< 3.9 mmol/L or symptoms Reduce by 4 units Reduce by 4 units
3.9-5.0 mmol/L Reduce by 2 units Reduce by 2 units
5.0-7.2 mmol/L No change required No change required
7.2-11.1 mmol/L Increase by 2 units Increase by 2 units
>11.1 mmol/L Increase by 4 units Increase by 4 units
3. Changes to pre-mixed insulin dosing during intermittent fasting
Once daily dosing Twice daily dosing Three times daily
dosing
Take normal dose at
lunch
Take normal dose at
lunch
Omit morning dose.
Adjust lunch and
dinner dose
Reduce dinner dose by
25-50%
Carry out dose titration
every 3 days (see
below)
Fasting/pre-lunch/pre-dinner dxt Pre-mixed insulin modification
<3.9 mmol/L or symptoms Reduce by 4 units
3.9-5.0 mmol/L Reduce by 2 units
5.0-7.0 mmol/L No change required
7.0-11.1 mmol/L Increase by 2 units
>11.1 mmol/L Increase by 4 units