This presentation was authored by Meaghan Anderson MS RD LD CDE, Senior Diabetes Clinical Manager-Houston North - Medtronic Diabetes specially for the Advanced Diabetes Seminar at TLC on April 26, 2014.
The document provides information about optimizing diabetes control through the use of an insulin pump. It discusses setting and testing basal rates to maintain stable blood glucose levels. It also covers using alternate and temporary basal rates for scheduled or unplanned changes in activity. Additionally, it explains optimizing bolus insulin through testing and adjusting the insulin-to-carb ratio and insulin sensitivity factor. Other topics include timing boluses, disconnecting from the pump, using a super bolus, and the importance of carb counting and blood glucose testing.
This document discusses insulin pump therapy and its goals of maintaining near-normal glycemia while avoiding crises and minimizing long-term complications. It describes how insulin pumps can more closely mimic physiological insulin secretion by providing basal insulin continuously and bolus doses at meals. Smart insulin pumps now include bolus calculators that help account for active insulin and minimize dosing errors, improving glycemic control for many patients with diabetes.
Authored by Brant P. Foster, RN, a long time friend and contributor to the Texas Lions Camp. This seminar is for the Advanced Diabetes Seminar 2014 at TLC.
The document discusses insulin pumps and their use for managing diabetes. It describes how insulin pumps work by continuously monitoring blood sugar levels and automatically delivering insulin to maintain safe blood sugar ranges. The document outlines important design considerations for insulin pumps, such as safety, reliability, and testing to validate the design and software. It also discusses potential hazards and failure modes that must be addressed.
The document provides information on using temporary basal rates and advanced bolus options on insulin pumps. It discusses when to use temporary basal rate increases or decreases, such as for illness, exercise, or changes in activity level. It also reviews normal, extended, and dual/split bolus options and provides examples of when each would be appropriate. The document highlights tools like basal patterns, alarms, and pump suspensions that can help manage insulin needs and support forgetfulness. It concludes with tips for pump use and answers to common pump questions.
This document provides information on using temporary basal rates and advanced bolus options on insulin pumps. It discusses when to increase or decrease temporary basal rates for situations like illness, exercise, or fasting labs. Examples are given of setting temporary basal rates for activities like basketball practice when blood sugar may run low. The document also covers normal, extended, and dual/extended bolus options and provides examples of when each would be best for different types of meals. The concept of a "super bolus" is introduced which delivers additional insulin by suspending part of the basal rate. Tools for reminders and multiple basal patterns are also mentioned.
The document summarizes a randomized study comparing basal-bolus insulin therapy to sliding scale regular insulin for managing hyperglycemia in non-critically ill patients. The study found that 66% of patients treated with basal insulin glargine plus bolus insulin glulisine were within the glucose target of 140 mg/dL, compared to 38% of patients treated with sliding scale regular insulin. Basal-bolus therapy provides more effective glycemic control with no increase in hypoglycemia. The document then provides details on calculating and adjusting basal and bolus insulin doses.
Type 1 diabetes is an autoimmune disease where the pancreas cannot produce insulin. It affects about 5% of diabetics and often develops before age 30. For athletes with type 1 diabetes, maintaining steady blood glucose levels is crucial for performance, as hypoglycemia can cause fatigue and reduced endurance. Pre-workout meals and carbohydrate intake during and after exercise are important, as is carefully timing insulin to avoid hypoglycemia. With careful management, type 1 diabetes does not have to limit athletic performance.
The document provides information about optimizing diabetes control through the use of an insulin pump. It discusses setting and testing basal rates to maintain stable blood glucose levels. It also covers using alternate and temporary basal rates for scheduled or unplanned changes in activity. Additionally, it explains optimizing bolus insulin through testing and adjusting the insulin-to-carb ratio and insulin sensitivity factor. Other topics include timing boluses, disconnecting from the pump, using a super bolus, and the importance of carb counting and blood glucose testing.
This document discusses insulin pump therapy and its goals of maintaining near-normal glycemia while avoiding crises and minimizing long-term complications. It describes how insulin pumps can more closely mimic physiological insulin secretion by providing basal insulin continuously and bolus doses at meals. Smart insulin pumps now include bolus calculators that help account for active insulin and minimize dosing errors, improving glycemic control for many patients with diabetes.
Authored by Brant P. Foster, RN, a long time friend and contributor to the Texas Lions Camp. This seminar is for the Advanced Diabetes Seminar 2014 at TLC.
The document discusses insulin pumps and their use for managing diabetes. It describes how insulin pumps work by continuously monitoring blood sugar levels and automatically delivering insulin to maintain safe blood sugar ranges. The document outlines important design considerations for insulin pumps, such as safety, reliability, and testing to validate the design and software. It also discusses potential hazards and failure modes that must be addressed.
The document provides information on using temporary basal rates and advanced bolus options on insulin pumps. It discusses when to use temporary basal rate increases or decreases, such as for illness, exercise, or changes in activity level. It also reviews normal, extended, and dual/split bolus options and provides examples of when each would be appropriate. The document highlights tools like basal patterns, alarms, and pump suspensions that can help manage insulin needs and support forgetfulness. It concludes with tips for pump use and answers to common pump questions.
This document provides information on using temporary basal rates and advanced bolus options on insulin pumps. It discusses when to increase or decrease temporary basal rates for situations like illness, exercise, or fasting labs. Examples are given of setting temporary basal rates for activities like basketball practice when blood sugar may run low. The document also covers normal, extended, and dual/extended bolus options and provides examples of when each would be best for different types of meals. The concept of a "super bolus" is introduced which delivers additional insulin by suspending part of the basal rate. Tools for reminders and multiple basal patterns are also mentioned.
The document summarizes a randomized study comparing basal-bolus insulin therapy to sliding scale regular insulin for managing hyperglycemia in non-critically ill patients. The study found that 66% of patients treated with basal insulin glargine plus bolus insulin glulisine were within the glucose target of 140 mg/dL, compared to 38% of patients treated with sliding scale regular insulin. Basal-bolus therapy provides more effective glycemic control with no increase in hypoglycemia. The document then provides details on calculating and adjusting basal and bolus insulin doses.
Type 1 diabetes is an autoimmune disease where the pancreas cannot produce insulin. It affects about 5% of diabetics and often develops before age 30. For athletes with type 1 diabetes, maintaining steady blood glucose levels is crucial for performance, as hypoglycemia can cause fatigue and reduced endurance. Pre-workout meals and carbohydrate intake during and after exercise are important, as is carefully timing insulin to avoid hypoglycemia. With careful management, type 1 diabetes does not have to limit athletic performance.
This document discusses the differences between basal-bolus and sliding scale insulin regimens. It explains that basal insulin provides a constant background level, while bolus insulin covers mealtime needs. Sliding scale alone is reactive and can cause blood sugar fluctuations, while basal-bolus is proactive and mimics normal insulin delivery. During hospitalization, patients are best managed with basal-bolus rather than oral agents due to its flexibility and ability to be easily titrated.
Insulin pumps can help manage diabetes during pregnancy by more closely mimicking normal insulin physiology compared to multiple daily injections. Starting insulin pump settings during pregnancy typically involve dividing total daily insulin dose in half, with 50% for basal rates given continuously over 24 hours and 50% for bolus doses with meals. Basal and bolus rates often need adjustment throughout pregnancy as insulin resistance and needs increase. Close monitoring of blood sugars is important for optimizing pump settings to help prevent hyperglycemia and hypoglycemia. After delivery, insulin requirements usually decrease rapidly but may need to be adjusted based on breastfeeding and return of normal glucose levels.
Gestational diabetes develops due to increased insulin resistance during pregnancy. It can cause complications for both mother and fetus if uncontrolled. The standard treatment is insulin therapy, but oral hypoglycemic drugs like glyburide may be used. Glyburide does not cross the placenta and has not been shown to cause fetal anomalies. It can be started at a low dose of 2.5 mg once daily before meals and increased slowly as needed to control blood sugar levels while minimizing risks for the mother and fetus. Lifestyle changes like diet and exercise are also important for managing gestational diabetes.
1) This document discusses the initiation and adjustment of insulin therapy for type 2 diabetes. It recommends starting with a long-acting basal insulin at bedtime and titrating the dose up gradually until fasting blood glucose is at target levels.
2) If HbA1c remains above 7% after 2-3 months, short-acting insulins should be added at mealtimes starting with breakfast. The doses are then titrated based on pre-meal blood glucose readings.
3) If HbA1c is still not at target after a further 2-3 months, a third daily insulin injection may be needed and post-meal blood glucose should be checked to guide adjustments. The goal is to approximate normal pancreatic
Insulin therapy: art of initiation and titration Saikumar Dunga
The document outlines guidelines for initiating and titrating insulin therapy for type 2 diabetes. It recommends starting with either bedtime intermediate-acting or morning/bedtime long-acting insulin, and titrating the dose to reach fasting glucose targets. If HbA1c remains above 7% after 2-3 months, additional injections of rapid-acting insulin should be added at mealtimes based on pre-meal glucose levels. Further intensification, such as checking postprandial levels and adjusting prandial insulin, is recommended if HbA1c is still not at target. The guidelines provide a step-by-step approach to optimizing insulin regimens based on glucose monitoring.
This document provides information about basic insulin pumping. It describes what an insulin pump is, potential benefits, and challenges. It discusses calculating basal rates, bolus doses, and correction factors. It provides guidance on pump maintenance like changing sites and settings. It addresses common questions around pump use, troubleshooting, and ensuring settings are optimized. The overall message is that pumps require diligent self-care and monitoring to achieve good blood sugar control.
The document provides a 3-step guide for interpreting iPro2 Professional CGM reports:
1. Overlay glucose data by meal to examine overnight, pre-prandial, and post-prandial periods.
2. Closely examine the 3 critical periods to identify causes of hypoglycemia or hyperglycemia.
3. Use daily summaries and patient logs to help identify relationships between behaviors, medications, and glucose levels.
The document discusses insulin therapy and glucose monitoring. It provides details on the different types of insulin including rapid, short, intermediate and long acting insulins. It describes insulin administration including sites, storage, precautions and complications. It also discusses glucose monitoring methods like fasting blood glucose, oral glucose tolerance test and self monitoring of blood glucose. The normal values and nursing considerations for these tests are outlined.
This document discusses basics of insulin therapy including:
- The discovery of insulin in the 1920s and types of insulin including basal, mealtime, premixed, and newer combinations.
- Insulin action profiles, indications for insulin use, administration techniques using vials, syringes and pens, and common insulin regimens for type 2 diabetes including once or twice daily basal insulin +/- mealtime insulin or premixed insulin.
- Proper storage, mixing, and injection of insulin as well as recommended sites for injection are also reviewed.
This document provides guidelines for initiating and adjusting insulin therapy for type 2 diabetes. It outlines a step-by-step regimen beginning with initiating either bedtime intermediate-acting insulin or bedtime or morning long-acting insulin. It instructs to monitor fasting blood glucose and increase the insulin dose until the target range is achieved. Additional injections of rapid-acting insulin are added before meals if blood glucose levels remain out of range. The regimen is monitored every 3 months by checking HbA1c and adjusting insulin doses up or down based on blood glucose levels and HbA1c targets.
This document discusses insulin therapy, including its pharmacodynamics, mechanisms of action, types of insulin, insulin regimens, administration techniques, side effects, and patient education. Insulin is secreted by the pancreas and lowers blood glucose levels by facilitating glucose uptake into cells. It acts on the liver, muscle, adipose tissue, and other organs. Types include rapid, short, intermediate and long-acting insulins. Patient education focuses on proper administration, storage, monitoring, hypoglycemia treatment, and lifestyle factors.
This document discusses insulin therapy for diabetes. It begins with a brief history of insulin's discovery in 1921 by Banting and Best in Toronto. It then covers normal insulin secretion patterns and the types of insulin available, including rapid-acting, short-acting, intermediate-acting, premixed, basal, and extended long-acting analog insulins. The document discusses initiating and titrating insulin using the ADA treatment algorithm, beginning with basal insulin and adding bolus insulin as needed based on blood glucose levels and HbA1c targets. It also covers starting and adjusting premixed insulin doses.
Vanita R. Aroda, MD, prepared type 2 diabetes mellitus infographics for this CME activity titled, "Putting Basal Insulin Therapy to Work for Patients With Type 2 Diabetes Mellitus." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2kdVkuJ. CME credit will be available until September 12, 2020.
Insulin is a polypeptide hormone produced by the pancreas that has profound effects on carbohydrate, fat, and protein metabolism. Insulin deficiency results in hyperglycemia and other metabolic issues. There are various types of insulin that are classified by their onset and duration of action, including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed insulins. Common insulin regimens include split-mixed, multiple injection, basal-bolus, and continuous subcutaneous insulin infusion. Insulin is administered via syringes, pens, or pumps and is injected into approved sites in the body. Potential side effects of insulin therapy include hypoglycemia, weight gain, and local injection
The document summarizes insulin therapy for diabetes mellitus. It describes the cells in the pancreas that secrete insulin and other hormones. It details the discovery and purification of insulin in the 1920s which revolutionized treatment of diabetes. The document discusses different insulin formulations including short-acting and long-acting types. It explains factors that affect insulin absorption and common dosing regimens for insulin therapy.
Insulin therapy in Diabetes Mellitus discusses various types of insulin, newer insulin analogs, and insulin regimens for managing type 1 diabetes mellitus. Rapid-acting insulin analogs have advantages over regular insulin such as quicker onset of action and less risk of hypoglycemia. Long-acting insulin analogs like glargine have advantages over NPH insulin such as a more consistent time action profile. The document discusses split-mix and basal-bolus insulin regimens and factors to consider when choosing a regimen. It also covers complications of insulin therapy, monitoring of blood glucose and HbA1c levels, and sick day management for patients with type 1 diabetes.
The document discusses guidelines for initiating insulin therapy in patients with type 2 diabetes not controlled on oral antidiabetic drugs (OADs). It recommends starting with either bedtime intermediate-acting insulin or bedtime or morning long-acting insulin, beginning at a dose of 10 units or 0.2 units/kg. The insulin dose is then titrated up based on fasting blood glucose levels until the target range is achieved. Additional injections of rapid-acting insulin may be added if pre-meal blood glucose levels remain out of range.
This document discusses common errors in insulin therapy. It covers topics like delaying insulin initiation, improper injection techniques, incorrect insulin regimens, and failure to target all glycemic measures including fasting plasma glucose, post-prandial glucose, and A1C. The document emphasizes the importance of properly educating patients on insulin administration and management to achieve optimal glucose control and avoid both short-term and long-term consequences of uncontrolled diabetes.
This document discusses two case studies of patients with type 2 diabetes mellitus. For the first case, a 50-year old female patient with HbA1c of 8.5-9% on oral medications, the summary recommends starting basal insulin such as glargine or detemir 15-20 units at bedtime. For the second case, a 68-year old obese male patient with HbA1c of 10.5% on maximum oral medications, the summary recommends starting a total daily dose of insulin of 0.3-0.5 units/kg, starting with premixed insulin such as Mixtard 18/10 units. Both cases emphasize individualizing treatment targets and adjusting insulin doses based on self-
Implantable biosensor with programmed insulin pumpjitisha chhettri
The document discusses various types of implanted insulin pumps, including open loop pumps controlled manually by the user and closed loop "artificial pancreas" pumps that automatically adjust insulin levels based on continuous glucose monitor (CGM) readings. It describes the components of an artificial pancreas device system (APDS), including the CGM, blood glucose meter, control algorithm, and infusion pump. It also covers fabrication methods for thin film insulin pumps using shape memory alloys, the importance of check valves, and a block diagram of an insulin pump system with a glucose sensor and microcontroller.
The document discusses insulin pumps as an alternative treatment for diabetes compared to traditional multiple daily injections. Insulin pumps provide continuous insulin delivery through an infusion set and are programmed to deliver basal and bolus doses. While insulin pumps are more expensive initially than injections, they provide benefits like better blood glucose control and more flexibility with meals and activities. The technology has advanced significantly since the first prototype pump in 1964 and continues to improve, but some disadvantages remain like potential weight gain and the need to remove the pump for certain activities.
This document discusses the differences between basal-bolus and sliding scale insulin regimens. It explains that basal insulin provides a constant background level, while bolus insulin covers mealtime needs. Sliding scale alone is reactive and can cause blood sugar fluctuations, while basal-bolus is proactive and mimics normal insulin delivery. During hospitalization, patients are best managed with basal-bolus rather than oral agents due to its flexibility and ability to be easily titrated.
Insulin pumps can help manage diabetes during pregnancy by more closely mimicking normal insulin physiology compared to multiple daily injections. Starting insulin pump settings during pregnancy typically involve dividing total daily insulin dose in half, with 50% for basal rates given continuously over 24 hours and 50% for bolus doses with meals. Basal and bolus rates often need adjustment throughout pregnancy as insulin resistance and needs increase. Close monitoring of blood sugars is important for optimizing pump settings to help prevent hyperglycemia and hypoglycemia. After delivery, insulin requirements usually decrease rapidly but may need to be adjusted based on breastfeeding and return of normal glucose levels.
Gestational diabetes develops due to increased insulin resistance during pregnancy. It can cause complications for both mother and fetus if uncontrolled. The standard treatment is insulin therapy, but oral hypoglycemic drugs like glyburide may be used. Glyburide does not cross the placenta and has not been shown to cause fetal anomalies. It can be started at a low dose of 2.5 mg once daily before meals and increased slowly as needed to control blood sugar levels while minimizing risks for the mother and fetus. Lifestyle changes like diet and exercise are also important for managing gestational diabetes.
1) This document discusses the initiation and adjustment of insulin therapy for type 2 diabetes. It recommends starting with a long-acting basal insulin at bedtime and titrating the dose up gradually until fasting blood glucose is at target levels.
2) If HbA1c remains above 7% after 2-3 months, short-acting insulins should be added at mealtimes starting with breakfast. The doses are then titrated based on pre-meal blood glucose readings.
3) If HbA1c is still not at target after a further 2-3 months, a third daily insulin injection may be needed and post-meal blood glucose should be checked to guide adjustments. The goal is to approximate normal pancreatic
Insulin therapy: art of initiation and titration Saikumar Dunga
The document outlines guidelines for initiating and titrating insulin therapy for type 2 diabetes. It recommends starting with either bedtime intermediate-acting or morning/bedtime long-acting insulin, and titrating the dose to reach fasting glucose targets. If HbA1c remains above 7% after 2-3 months, additional injections of rapid-acting insulin should be added at mealtimes based on pre-meal glucose levels. Further intensification, such as checking postprandial levels and adjusting prandial insulin, is recommended if HbA1c is still not at target. The guidelines provide a step-by-step approach to optimizing insulin regimens based on glucose monitoring.
This document provides information about basic insulin pumping. It describes what an insulin pump is, potential benefits, and challenges. It discusses calculating basal rates, bolus doses, and correction factors. It provides guidance on pump maintenance like changing sites and settings. It addresses common questions around pump use, troubleshooting, and ensuring settings are optimized. The overall message is that pumps require diligent self-care and monitoring to achieve good blood sugar control.
The document provides a 3-step guide for interpreting iPro2 Professional CGM reports:
1. Overlay glucose data by meal to examine overnight, pre-prandial, and post-prandial periods.
2. Closely examine the 3 critical periods to identify causes of hypoglycemia or hyperglycemia.
3. Use daily summaries and patient logs to help identify relationships between behaviors, medications, and glucose levels.
The document discusses insulin therapy and glucose monitoring. It provides details on the different types of insulin including rapid, short, intermediate and long acting insulins. It describes insulin administration including sites, storage, precautions and complications. It also discusses glucose monitoring methods like fasting blood glucose, oral glucose tolerance test and self monitoring of blood glucose. The normal values and nursing considerations for these tests are outlined.
This document discusses basics of insulin therapy including:
- The discovery of insulin in the 1920s and types of insulin including basal, mealtime, premixed, and newer combinations.
- Insulin action profiles, indications for insulin use, administration techniques using vials, syringes and pens, and common insulin regimens for type 2 diabetes including once or twice daily basal insulin +/- mealtime insulin or premixed insulin.
- Proper storage, mixing, and injection of insulin as well as recommended sites for injection are also reviewed.
This document provides guidelines for initiating and adjusting insulin therapy for type 2 diabetes. It outlines a step-by-step regimen beginning with initiating either bedtime intermediate-acting insulin or bedtime or morning long-acting insulin. It instructs to monitor fasting blood glucose and increase the insulin dose until the target range is achieved. Additional injections of rapid-acting insulin are added before meals if blood glucose levels remain out of range. The regimen is monitored every 3 months by checking HbA1c and adjusting insulin doses up or down based on blood glucose levels and HbA1c targets.
This document discusses insulin therapy, including its pharmacodynamics, mechanisms of action, types of insulin, insulin regimens, administration techniques, side effects, and patient education. Insulin is secreted by the pancreas and lowers blood glucose levels by facilitating glucose uptake into cells. It acts on the liver, muscle, adipose tissue, and other organs. Types include rapid, short, intermediate and long-acting insulins. Patient education focuses on proper administration, storage, monitoring, hypoglycemia treatment, and lifestyle factors.
This document discusses insulin therapy for diabetes. It begins with a brief history of insulin's discovery in 1921 by Banting and Best in Toronto. It then covers normal insulin secretion patterns and the types of insulin available, including rapid-acting, short-acting, intermediate-acting, premixed, basal, and extended long-acting analog insulins. The document discusses initiating and titrating insulin using the ADA treatment algorithm, beginning with basal insulin and adding bolus insulin as needed based on blood glucose levels and HbA1c targets. It also covers starting and adjusting premixed insulin doses.
Vanita R. Aroda, MD, prepared type 2 diabetes mellitus infographics for this CME activity titled, "Putting Basal Insulin Therapy to Work for Patients With Type 2 Diabetes Mellitus." For the full presentation, downloadable infographics, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2kdVkuJ. CME credit will be available until September 12, 2020.
Insulin is a polypeptide hormone produced by the pancreas that has profound effects on carbohydrate, fat, and protein metabolism. Insulin deficiency results in hyperglycemia and other metabolic issues. There are various types of insulin that are classified by their onset and duration of action, including rapid-acting, short-acting, intermediate-acting, long-acting, and premixed insulins. Common insulin regimens include split-mixed, multiple injection, basal-bolus, and continuous subcutaneous insulin infusion. Insulin is administered via syringes, pens, or pumps and is injected into approved sites in the body. Potential side effects of insulin therapy include hypoglycemia, weight gain, and local injection
The document summarizes insulin therapy for diabetes mellitus. It describes the cells in the pancreas that secrete insulin and other hormones. It details the discovery and purification of insulin in the 1920s which revolutionized treatment of diabetes. The document discusses different insulin formulations including short-acting and long-acting types. It explains factors that affect insulin absorption and common dosing regimens for insulin therapy.
Insulin therapy in Diabetes Mellitus discusses various types of insulin, newer insulin analogs, and insulin regimens for managing type 1 diabetes mellitus. Rapid-acting insulin analogs have advantages over regular insulin such as quicker onset of action and less risk of hypoglycemia. Long-acting insulin analogs like glargine have advantages over NPH insulin such as a more consistent time action profile. The document discusses split-mix and basal-bolus insulin regimens and factors to consider when choosing a regimen. It also covers complications of insulin therapy, monitoring of blood glucose and HbA1c levels, and sick day management for patients with type 1 diabetes.
The document discusses guidelines for initiating insulin therapy in patients with type 2 diabetes not controlled on oral antidiabetic drugs (OADs). It recommends starting with either bedtime intermediate-acting insulin or bedtime or morning long-acting insulin, beginning at a dose of 10 units or 0.2 units/kg. The insulin dose is then titrated up based on fasting blood glucose levels until the target range is achieved. Additional injections of rapid-acting insulin may be added if pre-meal blood glucose levels remain out of range.
This document discusses common errors in insulin therapy. It covers topics like delaying insulin initiation, improper injection techniques, incorrect insulin regimens, and failure to target all glycemic measures including fasting plasma glucose, post-prandial glucose, and A1C. The document emphasizes the importance of properly educating patients on insulin administration and management to achieve optimal glucose control and avoid both short-term and long-term consequences of uncontrolled diabetes.
This document discusses two case studies of patients with type 2 diabetes mellitus. For the first case, a 50-year old female patient with HbA1c of 8.5-9% on oral medications, the summary recommends starting basal insulin such as glargine or detemir 15-20 units at bedtime. For the second case, a 68-year old obese male patient with HbA1c of 10.5% on maximum oral medications, the summary recommends starting a total daily dose of insulin of 0.3-0.5 units/kg, starting with premixed insulin such as Mixtard 18/10 units. Both cases emphasize individualizing treatment targets and adjusting insulin doses based on self-
Implantable biosensor with programmed insulin pumpjitisha chhettri
The document discusses various types of implanted insulin pumps, including open loop pumps controlled manually by the user and closed loop "artificial pancreas" pumps that automatically adjust insulin levels based on continuous glucose monitor (CGM) readings. It describes the components of an artificial pancreas device system (APDS), including the CGM, blood glucose meter, control algorithm, and infusion pump. It also covers fabrication methods for thin film insulin pumps using shape memory alloys, the importance of check valves, and a block diagram of an insulin pump system with a glucose sensor and microcontroller.
The document discusses insulin pumps as an alternative treatment for diabetes compared to traditional multiple daily injections. Insulin pumps provide continuous insulin delivery through an infusion set and are programmed to deliver basal and bolus doses. While insulin pumps are more expensive initially than injections, they provide benefits like better blood glucose control and more flexibility with meals and activities. The technology has advanced significantly since the first prototype pump in 1964 and continues to improve, but some disadvantages remain like potential weight gain and the need to remove the pump for certain activities.
The document describes an insulin pump that measures a patient's blood sugar levels and automatically injects insulin to maintain safe levels. It functions by taking periodic glucose readings and comparing them to determine if insulin should be injected to counter rising sugar levels. The goal is to keep sugar within a safe band like a healthy pancreas would. The pump hardware, software requirements, and safety considerations are discussed to minimize risks like overdose or underdose from failures.
Various insulin pumps used to deliver insulin to the human body and its application along with its advantages and disadvantages are outlined in this presentation.
Perioperative Management of Patients with an Insulin PumpAllina Health
A team at Abbott Northwestern Hospital developed guidelines for managing patients with insulin pumps undergoing surgery. Previously, there was no systematic approach, putting patients at risk for severe hypo- and hyperglycemia. The team included diabetes, hospitalist, anesthesia, surgery, nursing and pharmacy staff. They created processes for identifying insulin pump patients pre-op, documenting pump settings, and developing pre-op plans for alternative insulin therapies when pumps cannot be used. Nurses were trained on the guidelines. Since implementation, most patients' blood sugars have remained within target ranges during surgery, and patient satisfaction with team coordination has increased.
Testing plays an important role in the certification process for systems and software. The certification process involves verification and validation activities to determine if a system meets its specified requirements. Testing is used for both verification and validation at various stages - from unit testing of individual components to system integration testing and user acceptance testing. Standards like DO-178B for aerospace and IEC 60601-1-4 for biomedical engineering define requirements for testing and coverage criteria that must be met for certification based on the criticality of the system. A comprehensive testing approach throughout the development lifecycle is needed to identify defects and improve safety for certification.
The DANA R insulin pump helps maintain
normal glucose levels discretely using
the ANYDANA application - now available for
most Android smart phones.
The web based ANYDANA Program is being
developed so that the Any DANA application send
pump settings, history, and the patients’ data there.
Your physician could then review and analyze all of
the information and forward changes despite long
distance.
El documento presenta el Plan de Gestión Integral de Residuos Sólidos para el municipio de Choachí, Cundinamarca. Incluye el agradecimiento a las personas que participaron en su elaboración, la introducción explicando la metodología y objetivos, y el marco legal que rige la gestión de residuos. Además, describe la organización municipal establecida para formular el plan y el capítulo de diagnóstico.
The document summarizes information about insulin pumps. Insulin pumps are external devices that mimic the pancreas by continuously measuring blood sugar levels and injecting insulin to maintain normal levels. Traditional pumps include the pump unit to control insulin delivery, a disposable insulin reservoir, and a disposable infusion set including a cannula and tubing. Insulin pumps offer benefits over multiple daily injections such as increased flexibility and more precise insulin delivery to reduce complications. However, disadvantages include risks of infection and malfunction leading to ketoacidosis as well as the high cost of pumps.
Insulin is used to treat diabetes by regulating blood sugar levels. There are various types of insulin differentiated by their onset, peak time and duration of effect. Rapid-acting insulins work within 15 minutes, short-acting within 30 minutes to 1 hour, intermediate within 2-4 hours and long-acting up to 24 hours. Proper administration and storage of insulin is required to ensure safety and efficacy.
Our second one hour Seminar will run on November 13th @ 6:30pm. This advanced Seminar is for the athletes looking to get serious about their diets. We’ll cover things like:
Intermittent Fasting
Macro Counting
This document summarizes an obesity treatment program that uses human chorionic gonadotropin (HCG) injections along with a very low calorie diet. It discusses how HCG triggers the body to burn abnormal fat stores for energy while dieting. Testimonials are provided from patients who lost 10-30 pounds in 30 days on the program by reducing body fat percentage and waist circumference. The program is described as effective for rapid weight loss, resetting metabolism, and providing lasting results for those who have struggled with yo-yo dieting.
2014 typeonenation pump talk for nurses Austin, Texas June 21Stephen Ponder
Slide Deck for the 2014 School RN talk on Insulin Pump use by Stephen Ponder MD, FAAP CDE on June 21, 2014 in Austin, Texas at the TypeOneNation conference.
The document discusses insulin pump therapy and technologies for managing diabetes. It provides information on:
1. Education needed before starting insulin pump therapy, including determining basal and bolus rates.
2. Safety measures to prevent hyperglycemic crises and inpatient considerations for insulin pump use.
3. Advanced pump features like temporary basal rates, prolonged boluses, and data downloads that can help fine-tune insulin delivery and management of blood glucose levels.
This document provides information about managing blood pressure through a voluntary wellness program. The program offers incentives for completing health assessments and meeting six health criteria, such as maintaining total cholesterol below 200, blood pressure under 120/80, and not using tobacco. It describes blood pressure, risks of high blood pressure, and lifestyle changes to control it, such as getting adequate sleep, maintaining a healthy weight, following the DASH diet low in sodium and high in fruits/veggies, and engaging in regular physical activity. Tips for an accurate reading include being well-rested, relaxed, and not smoking or drinking caffeine beforehand.
Think about the excitement and pride as you unveil, strip down your swimwear confident relax and proud, feeling new and better and people comment on your impressive well-earned physique. whatever you have been failing for years but never seen results, If you just decide now it the time for that great change after months of letting yourself setback, here the plan to achieve the dream body with incredible training and diet program, you will see the hard work translates into a lean muscular defined physique.
10 practical tips to make type 1 diabetes work for you tlc retreat 2013 ponderKevin McMahon
This document provides 10 practical tips to help manage type 1 diabetes. It begins with an overview of managing glucose flux and drift, understanding how diabetes tools like insulin, food, exercise, and monitors work and their limitations. It emphasizes recognizing trends versus randomness, making prudent changes, and treating diabetes management like a team sport. The document also covers common emergencies, how other factors like family impact management, and new developments in type 1 diabetes treatment. It aims to help readers better understand and control their condition through mastery of these diabetes management principles and tools.
29 ways to lose weight extremely fast, effective, and scientifically proven.pdfGhulam Sarwar
Are you looking to lose weight to improve your appearance, your health, or even both? If you are, you may be looking for advice. The good news is that there are a number of tips that you can use to help you successfully lose weight and hopefully achieve your weight loss goal.
When it comes to losing weight, the best thing that you can do is eat healthy. Eating healthy involves watching the foods that you eat, not necessarily how much food you eat. Of course, you may want to restrict the amount of foods that you eat, when on a diet, but it is more important to focus on the foods that you do eat. For instance, if you were to eat fruit instead of chips, you could have more fruit snacks with your meals than you would be able to if you were just to eat junk food.
Since eating healthy is an important component of losing weight, you may be wondering how you can go about doing so. One of the first things that you should do is find and familiarize yourself with healthy meals. You can do this by way of standard internet search or by buying a collection of healthy eating recipe books. To reduce the boredom often associated with healthy eating, especially if you are not use to it, it is important that you “spice,” up your foods and try to not eat the same meals over and over again each week.
In connection with healthy eating, regular exercise is also important to weight loss. If you are looking to lose weight, you should start an exercise plan for yourself. Exercise is important as it burns off calories. When you burn calories, the amount of calories that your body absorbs decreases. This is, essentially, what makes it possible for you to lose weight. If you haven’t been exercising regularly in the past, it is important that you take it slow. Exercise is a great way to lose weight, but you do not want to overdo it, especially at first.
If you don’t currently have an exercise plan or program in place, you may be wondering more about what you can do. One of the many ways that you can go about finding exercises or workouts to do is by buying a collection of fitness magazines. Many fitness magazines have detailed exercises outlined in them, often accompanied by pictures. You may also be able to find free instructional workout videos or exercise moves online. As a reminder, it is important to start out slow or at least start with exercises that would be easy for you to.
Eating healthy and regular exercise are both important components of losing weight, but there are additional tips that you can use to help you lose weight. One of those tips involves finding a workout partner or a workout buddy. This is a person who can exercise with you, whether your exercise involves visiting a local gym or just going for a walk at a local shopping center. Having a workout partner may help to keep you motivated and it may help to keep exercising and losing weight fun and exciting for you.
Think about replacing the extra weight with excitement and pride as you unveil your beach body. You will feel lighter, sexier and confident. Whatever you have been feeling: setback, disappointment, lack of visible results… Now it is the time for that fabulous great change after months of letting yourself down, here is the plan to achieve the dream body. I have the recipe: blend of incredible training and a diet program. Follow my rules, work hard and soon you will see the result: your new lean body and muscular tone physique.
This document provides an athlete eating guide with recommendations for meal timing and composition throughout the day to support performance and recovery. It recommends eating 6-7 small meals per day with plenty of water and getting protein, carbohydrates and nutrients within 60 minutes of workouts. Sample meal plans are provided that emphasize high-quality protein, complex carbs and hydration. Supplement recommendations focus on creatine, glutamine and protein/amino acids around workouts. The effects of alcohol on performance are discussed. Maintaining proper hydration is highlighted as critical for peak athletic performance.
This document provides information about a program to help people lose weight and improve their health and fitness. It outlines a 6-day per week plan including consuming protein shakes, meal replacements, and supplements to support weight loss goals. The plan emphasizes developing healthy habits through eating whole foods, staying hydrated, getting enough sleep, and exercising regularly, including interval cardio and resistance training. Customers can order the products retail or sign up for discounted monthly subscriptions.
This document discusses a 1500 calorie diet program for losing weight and burning fat. It describes the program as involving 6 meals per day of around 250 calories each, containing protein, carbohydrates, and fats. The program is said to allow significant weight loss without drastically reducing calories. It also includes exercise recommendations for fat burning and strength training.
Insulin therapy- art of initiation and titrationSaikumar Dunga
The document outlines guidelines for initiating and titrating insulin therapy. It recommends starting with either bedtime intermediate-acting or morning/bedtime long-acting insulin, and titrating the dose to reach fasting glucose targets. If HbA1c remains above 7% after 2-3 months, additional injections of rapid-acting insulin should be added at mealtimes based on pre-meal glucose levels. Further intensification, such as checking postprandial levels and adjusting prandial insulin, is recommended if HbA1c is still not at target. The guidelines provide a step-wise approach to optimizing insulin regimens based on glucose and HbA1c monitoring.
Watch the results before your eyes:
http://www.facebook.com/pages/Shapeworks-Tips-For-Better-Results/174161048871?v=app_2392950137#/video/video.php?v=213325257066
godd carbs vs bad carbs: how this could save your lifereaslide
This document discusses the differences between "good" and "bad" carbohydrates. It notes that carbohydrates control insulin levels and fat storage, so limiting carb intake can help with weight loss. Not all carbs are bad - fruits and vegetables are preferable sources due to their nutrient content and lower carb counts per serving compared to grains, legumes, and processed foods. The document recommends limiting intake of grains, sugars, legumes, and processed foods, and consuming 0-100g of carbs per day for weight loss or maintenance.
This document discusses nutrition guidelines for exercise and sport. It covers nutrient needs for active individuals, including dietary reference intakes and recommendations for carbohydrate, protein, fat, fluid and pre-workout meal intake. Guidelines are provided for different types of sports and phases of training, including carbohydrate loading. The needs for weight gain and muscle building are also outlined. Nutrient timing for resistance training is discussed.
The document discusses how the HCG Life Drops weight loss program works. It explains that HCG activates the hypothalamus to mobilize abnormal stored body fat to be used as energy when following a very low calorie diet of 500 calories per day. The program is divided into 4 stages, where stages 1-3 involve taking the drops daily and following the low calorie diet, and stage 4 gradually increases calorie intake while maintaining the new weight. The science behind it is that HCG reprograms the brain's metabolism to start burning fat like a thin person rather than storing it. Strict adherence to the program, including the low calorie intake, is required to achieve weight loss of 1-2 pounds per day.
Iaso HCG Diet Life Drops Program Guide and FAQAlex Alojado
HCG (Human Chorionic Gonadotropin) is what triggers the hypothalamus region to mobilize stored fat into the bloodstream to be used as food. It is believed to reset your metabolism and to protect your body’s good fat and keep muscle tissue from breaking down. (which occurs in other low calorie diets without using HCG).
This document provides information and advice for managing the emotional challenges of living with type 1 diabetes (T1D). It discusses how the demands of diabetes management can take an emotional toll on families and lead to distress, conflicts, burnout and feelings of being overwhelmed. It emphasizes that distress and burnout are common for all families dealing with T1D and offers suggestions for recognizing signs that outside support is needed. The document provides recommendations for setting realistic goals, using positive language, praising diabetes management behaviors, finding humor, getting support and focusing on living well with T1D despite the challenges.
This document discusses managing diabetes emergencies such as high blood glucose levels and ketones. It provides guidance on correcting high blood glucose and ketone levels, identifying the cause, and learning from the experience. Specific tips are given for fluid management and insulin adjustments when sick with high blood glucose and ketones. Signs for when to call the diabetes care team are outlined. Instructions are also provided for using mini-dose glucagon to treat hypoglycemia during illness. The presentation aims to help patients and care teams find patterns in blood glucose levels to better manage diabetes and emergencies.
Researchers are making progress toward the artificial pancreas (AP) with 2016 focusing on real-world testing of algorithms. Key areas of interest for 2017 include transparency of researcher methods and data, effort required by patients, and reimbursement discussions. Continuous glucose monitoring accuracy and wear time remain barriers, as do pump reliability and immune responses. Both algorithmic and heuristic approaches are being studied, with personalization seen as important. Success has also come from grassroots integration and sharing of existing technologies.
This document contains notes from a presentation on Sugar Surfing, which is described as a metaphor for "Dynamic Diabetes Self-Management" that goes beyond fixed dosing formulas. It involves learning to steer one's glucose responses in the moment using pattern management. Examples are provided of glucose readings from individuals of various ages who practice Sugar Surfing, demonstrating how it can be done regardless of insulin method or diet. Key concepts of Sugar Surfing like pivots, drops, shelves and following trends are defined and illustrated with graphs.
This document discusses how people with diabetes can participate in sports and exercise safely by managing their blood glucose levels. It explains that all sports are allowed for people with diabetes, but they need a plan to monitor and adjust insulin doses and carbohydrate intake before, during, and after physical activity, as exercise can either increase or decrease blood glucose depending on its intensity and duration. The document provides specific tips, such as checking blood sugar more frequently during exercise and consuming carbohydrates to prevent or treat low blood sugar. It emphasizes the importance of education coaches and teammates about diabetes management as well as having necessary supplies available for physical activity.
Meaghan Anderson presented on challenging food situations for people with diabetes. She discussed macronutrients and their impact on blood glucose, how to calculate carbohydrates and estimate insulin needs. She explained glycemic index and load, and emphasized the importance of chewing food and using carb counting to estimate blood sugar impact of meals.
This document provides information on counting carbohydrates for managing blood sugar levels for those with diabetes. It discusses that carbohydrates have the greatest effect on post-meal blood sugar, and counting carbs allows for better glucose control and more flexibility. Standard serving sizes are outlined for various food groups containing carbohydrates like breads, fruits, milk, and starchy vegetables. Artificial sweeteners and proper portion sizes are also discussed as important factors for blood sugar management.
This document discusses the benefits and cautions of using social media related to diabetes. It provides examples of social media platforms and blogs for connecting with others about diabetes experiences and education. Key benefits highlighted include accessing real-time support, educational content, and humor from others dealing with diabetes. However, cautions mentioned include varying treatment needs between individuals, relying too heavily on social media, and potential online safety issues.
This document discusses types of support for managing diabetes and provides suggestions for building a supportive network. It identifies emotional and hands-on support, potential support people like family, friends, and care teams, and recommends asking supports to help with specific diabetes tasks. The document also notes that communicating treatment needs calmly, praising behavior, and problem-solving together are most helpful, while blaming, shaming, nagging or denying worries are not supportive. It encourages expressing experiences to gain support and finding balance through fun family activities and self-care.
This document discusses the challenges of managing diabetes and the toll it can take on families. It notes that while behavior is important for blood glucose control, many other factors also influence levels. Parents often feel responsible for blood glucose numbers outside of their control. The document acknowledges that distress, burnout, conflicts and feeling overwhelmed are common experiences for families dealing with diabetes. However, it provides suggestions for improving diabetes management and quality of life, such as focusing on strengths, catching children being good with their management, using praise over criticism, setting realistic goals, and finding humor.
This presentation was authored by Meaghan Anderson MS RD LD CDE, Senior Diabetes Clinical Manager-Houston North - Medtronic Diabetes specially for the Advanced Diabetes Seminar at TLC on April 26, 2014.
This document provides guidance on treating low blood sugar, including what to do if someone is unconscious or seizing. It discusses the contents of a "go bag" for treating low blood sugar, such as glucose tabs, juice boxes, candy, glucose gel/honey packets, and Glucagon. It outlines the "Rule of 15" for treating low blood sugar - giving 15 grams of carbohydrates, waiting 15 minutes, then rechecking blood sugar and repeating if needed. It provides instructions for using gel/honey if the person cannot eat or swallow, and using Glucagon if they are unconscious or seizing. The document also briefly discusses guidelines for treating high blood sugar.
Authored by Brant P. Foster, RN, a long time friend and contributor to the Texas Lions Camp. This seminar is for the Advanced Diabetes Seminar 2014 at TLC.
A presentation for the April 26, 2014 Advanced Diabetes Seminar at Texas Lions Camp. Author is my friend and colleague Nelda Rodriguez-Caceres, RN, CDE -
ADA Outpatient Diabetes Program Coordinator
Diabetes Care Coordinator - Shoreline & CHRISTUS Spohn Hospital Corpus Christi.
This document provides guidance on navigating diabetes emergencies by correcting high blood glucose, identifying the cause, learning from the experience, and considering factors like fluids, insulin adjustments, nutrition, and activity level. It also includes examples of blood glucose and ketone levels over time and guidance on when to call the diabetes care team, as well as details on using mini-dose glucagon for hypoglycemia during illness.
This presentation is authored by my good friend and colleague, Dr. Barb Schreiner. The presentation is for the Advanced Diabetes Seminar presented at Texas Lions Camp, Saturday, April 26, 2014.
This is a presentation authored and presented by my friend and colleague at Baylor College of Medicine, Dr. Barbara Anderson. This is a module in the 2014 Advanced Diabetes Seminar at Texas Lions Camp.
During this presentation, Dr. Anderson dives deeper to provide insight into the timely and relevant topic: “Grandparents have an important role on the diabetes team.”
This is a presentation authored and developed by my friend and colleague Dr. Barbara Anderson of Baylor College of Medicine. The presentation is a module in the 2014 Advanced Diabetes Seminar, hosted by Texas Lions Camp.
In this discussion, Dr. Anderson dives into the topic of “Diabetes Family Teamwork with Teens: What is Success?”
Architects and architecture play a critical role in creating an inviting and safe atmosphere for the end user, but they are not clairvoyant about client culture. Organizations are best served and more likely to achieve their desired outcome by spending time educating designers about their organizational culture, vision and what will spell success when the project is completed.
The more information about the organization concerning outcomes and results that can be conveyed before the design phase even commences, the more likely the desired outcome will be achieved.
It was my privilege to present some of these ideas at the Texas Society of Architects in Austin.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
Summer is a time for fun in the sun, but the heat and humidity can also wreak havoc on your skin. From itchy rashes to unwanted pigmentation, several skin conditions become more prevalent during these warmer months.
NAVIGATING THE HORIZONS OF TIME LAPSE EMBRYO MONITORING.pdfRahul Sen
Time-lapse embryo monitoring is an advanced imaging technique used in IVF to continuously observe embryo development. It captures high-resolution images at regular intervals, allowing embryologists to select the most viable embryos for transfer based on detailed growth patterns. This technology enhances embryo selection, potentially increasing pregnancy success rates.
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdfrightmanforbloodline
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
Test bank for karp s cell and molecular biology 9th edition by gerald karp.pdf
- Video recording of this lecture in English language: https://youtu.be/Pt1nA32sdHQ
- Video recording of this lecture in Arabic language: https://youtu.be/uFdc9F0rlP0
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Breast cancer: Post menopausal endocrine therapyDr. Sumit KUMAR
Breast cancer in postmenopausal women with hormone receptor-positive (HR+) status is a common and complex condition that necessitates a multifaceted approach to management. HR+ breast cancer means that the cancer cells grow in response to hormones such as estrogen and progesterone. This subtype is prevalent among postmenopausal women and typically exhibits a more indolent course compared to other forms of breast cancer, which allows for a variety of treatment options.
Diagnosis and Staging
The diagnosis of HR+ breast cancer begins with clinical evaluation, imaging, and biopsy. Imaging modalities such as mammography, ultrasound, and MRI help in assessing the extent of the disease. Histopathological examination and immunohistochemical staining of the biopsy sample confirm the diagnosis and hormone receptor status by identifying the presence of estrogen receptors (ER) and progesterone receptors (PR) on the tumor cells.
Staging involves determining the size of the tumor (T), the involvement of regional lymph nodes (N), and the presence of distant metastasis (M). The American Joint Committee on Cancer (AJCC) staging system is commonly used. Accurate staging is critical as it guides treatment decisions.
Treatment Options
Endocrine Therapy
Endocrine therapy is the cornerstone of treatment for HR+ breast cancer in postmenopausal women. The primary goal is to reduce the levels of estrogen or block its effects on cancer cells. Commonly used agents include:
Selective Estrogen Receptor Modulators (SERMs): Tamoxifen is a SERM that binds to estrogen receptors, blocking estrogen from stimulating breast cancer cells. It is effective but may have side effects such as increased risk of endometrial cancer and thromboembolic events.
Aromatase Inhibitors (AIs): These drugs, including anastrozole, letrozole, and exemestane, lower estrogen levels by inhibiting the aromatase enzyme, which converts androgens to estrogen in peripheral tissues. AIs are generally preferred in postmenopausal women due to their efficacy and safety profile compared to tamoxifen.
Selective Estrogen Receptor Downregulators (SERDs): Fulvestrant is a SERD that degrades estrogen receptors and is used in cases where resistance to other endocrine therapies develops.
Combination Therapies
Combining endocrine therapy with other treatments enhances efficacy. Examples include:
Endocrine Therapy with CDK4/6 Inhibitors: Palbociclib, ribociclib, and abemaciclib are CDK4/6 inhibitors that, when combined with endocrine therapy, significantly improve progression-free survival in advanced HR+ breast cancer.
Endocrine Therapy with mTOR Inhibitors: Everolimus, an mTOR inhibitor, can be added to endocrine therapy for patients who have developed resistance to aromatase inhibitors.
Chemotherapy
Chemotherapy is generally reserved for patients with high-risk features, such as large tumor size, high-grade histology, or extensive lymph node involvement. Regimens often include anthracyclines and taxanes.
Travel Clinic Cardiff: Health Advice for International TravelersNX Healthcare
Travel Clinic Cardiff offers comprehensive travel health services, including vaccinations, travel advice, and preventive care for international travelers. Our expert team ensures you are well-prepared and protected for your journey, providing personalized consultations tailored to your destination. Conveniently located in Cardiff, we help you travel with confidence and peace of mind. Visit us: www.nxhealthcare.co.uk
8 Surprising Reasons To Meditate 40 Minutes A Day That Can Change Your Life.pptxHolistified Wellness
We’re talking about Vedic Meditation, a form of meditation that has been around for at least 5,000 years. Back then, the people who lived in the Indus Valley, now known as India and Pakistan, practised meditation as a fundamental part of daily life. This knowledge that has given us yoga and Ayurveda, was known as Veda, hence the name Vedic. And though there are some written records, the practice has been passed down verbally from generation to generation.
Know the difference between Endodontics and Orthodontics.Gokuldas Hospital
Your smile is beautiful.
Let’s be honest. Maintaining that beautiful smile is not an easy task. It is more than brushing and flossing. Sometimes, you might encounter dental issues that need special dental care. These issues can range anywhere from misalignment of the jaw to pain in the root of teeth.
How, When and Why to Use Advanced Insulin Pump Features
1. How, When and Why to Use
Advanced Insulin Pumping Tactics
Meaghan Anderson, MS RD LD CDE
2. How to use the temp basal and bolus options
When to use these options
Why to use these options
Learn the other bells and whistles on your pump
Objectives
3. What is it?
Allows you to immediately increase or decrease your
basal rate, for the temporary time you set
Set for 30 minutes to 24 hours in 3o minute increments
Can be canceled
Temporary Basal Rate
4. Percent of basal
a percentage increase or decrease of current basal
rate(s)
Rate can be reduced to 0% and increased up to 200%
Max sure you max basal rate is set to be double your highest
basal rate
Insulin rate
a fixed basal in units per hour (U/H), which is
independent of current basal rate
Temp Basal Rates can be set based
on preference:
6. There is a decreased need for insulin when we are
more active, basal rates are set for a “typical day”
There is an increased need for insulin when we are
stressed, ill or less active
Keep in mind the peak action of insulin when setting a
decreased basal rate
Why to use…
7. Basketball Practice
George has a 2 hour
basketball practice
His blood glucose 1 hour
before practice is 136
mg/dl
He has noticed a trend in
low blood sugars during
practice
Recommentation…
Reduce basal rate to 50%
for 4 hours
Set the reduction to start
1 hour before practice
Monitor hourly to see if it
is working
8. What if…
Hour BG
Pre 136
1 hr 122
2 hr 167
3 hr 184
4 hr 192
Consider reducing
percent decrease…
Temp basal set for four
hours and reduce to 65%
of usual rate
9. Sick Day
Kate as been ill for the
last 24 hours and blood
glucose is consistently
>200
What could she try to get
blood sugars closer to
normal?
Increase basal by 20% for
four hours, continue to
increase in 20%
increments until blood
glucose levels are closer
to normal
Monitor frequently
12. NORMAL BOLUS
Bolus amount delivers as
soon as amount is
confirmed
Used for meals with
average fat and carb
content
Also used for correction
boluses
13. Square/Extended Bolus
The bolus amount
delivers evenly over the
period of time you set
Primarily used by those
who have delayed
digestion (gastroparesis)
Used when eating carbs
over an extended period
of time
14. Dual/Extended Bolus
Bolus amount is split
Used for meals both high
in fat and carb, which
may delay digestion (ie
pizza, Chinese or Mexican
food)
Percent you set to deliver
now and as a square
wave will vary based on
meal content as well as
premeal blood glucose
15. Mamacita’s
Frank has added up his
carbohydrates and he is
going to eat 105 gm of
carb (fajitas, rice, beans,
chips)
His premal glucose is 110
mg/dl
What should Frank do?
Program a dual/extended
bolus
50-50 split for 2-4 hours
Monitor frequently so he
know next time if this
was the best way to
deliver the insulin
16. Results
Hour BG
Pre 110
1 70
2 110
3 145
4 170
Since one hour post meal
BG is low consider giving
less insulin upfront (25/75
split
More insulin delivered
later should also help 3
and 4 hour BGs be closer
to target
17. FRUIT LOOPS
Sara is going to eat 70
grams worth of cereal
with milk.
Her current glucose is 105
mg/dl
What is her best bolus
option?
Normal bolus
Remember to take insulin
15-20 minutes prior to
eating to prevent abrupt
spike in blood sugar
18. Results
Hour BG
Pre 105
2 155
4 116
Perfect!
Two hour post prandial
glucose is expected to be
40-60 points higher the
pre meal glucose
20. Alarm clock
Set it for normal eating times to remind you to check
blood sugars and bolus
Missed Bolus Reminder
Eat at noon
Set reminder from 1130 to 1230
BG Reminder
Available on both pumps and glucose meters
Tools for the forgetful…
21. A great tool for those who have varied lifestyle for
greater than 24 hours
Examples
Sleep in on weekends
Active weekday, couch potato weekend
MWF Schedule for T/Th
Menstrual cycle
Basal Patterns
22. Average blood sugar
Carb intake
Total Insulin
Basal units and percentage
Bolus units and percentage
Number of correction and food boluses
Daily Totals