This document discusses the management and treatment of type 2 diabetes from a cardiology perspective. It outlines lifestyle changes like weight loss, healthy eating, and exercise that can help control blood sugar levels and prevent complications. It then describes various classes of diabetes medications, including how they work and common side effects. The document provides examples of brand and generic drugs within each class, along with their manufacturers and average prices in Egypt.
This is part two of the diabetes presentation aimed for pharmacists and allied health professional who are interested in tailoring special pharmaceutical care plans for diabetic patients.
A brief description of Diabetes with management guidelines
according to different diabetes foundation and their treatment with drugs and their MOA dose and side effects
This is part two of the diabetes presentation aimed for pharmacists and allied health professional who are interested in tailoring special pharmaceutical care plans for diabetic patients.
A brief description of Diabetes with management guidelines
according to different diabetes foundation and their treatment with drugs and their MOA dose and side effects
Body produces insulin, but the insulin does not able to control blood glucose level due to the body’s low sensitivity to insulin called insulin resistance. Diabetes oral medications are needed to maintain normal blood glucose level.
A short lecture highlighting the most important aspects of pharmacological management of DM in general. It discusses the use of insulin in type I diabetes mellitus and the approach with hypoglycemic agents in type II.
Advances and Management of Diabetes MellitusPratiksha Doke
Diabetes mellitus is an endocrinological and/or metabolic disorder with an increasing global prevalence and incidence. High blood glucose levels are symptomatic of diabetes mellitus as a consequence of inadequate pancreatic insulin secretion or poor insulin-directed mobilization of glucose by target cells. Diabetes mellitus is aggravated by and associated with metabolic complications that can subsequently lead to premature death. This presentation explores diabetes mellitus in terms of its types, causes and management interventions for improved lifestyle for patient.
Similar to Treatment of diabetes mellitus t2 samir rafla (20)
To every girl and every woman, this word is provided: You are princess, You’re ambassador to the king , You’re a servant of the King, Jesus Christ is the king, Jesus is in your heart, You can befriend Jesus
A beautiful paper published by Eugene Braunwald
European Heart Journal, Volume 42, Issue 24, 21 June 2021, Pages 2327–2328, https://doi.org/10.1093/eurheartj/ehab264
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
1. Treatment of diabetes Mellitus T2 from view
point of cardiology link
Samir Rafla
Emeritus professor of Cardiology,
Alexandria University, Faculty of Medicine,
Cardiology Department. Egypt.
2. Management of type 2 diabetes includes:
- Weight loss
- Healthy eating
- Regular exercise
- Blood sugar monitoring
- Possibly, diabetes medication or insulin therapy
3. • These steps will help keep your blood sugar level closer to normal, which can
delay or prevent complications. Weight loss:
1 Losing weight can lower your blood sugar levels. Losing just 5 to 10 percent of
your body weight can make a difference.
2 Healthy eating: Contrary to popular perception, there's no specific diabetes
diet. However, it's important to center your diet around:
• Fewer calories. Fewer refined carbohydrates, especially sweets
• Fewer foods containing saturated fats
• More vegetables and fruits. More foods with fiber
4. • 3 Physical activity: Aim for at least 30 to 60 minutes of moderate (or
15 to 30 minutes of vigorous) aerobic exercise most days of the
week. Remember that physical activity lowers blood sugar. It's also
important to reduce the amount of time you spend in inactive
activities, such as watching TV. Try to move around a bit every 30
minutes.
• 4 Monitoring your blood sugar:
• 5 Diabetes medications and insulin therapy
5. • Oral Drugs for Diabetes:
• Each class of medicine works in different ways to lower blood
sugar. A drug may work by:
• Stimulating the pancreas to produce and release more insulin
• Inhibiting the production and release of glucose from the liver
• Blocking the action of stomach enzymes that break down
carbohydrates
• Improving the sensitivity of cells to insulin
• Inhibiting the reabsorption of glucose in the kidneys
6. • Biguanides
• Medications: Metformin (Glucophage, others)
• Action: Inhibit the release of glucose from the liver, Improve
sensitivity to insulin
• Advantages: Very effective, May promote modest weight loss, Low
cost
• Possible side effects: Nausea, Diarrhea,
Very rarely, the harmful buildup of lactic acid (lactic acidosis) when
used in patients with kidney or liver failure.
7. Sulfonylureas. These medications help your body secrete more insulin.
Medications
Glipizide
Gliclazise (Diamicron)
Glimepiride (Amaryl, Glimet, Glaryl, Dolcyl)
Glyburide , Glibeneclamide ( Daonil )
Action
Stimulate the release of insulin
Advantages
Low cost
Effective in lowering blood sugar
Possible side effects: Hypoglycemia,
Weight gain; Skin rash
8. Thiazolidinediones
Medications: Pioglitazone (Actos)
Action: Improve sensitivity to insulin
Inhibit the release of glucose from the liver
Advantages
May slightly increase high-density lipoprotein (HDL), or "good"
cholesterol
Possible side effects
Weight gain, Heart failure, Heart attack
Fractures, Possible increased risk of bladder cancer with pioglitazone
These medications shouldn't be used in people with kidney disease or heart
problems.
9. Meglitinides.
These medications — such as repaglinide (Gluconorm,
Novonorm – Novo Nordisk- 0.5, 1, 2 mg tablets ) and
Nateglinide (Starlidine 60, 120 mg ) — work like
sulfonylureas by stimulating the pancreas to secrete
more insulin, but they're faster acting.
10. DPP-4 inhibitors. Dipeptidyl-peptidase 4 (DPP-4) inhibitors
Medications:
- Vildagliptin (Galvus, Galvus met, Vildagluse, Vildagluse plus,
Icandra)
- Saxagliptin (Onglyza, )
- Sitagliptin (Januvia)
- Linagliptin (Tradjenta, Linajenta 5 mg)
- Alogliptin
Action
Stimulate the release of insulin when blood glucose is rising
Inhibit the release of glucose from the liver
11. Advantages
Don't cause weight gain
Don't cause hypoglycemia (unless combined with insulin
or a sulfonylurea)
Possible side effects
Upper respiratory tract infection
Sore throat
Headache
12. Alpha-glucosidase inhibitors
Medications
Acarbose (Glucobay 50, 100 mg )
Miglitol ( )
Action
Slow the breakdown of starches and some sugars
Advantages
Don't cause weight gain
Don't cause hypoglycemia (unless combined with insulin or a
sulfonylurea)
Possible side effects
Stomach pain
Gas; Diarrhea
13. GLP-1 receptor agonists.
Examples of GLP-1 receptor agonists: Exenatide ( ), liraglutide
(Victoza- Novo Nordisk 3ml pre filled pen s.c.) and semaglutide ( )
These injectable medications slow digestion and help lower blood
sugar levels. Their use is often associated with weight loss.
Possible side effects include nausea and an increased risk of
pancreatitis. are.
14. Sodium-glucose transporter 2 (SGLT2) inhibitors
Medications
Dapagliflozin (Forxiga-AstraZeneca. 10 mg tab)
Empagliflozin (Jardiance (Boehringer Ingelheim), Glimpacare,
Mellitofix, Mellitofix Met).
Canagliflozin (Invokana- Janssen Cilag=Soficopharm 100 mg tab)
Action: These drugs prevent the kidneys from reabsorbing sugar
into the blood. Instead, the sugar is excreted in the urine (Block
glucose from being reabsorbed by the kidneys)
15. Advantages:
Medications in this drug class may reduce the risk of heart attack
and stroke in people with a high risk of those conditions. May
promote weight loss, May lower blood pressure
Possible side effects:
Urinary tract infections
Yeast infections
Rare, serious genital infection, low blood pressure, and a higher
risk of diabetic ketoacidosis.
16. Group Name Trade name Company Price
Biguanides Metformin Glucophage
Glucophage XR
Cidophage
1000 mg, 30 tab =
Sulfonylureas
Gliclazide Diamicron Servier 60 mg 30 tab 50.25L
Glimepiride (Amaryl) Sanofi 2 mg 30-tab 42 L
2/500 -30-tab 45 L
Glimet
Glaryl
Marcyrl
Global Napi
2.5/40; 5/800 -30 tab 22, 27 L
Glyburide
Thiazolidinediones Pioglitazone Actos
Table- Anti Diabetic drugs (short list)
17. Dipeptidyl-peptidase 4 (DPP-4) inhibitors
Vildagliptin Galvus
Galvus met
Novartis 50 mg 28-tab 137 L
Vildagliptin Gliptus
Gliptus plus
EVA Pharma 50 mg 30 tab 104
50/1000 mg 30-tab 104L
Icandra Mash Premier 50 mg 30-tab 69
Sitagliptin (Januvia)
Janumet
Merck Sharp &
Dohme
50 mg 28 t/b 220 L
50/1000- 56 tab 220;308 L
Linagliptin (Tradjenta) Boehringer
Ingelheim
5mg 30 tab- 235; 329L
Glimbacare MultiCare 21-tab 160.5 L
Saxagliptin Onglyza Bristol Myers
Squibb
18. Sodium-glucose transporter 2 (SGLT2) inhibitors
Dapagliflozin (Forxiga) AstraZeneca 10 mg 30 tab/box 333 L
Empagliflozin (Jardiance) Boehringer
Ingelheim
25 mg 30 t/b 496.5 L
Glimbacare MultiCare 21-tab 160.5 L
Mellitofix EVA pharma 25 mg 30 t/b 297 L
Mellitofix Met EVA pharma 12.5/1000 30 t/b 171 L