DNA replication involves making a copy of the DNA before cell division. There are three proposed models of replication: conservative, dispersive, and semi-conservative. The Meselson-Stahl experiment provided evidence supporting the semi-conservative model where each new DNA strand contains one original strand and one new strand. DNA replication requires many enzymes working together, including helicase to unwind DNA, primase to add RNA primers, DNA polymerase to add complementary bases to the primers, DNA polymerase I to replace the primers with DNA, and ligase to join the fragments.