The DNA repair mechanism plays an important role in maintaining DNA fidelity and avoiding lesions and mutations. The XPD protein functions like a scanner that travels along the DNA double helix, searching for signs of damage. When it finds damage, XPD stops and marks the DNA because the cell needs to fix it. This protein may be a solution for improving cancer treatments by helping researchers identify specific ways to use chemotherapy while decreasing risks and increasing patient survival. The KLF8 protein determines the possibility of tumor recurrence in breast and ovarian cancers by helping tumors regenerate, so stopping KLF8 could improve outcomes for many women with those cancers.

1. DNA REPAIR
Sara Castrillón Correa

2. FOLDING

3. FOLDING

4. The DNA repair mechanism has
an importan rol in mantein
fidelity of DNA, avoiding lessons
and mutations

5. SCANNER OF HEREDITARY DEFECTS
Science news
(January 24,2013)

6. XPD protein is involved in
transcription-couple
nucleotide excision repair

7. XPD protein can function like a scanner that
pass arround DNA doublé hélix, trying to find
signs of damage.when it does XPD stops and
mark DN,because the cell need to fix it

8. • DNA Repair affect the treatmet agains cancer,with
XPDand damage recognition , the treatments will
improve, especially with chemotherapy

9. OBSERVATION
XPD protein will be the solution in a long term for an
appropriate treatment in cáncer diseases,because
this protein will help the researchers to find a
specific way to use chemotherapy that will work
decreasing the actual risk that has this invasive
treatment and increase the survival of the patient.

10. DNA- REPAIRING PROTEIN MAY BE THE KEY TO PREVENTING RECURRENCE OF SOME
CANCERS
Science News
(January 28, 2013)

11. • Jihe Zhao found a protein present in
some cancer KLF8, that determined the
possibility of recurrence of the
tumor,because KLF8 help the tumor to
regenerate.

12. KLF8 is present in Breast and
Ovarian cancer

13. The test was with an specific treatment of
breast cancer( doxorrubicin) and the
result show that this protein increase cell
resistance

14. OBSERVATION
In pathologies like breast and ovarían cáncer the probality of
recurrence is hight, and the best oportunitty to change it is
try to stop the KLF8 as a part of regular therapy. That
therapy would help a lot of women to improve quality of life.

15. MEDICAL UTILITY

16. Locate DNA damage
CAUSES
Disease, UV light, radiation and metabolic
processes
Correct Treatment and diagnosis specific to ADN
damage

17. For us medical students
this approximation will
help us in a correct
diagnosis and therapy,
that reflected in our
patient.

18. REFERENCES
– MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín:
UPB. Fac. de Medicina, 2006. 208 p.
– FRIEDBERG,Errol; WALKER,Graham; SIEDE;Wolfram. DNA Repair and
mutagenesis. American Society for microbiology. 1995. 2-31 p.

19. CIBERGRAFIA
• http://www.sciencedaily.com/releases/2013/01/130124133952.htm. Science Daily: News &
Article in Science, Health,Enviroment & Technology. A Scanner for hereditary defects: New
possibilities in genetic damage recognition for improving cáncer treatment
•
• http://www.youtube.com/watch?feature=player_embedded&v=cOkWG85ReT4. Repairing
DNA: Our best defense against cáncer
•
• http://www.sciencedaily.com/releases/2013/01/130128104626.htm. Science Daily: News &
Article in Science, Health,Enviroment & Technology. DNA Repairing protein may be the key to
preventing recurrence of some cancers.