The document summarizes research on DNA repair mechanisms and their link to certain cancers. It discusses how mutations in BRCA1 and BRCA2 genes can increase risks of aggressive uterine cancer and metastatic prostate cancer by impairing homologous recombination DNA repair. Early detection of DNA repair mutations can help identify risk and allow preventative measures like hysterectomy or personalized therapies to reduce cancer development and improve patient outcomes.

1. DNA- REPAIR
VALERIA GUERRA ESPINOSA
MEDICINE STUDENT
2016

4. INTRODUCTION
 The human body has
several mechanisms
of gene repair, which
is beneficial in
avoiding multiple
mutations that can
occur in the cell
cycle, in spite of this,
the mechanisms may
fail and express
themselves as serious
diseases like
aggressive uterine
and metastic protaste
cancer
There are multiple
mechanisms to repair ADN,
in this case the sisteym which
is affected is the double
strand break repair by
homologous recombination

5. BRCA1 MUTATION LINKED
TO HIGHLY AGRESSIVE
UTERINE CANCER
JAMA ONCOLOGY
2016, JUNE 30.

6. BRCA1 AND BRCA2
INCREASE THE RISK TO
SUFFER UTERINE CANCER
TOO.
BRCA1 gene is located on
the long (q) arm of
chromosome 17 and The
BRCA2 gene is located on the
long (q) arm of chromosome
13

7. If BRCA1 or BRCA2 itself is
damaged by a BRCA
mutation , damaged DNA is
not repaired properly, and
this increases the risk for
aggressive uterine cancer,
the mechanism for repair is
called homologous
recombination and it can
even cause bloom
syndrome and fanconi
anemia.

8. ¿HYSTERECTOMY?
 To reduce this huge risk
for the patients who has the
BRCA1 or BRCA2 this kind of
surgery process could
reduces the appareance of
the disease.

9. STUDENT’S OBSERVATION
By having this knowledge and
reserach, it allows us to introduce
our patients to certain solutions, like
hysterectomy, that would decrease
the risk and prevent the ocurrence
of this type of cancer
It’s important for us
have the necessary
knowledge
to give our patient the best
treatment and the most
appropriate.
always with the purpose of
reducing the risk

10. HIGHER INCIDENCE OF
GERMLINE DNA REPAIR
MUTATIONS IN MEN WITH
METASTIC PROTASTE
CANCER.
THE NEW ENGLAND
JOURNAL OF MEDICINE
2016, AUGUST 4.

11. METASTATIC
PROSTATE CANCER
Cancer cells have the potential
to spread from the prostate to
other parts of the body where
they can grow into new tumours.
This process is called metastasis

12. DNA- REPAIR
GENES
The principal object of this
study was analize the frecuency
of DNA- repair wich are know to
be associated with cancer
predisposition.

13. PERSONALIZING
AND TARGET
THERAPY
this type of cancer treatment
that uses drugs or other
substances to more precisely
identify and attack cancer
cells

14. STUDENT’S OBSERVATION
The use of different customized
therapies that allows locating this
kind of mistakes may have a huge
impact. They will make more
visible all mutations and also
avoid it's development.
The most important is
that with this we find
another kind wich is
very beneficial for
them and usually
doing little damage
to normal cells

15. MEDICAL UTILITY

16. WE COULD IMPROVE
OUR PATIENTS LIVES
For both diseases, there are
many advanced ways to
reduce the risk.

17. Allows us to give
certain solutions
Through the hysterectomy in
uterine cancer and targetic
theraphy for those who has
metastatic protaste cancer .

18. With an early
detection we could
give hope to our
patients
An early detection for DNA- repair
mutation can also avoid the
development of the cancer

19. BIBLIOGRAPHY
-COLUMBIA UNIVERSITY MEDICAL CENTER (2016, JUNE 30). BRCA1 mutation
linked to highly agressive uterine cancer. JAMA oncology. Retrieve July 12, 2016 from
http://www.upi.com/Health_News/2016/07/12/BRCA1-mutation-linked-to-highly-
aggressive-uterine-cancer/2011468341308/
-NEW ENGLAND( 2016, AUGUST 4). Higher incidence of germline DNA-repair
mutations in men with metastatic prostate cancer. The New England journal of medicine.
Retrieve August 4, 2016 from
http://www.2minutemedicine.com/higher-incidence-dna-repair-mutations-in-men-with-
metastatic-prostate-cancer/
-MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de
Medicina, 2006. 208 p.

20. The best way to
find yourself is to
lose yourself in the
service of others.